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3'-phosphoadenylylsulfate + benzyl alcohol
adenosine 3',5'-bisphosphate + benzyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + (S)-dehydroepiandrosterone
adenosine 3',5'-bisphosphate + (S)-dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
SULT1B1
-
-
?
3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone
adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5alpha,6alpha-epoxycholesterol
adenosine 3',5'-bisphosphate + 5alpha,6alpha-epoxycholesteryl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 5beta,6beta-epoxycholesterol
adenosine 3',5'-bisphosphate + 5beta,6beta-epoxycholesteryl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 6-hydroxy-4-methylbenzo[d]thiazole-2-carbonitrile
adenosine 3',5'-bisphosphate + ?
i.e. proluciferin substrate UGT-Glo substrate A, GSA
-
-
?
3'-phosphoadenylyl sulfate + 7-oxo-cholesterol
adenosine 3',5'-bisphosphate + 7-oxo-cholesteryl 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 7-oxocholesterol
adenosine 3',5'-bisphosphate + 7-oxocholesterol 3-sulfate
SULT2B1b, SULT2B1a, and SULT2A1
-
-
?
3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesterol
adenosine 3',5'-bisphosphate + 7alpha-hydroxycholesterol 3-sulfate
SULT2B1b, the 7alpha derivative is highly preferred
-
-
?
3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesterol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 7beta-hydroxycholesterol
adenosine 3',5'-bisphosphate + 7beta-hydroxycholesterol 3-sulfate
SULT2B1b, the 7alpha derivative is highly preferred
-
-
?
3'-phosphoadenylyl sulfate + 7beta-hydroxycholesterol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + androsterone
adenosine 3',5'-bisphosphate + androsterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesteryl 3-sulfate
3'-phosphoadenylyl sulfate + cholesterol 7alpha-hydroperoxide
adenosine 3',5'-bisphosphate + ?
SULT2B1b
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + genistein
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholic acid
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + lithocholic acid
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
3'-phosphoadenylyl sulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
3'-phosphoadenylyl sulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + raloxifene
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + taurolithocholic acid
adenosine 3',5'-bisphosphate + taurolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + tibolone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + 1'-hydroxysafrole
adenosine 3',5'-bisphosphate + ?
-
isoenzyme DHEA-ST, sulfation and bioactivation to a lesser extent
-
-
?
3'-phosphoadenylylsulfate + 1-hydroxymethylpyrene
adenosine 3',5'-bisphosphate + ?
-
isoenzyme DHEA-ST, sulfation and bioactivation
-
-
?
3'-phosphoadenylylsulfate + 17-beta-estradiol
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol
adenosine 3',5'-bisphosphate + 17alpha-ethinylestradiol sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
adenosine 3',5'-bisphosphate + 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl
adenosine 3',5'-bisphosphate + 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 2-hydroxy-catecholestrogen
adenosine 3',5'-bisphosphate + ?
-
best substrate for this enzyme, also catalyzes the transformation of 4-hydroxy-estrogens and 16-hydroxy-estrogens, but with a lower affinity
-
-
r
3'-phosphoadenylylsulfate + 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
adenosine 3',5'-bisphosphate + 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 3,3'-diiodothyronine
adenosine 3',5'-bisphosphate + ?
-
sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group
-
-
?
3'-phosphoadenylylsulfate + 3,5-diiodothyronine
adenosine 3',5'-bisphosphate + ?
-
sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group
-
-
?
3'-phosphoadenylylsulfate + 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
adenosine 3',5'-bisphosphate + 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4,4'-isopropylidenediphenol
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + 4-(1,1,3,3-tetramethylbutyl)phenol
adenosine 3',5'-bisphosphate + 4-(1,1,3,3-tetramethylbutyl)phenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-hydroxy-3,5-dichlorobiphenyl
adenosine 3',5'-bisphosphate + 4-hydroxy-3,5-dichlorobiphenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-n-nonylphenol
adenosine 3',5'-bisphosphate + 4-n-nonylphenyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + ?
-
isoform SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymethylbenzo[a]pyrene
adenosine 3',5'-bisphosphate + ?
-
isoenzyme DHEA-ST, sulfation and bioactivation
-
-
?
3'-phosphoadenylylsulfate + alpha-hydroxytamoxifen
adenosine 3',5'-bisphosphate + ?
-
isoenzyme DHEA-ST, sulfation and bioactivation to a lesser extent
-
-
?
3'-phosphoadenylylsulfate + alpha-hydroxytamoxifen
adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
all enantiomers are substrates: E-(+)-alpha-hydroxytamoxifen, E-(-)-alpha-hydroxytamoxifen, Z-(+)-alpha-hydroxytamoxifen and Z-(-)-alpha-hydroxytamoxifen. The ratio of turnover-number to KM-value is higher with the Z enantiomers than with the E enantiomers
-
-
?
3'-phosphoadenylylsulfate + androstenediol
adenosine 3',5'-bisphosphate + androstenediol sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + androsterone
adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + benzyl alcohol
adenosine 3',5'-bisphosphate + benzyl sulfate
-
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-O-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + budesonide-22R
adenosine 3',5'-bisphosphate + budesonide-22R,11 sulfate + budesonide-22R,21 sulfate
synthetic glucocorticosteroid, used in treatment of asthma and allergic reactions, rhinitis, and inflammatory bowel disease
-
-
r
3'-phosphoadenylylsulfate + budesonide-22S
adenosine 3',5'-bisphosphate + budesonide-22S,11 sulfate + budesonide-22S,21 sulfate
synthetic glucocorticosteroid, used in treatment of asthma and allergic reactions, rhinitis, and inflammatory bowel disease
-
-
r
3'-phosphoadenylylsulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol sulfate
3'-phosphoadenylylsulfate + cortisol
adenosine 3',5'-bisphosphate + cortisol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylylsulfate + diiodothyronine
adenosine 3',5'-bisphosphate + ?
-
sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
-
isoform SULT1A3
-
-
?
3'-phosphoadenylylsulfate + E-(+)-alpha-hydroxytamoxifen
adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
-
-
-
?
3'-phosphoadenylylsulfate + E-(-)-alpha-hydroxytamoxifen
adenosine 3',5'-bisphosphate + sulfuric acid mono-[(E)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
-
-
-
?
3'-phosphoadenylylsulfate + estrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + ethanol
adenosine 3',5'-bisphosphate + ethyl sulfate
-
high activity with SULT1A2, SULT1B1, SULT2A1 and SULT1A3. SULT1A3 might be the predominant form for the sulphonation of ethanol
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + hycanthone
adenosine 3',5'-bisphosphate + ?
-
isoenzyme DHEA-ST, sulfation and bioactivation
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + ?
-
antihypertensive agent and hair growth stimulator, activation by sulfation
-
-
?
3'-phosphoadenylylsulfate + N-hydroxy-2-acetylaminofluorene
adenosine 3',5'-bisphosphate + ?
-
isoenzyme DHEA-ST, sulfation and bioactivation to a lesser extent
-
-
?
3'-phosphoadenylylsulfate + R-(+)-1-naphthyl-1-ethanol
adenosine 3',5'-bisphosphate + ?
-
S-(-)-enantiomer is not a substrate for the enzyme
-
-
?
3'-phosphoadenylylsulfate + R-(+)-2-naphthyl-1-ethanol
adenosine 3',5'-bisphosphate + ?
-
both enantiomers are substrates for the enzyme
-
-
?
3'-phosphoadenylylsulfate + S-(-)-2-naphthyl-1-ethanol
adenosine 3',5'-bisphosphate + ?
-
both enantiomers are substrates for the enzyme
-
-
?
3'-phosphoadenylylsulfate + testosterone
adenosine 3',5'-bisphosphate + testosterone 3-sulfate
-
17-hydroxyl of testosterone
-
-
r
3'-phosphoadenylylsulfate + tetraiodothyronine
adenosine 3',5'-bisphosphate + ?
