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Information on EC 2.8.2.14 - bile-salt sulfotransferase
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2.8.2.14 bile-salt sulfotransferaseIUBMB Comments
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species . This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 .
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Word Map
- 2.8.2.14
-
hydroxysteroids
-
sulfotransferases
-
sults
- dhea-st
-
lithocholic
- sult2b1a
-
hsult2a1
- alpha-hydroxytamoxifen
-
reticularis
-
sulfurylation
-
phenol-sulfating
- 2,6-dichloro-4-nitrophenol
-
sulfotransferase-mediated
- medicine
-
lca-induced
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
3'-phosphoadenylyl-sulfate:taurolithocholate sulfotransferase, 3beta-hydroxy-5-cholenoate sulfotransferase, BAST, BAST I, bile acid sulfotransferase I, bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase, BSS, BSS I, BSS II, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3'-phosphoadenylyl-sulfate:taurolithocholate sulfotransferase
-
-
-
-
3beta-hydroxy-5-cholenoate sulfotransferase
BAST I
-
-
-
-
bile acid sulfotransferase I
-
-
-
-
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase
-
-
-
-
bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase
-
-
-
-
BSS
BSS I
BSS II
dehydroepiandrosterone sulfotransferase
glycolithocholate sulfotransferase
-
-
-
-
steroid/bile acid-sulfotransferase
-
-
-
-
SULT2A1
SULT2A1
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
-
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate
both conjugated and unconjugated bile salts can act as acceptors
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].
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CAS REGISTRY NUMBER
COMMENTARY
65802-92-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenosine-5'-phosphosulfate + oestrone
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
3'-phosphoadenylyl sulfate + isolithocholic acid
adenosine 3',5'-bisphosphate + isolithocholate sulfate
-
5beta-cholanoic acid-3beta-ol
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + 3alpha,7alpha,12alpha-cholic acid
adenosine 3',5'-bisphosphate + 3alpha,7alpha,12alpha-cholic acid sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate
adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate
3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol
adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate
3'-phosphoadenylyl-sulfate + 5alpha-cholanoic acid-3beta-ol
adenosine 3',5'-bisphosphate + 5alpha-cholanic acid-3beta-ol sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + 5beta-scymnol
adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate
-
bile steroid
-
?
3'-phosphoadenylyl-sulfate + allocholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
3'-phosphoadenylyl-sulfate + cholic acid
adenosine 3',5'-bisphosphate + cholic acid sulfate
3'-phosphoadenylyl-sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate
3'-phosphoadenylyl-sulfate + glycine conjugated chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + glycine conjugated deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + glycine conjugated lithocholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + glycine conjugated ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
3'-phosphoadenylyl-sulfate + glycocholate
adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
3'-phosphoadenylyl-sulfate + hyodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
3'-phosphoadenylyl-sulfate + petromyzonol
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated lithocholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + taurine conjugated ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
3'-phosphoadenylyl-sulfate + taurocholate
adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
3'-phosphoadenylyl-sulfate + ursodeoxycholate
adenosine 3',5'-bisphosphate + ursodeoxycholate sulfate
-
-
-
?
3'-phosphoadenylylsulfate + chenodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + cholic acid
adenosine 3',5'-bisphosphate + ?
lowest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
3'-phosphoadenylylsulfate + deoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + lithocholic acid
adenosine 3',5'-bisphosphate + ?
highest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + ursodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate
adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate
-
isoenzyme BSS I
-
-
?
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate
adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate
-
isoenzyme BSS I
-
-
?
3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol
adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + 5-cholenic acid-3beta-ol
adenosine 3',5'-bisphosphate + 5-cholenic acid-3-beta-ol sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
sulfation at the 7-OH position
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + chenodeoxycholate
adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + cholic acid
adenosine 3',5'-bisphosphate + cholic acid sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + cholic acid
adenosine 3',5'-bisphosphate + cholic acid sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate
-
sulfation at the 12-OH position
-
?
3'-phosphoadenylyl-sulfate + deoxycholate
adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycochenodeoxycholate
adenosine 3',5'-bisphosphate + glycochenodeoxycholate monosulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycocholate
adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycocholate
adenosine 3',5'-bisphosphate + glycocholate 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + ?
-
best substrate
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + ?
highest affinity substrate
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + lithocholate
adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + taurochenodeoxycholate
adenosine 3',5'-bisphosphate + taurochenodeoxycholate monosulfate + taurochenodeoxycholate disulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + taurocholate
adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
-
-
-
-
?
