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3'-phosphoadenosine-5'-phosphosulfate + oestrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
3'-phosphoadenylyl sulfate + isolithocholic acid
adenosine 3',5'-bisphosphate + isolithocholate sulfate
-
5beta-cholanoic acid-3beta-ol
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate
adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate
3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol
adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + 5alpha-cholanoic acid-3beta-ol
adenosine 3',5'-bisphosphate + 5alpha-cholanic acid-3beta-ol sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + 5beta-scymnol
adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate
-
bile steroid
-
?
3'-phosphoadenylyl-sulfate + allocholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
3'-phosphoadenylyl-sulfate + cholic acid
adenosine 3',5'-bisphosphate + cholic acid sulfate
3'-phosphoadenylyl-sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate
3'-phosphoadenylyl-sulfate + glycine conjugated chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycine conjugated deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycine conjugated lithocholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycine conjugated ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
3'-phosphoadenylyl-sulfate + glycocholate
adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
3'-phosphoadenylyl-sulfate + hyodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
3'-phosphoadenylyl-sulfate + petromyzonol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated lithocholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
3'-phosphoadenylyl-sulfate + taurocholate
adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
3'-phosphoadenylyl-sulfate + ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + ursodeoxycholate
adenosine 3',5'-bisphosphate + ursodeoxycholate sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chenodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + cholic acid
adenosine 3',5'-bisphosphate + ?
-
lowest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
3'-phosphoadenylylsulfate + deoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + lithocholic acid
adenosine 3',5'-bisphosphate + ?
-
highest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + ursodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + glycolithocholate

adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate

adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate

adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate
-
isoenzyme BSS I
-
-
?
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate
adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate
-
isoenzyme BSS I
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate

adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
sulfation at the 7-OH position
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + cholic acid

adenosine 3',5'-bisphosphate + cholic acid sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + cholic acid
adenosine 3',5'-bisphosphate + cholic acid sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate

adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate
-
sulfation at the 12-OH position
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate

adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycocholate

adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycocholate
adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate

adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
-
-
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate

adenosine 3',5'-bisphosphate + ?
-
best substrate
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + ?
-
highest affinity substrate
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate

adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
-
-
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate

adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + taurocholate

adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurocholate
adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone

adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
isoform SULT2A1
-
-
?
additional information

?
-
-
purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, phenol, tyramine, and serotonin
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
purified enzyme displays no activity toward estrone, testosterone, or phenol
-
-
-
additional information
?
-
-
no bile salt disulfate formation detected
-
-
-
additional information
?
-
-
is a target for transcriptional induction by the vitamin D receptor
-
-
-
additional information
?
-
-
no activity with cholate, glycine conjugated cholate and taurine conjugated cholate
-
-
-
additional information
?
-
-
no activity with glycocholic acid, taurocholic acid, and cholic acid
-
-
-
additional information
?
-
-
5-cholenic acid-3-beta-ol and 5-beta-cholanic acid-3-beta-ol (isolithocholate) are no substrates
-
-
-
additional information
?
-
-
purified enzyme does not react with estrone or dihydroepiandrosterone
-
-
-
additional information
?
-
-
purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, or cortisol
-
-
-
additional information
?
-
-
rate of sulfation is higher with conjugated bile salts than with unconjugated
-
-
-
additional information
?
-
-
is a target for transcriptional induction by the vitamin D receptor
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + chenodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + cholic acid
adenosine 3',5'-bisphosphate + ?
-
lowest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha
-
-
?
3'-phosphoadenylylsulfate + deoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + lithocholic acid
adenosine 3',5'-bisphosphate + ?
-
highest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + ursodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + taurolithocholate

adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
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alternate pathway of bile acid synthesis
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is a target for transcriptional induction by the vitamin D receptor
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is a target for transcriptional induction by the vitamin D receptor
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Chen, L.J.; Bolt, R.J.; Admirand, W.H.
Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts
Biochim. Biophys. Acta
480
219-227
1977
Rattus norvegicus
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Chen, L.J.; Imperato, T.J.; Bolt, R.J.
Enzymatic sulfation of bile salts. II. Studies on bile salt sulfotranferase from rat kidney
Biochim. Biophys. Acta
522
443-451
1978
Rattus norvegicus
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Loeoef, L.; Wengle, B.
Enzymatic sulphation of bile salts in human liver
Biochim. Biophys. Acta
530
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1978
Homo sapiens
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Loeoef, L.; Hjerten, S.
Partial purification of a human liver sulphotransferase active towards bile salts
Biochim. Biophys. Acta
617
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1980
Homo sapiens
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Chen, L.J.
Bile salt sulfotransferase
Methods Enzymol.
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1981
Cavia porcellus, Homo sapiens, Mesocricetus auratus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
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Barnes, S.; Spenney, J.G.
Evidence for heterogeneity of hepatic bile salt sulfotransferases in female hamsters and rats
Biochim. Biophys. Acta
704
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1982
Mesocricetus auratus, Rattus norvegicus, Rattus norvegicus Wistar
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Chen, L.J.
Bile salt sulfotransferase in guinea pig liver
Biochim. Biophys. Acta
717
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1982
Cavia porcellus
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Chen, L.J.; Segel, I.H.
Purification and characterization of bile salt sulfotransferase from human liver
Arch. Biochem. Biophys.
241
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1985
Homo sapiens
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Barnes, S.; Waldrop, R.; Crenshaw, J.; King, R.J.; Taylor, K.B.
Evidence for an ordered reaction mechanism for bile salt:3phosphoadenosine-5-phosphosulfate:sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate
J. Lipid Res.
27
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1986
Macaca mulatta
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Kane, R.E.; Chen, L.J.
Hepatic bile salt sulfotransferases in the rat: sulfation of 3beta-hydroxy-5-cholenoate during development
J. Ped. Gastroent. Nutri.
12
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1991
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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Obinata, K.; Carlstroem, K.; Hjelte, L.; Strandvik, B.
The effect of essential fatty acid deficiency on hepatic bile salt sulfotransferase in rats
J. Steroid Biochem. Mol. Biol.
42
625-627
1992
Rattus norvegicus
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Singer, S.S.; Dravis, D.; Henkels, K.; Trulzsch, D.V.
Fatty acid binding protein inhibits glycolithocholate sulfation
Biochem. Int.
27
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1992
Rattus norvegicus
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Macrides, T.A.; Faktor, D.A.; Kalafatis, N.; Amiet, R.G
Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyzes the sulfation of the shark bile steroid 5beta-scymnol
Comp. Biochem. Physiol. B
107
461-469
1994
Heterodontus portusjacksoni
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Obinata, K.; Nemeth, A.; Ellin, A.; Strandvik, B.
Bile salt sulphotransferase activity in the liver of cholestatic infants
Scand. J. Clin. Lab. Invest.
54
285-290
1994
Homo sapiens
brenda
Chen, W.T.; Liu, M.C.; Yang, Y.S.
Fluorometric assay for alcohol sulfotransferase
Anal. Biochem.
339
54-60
2005
Homo sapiens
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Seely, J.; Amigh, K.S.; Suzuki, T.; Mayhew, B.; Sasano, H.; Giguere, V.; Laganiere, J.; Carr, B.R.; Rainey, W.E.
Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha
Endocrinology
146
3605-3613
2005
Homo sapiens
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Stanley, E.L.; Hume, R.; Coughtrie, M.W.H.
Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification
Mol. Cell. Endocrinol.
240
32-42
2005
Homo sapiens
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Echchgadda, I.; Song, C.S.; Roy, A.K.; Chatterjee, B.
Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor
Mol. Pharmacol.
65
720-729
2004
Homo sapiens, Rattus norvegicus
brenda
Seo, Y.K.; Chung, Y.T.; Kim, S.; Echchgadda, I.; Song, C.S.; Chatterjee, B.
Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin
Gene
386
218-223
2007
Mus musculus
brenda
Echchgadda, I.; Song, C.S.; Oh, T.; Ahmed, M.; De La Cruz, I.J.; Chatterjee, B.
The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase
Mol. Endocrinol.
21
2099-2111
2007
Homo sapiens, Homo sapiens (Q06520)
brenda
Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases
Biochem. J.
422
455-462
2009
Homo sapiens (Q06520)
brenda
Kurogi, K.; Krasowski, M.D.; Injeti, E.; Liu, M.Y.; Williams, F.E.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs)
J. Steroid Biochem. Mol. Biol.
127
307-314
2011
Homo sapiens
brenda
Huang, J.; Bathena, S.P.; Tong, J.; Roth, M.; Hagenbuch, B.; Alnouti, Y.
Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)
Xenobiotica
40
184-194
2010
Homo sapiens, Homo sapiens (Q06520)
brenda