-
sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group
-
-
?
3'-phosphoadenylylsulfate + triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group
-
-
?
3'-phosphoadenylylsulfate + Z-(+)-alpha-hydroxytamoxifen
adenosine 3',5'-bisphosphate + sulfuric acid mono-[(Z)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
-
-
-
?
3'-phosphoadenylylsulfate + Z-(-)-alpha-hydroxytamoxifen
adenosine 3',5'-bisphosphate + sulfuric acid mono-[(Z)-4-[4-(2-dimethylaminoethoxy)-phenyl]-3,4-diphenylbut-3-enyl] ester
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview
-
-
?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
in renal target tissue, substrate of SULT1B1
-
-
?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
preferred substrate of SULT2B1b
-
-
?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
SULT2B1b, SULT2B1a, and SULT2A1
-
-
?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesteryl 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesteryl 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
preferred substrate of SULT2B1b
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
SULT2A1, low activity with SULT2B1b and SULT2B1a
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
the sulfation, catalyzed by SULT, is important in the regulation of biological activities of hormones and neurotransmitters, the metabolism of drugs, and the detoxification of xenobiotic toxicants. Sulfation also leads to the bioactivation of procarcinogens. Human SULT2A1 is a major sulfotransferase catalyzing the sulfation of hydroxysteroids and xenobiotic alcohols, mechanisms controlling the regulation of hSULT2A1, overview
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
i.e. PAPS and DHEA
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
i.e. PAPS and DHEA
-
-
?
3'-phosphoadenylyl sulfate + lithocholic acid
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + lithocholic acid
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
substrate complex structure analysis
-
-
?
3'-phosphoadenylyl sulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
-
preferred substrate of SULT2B1a
-
-
?
3'-phosphoadenylyl sulfate + raloxifene
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + raloxifene
adenosine 3',5'-bisphosphate + ?
substrate complex structure analysis
-
-
?
3'-phosphoadenylylsulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol sulfate
-
-
-
?
3'-phosphoadenylylsulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
645778, 645779, 645780, 645782, 645783, 645785, 645786, 645789, 645790, 645791, 645795 -
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
steroid and bile-acid metabolism
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
sulfation is an important pathway in the metabolism of thyroid hormones, sulfated iodothyronines are elevated in nonthyroidal illnesses and in the normal fetal circulation
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
critical step in the provision of substrates for estrogen biosynthesis by the placenta during pregnancy, sulfation represents a major enzymatic reaction in the metabolism, excretion and homeostasis of steroid hormones and bile acids in addition to numerous other endogenous compounds and xenobiotics, regulating steroid hormone bioactivity
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
biotransformation of xenobiotics and hormones through sulfate conjugation, important metabolic pathway
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
biosynthesis of proteoglycans
-
-
r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
catalyzes sulfonation of exogenous products like drugs and xenobiotics as well as endogenous compounds such as steroids and bile acids by transferring a sulfonate moiety from the cofactor 3'-phosphoadenosine-5'-phosphosulfate to a hydroxyl group of the substrate, this leads to detoxification or elimination because sulfation increases the hydrophilicity of chemical compounds and therefore their excretion, hEST1 also involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens
-
-
r
additional information
?
-
-
estrone and phenolic steroids are no substrates
-
-
?
additional information
?
-
-
cortisol, corticosterone, betamathasone and dexamethasone are no substrates
-
-
?
additional information
?
-
-
hepatic clearance and metabolism of sex steroids
-
-
?
additional information
?
-
-
isoform DHEA-ST, sulfate conjugation involved in bioactivation of compounds to reactive electrophilic forms, the hydroxymethyl group is sulfated and undergoes subsequent sponaneous rearrangement to release the sulfate moiety and generate an electrophilic benzylic carbocation that can react with cellular nucleophiles such as DNA, RNA, and protein
-
-
?
additional information
?
-
-
regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor
-
-
?
additional information
?
-
SULT2B1 isoforms show selectivity for the sulfation of 3beta-hydroxysteroids including dehydroepiandrosterone and pregnenolone, and demonstrate little activity with 3alpha-hydroxysteroids and estrogens, SULT2B1a possesses a higher pregnenolone sulfation activity than SULT2B1b whereas SULT2B1b has a higher cholesterol sulfation activity, SULT2B1b is also capable of conjugating several drugs and xenobiotics including genistein, tibolone, and raloxifene
-
-
?
additional information
?
-
-
SULT2B1 isoforms show selectivity for the sulfation of 3beta-hydroxysteroids including dehydroepiandrosterone and pregnenolone, and demonstrate little activity with 3alpha-hydroxysteroids and estrogens, SULT2B1a possesses a higher pregnenolone sulfation activity than SULT2B1b whereas SULT2B1b has a higher cholesterol sulfation activity, SULT2B1b is also capable of conjugating several drugs and xenobiotics including genistein, tibolone, and raloxifene
-
-
?
additional information
?
-
SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview
-
-
?
additional information
?
-
role for 3'-phosphoadenylyl sulfate in priming the conformation of substrate binding loops, overview, substrate specificity and binding structure of SULT1B1, overview
-
-
?
additional information
?
-
-
SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation
-
-
?
additional information
?
-
SULT2B1b is selective for the sulfation of 3beta-hydroxysteroids, such as DHEA, pregnenolone, androstenediol, and 5alpha-androstane-3beta,17beta-diol, no sulfation is detectable with 3alpha-hydroxysteroids or estrogens as substrates
-
-
?
additional information
?
-
-
SULT2B1b is selective for the sulfation of 3beta-hydroxysteroids, such as DHEA, pregnenolone, androstenediol, and 5alpha-androstane-3beta,17beta-diol, no sulfation is detectable with 3alpha-hydroxysteroids or estrogens as substrates
-
-
?
additional information
?
-
-
SULT2B1b sulfates oxosterols, overview
-
-
?
additional information
?
-
SULT2B1b sulfates oxosterols, overview
-
-
?
additional information
?
-
-
EST is an enzyme that seems to play an important role in the growth of hormone-dependent tumors of the breast, prostate, and endometrium, EST expression is downregulated in endometrial stromal sarcomas, ESS. If the enzyme EST is missing in ESS, it is possible that the intratumoral levels of bio-active estrogen are high, and ESS tumor growth and progression are to be expected, overview
-
-
?
additional information
?
-
-
pentachlorophenols, tetrachlorophenols, and trichlorophenols are substrates of isozyme SULT2A1, while mono- and dichlorophenol are poor substrates, cf. EC 2.8.2.15
-
-
?
additional information
?
-
SULT2A1 catalyzes the sulfation of hydroxysteroids such as dehydroepiandrosterone and various alcohol-containing androgens
-
-
-
additional information
?
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SULT2A1 catalyzes the sulfation of hydroxysteroids such as dehydroepiandrosterone and various alcohol-containing androgens
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additional information
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cytosolic sulfotransferases (SULTs) can catalyze the sulfonation of small molecules by transferring a sulfonate group from the unique cofactor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the substrates
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additional information
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isozymes SULT2B1a and SULT2B1b catalyze sulfonation of 3beta-hydroxysteroids, pregnenolone, 17alpha-hydroxypregnenolone and DHEA
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additional information
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isozymes SULT2B1a and SULT2B1b catalyze sulfonation of 3beta-hydroxysteroids, pregnenolone, 17alpha-hydroxypregnenolone and DHEA
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additional information
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SULT2A1 has broad substrate specificity, it can catalyze sulfonation of many hydroxysteroids, including DHEA, epiandrosterone, androsterone, testosterone, E2, cholesterol, various bile acids, pregnenolone, 17-ethinyl-E2 and cortisol
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additional information
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SULT2A1 has broad substrate specificity, it can catalyze sulfonation of many hydroxysteroids, including DHEA, epiandrosterone, androsterone, testosterone, E2, cholesterol, various bile acids, pregnenolone, 17-ethinyl-E2 and cortisol
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3'-phosphoadenylyl sulfate + 17alpha-hydroxypregnenolone
adenosine 3',5'-bisphosphate + 17alpha-hydroxypregnenolone sulfate
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?