3'-phosphoadenylyl-sulfate + taurocholate
adenosine 3',5'-bisphosphate + taurocholate monosulfate + taurocholate disulfate + taurocholate trisulfate
-
-
-
?
3'-phosphoadenylyl-sulfate + ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylyl-sulfate + ursodeoxycholate
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
isoform SULT2A1
-
-
?
additional information
?
-
-
purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, phenol, tyramine, and serotonin
-
-
?
additional information
?
-
-
purified enzyme displays no activity toward estrone, testosterone, or phenol
-
-
?
additional information
?
-
-
is a target for transcriptional induction by the vitamin D receptor
-
-
?
additional information
?
-
-
no activity with cholate, glycine conjugated cholate and taurine conjugated cholate
-
-
?
additional information
?
-
no activity with cholate, glycine conjugated cholate and taurine conjugated cholate
-
-
?
additional information
?
-
-
no activity with glycocholic acid, taurocholic acid, and cholic acid
-
-
?
additional information
?
-
-
5-cholenic acid-3-beta-ol and 5-beta-cholanic acid-3-beta-ol (isolithocholate) are no substrates
-
-
?
additional information
?
-
-
purified enzyme does not react with estrone or dihydroepiandrosterone
-
-
?
additional information
?
-
-
purified enzyme does not react with estrone, estradiol, testosterone, dehydroepiandrosterone, cholesterol, or cortisol
-
-
?
additional information
?
-
-
rate of sulfation is higher with conjugated bile salts than with unconjugated
-
-
?
additional information
?
-
-
is a target for transcriptional induction by the vitamin D receptor
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + glycolithocholate
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + chenodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + cholic acid
adenosine 3',5'-bisphosphate + ?
lowest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate
-
transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha
-
-
?
3'-phosphoadenylylsulfate + deoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylylsulfate + lithocholic acid
adenosine 3',5'-bisphosphate + ?
highest affinity to sulfation by SULT2A1
-
-
?
3'-phosphoadenylylsulfate + ursodeoxycholic acid
adenosine 3',5'-bisphosphate + ?
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
sulfation of hepatotoxic monohydroxy bile salts as important detoxification mechanism to avoid hepatic damages by the substrates, protective mechanism against accumulation of hepatotoxic bile salts
-
?
3'-phosphoadenylyl sulfate + taurolithocholate
adenosine 3',5'-bisphosphate + taurolithocholate sulfate
-
alternate pathway of bile acid synthesis
-
?
additional information
?
-
-
is a target for transcriptional induction by the vitamin D receptor
-
-
?
additional information
?
-
-
is a target for transcriptional induction by the vitamin D receptor
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
Mg2+
the addition of 2 mM MgCl2 to the reaction causes a 20% increase in sulfation activity, whereas higher concentrations of Mg2+ inhibit enzyme activity
Mg2+
the presence of MgCl2 is not required for the SULT2A1 enzyme activity. However, the addition of 2 mM MgCl2 to the reaction causes a 20% increase in sulfation activity, whereas higher concentrations of Mg2+ inhibit SULT2A1 activity
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
3-ketolithocholate
-
isoenzyme BSS I completely inhibited, isoenzyme BSS II only 13%
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
constitutive androstane receptor
3.5fold induction of SULT2A1 mRNAs in human cell lines of enterohepatic origin, such as Caco-2 intestinal cells and HepG2 hepatoma cells transfected with the CAR plasmid
-
pregnane X receptor
1.7fold induction of SULT2A1 mRNAs in human cell lines of enterohepatic origin, such as Caco-2 intestinal cells and HepG2 hepatoma cells transfected with the PXR plasmid
-
pregnenolone-16alpha-carbonitrile
-
aging does not change the induction of enzyme by synthetic steroid pregnenolone-16alpha-carbonitrile
vitamin D3
-
aging does not change the induction of enzyme by hormonally active vitamin D3
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Dehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma.
Breast Neoplasms
Identification and characterization of cytosolic sulfotransferase activities in MCF-7 human breast carcinoma cells.
Carcinogenesis
Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
Carcinoma
Dehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma.
Carcinoma
Identification and characterization of cytosolic sulfotransferase activities in MCF-7 human breast carcinoma cells.
Carcinoma
Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
Carcinoma, Hepatocellular
Down-regulation of dehydroepiandrosterone sulfotransferase gene in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo.
Cholestasis
Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites.
Herpes Zoster
Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells.
Liver Diseases
Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by ROR? and ROR? and its potential relevance to human liver diseases.
Neoplasms
Dehydroepiandrosterone sulfotransferase as a possible shunt for the control of steroid metabolism in human mammary carcinoma.
