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3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5-beta-cholestane-27-yl
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-yl sulfate
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
3'-phosphoadenosine 5'-phosphosulfate + 5alpha-cyprinol
adenosine 3',5'-diphosphate + 5alpha-cyprinol sulfate
3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol
adenosine 3',5'-diphosphate + 5beta-scymnol sulfate
3'-phosphoadenosine 5'-phosphosulfate + testosterone
adenosine 3',5'-diphosphate + testosterone sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
3'-phosphoadenylyl sulfate + 5beta-cyprinol
adenosine 3',5'-bisphosphate + 5beta-cyprinol sulfate
additional information
?
-
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
-
trivial name 5beta-scymnol
trivial name bbeta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
Trygonoptera sp.
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate, trivial name beta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5alpha-cyprinol
adenosine 3',5'-diphosphate + 5alpha-cyprinol sulfate
-
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5alpha-cyprinol
adenosine 3',5'-diphosphate + 5alpha-cyprinol sulfate
-
150% of activity with 5beta-scymnol
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5alpha-cyprinol
adenosine 3',5'-diphosphate + 5alpha-cyprinol sulfate
-
62% of activity with 5beta-scymnol
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5alpha-cyprinol
adenosine 3',5'-diphosphate + 5alpha-cyprinol sulfate
Trygonoptera sp.
-
250% of activity with 5beta-scymnol
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5alpha-cyprinol
adenosine 3',5'-diphosphate + 5alpha-cyprinol sulfate
-
174% of activity with 5beta-scymnol
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol
adenosine 3',5'-diphosphate + 5beta-scymnol sulfate
-
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol
adenosine 3',5'-diphosphate + 5beta-scymnol sulfate
-
sulfation occurs at either the C-26 or C-27 position
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
3alpha,7alpha,12alpha,26,27-pentahydroxy-5alpha-cholestane
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
3alpha,7alpha,12alpha,26,27-pentahydroxy-5alpha-cholestane
-
-
?
3'-phosphoadenylyl sulfate + 5beta-cyprinol
adenosine 3',5'-bisphosphate + 5beta-cyprinol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5beta-cyprinol
adenosine 3',5'-bisphosphate + 5beta-cyprinol sulfate
-
-
-
?
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. The sulfation of both of 5alpha-cyprinol and 5beta-cyprinol by zebrafish Sult2st2 and Sult2st3 can be fitted to substrate inhibition kinetics. No activity with 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholestanoic acid (5alpha-TriOH CA), dehydroepiandrosterone (DHEA) is a poor substrate
-
-
-
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. The sulfation of both of 5alpha-cyprinol and 5beta-cyprinol by zebrafish Sult2st2 and Sult2st3 can be fitted to substrate inhibition kinetics. No activity with 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholestanoic acid (5alpha-TriOH CA), dehydroepiandrosterone (DHEA) is a poor substrate
-
-
-
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. The sulfation of both of 5alpha-cyprinol and 5beta-cyprinol by zebrafish Sult2st2 and Sult2st3 can be fitted to substrate inhibition kinetics. No activity with 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholestanoic acid (5alpha-TriOH CA), dehydroepiandrosterone (DHEA) is a poor substrate
-
-
-
additional information
?
-
-
NMR and mass spectrometry analysis of the reaction products. The sulfation of both of 5alpha-cyprinol and 5beta-cyprinol by zebrafish Sult2st2 and Sult2st3 can be fitted to substrate inhibition kinetics. No activity with 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholestanoic acid (5alpha-TriOH CA), dehydroepiandrosterone (DHEA) is a poor substrate
-
-
-
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. Zebrafish Sult3st4 shows substrate inhibition kinetics for 5alpha-cyprinol and Michaelis-Menten kinetics for beta-cyprinol. High activity with dehydroepiandrosterone (DHEA), cf. EC 2.8.2.2
-
-
-
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. Zebrafish Sult3st4 shows substrate inhibition kinetics for 5alpha-cyprinol and Michaelis-Menten kinetics for beta-cyprinol. High activity with dehydroepiandrosterone (DHEA), cf. EC 2.8.2.2
-
-
-
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. Zebrafish Sult3st4 shows substrate inhibition kinetics for 5alpha-cyprinol and Michaelis-Menten kinetics for beta-cyprinol. High activity with dehydroepiandrosterone (DHEA), cf. EC 2.8.2.2
-
-
-
additional information
?
-
-
NMR and mass spectrometry analysis of the reaction products. Zebrafish Sult3st4 shows substrate inhibition kinetics for 5alpha-cyprinol and Michaelis-Menten kinetics for beta-cyprinol. High activity with dehydroepiandrosterone (DHEA), cf. EC 2.8.2.2
-
-
-
additional information
?