3'-phosphoadenylyl sulfate + 7-oxocholesterol
adenosine 3',5'-bisphosphate + 7-oxocholesterol 3-sulfate
SULT2B1b, SULT2B1a, and SULT2A1
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?
3'-phosphoadenylyl sulfate + androsterone
adenosine 3',5'-bisphosphate + androsterone 3-sulfate
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?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview
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?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
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?
3'-phosphoadenylyl sulfate + glycolithocholic acid
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
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?
3'-phosphoadenylyl sulfate + lithocholic acid
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
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?
3'-phosphoadenylyl sulfate + pregnenolone
adenosine 3',5'-bisphosphate + pregnenolone sulfate
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?
3'-phosphoadenylyl sulfate + taurolithocholic acid
adenosine 3',5'-bisphosphate + taurolithocholate 3-sulfate
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?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
additional information
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3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
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?
3'-phosphoadenylyl sulfate + cholesterol
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
SULT2B1b, SULT2B1a, and SULT2A1
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
SULT2A1, low activity with SULT2B1b and SULT2B1a
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?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
the sulfation, catalyzed by SULT, is important in the regulation of biological activities of hormones and neurotransmitters, the metabolism of drugs, and the detoxification of xenobiotic toxicants. Sulfation also leads to the bioactivation of procarcinogens. Human SULT2A1 is a major sulfotransferase catalyzing the sulfation of hydroxysteroids and xenobiotic alcohols, mechanisms controlling the regulation of hSULT2A1, overview
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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steroid and bile-acid metabolism
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r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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sulfation is an important pathway in the metabolism of thyroid hormones, sulfated iodothyronines are elevated in nonthyroidal illnesses and in the normal fetal circulation
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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critical step in the provision of substrates for estrogen biosynthesis by the placenta during pregnancy, sulfation represents a major enzymatic reaction in the metabolism, excretion and homeostasis of steroid hormones and bile acids in addition to numerous other endogenous compounds and xenobiotics, regulating steroid hormone bioactivity
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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biotransformation of xenobiotics and hormones through sulfate conjugation, important metabolic pathway
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3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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biosynthesis of proteoglycans
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r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
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catalyzes sulfonation of exogenous products like drugs and xenobiotics as well as endogenous compounds such as steroids and bile acids by transferring a sulfonate moiety from the cofactor 3'-phosphoadenosine-5'-phosphosulfate to a hydroxyl group of the substrate, this leads to detoxification or elimination because sulfation increases the hydrophilicity of chemical compounds and therefore their excretion, hEST1 also involved in the production of stable precursors for local steroid biosynthesis or in activation of promutagenic estrogen metabolites into carcinogens
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r
additional information
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regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor
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additional information
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SULT2B1 isoforms show selectivity for the sulfation of 3beta-hydroxysteroids including dehydroepiandrosterone and pregnenolone, and demonstrate little activity with 3alpha-hydroxysteroids and estrogens, SULT2B1a possesses a higher pregnenolone sulfation activity than SULT2B1b whereas SULT2B1b has a higher cholesterol sulfation activity, SULT2B1b is also capable of conjugating several drugs and xenobiotics including genistein, tibolone, and raloxifene
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additional information
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SULT2B1 isoforms show selectivity for the sulfation of 3beta-hydroxysteroids including dehydroepiandrosterone and pregnenolone, and demonstrate little activity with 3alpha-hydroxysteroids and estrogens, SULT2B1a possesses a higher pregnenolone sulfation activity than SULT2B1b whereas SULT2B1b has a higher cholesterol sulfation activity, SULT2B1b is also capable of conjugating several drugs and xenobiotics including genistein, tibolone, and raloxifene
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additional information
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SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview
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additional information
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EST is an enzyme that seems to play an important role in the growth of hormone-dependent tumors of the breast, prostate, and endometrium, EST expression is downregulated in endometrial stromal sarcomas, ESS. If the enzyme EST is missing in ESS, it is possible that the intratumoral levels of bio-active estrogen are high, and ESS tumor growth and progression are to be expected, overview
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additional information
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SULT2A1 catalyzes the sulfation of hydroxysteroids such as dehydroepiandrosterone and various alcohol-containing androgens
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additional information
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SULT2A1 catalyzes the sulfation of hydroxysteroids such as dehydroepiandrosterone and various alcohol-containing androgens
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Association Study of CYP17 and HSD11B1 in Polycystic Ovary Syndrome Utilizing Comprehensive Gene Coverage.
Abortion, Spontaneous
Triclosan causes spontaneous abortion accompanied by decline of estrogen sulfotransferase activity in humans and mice.
ACTH-Secreting Pituitary Adenoma
Expression of genes related to corticotropin production and glucocorticoid feedback in corticotroph adenomas of dogs with Cushing's disease.
Acute Kidney Injury
Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.
Acute Lung Injury
Hepatic Estrogen Sulfotransferase Distantly Sensitizes Mice to Hemorrhagic Shock-Induced Acute Lung Injury.
Adenocarcinoma
Cloning and expression of cDNA encoding human placental estrogen sulfotransferase.
Adenocarcinoma
Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone.
Adenocarcinoma of Lung
Knockdown of HSDL2 inhibits lung adenocarcinoma progression via down-regulating AKT2 expression.
Adenoma
A compound adrenal medullary tumor (pheochromocytoma and ganglioneuroma) and a cortical adenoma in the ipsilateral adrenal gland. A case report with enzyme histochemical and immunohistochemical studies.
Adenoma
Adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia as a distinct subtype of Cushing's syndrome. Enzyme histochemical and ultrastructural study of four cases with a review of the literature.
Adenoma
Histochemical investigation of aldosterone-secreting cells adenoma of the adrenal cortex.
Adrenal Hyperplasia, Congenital
Assisted Reproduction in Congenital Adrenal Hyperplasia.
Adrenal Hyperplasia, Congenital
Gender assignment and medical history of individuals with different forms of intersexuality: evaluation of medical records and the patients' perspective.
Adrenal Hyperplasia, Congenital
Uniparental Isodisomy of Chromosome 1 Unmasking an Autosomal Recessive 3-Beta Hydroxysteroid Dehydrogenase Type II-Related Congenital Adrenal Hyperplasia.
Adrenal Hyperplasia, Congenital
[A novel homozygous mutation p.E25X in the HSD3B2 gene causing salt wasting 3?-hydroxysteroid dehydrogenases deficiency in a Chinese pubertal girl: a delayed diagnosis until recurrent ovary cysts].
Adrenal Rest Tumor
Testicular Adrenal Rest Tumor In Brothers With Novel Mutation In 3-Beta Hydroxysteroid Dehydrogenase -2 Gene.
Adrenocortical Adenoma
Enzyme histocytochemical studies in human adrenocortical adenomas. [I]. Primary aldosteronism.
Adrenocortical Hyperfunction
An inhibitor of 11-? hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells.
Adrenocortical Hyperfunction
Efficacy of trilostane for the treatment of equine Cushing's syndrome.
Adrenocortical Hyperfunction
Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-? hydroxysteroid dehydrogenase type 1.
alcohol sulfotransferase deficiency
Gender assignment and medical history of individuals with different forms of intersexuality: evaluation of medical records and the patients' perspective.
Alopecia
Steroid chemistry and hormone controls during the hair follicle cycle.
Alzheimer Disease
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Alzheimer Disease
Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains.
Androgen-Insensitivity Syndrome
Gender assignment and medical history of individuals with different forms of intersexuality: evaluation of medical records and the patients' perspective.
Androgen-Insensitivity Syndrome
Novel Mutation Among Two Sisters With 17? Hydroxysteroid Dehydrogenase Type 3 Deficiency.
