Reference on EC 2.8.2.20 - protein-tyrosine sulfotransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, R.W.H.; Huttner, W.B.
Tyrosine-O-sulfated proteins of PC12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase
J. Biol. Chem.
258
11326-11334
1983
Rattus norvegicus
Vargas, F.; Schwartz, J.C.
Apparent identity of cerebral tyrosylsulfotransferase activities using either a cholecystokinin derivative or an acidic amino acid polymer as substrate
FEBS Lett.
211
234-238
1987
Rattus norvegicus
Rens-Domiano, S.; Roth, J.A.
Characterization of tyrosylprotein sulfotransferase from rat liver and other tissues
J. Biol. Chem.
264
899-905
1989
Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
Lin, W.; Larsen, K.; Hortin, G.L.; Roth, J.A.
Recognition of substrates by tyrosylprotein sulfotransferase. Determination of affinity by acidic amino acids near the target sites
J. Biol. Chem.
267
2876-2879
1992
Rattus norvegicus
Kasinathan, C.; Sundaram, P.; Slomiany, B.L.; Slomiany, A.
Inhibition of tyrosylprotein sulfotransferase by sphingosine and its reversal by acidic phospholipids
Biochemistry
32
1194-1198
1993
Rattus norvegicus
Niehrs, C.; Huttner, W.B.
Purification and characterization of tyrosylprotein sulfotransferase
EMBO J.
9
35-42
1990
Bos taurus
Niehrs, C.; Huttner, W.B.; Carvallo, D.; Degryse, E.
Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferases
J. Biol. Chem.
265
9314-9318
1990
Bos taurus, Hirudo medicinalis
Niehrs, C.; Kraft, M.; Lee, R.W.H.; Huttner, W.B.
Analysis of the substrate specificity of tyrosylprotein sulfotransferase using synthetic peptides
J. Biol. Chem.
265
8525-8532
1990
Bos taurus
Suiko, M.; Fernando, P.H.P.; Sakakibara, Y.; Nakajima, H.; Liu, M.C.; Abe, S.; Nakatsu, S.
Post-translational modification of protein by tyrosine sulfation: active sulfate PAPS is the essential substrate for this modification
Nucleic Acids Symp. Ser.
27
183-184
1992
Bos taurus
Kasinathan, C.; Sundaram, P.; Slomiany, B.L.; Slomiany, A.
Identification of tyrosylprotein sulfotransferase in rat gastric mucosa
Enzyme
46
179-187
1993
Rattus norvegicus
Niehrs, C.; Stinchcombe, J.C.; Huttner, W.B.
Two membrane-bound forms of tyrosylprotein sulfotransferase as revealed by phase partitioning in Triton X-114
Eur. J. Cell Biol.
58
35-43
1992
Bos taurus, Rattus norvegicus
Sundaram, P.; Slomiany, A.; Slomiany, B.L.; Kasinathan, C.
Tyrosylprotein sulfotransferase in rat submandibular salivary glands
Int. J. Biochem.
24
663-667
1992
Rattus norvegicus
Lin, W.H.; Roth, J.A.
Characterization of a tyrosylprotein sulfotransferase in human liver
Biochem. Pharmacol.
40
629-635
1990
Homo sapiens
Rens-Domiano, S.; Hortin, G.L.; Roth, J.A.
Sulfation of tert-butoxycarbonylcholecystokinin and other peptides by rat liver tyrosylprotein sulfotransferase
Mol. Pharmacol.
36
647-653
1989
Rattus norvegicus
Goettsch, S.; Goettsch, W.; Morawietz, H.; Bayer, P.
Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells
Biochem. Biophys. Res. Commun.
294
541-546
2002
Homo sapiens
Hanai, H.; Nakayama, D.; Yang, H.; Matsubayashi, Y.; Hirota, Y.; Sakagami, Y.
Existence of a plant tyrosylprotein sulfotransferase: novel plant enzyme catalyzing tyrosine O-sulfation of preprophytosulfokine variants in vitro
FEBS Lett.
470
97-101
2000
Asparagus officinalis, Daucus carota, Solanum lycopersicum, Nicotiana tabacum, Oryza sativa
Kasinathan, C.; Ramaprasad, P.; William, S.; Espina, N.
Stimulation of tyrosylprotein sulfotransferase activity by ethanol: role of increased enzyme level
Alcohol
15
271-276
1998
Rattus norvegicus
Kasinathan, C.; Rizwan, M.; Slomiany, A.; Slomiany, B.L.
Effect of sofalcone on tyrosylprotein sulfotransferase
Gen. Pharmacol.
25
1017-1020
1994
Rattus norvegicus
Kasinathan, C.; Sundaram, R.; William, S.
