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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
sulfotransferase, uridine diphosphoacetylgalactosamine 4-sulfate, uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase, uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase,
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sulfotransferase, uridine diphosphoacetylgalactosamine 4-sulfate
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uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase
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uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase
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3'-phosphoadenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + UDP-N-acetyl-D-galactosamine 4,6-bissulfate
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sulfate group transfer
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3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase
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3'-phosphoadenylylsulfate + chondroitin
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3'-phosphoadenylylsulfate + delta4,5-glucuronido-N-acetylgalactosamine 4-sulfate
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poor substrate
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3'-phosphoadenylylsulfate + dermatan
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incorporates sulfate exclusively at C4 position of N-acetylgalactosamine residues
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3'-phosphoadenylylsulfate + N-acetylgalactosamine 1-phosphate 4-sulfate
adenosine 3',5'-bisphosphate + N-acetylgalactosamine 1,6-bissulfate
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3'-phosphoadenylylsulfate + N-acetylgalactosamine 4-sulfate
adenosine 3',5'-bisphosphate + N-acetylgalactosamine 4,6-bissulfate
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3'-phosphoadenylylsulfate + UDP-N-acetylgalactosamine 4-sulfate
adenosine 3',5'-bisphosphate + UDP-N-acetylgalactosamine-4,6-bissulfate
additional information
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3'-phosphoadenylylsulfate + chondroitin
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poor substrate
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3'-phosphoadenylylsulfate + chondroitin
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incorporates sulfate at C4 and C6 position of N-acetylgalactosamine residues
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3'-phosphoadenylylsulfate + UDP-N-acetylgalactosamine 4-sulfate
adenosine 3',5'-bisphosphate + UDP-N-acetylgalactosamine-4,6-bissulfate
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3'-phosphoadenylylsulfate + UDP-N-acetylgalactosamine 4-sulfate
adenosine 3',5'-bisphosphate + UDP-N-acetylgalactosamine-4,6-bissulfate
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component of microsomal multienzyme system involved in UDP-N-acetylgalactosamine 6-sulfate biosynthesis
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3'-phosphoadenylylsulfate + UDP-N-acetylgalactosamine 4-sulfate
adenosine 3',5'-bisphosphate + UDP-N-acetylgalactosamine-4,6-bissulfate
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i.e. 3'-phosphoadenosine 5'-phosphosulfate or PAPS, catalyses the transfer of sulfate to position 6 of N-acetylgalactosamine moiety of UDP-N-acetylgalactosamine sulfate
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additional information
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no substrates are N-acetylgalactosamine, UDP-N-galactosamine, chondrosin, delta4,5-glucuronido-N-acetylgalactosamine, N-acetylgalactosamine 6-sulfate, delta4,5-glucuronido-N-acetylgalactosamine 6-sulfate, chondroitin sulfate A, B or C, oversulfated chondroitin sulfate from shark cartilage, hyaluronic acid, kerato sulfate or heparin
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additional information
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biosynthesis of dermatan sulfate
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3'-phosphoadenylylsulfate + UDP-N-acetylgalactosamine 4-sulfate
adenosine 3',5'-bisphosphate + UDP-N-acetylgalactosamine-4,6-bissulfate
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component of microsomal multienzyme system involved in UDP-N-acetylgalactosamine 6-sulfate biosynthesis
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additional information
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biosynthesis of dermatan sulfate
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Ca2+
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enzyme is stimulated at concentrations of 5-20 mM
Mg2+
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enzyme is stimulated at concentrations of 5-20 mM
Mn2+
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enzyme is stimulated at concentrations of 5-20 mM
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1.56 - 4.22
chondroitin
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pH 6, 37°C, Km value depends on number of disaccharides of the receptor
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DELTA4,5-glucuronido-N-acetylgalactosamine 4-sulfate
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pH 4.8, 38°C
0.27 - 0.61
dermatan
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pH 6, 37°C, Km value depends on number of disaccharides of the receptor
0.13
N-acetylgalactosamine 1-phosphate 4-sulfate
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pH 4.8, 38°C
1.4
N-acetylgalactosamine 4-sulfate
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pH 4.8, 38°C
0.05
UDP-N-acetylgalactosamine 4-sulfate
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pH 4.8, 38°C
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5 - 8
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30% activity at pH 5, 15% activity at pH 8
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37
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assay at
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Quail
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brenda
White Leghorn hen
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brenda
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brenda
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brenda
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brenda
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magnum, i.e. albumen-secreting region, predominantly in tubular glands
brenda
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distribution in magnum
brenda
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predominantly in tubular glands and isthmus
brenda
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distribution in magnum
brenda
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predominantly
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brenda
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brenda
additional information
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subcellular distribution
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brenda
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partial
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Harada, T.; Shimizu, S.; Nakanishi, Y.; Suzuki, S.
Enzymatic transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate to uridine diphosphate N-acetylgalactosamine 4-sulfate
J. Biol. Chem.
242
2288-2294
1967
Gallus gallus
brenda
Otsu, K.; Inoue, H.; Nakanishi, Y.; Kato, S.; Tsuji, M.; Suzuki, S.
A sulfotransferase-sulfatase system in avian oviduct which catalyzes a conversion of UDP-N-acetylgalactosamine 4-sulfate to the 6-sulfate isomer
J. Biol. Chem.
259
6403-6410
1984
Coturnix coturnix
brenda
Eklund, E.; Roden, L.; Malmstrom, M.; Malmstrom, A.
Dermatan is a better substrate for 4-O-sulfation than chondroitin: Implications in the generation of 4-O-sulfated, L-iduronate-rich galactosaminoglycans
Arch. Biochem. Biophys.
383
171-177
2000
Homo sapiens
brenda
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2.8.2.7 UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
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