Androgen-Insensitivity Syndrome
[Proceedings: Male pseudohermaphroditism due to testicular 17 beta hydroxysteroid deshydrogenase deficiency (author's transl)]
Atherosclerosis
Human estrogen sulfotransferase and its related fluorescently labeled decapeptides specifically interact with oxidized low-density lipoprotein.
Atherosclerosis
Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
Breast Neoplasms
A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.
Breast Neoplasms
A library approach to the generation of bisubstrate analogue sulfotransferase inhibitors.
Breast Neoplasms
A relationship between estrogen sulfurylation and estrogen and progesterone receptor status in human mammary carcinoma.
Breast Neoplasms
Breast cancer pathogenesis is linked to the intra-tumoral estrogen sulfotransferase (hSULT1E1) expressions regulated by cellular redox dependent Nrf-2/NF?? interplay.
Breast Neoplasms
Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer.
Breast Neoplasms
Effect of nomegestrol acetate on human estrogen sulfotransferase activity in the hormone-dependent MCF-7 and T-47D breast cancer cell lines.
Breast Neoplasms
Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma.
Breast Neoplasms
Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma.
Breast Neoplasms
Estrogen sulfotransferases in breast and endometrial cancers.
Breast Neoplasms
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Breast Neoplasms
Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer.
Breast Neoplasms
Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study.
Breast Neoplasms
Expression of hydroxysteroid sulphotransferase is related to estrogen receptor status in human mammary cancer.
Breast Neoplasms
Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects.
Breast Neoplasms
Human estrogen sulfotransferase (hEST1) activities and its mRNA in various breast cancer cell lines. Effect of the progestin, promegestone (R-5020).
Breast Neoplasms
Immunohistochemical localisation of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study.
Breast Neoplasms
In situ production of estrogens in human breast carcinoma.
Breast Neoplasms
In vitro inhibition of estrogen sulfoconjugation by some 2- and 4-substituted estra-1,3,5(10)-trien-17 beta-ols1a.
Breast Neoplasms
Insulin-like growth factor type I and insulin-like growth factor type II stimulate oestradiol-17 beta hydroxysteroid dehydrogenase (reductive) activity in breast cancer cells.
Breast Neoplasms
Intracrinology of breast microenvironment: hormonal status in nipple aspirate fluid and its relationship to breast cancer.
Breast Neoplasms
Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208.
Breast Neoplasms
Local biosynthesis and metabolism of oestrogens in the human breast.
Breast Neoplasms
Metabolic fate of estradiol in human mammary cancer cells in culture: estrogen sulfate formation and cooperativity exhibited by estrogen sulfotransferase.
Breast Neoplasms
Modulation of oestrone sulphatase activity in breast cancer cell lines by growth factors.
Breast Neoplasms
Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.
Breast Neoplasms
Progestagen component in combined hormone replacement therapy in postmenopausal women and breast cancer risk: a debated clinical issue.
Breast Neoplasms
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients.
Breast Neoplasms
Properties of estrogen and hydroxysteroid sulphotransferases in human mammary cancer.
Breast Neoplasms
Quantitative determination of oestradiol-17 beta hydroxysteroid dehydrogenase: increased sensitivity by HPLC separation of the hormones permits the measurement of enzyme activity in cryostat sections.
Breast Neoplasms
Recent data on estrogen sulfatases and sulfotransferases activities in human breast cancer.
Breast Neoplasms
Regulation of estrogen sulfotransferase by estrogen in MCF-7 human mammary cancer cells.
Breast Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer.
Breast Neoplasms
Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma.
Breast Neoplasms
Sulfation of estradiol in human epidermal keratinocyte.
Breast Neoplasms
The effect of epidermal growth factor, transforming growth factor and breast tumour homogenates on the activity of oestradiol 17 beta hydroxysteroid dehydrogenase in cultured adipose tissue.
Breast Neoplasms
The regulation of hydroxysteroid 17?-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer.
Breast Neoplasms
The relationship between 17 beta hydroxysteroid dehydrogenase and breast tumour site and size.
Breast Neoplasms
The role of 17?HSDs in breast tissue and breast cancers.
Breast Neoplasms
[Genetic polymorphism and variability of steroid hormone metabolism: connection with risk of developing breast neoplasms]
Carcinogenesis
Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer.
Carcinogenesis
Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
Carcinogenesis
Lentivirus-mediated overexpression of HSDL2 suppresses cell proliferation and induces apoptosis in cholangiocarcinoma.
Carcinogenesis
Rat liver 3 alpha-hydroxysteroid dehydrogenase.
Carcinogenesis
[Expression of estrogen sulfotransferase in breast tissues and the regulation of ESTmRNA by estrogen]
Carcinoma
11? hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma.
Carcinoma
17? hydroxysteroid dehydrogenase type 12 (HSD17B12) is a marker of poor prognosis in ovarian carcinoma.
Carcinoma
Clinicopathological Significance of Estrogen Receptor ? and Estrogen Synthesizing/Metabolizing Enzymes in Urothelial Carcinoma of Urinary Bladder.
Carcinoma
Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma.
Carcinoma
Identification of Hydroxysteroid (17?) dehydrogenase type 12 (HSD17B12) as a CD8(+) T-cell-defined human tumor antigen of human carcinomas.
Carcinoma
Immunohistochemical localisation of hydroxysteroid sulphotransferase in human breast carcinoma tissue: a preliminary study.
Carcinoma
Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors.
Carcinoma
Steroid sulfatase and estrogen sulfotransferase in human carcinomas.
Carcinoma
Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.
Carcinoma, Hepatocellular
Hydroxysteroid 17-Beta Dehydrogenase 6 Is a Prognostic Biomarker and Correlates with Immune Infiltrates in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure.
Carcinoma, Intraductal, Noninfiltrating
Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma.
Carcinoma, Non-Small-Cell Lung
11? hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen.
Carcinoma, Ovarian Epithelial
Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer.
Cholangitis, Sclerosing
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Chorioamnionitis
The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta.
Choriocarcinoma
Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo.
Choriocarcinoma
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Colitis, Ulcerative
Bacterial bile metabolising gene abundance in Crohn's, ulcerative colitis and type 2 diabetes metagenomes.
Coronary Artery Disease
Mediastinal adipose tissue expresses a pathogenic profile of 11 ?-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease.
Crohn Disease
Bacterial bile metabolising gene abundance in Crohn's, ulcerative colitis and type 2 diabetes metagenomes.
Cryptorchidism
Effect of cryptorchidism and orchidopexy on 3B hydroxysteroid dehydrogenase activity in rat testicle.
Cryptorchidism
Expression of anti-Müllerian hormone, CDKN1B, connexin 43, androgen receptor and steroidogenic enzymes in the equine cryptorchid testis.
Cystadenoma, Serous
Activation of Androgens by Hydroxysteroid (17{beta}) Dehydrogenase 1 in Vivo as a Cause of Prenatal Masculinization and Ovarian Benign Serous Cystadenomas.
Cystic Fibrosis
Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis.
Depression, Postpartum
Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones: A longitudinal population-based study.
Diabetes Mellitus
11? Hydroxysteroid dehydrogenase - 1 activity in type 2 diabetes mellitus: a comparative study.
Diabetes Mellitus
Bacterial bile metabolising gene abundance in Crohn's, ulcerative colitis and type 2 diabetes metagenomes.
Diabetes Mellitus, Type 1
Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes.
Diabetes Mellitus, Type 2
11? Hydroxysteroid dehydrogenase - 1 activity in type 2 diabetes mellitus: a comparative study.
Diabetes Mellitus, Type 2
Bacterial bile metabolising gene abundance in Crohn's, ulcerative colitis and type 2 diabetes metagenomes.
Diabetes Mellitus, Type 2
Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Diabetes Mellitus, Type 2
Lower Renal Function Is Associated With Derangement of 11-? Hydroxysteroid Dehydrogenase in Type 2 Diabetes.
Diabetes Mellitus, Type 2
Mapping and association studies of diabetes related genes in the pig.
Diabetes Mellitus, Type 2
Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes.
Disorder of Sex Development, 46,XY
Ten years experience with masculinizing genitoplasty in male pseudohermaphroditism due to 17 beta-hydroxysteroid dehydrogenase deficiency.