Effect of prostaglandins on tyrosylprotein sulfotransferase activity in rat submandibular salivary glands
Gen. Pharmacol.
26
577-580
1995
Rattus norvegicus
Lin, W.H.; Marcucci, K.; Roth, J.A.
Effect of manganese on tyrosylprotein sulfotransferase activity in PC12 cells
Biochem. Pharmacol.
47
1575-1580
1994
Rattus norvegicus
Moore, K.L.
The biology and enzymology of protein tyrosine O-sulfation
J. Biol. Chem.
278
24243-24246
2003
Homo sapiens, Mammalia, no activity in yeast, no activity in prokaryotes, Drosophila melanogaster (Q9VYB7)
Ouyang, Y.; Lane, W.S.; Moore, K.L.
Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins
Proc. Natl. Acad. Sci. USA
95
2896-2901
1998
Homo sapiens (O60507), Homo sapiens, Mus musculus (O70281), Mus musculus, Rattus norvegicus
Ramaprasad, P.; Kasinathan, C.
In vivo induction of tyrosylprotein sulfotransferase by ethanol: role of increased enzyme synthesis
Alcohol. Clin. Exp. Res.
22
1120-1124
1998
Rattus norvegicus
Ramaprasad, P.; Kasinathan, C.
Isolation of tyrosylprotein sulfotransferase from rat liver
Gen. Pharmacol.
30
555-559
1998
Rattus norvegicus
Seibert, C.; Cadene, M.; Sanfiz, A.; Chait, B.T.; Sakmar, T.P.
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence
Proc. Natl. Acad. Sci. USA
99
11031-11036
2002
Homo sapiens
William, S.; Ramaprasad, P.; Kasinathan, C.
Purification of tyrosylprotein sulfotransferase from rat submandibular salivary glands
Arch. Biochem. Biophys.
338
90-96
1997
Rattus norvegicus
Mishiro, E.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
Zebrafish tyrosylprotein sulfotransferase: molecular cloning, expression, and functional characterization
Biochem. Cell Biol.
82
295-303
2004
Danio rerio (Q6WZB4), Danio rerio
Kim, T.H.; Hwang, S.B.; Jeong, P.Y.; Lee, J.; Cho, J.W.
Requirement of tyrosylprotein sulfotransferase-A for proper cuticle formation in the nematode C. elegans
FEBS Lett.
579
53-58
2005
Caenorhabditis elegans
Kasinathan, C.; Ramaprasad, P.; Sundaram, P.
Identification and characterization of tyrosylprotein sulfotransferase from human saliva
Int. J. Biol. Sci.
1
141-145
2005
Homo sapiens
Mishiro, E.; Sakakibara, Y.; Liu, M.; Suiko, M.
Differential enzymatic characteristics and tissue-specific expression of human TPST-1 and TPST-2
J. Biochem.
140
731-737
2006
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
Hoffhines, A.J.; Damoc, E.; Bridges, K.G.; Leary, J.A.; Moore, K.L.
Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody
J. Biol. Chem.
281
37877-37887
2006
Mus musculus
Borghei, A.; Ouyang, Y.B.; Westmuckett, A.D.; Marcello, M.R.; Landel, C.P.; Evans, J.P.; Moore, K.L.
Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility
J. Biol. Chem.
281
9423-9431
2006
Mus musculus
Goettsch, S.; Badea, R.A.; Mueller, J.W.; Wotzlaw, C.; Schoelermann, B.; Schulz, L.; Rabiller, M.; Bayer, P.; Hartmann-Fatu, C.
Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment
J. Mol. Biol.
361
436-449
2006
Homo sapiens
Sasaki, N.; Hosoda, Y.; Nagata, A.; Ding, M.; Cheng, J.M.; Miyamoto, T.; Okano, S.; Asano, A.; Miyoshi, I.; Agui, T.
A mutation in Tpst2 encoding tyrosylprotein sulfotransferase causes dwarfism associated with hypothyroidism
Mol. Endocrinol.
21
1713-1721
2007
Mus musculus
Kasinathan, C.; Jean, S.; Manowitz, P.
Tyrosine sulfation of arylsulfatase A and its peptide
Protein Pept. Lett.
13
357-361
2006
Homo sapiens
Seibert, C.; Veldkamp, C.T.; Peterson, F.C.; Chait, B.T.; Volkman, B.F.; Sakmar, T.P.
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases
Biochemistry
47
11251-11262
2008
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
Nishimura, M.; Naito, S.
Tissue-specific mRNA expression profiles of human carbohydrate sulfotransferase and tyrosylprotein sulfotransferase
Biol. Pharm. Bull.
