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Disease on EC 2.8.2.8 - [heparan sulfate]-glucosamine N-sulfotransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Albuminuria
Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis.
Amyotrophic Lateral Sclerosis
NDST3 deacetylates ?-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
Anophthalmos
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.
Asthma
Endothelial and leukocyte heparan sulfates regulate the development of allergen-induced airway remodeling in a mouse model.
Ataxia
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Breast Neoplasms
Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer.
Carcinoma
Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
IDUA, NDST1, SAP30L, CRYBA4, and SI as novel prognostic signatures clear cell renal cell carcinoma.
MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803.
Carcinoma, Lewis Lung
Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Carcinoma, Renal Cell
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
IDUA, NDST1, SAP30L, CRYBA4, and SI as novel prognostic signatures clear cell renal cell carcinoma.
Colorectal Neoplasms
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.
Coronary Disease
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
Cranial Nerve Diseases
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Craniofacial Abnormalities
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Demyelinating Diseases
Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production.
Double Outlet Right Ventricle
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.
Embolic Stroke
Integrative Analysis Identified IRF6 and NDST1 as Potential Causal Genes for Ischemic Stroke.
Encephalitis, Japanese
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
Frontotemporal Dementia
NDST3 deacetylates ?-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
Glioblastoma
MiRNA-191 functions as an oncogene in primary glioblastoma by directly targeting NDST1.
Heart Septal Defects, Ventricular
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.
Hernias, Diaphragmatic, Congenital
Down-regulation of N-deacetylase-N-sulfotransferase-1 signaling in the developing diaphragmatic vasculature of nitrofen-induced congenital diaphragmatic hernia.
Holoprosencephaly
Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly.
Infections
Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
Intellectual Disability
NDST1 missense mutations in autosomal recessive intellectual disability.
Two Cases of Recessive Intellectual Disability Caused by NDST1 and METTL23 Variants.
Ischemic Stroke
Integrative Analysis Identified IRF6 and NDST1 as Potential Causal Genes for Ischemic Stroke.
Mastocytoma
3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction.
cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.
Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line.
Melanoma
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy.
Epac1 promotes melanoma metastasis via modification of heparan sulfate.
Mucopolysaccharidoses
NDST1 Preferred Promoter Confirmation and Identification of Corresponding Transcriptional Inhibitors as Substrate Reduction Agents for Multiple Mucopolysaccharidosis Disorders.
Neoplasm Metastasis
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
Neoplasms
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
Cell surface heparan sulfate promotes replication of Toxoplasma gondii.
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.
Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.
Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
Heparan sulfate proteoglycans mediate renal carcinoma metastasis.
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer.
NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer.
Transcriptional Activity of Heparan Sulfate Biosynthetic Machinery is Specifically Impaired in Benign Prostate Hyperplasia and Prostate Cancer.
Nephrosis
Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis.
Neurodegenerative Diseases
NDST3 deacetylates ?-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
Oligodendroglioma
Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.
Paralysis
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Perinatal Death
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.
Proteinuria
Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis.
Pulmonary Atelectasis
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.
Respiratory Distress Syndrome, Newborn
Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.
Respiratory Insufficiency
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Thrombosis
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Truncus Arteriosus, Persistent
Heparan sulfate expression in the neural crest is essential for mouse cardiogenesis.
Vascular System Injuries
Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling.
Yellow Fever
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection.
[heparan sulfate]-glucosamine n-sulfotransferase deficiency
A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.
Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.
Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.
Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to VEGF-C.
Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1.
Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.