Disorder of Sex Development, 46,XY
[Proceedings: Male pseudohermaphroditism due to testicular 17 beta hydroxysteroid deshydrogenase deficiency (author's transl)]
Disorders of Sex Development
The novel founder homozygous V225M mutation in the HSD17B3 gene causes aberrant splicing and XY-DSD.
Ectromelia
The genome of swinepox virus.
Endometrial Hyperplasia
Changes in lipoproteins with various sex steroids.
Endometrial Hyperplasia
In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia.
Endometrial Hyperplasia
Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice.
Endometrial Neoplasms
Characterization of cytosolic estrogen sulfotransferase from RL95-2 endometrial cancer cells.
Endometrial Neoplasms
Estrogen sulfotransferase and sulfatase: Roles in the regulation of estrogen activity in human uterine endometrial carcinomas.
Endometrial Neoplasms
Estrogen sulfotransferase expression in endometrial stromal sarcomas: an immunohistochemical study.
Endometrial Neoplasms
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Endometrial Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.
Endometrial Neoplasms
The sulfatase pathway as estrogen supply in endometrial cancer.
Endometriosis
Effects of steroid hormone on estrogen sulfotransferase and on steroid sulfatase expression in endometriosis tissue and stromal cells.
Endometriosis
Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance.
Endometriosis
Estrogen metabolizing enzymes in endometrium and endometriosis.
Endometriosis
Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: evidence for unbalanced estradiol production in endometriosis.
Endometriosis
Seven Hormonal Biomarkers for Diagnosing Endometriosis: Meta-Analysis and Adjusted Indirect Comparison of Diagnostic Test Accuracy.
Essential Hypertension
Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-? hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India.
Fatty Liver
Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolic-associated Fatty Liver Disease.
Fatty Liver
Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease.
Fatty Liver
Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target.
Folic Acid Deficiency
Effects of folic acid deficiency in pregnant Wistar rats on the activities of D5-3 beta hydroxysteroid dehydrogenase and glucose-6 phosphate dehydrogenase in the ovaries of their litters.
Gastroesophageal Reflux
Do bile acids reflux into the esophagus? A study in normal subjects and patients with gastroesophageal reflux disease.
Gastrointestinal Stromal Tumors
Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors.
Glioma
Lentivirus-mediated overexpression of HSDL2 suppresses cell proliferation and induces apoptosis in cholangiocarcinoma.
Glioma
Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling.
Gonadal Dysgenesis
Gender assignment and medical history of individuals with different forms of intersexuality: evaluation of medical records and the patients' perspective.
Hemangioma
Evidence by molecular profiling for a placental origin of infantile hemangioma.
Hepatitis
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Hepatitis, Chronic
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Herpes Zoster
Effects of culture conditions on the developmental programme of mouse blastocysts.
Herpes Zoster
Quantitative proteomic reveals the dynamic of protein profile during final oocyte maturation in zebrafish.
Herpes Zoster
The genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute exposure to the androgen, 17beta-trenbolone.
Hirsutism
[Hirsutism with partial blockage of 3 beta OL hydroxysteroid dehydrogenase (author's transl)]
Hydatidiform Mole
Histochemical demonstration of hydroxysteroid dehydrogenases in hydatidiform mole.
Hydatidiform Mole
[Serum and tissue 17 beta hydroxysteroid dehydrogenase and estrogens in hydatidiform mole]
Hyperaldosteronism
Enzyme histocytochemical studies in human adrenocortical adenomas. [I]. Primary aldosteronism.
Hyperglycemia
Dexamethasone-induced hyperglycemia in obese Avy/a (viable yellow) female mice entails preferential induction of a hepatic estrogen sulfotransferase.
Hypertension
Apparent Mineralocorticoid Excess by a Novel Mutation and Epigenetic Modulation by HSD11B2 Promoter Methylation.
Hypertension
Common Variation at the 11-Beta Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) Gene Is Associated with Left Ventricular Mass.
Hypertension
Does the maternal micronutrient deficiency (copper or zinc or vitamin E) modulate the expression of placental 11 beta hydroxysteroid dehydrogenase-2 per se predispose offspring to insulin resistance and hypertension in later life?
Hypertension
Maternal hypertension and progeny blood pressure: role of aldosterone and 11beta-HSD.
Hyperthyroidism
Characterization of iodothyronine sulfotransferase activity in rat liver.
Hypokalemia
[Cushing syndrome by ectopic ACTH secretion: analysis of the physiopathologic mechanism of hypokalemia. Report of two cases]
Hypothyroidism
Characterization of iodothyronine sulfotransferase activity in rat liver.
Hypothyroidism
Urinary cortisol metabolites in the assessment of peripheral thyroid hormone action: overt and subclinical hypothyroidism.
Infertility
[17 beta hydroxysteroid dehydrogenase and creatine phosphokinase activities and the levels of sex hormones and their receptors in the uterus of patients with fibromyoma or endocrine sterility]
Infertility, Male
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Insulin Resistance
Assessment of 11-? hydroxysteroid dehydrogenase (11-?HSD1) 4478T>G and tumor necrosis factor-? (TNF-?)-308G>A polymorphisms with obesity and insulin resistance in Asian Indians in North India.
Insulin Resistance
Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women.
Insulin Resistance
Does the maternal micronutrient deficiency (copper or zinc or vitamin E) modulate the expression of placental 11 beta hydroxysteroid dehydrogenase-2 per se predispose offspring to insulin resistance and hypertension in later life?
Insulin Resistance
Effects of 11?-hydroxysteroid dehydrogenase-1 Inhibition on Hepatic Glycogenolysis and Gluconeogenesis.
Insulin Resistance
Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.
Insulin Resistance
Sexual dimorphism in 11 beta hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects.
Intellectual Disability
Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation.
Intestinal Diseases
Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis.
Kidney Diseases
Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes.
Kidney Failure, Chronic
Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes.
Kidney Failure, Chronic
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats.
Leiomyoma
[17 beta hydroxysteroid dehydrogenase and creatine phosphokinase activities and the levels of sex hormones and their receptors in the uterus of patients with fibromyoma or endocrine sterility]
Leukemia
Analysis of differential gene regulation in adequate versus inadequate secretory-phase endometrial complementary deoxyribonucleic acid populations from the rhesus monkey.
Leukemia
Different T-cell subtypes are associated with pathologically distinct forms of Moloney leukemia virus (M-MuLV)-induced lymphoma.
Liver Cirrhosis, Alcoholic
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Liver Cirrhosis, Biliary
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Liver Diseases
17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury.
Liver Diseases
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.
Liver Diseases
Associations of Hydroxysteroid 17-beta Dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolic-associated Fatty Liver Disease.
Liver Diseases
Characterization of Essential Domains in HSD17B13 for Cellular Localization and Enzymatic Activity.
Liver Diseases
Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers.
Liver Diseases
HSD17B13 rs72613567 protects against liver diseases and histological progression of nonalcoholic fatty liver disease: a systematic review and meta-analysis.
Liver Diseases
Hydroxysteroid 17-? dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease.
Liver Diseases
Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease.
Liver Diseases
Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target.
Liver Diseases
Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.
Liver Diseases
Reply to "Does the HSD17B13 rs72613567 splice variant actually yield a new type of alternative splicing".
Liver Diseases
Role of candidate gene variants in modulating the risk and severity of alcoholic hepatitis.
Liver Diseases
Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease.
Liver Diseases, Alcoholic
Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target.
Liver Neoplasms
16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells.
Liver Neoplasms
Expression of 17beta-hydroxysteroid dehydrogenases and other estrogen-metabolizing enzymes in different cancer cell lines.
Lung Neoplasms
Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen.
Lymphoma
Different T-cell subtypes are associated with pathologically distinct forms of Moloney leukemia virus (M-MuLV)-induced lymphoma.
Magnesium Deficiency
Magnesium deficiency in pregnant rats alters methylation of specific cytosines in the hepatic hydroxysteroid dehydrogenase-2 promoter of the offspring.