30
821-825
2007
Homo sapiens, Homo sapiens (O60507)
Kasinathan, C.; Gandhi, N.; Ramaprasad, P.; Sundaram, P.; Ramasubbu, N.
Tyrosine sulfation of statherin
Int. J. Biol. Sci.
3
237-241
2007
Homo sapiens
Danan, L.M.; Yu, Z.; Hoffhines, A.J.; Moore, K.L.; Leary, J.A.
Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2
J. Am. Soc. Mass Spectrom.
19
1459-1466
2008
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
Yu, Y.; Hoffhines, A.J.; Moore, K.L.; Leary, J.A.
Determination of the sites of tyrosine O-sulfation in peptides and proteins
Nat. Methods
4
583-588
2007
Homo sapiens (O60507), Homo sapiens (O60704)
Ronai, Z.; Witt, H.; Rickards, O.; Destro-Bisol, G.; Bradbury, A.R.; Sahin-Toth, M.
A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2)
Biochem. J.
418
155-161
2009
Homo sapiens (O60704), Homo sapiens
Jen, C.H.; Moore, K.L.; Leary, J.A.
Pattern and temporal sequence of sulfation of CCR5 N-terminal peptides by tyrosylprotein sulfotransferase-2: an assessment of the effects of N-terminal residues
Biochemistry
48
5332-5338
2009
Homo sapiens
Mhidia, R.; Vallin, A.; Ollivier, N.; Blanpain, A.; Shi, G.; Christiano, R.; Johannes, L.; Melnyk, O.
Synthesis of peptide-protein conjugates using N-succinimidyl carbamate chemistry
Bioconjug. Chem.
21
219-228
2010
Homo sapiens
Kanan, Y.; Hoffhines, A.; Rauhauser, A.; Murray, A.; Al-Ubaidi, M.R.
Protein tyrosine-O-sulfation in the retina
Exp. Eye Res.
89
559-567
2009
Homo sapiens, Mus musculus
Westmuckett, A.D.; Hoffhines, A.J.; Borghei, A.; Moore, K.L.
Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency
Gen. Comp. Endocrinol.
156
145-153
2008
Mus musculus
Hoffhines, A.J.; Jen, C.H.; Leary, J.A.; Moore, K.L.
Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo
J. Biol. Chem.
284
3096-3105
2009
Mus musculus
Hosoda, Y.; Sasaki, N.; Agui, T.
Female infertility in grt mice is caused by thyroid hormone deficiency, not by insufficient TPST2 activity in the reproductive organs
J. Vet. Med. Sci.
70
1043-1049
2008
Mus musculus
Stone, M.J.; Chuang, S.; Hou, X.; Shoham, M.; Zhu, J.Z.
Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins
N. Biotechnol.
25
299-317
2009
Bos taurus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Chen, B.H.; Wang, C.C.; Lu, L.Y.; Hung, K.S.; Yang, Y.S.
Fluorescence assay for protein post-translational tyrosine sulfation
Anal. Bioanal. Chem.
405
1425-1429
2013
Drosophila melanogaster
Lu, L.; Chen, B.; Wu, J.; Wang, C.; Chen, D.; Yang, Y.
Implantation of post-translational tyrosylprotein sulfation into a prokaryotic expression system
ChemBioChem
12
377-379
2011
Homo sapiens
Danan, L.M.; Yu, Z.; Ludden, P.J.; Jia, W.; Moore, K.L.; Leary, J.A.
Catalytic mechanism of Golgi-resident human tyrosylprotein sulfotransferase-2: a mass spectrometry approach
J. Am. Soc. Mass Spectrom.
21
1633-1642
2010
Homo sapiens
Kim, T.H.; Kim, D.H.; Nam, H.W.; Park, S.Y.; Shim, J.; Cho, J.W.
Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans
Mol. Cells
29
413-418
2010
Caenorhabditis elegans, Caenorhabditis elegans N2
Teramoto, T.; Fujikawa, Y.; Kawaguchi, Y.; Kurogi, K.; Soejima, M.; Adachi, R.; Nakanishi, Y.; Mishiro-Sato, E.; Liu, M.C.; Sakakibara, Y.; Suiko, M.; Kimura, M.; Kakuta, Y.
Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction
Nat. Commun.
4
1572
2013
Homo sapiens (O60704), Homo sapiens
Zhou, W.; Wei, L.; Xu, J.; Zhai, Q.; Jiang, H.; Chen, R.; Chen, Q.; Sun, J.; Chu, J.; Zhu, L.; Liu, C.M.; Li, C.
