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Information on EC 2.8.2.3 - amine sulfotransferase and Organism(s) Mus musculus and UniProt Accession O35403

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.3 amine sulfotransferase
IUBMB Comments
A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine.
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This record set is specific for:
Mus musculus
UNIPROT: O35403
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
sult3a1, amine n-sulfotransferase, sult3a2, amine sulfotransferase, arylamine sulfotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amine N-sulfotransferase
-
amine N-sulfotransferase
arylamine sulfotransferase
-
-
-
-
cytosolic sulfotransferase
-
-
phenol sulfotransferase
-
-
-
-
sulfotransferase, aryl amine
-
-
-
-
SULT3A1
-
isoform
SULT3A2
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:amine N-sulfotransferase
A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-08-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1,8-naphthalenediamine
adenosine 3',5'-bisphosphate + 1,8-naphthalenediamine sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthylamine
adenosine 3',5'-bisphosphate + 1-naphthylsulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 4-chloroaniline
adenosine 3',5'-bisphosphate + (4-chlorophenyl)sulfamic acid
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + an amine
adenosine 3',5'-bisphosphate + a sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + aniline
adenosine 3',5'-bisphosphate + anilinesulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenylsulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 1,8-naphthalenediamine
adenosine 3',5'-bisphosphate + 1,8-naphthalenediamine sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 1-naphthylamine
adenosine 3',5'-bisphosphate + 1-naphthylsulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-chloroaniline
adenosine 3',5'-bisphosphate + (4-chlorophenyl)sulfamic acid
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + an amine
adenosine 3',5'-bisphosphate + a sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + aniline
adenosine 3',5'-bisphosphate + anilinesulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenylsulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + an amine
adenosine 3',5'-bisphosphate + a sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + an amine
adenosine 3',5'-bisphosphate + a sulfamate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,7-dichlorokynurenic acid
-
-
gavestinel
-
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Kynurenic acid
-
-
L689,560
-
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
-
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mefenamic acid
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0157
1-naphthol
SULT3A1
0.2331
1-Naphthylamine
SULT3A1
0.154
1-naphthol
SULT3A2
0.3026
1-Naphthylamine
SULT3A2
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.75
SULT3A1, 1-naphthylamine
8.75
SULT3A2, 1-naphthylamine
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ST3A1_MOUSE
293
0
35181
Swiss-Prot
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37000
SULT3A1, SDS-PAGE
35000
SULT3A2, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA agarose column chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of in Escherichia coli BL21
expressed in Escherichia coli BL21(DE3) cells
-
expression of in Escherichia coli BL21
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takahashi, S.; Sakakibara, Y.; Mishiro, E.; Kouriki, H.; Nobe, R.; Kurogi, K.; Yasuda, S.; Liu, M.C.; Suiko, M.
Molecular cloning, expression, and characterization of mouse amine N-sulfotransferases
Biochem. Biophys. Res. Commun.
375
531-535
2008
Mus musculus, Mus musculus (O35403)
Manually annotated by BRENDA team
Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases
Biochem. J.
422
455-462
2009
Mus musculus
Manually annotated by BRENDA team