Malnutrition
Periconceptional undernutrition and being a twin each alter kidney development in the sheep fetus during early gestation.
Mammary Neoplasms, Animal
Histochemical evaluation of ovarian hydroxysteroid dehydrogenase activity in bitches with mammary neoplasms.
Metabolic Diseases
Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.
Metabolic Diseases
Estrogen sulfotransferase: intracrinology meets metabolic diseases.
Mycetoma
Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility.
Myxoma
The genome of swinepox virus.
Neoplasm Metastasis
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Neoplasms
17 beta Hydroxysteroid dehydrogenase 1 "pseudogene" is differentially transcribed: still a candidate for the breast-ovarian cancer susceptibility gene (BRCA1).
Neoplasms
A correlation between estrogen sulfotransferase levels and estrogen receptor status in human primary breast carcinoma.
Neoplasms
A relationship between estrogen sulfurylation and estrogen and progesterone receptor status in human mammary carcinoma.
Neoplasms
Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.
Neoplasms
Aromatase and intracrinology of estrogen in hormone-dependent tumors.
Neoplasms
Assessment of 11-? hydroxysteroid dehydrogenase (11-?HSD1) 4478T>G and tumor necrosis factor-? (TNF-?)-308G>A polymorphisms with obesity and insulin resistance in Asian Indians in North India.
Neoplasms
Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events.
Neoplasms
Dehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma.
Neoplasms
Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study.
Neoplasms
Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen.
Neoplasms
Estrogen inhibits cell proliferation through in situ production in human thymoma.
Neoplasms
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors.
Neoplasms
Estrogen sulfotransferases in breast and endometrial cancers.
Neoplasms
Estrogen sulfurylation as an alternative indicator of hormone dependence in human breast cancer.
Neoplasms
Estrogen-like effects of tamoxifen on human endometrial carcinoma transplanted into nude mice.
Neoplasms
Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients.
Neoplasms
Expression of glucocorticoid receptor and 11beta hydroxysteroid dehydrogenase in a case of pulmonary epithelioid haemangioendothelioma.
Neoplasms
Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh-Day Adventists, control subjects, and bowel cancer patients.
Neoplasms
Genomic and non-genomic effects of glucocorticoids: implications for breast cancer.
Neoplasms
HSDL2 Acts as a Promoter in Pancreatic Cancer by Regulating Cell Proliferation and Lipid Metabolism.
Neoplasms
Human type 1 estrogen sulfotransferase: catecholestrogen metabolism and potential involvement in cancer promotion.
Neoplasms
Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors.
Neoplasms
Identification of Hydroxysteroid (17?) dehydrogenase type 12 (HSD17B12) as a CD8(+) T-cell-defined human tumor antigen of human carcinomas.
Neoplasms
Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers.
Neoplasms
Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208.
Neoplasms
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Neoplasms
Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily.
Neoplasms
Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy.
Neoplasms
Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.
Neoplasms
Nature-derived anticancer steroids outside cardica glycosides.
Neoplasms
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients.
Neoplasms
Role of Hydroxysteroid Dehydrogenase-Like 2 (HSDL2) in Human Ovarian Cancer.
Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer.
Neoplasms
Sulfation of estradiol in human epidermal keratinocyte.
Neoplasms
Testicular Adrenal Rest Tumor In Brothers With Novel Mutation In 3-Beta Hydroxysteroid Dehydrogenase -2 Gene.
Neoplasms
The steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors.
Neoplasms
The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.
Neoplasms
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Non-alcoholic Fatty Liver Disease
17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury.
Non-alcoholic Fatty Liver Disease
Characterization of Essential Domains in HSD17B13 for Cellular Localization and Enzymatic Activity.
Non-alcoholic Fatty Liver Disease
HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Hydroxysteroid 17-? dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Inhibition of LXR signaling by SULT2B1b promotes liver regeneration after partial hepatectomy in mouse models of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Is HSD17B13 Genetic Variant a Protector for Liver Dysfunction? Future Perspective as a Potential Therapeutic Target.
Non-alcoholic Fatty Liver Disease
NAFLD and renal function in children: is there a genetic link?
Non-alcoholic Fatty Liver Disease
Pediatric non-alcoholic fatty liver disease and kidney function: Effect of HSD17B13 variant.
Non-alcoholic Fatty Liver Disease
Reply to "Does the HSD17B13 rs72613567 splice variant actually yield a new type of alternative splicing".
Non-alcoholic Fatty Liver Disease
Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
The HSD17B13 rs72613567 variant is associated with lower levels of albuminuria in patients with biopsy-proven nonalcoholic fatty liver disease.
Obesity
Assessment of 11-? hydroxysteroid dehydrogenase (11-?HSD1) 4478T>G and tumor necrosis factor-? (TNF-?)-308G>A polymorphisms with obesity and insulin resistance in Asian Indians in North India.
Obesity
Genetic polymorphisms and obesity influence estradiol decline during the menopause.
Obesity
Glucocorticoids and neuroendocrine function.
Obesity
Mapping and association studies of diabetes related genes in the pig.
Obesity
The inflammatory consequences of psychologic stress: relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II.
Obesity, Abdominal
GH effect on enzyme activity of 11betaHSD in abdominal obesity is dependent on treatment duration.
Osteoporosis
Highly Potent 17?-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.
Osteoporosis
Type 2 17-? hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis.
Ovarian Neoplasms
Role of Hydroxysteroid Dehydrogenase-Like 2 (HSDL2) in Human Ovarian Cancer.
Ovarian Neoplasms
The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer.
Pituitary Neoplasms
Pathophysiological changes associated with the exposure of sustained delivery of glucocorticoids on pituitary adenoma cell line.
Pre-Eclampsia
Hydroxysteroid (17-?) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia.
Pre-Eclampsia
Plasma level of hydroxysteroid (17-?) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio.
Primary Ovarian Insufficiency
3 beta hydroxysteroid dehydrogenase autoantibodies in patients with idiopathic premature ovarian failure target N- and C-terminal epitopes.
Prostatic Neoplasms
Androgens and the molecular epidemiology of prostate cancer.
Prostatic Neoplasms
Molecular expression of 17 beta hydroxysteroid dehydrogenase types in relation to their activity in intact human prostate cancer cells.
Prostatic Neoplasms
Preclinical Pharmacokinetics, Tissue Distribution and Primary Safety Evaluation of a Novel Curcumin Analogue H10 Suspension, a Potential 17? Hydroxysteroid Dehydrogenase Type 3 Inhibitor.
Prostatic Neoplasms
Steroid sulfatase and estrogen sulfotransferase in human prostate cancer.
Prostatic Neoplasms
The Impact of Germline Genetic Variations in Hydroxysteroid (17-Beta) Dehydrogenases on Prostate Cancer Outcomes After Prostatectomy.
Proteinuria
Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat.
Renal Insufficiency, Chronic
Lower Renal Function Is Associated With Derangement of 11-? Hydroxysteroid Dehydrogenase in Type 2 Diabetes.
Rhinitis, Allergic
The expression of 11 beta hydroxysteroid dehydrogenase in severe allergic rhinitis.
Sarcoma
Estrogen sulfotransferase expression in endometrial stromal sarcomas: an immunohistochemical study.
Sarcoma, Endometrial Stromal
Estrogen sulfotransferase expression in endometrial stromal sarcomas: an immunohistochemical study.
Sertoli Cell-Only Syndrome
Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure.
Sertoli-Leydig Cell Tumor
Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study.
Sleep Deprivation
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Smallpox
The genome of swinepox virus.
steroid 11beta-monooxygenase deficiency
The prevalence of late onset congenital adrenal hyperplasia in hirsute women from Central Anatolia.
Uterine Cervical Neoplasms
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Vaccinia
The genome of swinepox virus.
Virus Diseases
The genome of fowlpox virus.
Wilms Tumor
New frontiers on the molecular underpinnings of hypospadias according to severity.