-
NMR and mass spectrometry analysis of the reaction products. Human SULT2A1 shows substrate inhibition kinetics for 5alpha-cyprinol and Michaelis-Menten kinetics for beta-cyprinol. High activity with dehydroepiandrosterone (DHEA), cf. EC 2.8.2.2
-
-
-
additional information
?
-
-
NMR and mass spectrometry analysis of the reaction products. Human SULT2A1 shows substrate inhibition kinetics for 5alpha-cyprinol and Michaelis-Menten kinetics for beta-cyprinol. High activity with dehydroepiandrosterone (DHEA), cf. EC 2.8.2.2
-
-
-
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3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol
adenosine 3',5'-diphosphate + 5beta-scymnol sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
3'-phosphoadenylyl sulfate + 5beta-cyprinol
adenosine 3',5'-bisphosphate + 5beta-cyprinol sulfate
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
Trygonoptera sp.
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate
-
?
3'-phosphoadenosine 5'-phosphosulfate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
adenosine 3',5'-diphosphate + (24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-sulfate
-
trivial name 5beta-scymnol
trivial name 5beta-scymnol sulfate
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5alpha-cyprinol
adenosine 3',5'-bisphosphate + 5alpha-cyprinol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5beta-cyprinol
adenosine 3',5'-bisphosphate + 5beta-cyprinol sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5beta-cyprinol
adenosine 3',5'-bisphosphate + 5beta-cyprinol sulfate
-
-
-
?
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0.018
(24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5-beta-cholestane-27-ol
Trygonoptera sp.
-
-
0.003 - 0.013
(24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
0.0044
3'-phosphoadenosine 5'-phosphosulfate
-
room temperature, pH 6.5
0.004
3'-phosphoadenosine-5'-phosphosulfate
-
pH 6.5
0.014
5beta-scymnol
-
pH 6.5
additional information
additional information
-
0.003
(24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
-
room temperature, pH 6.5
0.0038
(24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
-
25°C
0.0059
(24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
-
-
0.013
(24R)-3alpha,7alpha,12alpha,24,26-pentahydroxy-5beta-cholestane-27-ol
-
25°C
additional information
additional information
Michaelis-Menten kinetics, kinetic analysis
-
additional information
additional information
Michaelis-Menten kinetics, kinetic analysis
-
additional information
additional information
Michaelis-Menten kinetics, kinetic analysis
-
additional information
additional information
-
Michaelis-Menten kinetics, kinetic analysis
-
additional information
additional information
Michaelis-Menten kinetics for beta-cyprinol, kinetic analysis
-
additional information
additional information
-
Michaelis-Menten kinetics for beta-cyprinol, kinetic analysis
-
additional information
additional information
Michaelis-Menten kinetics for beta-cyprinol, kinetic analysis
-
additional information
additional information
Michaelis-Menten kinetics for beta-cyprinol, kinetic analysis
-
additional information
additional information
Michaelis-Menten kinetics for beta-cyprinol, kinetic analysis
-
additional information
additional information
-
Michaelis-Menten kinetics for beta-cyprinol, kinetic analysis
-
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Pettigrew, N.E.; Wright, P.F.A.; Macrides, T.A.
Investigation of 5beta-scymnol sulfotransferases from the kidney and testis of Heterodontus portusjacksoni
Comp. Biochem. Physiol. B
121B
243-249
1998
Heterodontus portusjacksoni
-
brenda
Pettigrew, N.E.; Wright, P.F.A.; Macrides, T.A.
5beta-Scymnol sulfotransferase isolated from the tissues of an Australian shark species
Comp. Biochem. Physiol. B
121B
299-307
1998
Heterodontus portusjacksoni
-
brenda
Pettigrew, N.E.; Wright, P.F.A.; Macrides, T.A.
5beta-Scymnol sulfotransferases from the liver of two Australian ray species
Comp. Biochem. Physiol. B
121B
341-348
1998
Trygonorrhina fasciata, Trygonoptera sp.
-
brenda
Macrides, T.A.; Faktor, D.A.; Kalafatis, N.; Amiet, R.G.
Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5 beta-scymnol
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
107
461-469
1994
Heterodontus portusjacksoni
brenda
Kurogi, K.; Yoshihama, M.; Horton, A.; Schiefer, I.; Krasowski, M.; Hagey, L.; Williams, F.; Sakakibara, Y.; Kenmochi, N.; Suiko, M.; Liu, M.
Identification and characterization of 5alpha-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio)
J. Steroid Biochem. Mol. Biol.
174
120-127
2017
Danio rerio (A0A0R4IT32), Danio rerio (A4FUP0), Danio rerio (Q1L874), Danio rerio, Homo sapiens (Q06520), Homo sapiens
brenda