Arabidopsis Tyrosylprotein sulfotransferase acts in the auxin/PLETHORA pathway in regulating postembryonic maintenance of the root stem cell niche
Plant Cell
22
3692-3709
2010
Arabidopsis thaliana
Zhou, W.; Duckworth, B.P.; Geraghty, R.J.
Fluorescent peptide sensors for tyrosylprotein sulfotransferase activity
Anal. Biochem.
461
1-6
2014
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
Marforio, T.D.; Giacinto, P.; Bottoni, A.; Calvaresi, M.
Computational evidence for the catalytic mechanism of tyrosylprotein sulfotransferases: a density functional theory investigation
Biochemistry
54
4404-4410
2015
Homo sapiens (O60704), Homo sapiens
Nedumpully-Govindan, P.; Li, L.; Alexov, E.G.; Blenner, M.A.; Ding, F.
Structural and energetic determinants of tyrosylprotein sulfotransferase sulfation specificity
Bioinformatics
30
2302-2309
2014
Homo sapiens (O60507), Homo sapiens (O60704)
Hartmann-Fatu, C.; Bayer, P.
Determinants of tyrosylprotein sulfation coding and substrate specificity of tyrosylprotein sulfotransferases in metazoans
Chem. Biol. Interact.
259
17-22
2016
Homo sapiens (O60507), Homo sapiens (O60704)
Hartmann-Fatu, C.; Trusch, F.; Moll, C.N.; Michin, I.; Hassinen, A.; Kellokumpu, S.; Bayer, P.
Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus
J. Mol. Biol.
427
1404-1412
2015
Homo sapiens
Jiang, Z.; Zhu, J.; Ma, Y.; Hong, C.; Xiao, S.; Jin, L.
Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c-Met and lymph node metastasis in human lung cancer
Mol. Med. Rep.
12
5217-5222
2015
Homo sapiens (O60507), Homo sapiens
Singh, W.; Karabencheva-Christova, T.; Black, G.; Sparagano, O.; Christov, C.
Conformational flexibility influences structure-function relationships in tyrosyl protein sulfotransferase-2
RSC Adv.
6
11344-11352
2016
Homo sapiens (O60704)
-
Singh, W.; Karabencheva-Christova, T.; Sparagano, O.; Black, G.; Petrov, P.; Christov, C.
Dimerization and ligand binding in tyrosylprotein sulfotransferase-2 are influenced by molecular motions
RSC Adv.
6
18542-18548
2016
Homo sapiens (O60704)
-
Wang, C.C.; Chen, B.H.; Lu, L.Y.; Hung, K.S.; Yang, Y.S.
Preparation of tyrosylprotein sulfotransferases for in vitro one-pot enzymatic synthesis of sulfated proteins/peptides
ACS Omega
3
11633-11642
2018
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens, Drosophila melanogaster (Q9VYB7), Drosophila melanogaster
Huang, B.Y.; Chen, P.C.; Chen, B.H.; Wang, C.C.; Liu, H.F.; Chen, Y.Z.; Chen, C.S.; Yang, Y.S.
High-throughput screening of sulfated proteins by using a genome-wide proteome microarray and protein tyrosine sulfation system
Anal. Chem.
89
3278-3284
2017
Drosophila melanogaster (Q9VYB7)
Zhou, W.; Wang, Y.; Xie, J.; Geraghty, R.J.
A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity
Biochem. Biophys. Res. Commun.
482
1207-1212
2017
Homo sapiens (O60507), Homo sapiens (O60704)
Byrne, D.P.; Li, Y.; Ngamlert, P.; Ramakrishnan, K.; Eyers, C.E.; Wells, C.; Drewry, D.H.; Zuercher, W.J.; Berry, N.G.; Fernig, D.G.; Eyers, P.A.
New tools for evaluating protein tyrosine sulfation tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
Biochem. J.
475
2435-2455
2018
Homo sapiens (O60507), Homo sapiens (O60704)
Yeoh, S.; Bayliss, R.
New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation
Biochem. J.
475
3035-3037
2018
Homo sapiens (O60507)
Seibert, C.; Sanfiz, A.; Sakmar, T.P.; Veldkamp, C.T.
Preparation and analysis of N-terminal chemokine receptor sulfopeptides using tyrosylprotein sulfotransferase enzymes
Methods Enzymol.
570
357-388
2016
Homo sapiens (O60507), Homo sapiens (O60704)
Zhong, Y.; Xie, J.; Wen, S.; Wu, W.; Tan, L.; Lei, M.; Shi, H.; Zhu, J.K.
TPST is involved in fructose regulation of primary root growth in Arabidopsis thaliana
Plant Mol. Biol.
103
511-525
2020
Arabidopsis thaliana (Q3EDG5), Arabidopsis thaliana Col-0 (Q3EDG5)
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