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0.03
2,2',5,5'-tetrachloro-4-biphenylsulfate
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.0013
2,2',5,5'-tetrachloro-4-hydroxybiphenyl
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.0049
2,3',4-trichloro-4'-hydroxybiphenyl
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.046
2,4'-dichloro-4-biphenylsulfate
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.0015
2,4'-dichloro-4-hydroxybiphenyl
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.023
3,3'-dichloro-4-hydroxybiphenyl
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.0018
4'-hydroxytoremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.012
4-chloro-4'-hydroxybiphenyl
Homo sapiens
recombinant SULT2A1, pH 7.4, 37°C
-
0.0044
4-hydroxytoremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.0029
7-methoxylasofoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.007 - 0.0129
acolbifene
0.00008 - 0.00029
arzoxifene
0.00013 - 0.00029
bazedoxifene
0.00006
bazedoxifene N-oxide
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.0014
cis-4-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthalenyl)phenol
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.0015 - 0.0036
clomifene
0.00016
des(1-azepanyl)ethylbazedoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.00075 - 0.0015
droloxifene
0.00025 - 0.001
lasofoxifene
0.0129
N-desmethyl-4-hydroxytoremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.0184
N-desmethyltoremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
-
0.0014 - 0.0122
nafoxidine
0.0023 - 0.003
ospemifene
0.00018 - 0.00041
raloxifene
0.0101 - 0.0163
tamoxifen
0.0032 - 0.011
toremifene
0.007
acolbifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0101
acolbifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.0129
acolbifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.00008
arzoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0002
arzoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.00029
arzoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.00013
bazedoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.00021
bazedoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.00029
bazedoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.0015
clomifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0032
clomifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.0036
clomifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.00075
droloxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0015
droloxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.0015
droloxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.00025
lasofoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0005
lasofoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.001
lasofoxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.0014
nafoxidine
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0066
nafoxidine
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.0122
nafoxidine
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.0023
ospemifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.00255
ospemifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.003
ospemifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.00018
raloxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.00028
raloxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.00041
raloxifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.0101
tamoxifen
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0137
tamoxifen
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
0.0163
tamoxifen
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.0032
toremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate taurolithocholic acid
0.0092
toremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate lithocholic acid
0.011
toremifene
Homo sapiens
liver cytosol, pH 7.4, 37°C, substrate glycolithocholic acid
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Suzuki, T.; Nakata, T.; Miki, Y.; Kaneko, C.; Moriya, T.; Ishida, T.; Akinaga, S.; Hirakawa, H.; Kimura, M.; Sasano, H.
Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma
Cancer Res.
63
2762-2770
2003
Homo sapiens
brenda
Hernandez, J.S.; Watson, R.W.G.; Wood, T.C.; Weinshilboum, R.M.
Sulfation of estrone and 17beta-estradiol in human liver. Catalysis by thermostable phenol sulfotransferase and by dehydroepiandrosterone sulfotransferase
Drug Metab. Dispos.
20
413-422
1992
Homo sapiens
brenda
Kong, A.N.T.; Yang, L.; Ma, M.; Tao, D.; Bjornsson, T.D.
Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver
Biochem. Biophys. Res. Commun.
187
448-454
1992
Homo sapiens
brenda
Comer, K.A.; Falany, J.L.; Falany, C.N.
Cloning and expression of human liver dehydroepiandrosterone sulphotransferase
Biochem. J.
289
233-240
1993
Homo sapiens
-
brenda
Barker, E.V.; Hume, R.; Hallas, A.; Coughtrie, W.H.
Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes
Endocrinology
134
982-989
1994
Homo sapiens
brenda
Falany, C.N.; Comer, K.A.; Dooley, T.P.; Glatt, H.
Human dehydroepiandrosterone sulfotransferase. Purification, molecular cloning, and characterization
Ann. N. Y. Acad. Sci.
774
59-72
1995
Homo sapiens
brenda
Strott, C.A.
Steroid sulfotransferases
Endocr. Rev.
17
670-697
1996
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Kudlacek, P.E.; Clemens, D.L.; Halgard, C.M.; Anderson, R.J.
Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate
Biochem. Pharmacol.
53
215-221
1997
Homo sapiens
brenda
Li, X.; Anderson, R.J.
Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases
Biochem. Biophys. Res. Commun.
263
632-639
1999
Homo sapiens
brenda
Narasaka, T.; Moriya, T.; Endoh, M.; Suzuki, T.; Shizawa, S.; Mizokami, Y.; Matsuoka, T.; Sasano, H.
17Beta-hydroxysteroid dehydrogenase type 2 and dehydroepiandrosterone sulfotransferase in the human liver
Endocr. J.
47
697-705
2000
Homo sapiens
brenda
Chang, H.J.; Zhou, M.; Lin, S.X.
Human dehydroepiandrosterone sulfotransferase: purification and characterization of a recombinant protein
J. Steroid Biochem. Mol. Biol.
77
159-165
2001
Homo sapiens
brenda
Faucher, F.; Lacoste, L.; Luu-The, V.
Human type 1 estrogen sulfotransferase: catecholestrogen metabolism and potential involvement in cancer promotion
Ann. N. Y. Acad. Sci.
963
221-228
2002
Homo sapiens
brenda
Meloche, C.A.; Sharma, V.; Swedmark, S.; Andersson, P.; Falany, C.N.
Sulfation of budesonide by human cytosolic sulfotransferase, dehydroepiandrosterone-sulfotransferase (DHEA-ST)
Drug Metab. Dispos.
30
582-585
2002
Homo sapiens (O00204)
brenda
Miki, Y.; Nakata, T.; Suzuki, T.; Darnel, A.D.; Moriya, T.; Kaneko, C.; Hidaka, K.; Shiotsu, Y.; Kusaka, H.; Sasano, H.
Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues
J. Clin. Endocrinol. Metab.
87
5760-5768
2002
Homo sapiens
brenda
Nishiyama, T.; Ogura, K.; Nakano, H.; Kaku, T.; Takahashi, E.; Ohkubo, Y.; Sekine, K.; Hiratsuka, A.; Kadota, S.; Watabe, T.
Sulfation of environmental estrogens by cytosolic human sulfotransferases
Drug Metab. Pharmacokinet.
17
221-228
2002
Homo sapiens, Homo sapiens (Q06520)
brenda
Rehse, P.H.; Zhou, M.; Lin, S.X.
Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate
Biochem. J.
364
165-171
2002
Homo sapiens
brenda
Lee, K.A.; Fuda, H.; Lee, Y.C.; Negishi, M.; Strott, C.A.; Pedersen, L.C.
Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms
J. Biol. Chem.
278
44593-44599
2003
Homo sapiens (O00204), Homo sapiens
brenda
Sheng, J.J.; Duffel, M.W.
Enantioselectivity of human hydroxysteroid sulfotransferase ST2A3 with naphthyl-1-ethanols
Drug Metab. Dispos.
31
697-700
2003
Homo sapiens
brenda
Schneider, H.; Glatt, H.
Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro
Biochem. J.
383
543-549
2004
Homo sapiens
brenda
Apak, T.I.; Duffel, M.W.
Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa
Drug Metab. Dispos.
32
1501-1508
2004
Homo sapiens, Rattus norvegicus
brenda
Stanley, E.L.; Hume, R.; Coughtrie, M.W.H.
Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification
Mol. Cell. Endocrinol.
240
32-42
2005
Homo sapiens
brenda
Fang, H.L.; Strom, S.C.; Cai, H.; Falany, C.N.; Kocarek, T.A.; Runge-Morris, M.
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor
Mol. Pharmacol.
67
1257-1267
2005
Homo sapiens
brenda
He, D.; Falany, C.N.
Characterization of proline-serine-rich carboxyl terminus in human sulfotransferase 2B1b: immunogenicity, subcellular localization, kinetic properties, and phosphorylation
Drug Metab. Dispos.
