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Information on EC 2.8.2.35 - dermatan 4-sulfotransferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.35 dermatan 4-sulfotransferase
IUBMB Comments
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
chst14, d4st-1, dermatan 4-o-sulfotransferase-1, chst14/d4st1, d4st1, dermatan 4-o-sulfotransferase 1, dermatan 4-o-sulfotransferase, n-acetylgalactosamine 4-o-sulfotransferase 1, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
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