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Information on EC 2.8.2.3 - amine sulfotransferase and Organism(s) Oryctolagus cuniculus and UniProt Accession O46640

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.3 amine sulfotransferase
IUBMB Comments
A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine.
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This record set is specific for:
Oryctolagus cuniculus
UNIPROT: O46640
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Word Map
The taxonomic range for the selected organisms is: Oryctolagus cuniculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
sult3a1, amine n-sulfotransferase, sult3a2, amine sulfotransferase, arylamine sulfotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amine N-sulfotransferase
-
-
-
-
arylamine sulfotransferase
-
-
-
-
phenol sulfotransferase
-
-
-
-
sulfotransferase, aryl amine
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:amine N-sulfotransferase
A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-08-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylsulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 4-chloroaniline
adenosine 3',5'-bisphosphate + N-sulfo-4-chloroaniline
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 4-phenyl-1,2,3,6-tetrahydropyridine
adenosine 3',5'-bisphosphate + 4-phenyl-1,2,3,6-tetrahydropyridine N-sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + aniline
adenosine 3',5'-bisphosphate + N-sulfoaniline
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + desipramine
adenosine 3',5'-bisphosphate + N-sulfo-desipramine
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylsulfamate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylsulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + aniline
adenosine 3',5'-bisphosphate + N-sulfoaniline
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylsulfamate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
activity is dependent on the presence of unprotonated amino groups
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.149
3'-phosphoadenylylsulfate
pH 7.4, 37°C
0.03
3'-phosphoadenylylsulfate
-
with 2-naphthylamine as second substrate, pH 8, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
rabbit
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ST3A1_RABIT
301
0
35943
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35880
calculated from nucleotide sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ramaswamy, S.G.; Jakoby, W.B.
Amine N-sulfotransferase
J. Biol. Chem.
262
10039-10043
1987
Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Roy, A.B.
The enzymic synthesis of aryl sulphamates
Biochim. Biophys. Acta
30
193
1958
Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Yoshinari, K.; Nagata, K.; Ogino, M.; Fujita, K.; Shiraga, T.; Iwasaki, K.; Hata, T.; Yamazoe, Y.
Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammals
J. Biochem.
123
479-486
1998
Oryctolagus cuniculus (O46640), Oryctolagus cuniculus
Manually annotated by BRENDA team