34
1749-1755
2006
Homo sapiens (O00204), Homo sapiens
brenda
Meinl, W.; Pabel, U.; Osterloh-Quiroz, M.; Hengstler, J.G.; Glatt, H.
Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue
Int. J. Cancer
118
1090-1097
2006
Homo sapiens (O00204)
brenda
Fuda, H.; Javitt, N.B.; Mitamura, K.; Ikegawa, S.; Strott, C.A.
Oxysterols are substrates for cholesterol sulfotransferase
J. Lipid Res.
48
1343-1352
2007
Homo sapiens, Homo sapiens (O00204)
brenda
Ji, Y.; Moon, I.; Zlatkovic, J.; Salavaggione, O.E.; Thomae, B.A.; Eckloff, B.W.; Wieben, E.D.; Schaid, D.J.; Weinshilboum, R.M.
Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics
J. Pharmacol. Exp. Ther.
322
529-540
2007
Homo sapiens
brenda
Falany, C.N.; He, D.; Dumas, N.; Frost, A.R.; Falany, J.L.
Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization
J. Steroid Biochem. Mol. Biol.
102
214-221
2006
Homo sapiens (O00204), Homo sapiens, Mus musculus (O35400), Rattus norvegicus (Q29YR5)
brenda
Allali-Hassani, A.; Pan, P.W.; Dombrovski, L.; Najmanovich, R.; Tempel, W.; Dong, A.; Loppnau, P.; Martin, F.; Thonton, J.; Edwards, A.M.; Bochkarev, A.; Plotnikov, A.N.; Vedadi, M.; Arrowsmith, C.H.
Structural and chemical profiling of the human cytosolic sulfotransferases
PLoS Biol.
5
1063-1078
2007
Homo sapiens (O00204)
-
brenda
Chen, X.; Zhang, J.; Baker, S.M.; Chen, G.
Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)
Toxicology
231
224-233
2007
Homo sapiens (Q06520)
brenda
Gulcan, H.O.; Liu, Y.; Duffel, M.W.
Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1
Chem. Res. Toxicol.
21
1503-1508
2008
Homo sapiens
brenda
Harris, R.; Turan, N.; Kirk, C.; Ramsden, D.; Waring, R.
Effects of endocrine disruptors on dehydroepiandrosterone sulfotransferase and enzymes involved in PAPS synthesis: genomic and nongenomic pathways
Environ. Health Perspect.
115 Suppl 1
51-54
2007
Homo sapiens
brenda
Fang, H.L.; Strom, S.C.; Ellis, E.; Duanmu, Z.; Fu, J.; Duniec-Dmuchowski, Z.; Falany, C.N.; Falany, J.L.; Kocarek, T.A.; Runge-Morris, M.
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor
J. Pharmacol. Exp. Ther.
323
586-598
2007
Homo sapiens
brenda
Lu, L.Y.; Hsieh, Y.C.; Liu, M.Y.; Lin, Y.H.; Chen, C.J.; Yang, Y.S.
Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1)
Mol. Pharmacol.
73
660-668
2008
Homo sapiens (Q06520)
brenda
Reich, O.; Singer, C.; Hudelist, G.; Regauer, S.
Estrogen sulfotransferase expression in endometrial stromal sarcomas: an immunohistochemical study
Pathol. Res. Pract.
203
85-87
2007
Homo sapiens
brenda
Yang, X.; Xu, Y.; Guo, F.; Ning, Y.; Zhi, X.; Yin, L.; Li, X.
Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo
PLoS ONE
8
e60853
2013
Homo sapiens (O00204), Homo sapiens
brenda
Ekuase, E.J.; Lehmler, H.J.; Robertson, L.W.; Duffel, M.W.
Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1
Chem. Biol. Interact.
212
56-64
2014
Homo sapiens (Q06520)
brenda
Ekuase, E.J.; van t Erve, T.J.; Rahaman, A.; Robertson, L.W.; Duffel, M.W.; Luthe, G.
Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes
Environ. Sci. Pollut. Res. Int.
23
2119-2127
2016
Homo sapiens (Q06520)
brenda
Rizner, T.L.
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Front. Pharmacol.
7
30
2016
Homo sapiens (O00204)
brenda
Zhang, L.; Kurogi, K.; Liu, M.; Schnapp, A.; Williams, F.; Sakakibara, Y.; Suiko, M.; Liu, M.
Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): A systematic analysis
J. Appl. Toxicol.
36
1090-1094
2016
Homo sapiens (O43704), Homo sapiens (P50225), Homo sapiens (P50226)
brenda
Bansal, S.; Lau, A.J.
Human liver cytosolic sulfotransferase 2A1-dependent dehydroepiandrosterone sulfation assay by ultra-high performance liquid chromatography-tandem mass spectrometry
J. Pharm. Biomed. Anal.
120
261-269
2016
Homo sapiens (Q06520)
brenda
Zhu, J.; Qi, R.; Liu, Y.; Zhao, L.; Han, W.
Mechanistic insights into the effect of ligands on structural stability and selectivity of sulfotransferase 2A1 (SULT2A1)
ACS Omega
4
22021-22034
2019
Homo sapiens (Q06520)
brenda
Sun, Y.; Machalz, D.; Wolber, G.; Parr, M.; Bureik, M.
Functional expression of all human sulfotransferases in fission yeast, assay development, and structural models for isoforms SULT4A1 and SULT6B1
Biomolecules
10
1-17
2020
Homo sapiens (Q6IMI4), Homo sapiens
brenda
Yip, C.K.Y.; Bansal, S.; Wong, S.Y.; Lau, A.J.
Identification of galeterone and abiraterone as inhibitors of dehydroepiandrosterone sulfonation catalyzed by human hepatic cytosol, SULT2A1, SULT2B1b, and SULT1E1
Drug Metab. Dispos.
46
470-482
2018
Homo sapiens (O00204), Homo sapiens (Q06520)
brenda
Parker, V.S.; Squirewell, E.J.; Lehmler, H.J.; Robertson, L.W.; Duffel, M.W.
Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1
Environ. Toxicol. Pharmacol.
58
196-201
2018
Homo sapiens (Q06520), Homo sapiens
brenda
Rizner, T.L.
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Front. Pharmacol.
7
30
2016
Homo sapiens (O00204), Homo sapiens (Q06520)
brenda
Feng, L.; Yuen, Y.L.; Xu, J.; Liu, X.; Chan, M.Y.; Wang, K.; Fong, W.P.; Cheung, W.T.; Lee, S.S.
Identification and characterization of a novel PPARalpha-regulated and 7alpha-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8)
J. Lipid Res.
58
1114-1131
2017
Homo sapiens (O00204)
brenda
Bansal, S.; Lau, A.J.
Inhibition of human sulfotransferase 2A1-catalyzed sulfonation of lithocholic acid, glycolithocholic acid, and taurolithocholic acid by selective estrogen receptor modulators and various analogs and metabolites
J. Pharmacol. Exp. Ther.
369
389-405
2019
Homo sapiens (Q06520)
brenda
Vickman, R.E.; Yang, J.; Lanman, N.A.; Cresswell, G.M.; Zheng, F.; Zhang, C.; Doerge, R.W.; Crist, S.A.; Mesecar, A.D.; Hu, C.D.; Ratliff, T.L.
Cholesterol sulfotransferase SULT2B1b modulates sensitivity to death receptor ligand TNFalpha in castration-resistant prostate cancer
Mol. Cancer Res.
17
1253-1263
2019
Homo sapiens (O00204)
brenda
Bi, Y.; Shi, X.; Zhu, J.; Guan, X.; Garbacz, W.G.; Huang, Y.; Gao, L.; Yan, J.; Xu, M.; Ren, S.; Ren, S.; Liu, Y.; Ma, X.; Li, S.; Xie, W.
Regulation of cholesterol sulfotransferase SULT2B1b by hepatocyte nuclear factor 4alpha constitutes a negative feedback control of hepatic gluconeogenesis
Mol. Cell. Biol.
38
e00654-17
2018
Homo sapiens (O00204), Mus musculus (O35400)
brenda