Neoplasms
Estrogen receptor and C19-5-ene-steroid concentrations in the nuclear fraction from human breast carcinoma tissue.
Neoplasms
Non-functioning adrenocortical carcinoma arising in an adrenal rest: immunohistochemical study of an adult patient.
Neoplasms
The steroid alcohol and estrogen sulfotransferases in rodent and human mammary tumors.
Neoplasms
Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome.
Prostatic Neoplasms
Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00886
deoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.04899
glycine conjugated chenodeoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.05459
glycine conjugated deoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.00192
glycine conjugated lithocholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.04957
glycine conjugated ursodeoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.04509
taurine conjugated chenodeoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.01836
taurine conjugated deoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.00186
taurine conjugated lithocholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.00993
taurine conjugated ursodeoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.01286
ursodeoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.01566
chenodeoxycholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.0014
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
0.00383
dehydroepiandrosterone
apparent value, at pH 5.5 and 7.4, at 37°C
0.00383
dehydroepiandrosterone
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
0.00202
lithocholate
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.00079
-
using hyodeoxycholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.00248
0.0028
-
using glycochenodeoxycholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.00354
-
using chenodeoxycholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.00359
-
using petromyzonol as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.00492
-
using ursodeoxycholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.00819
-
using deoxycholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.02361
-
using lithocholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
additional information
-
continuous fluorimetric assay for alcohol sulfotransferase whoses sensitivity is comparable to that of the end-point radioactive assay. Assay procedure can be adapted for high-throughput assay using a microplate reader
0.00248
-
using allochloate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
0.00248
-
using taurochenodeoxycholate as substrate, in 50 mM Mops buffer at pH 7.0, at 37°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4 - 9
5.5 - 10.5
4 - 9
a more than 10fold increase in enzyme activity is observed with increasing the pH from 4.0 to 5.5, while further increase in pH in 10 mM Tris-HCl buffer is associated with a decline in the enzyme activity
4 - 9
more than a 10fold increase in SULT2A1 activity is observed with increasing the pH from 4.0 to 5.5, while a further increase in pH in 10 mM Tris-HCl buffer (up to pH 9-0) is associated with a 50% decline in the optimum enzyme activity
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.3
5.85 - 6.69
-
isoelectric focusing, 2 major bands with different pI values
5.3
-
isoelectric focusing electrophoresis, method originally described by Svensson, maintained at 0°C
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
aging does not influence the response to the hormonal and xenobiotic signaling for enzyme Sult2A1 induction
-
-
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
-
high activity in adult liver and low activity in fetal liver, isoform SULT2A1
brenda
additional information
-
not detectable in brain, lung, heart, spleen, intestinal mucosa or red blood cells
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ST2A1_HUMAN
285
0
33780
Swiss-Prot
other Location (Reliability: 3)
ST2A1_MACFA
285
0
33920
Swiss-Prot
other Location (Reliability: 3)
ST2A1_MOUSE
285
0
33213
Swiss-Prot
other Location (Reliability: 2)
ST2A1_RAT
284
0
33135
Swiss-Prot
other Location (Reliability: 2)
ST2A2_MOUSE
285
0
33329
Swiss-Prot
other Location (Reliability: 2)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
130000
200000
-
3 different peaks of bile salt sulfotransferase activity, active with glycochenodeoxycholate and glycolithocholate, gel filtration
32000
-
3 different peaks of bile salt sulfotransferase activity, glycochenodeoxycholate as substrate, gel filtration
33780
x * 34000, SDS-PAGE, x * 33780, calculated from amino acid sequence
34000
x * 34000, SDS-PAGE, x * 33780, calculated from amino acid sequence
45000
-
3 different peaks of bile salt sulfotransferase activity, glycochenodeoxycholate as substrate, gel filtration
60000
-
3 different peaks of bile salt sulfotransferase activity, glycolithocholate as substrate, gel filtration
64000
-
3 different peaks of bile salt sulfotransferase activity, glycolithocholate as substrate, gel filtration
130000
-
3 different peaks of bile salt sulfotransferase activity, major activity, gel filtration
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing and thawing results in significant loss in activity, substantial stabilization with addition of sucrose
-
repeated freezing and thawing reduces activity considerably, addition of ethylene glycol preserves activity
-
SULT2A1 activity is consistently higher using NaH2PO4 buffer in a pH range from 5.5 to 6.5
SULT2A1 activity is consistently highest using NaH2PO4 buffer in a pH range from 5.5 to 6.5
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, crude enzyme may be stored for several months without loss of enzyme activity
-
-20°C, when stored frozen, activity in enzyme homogenate is preserved for at least 9 months
-
-30°C, ethylene glycol enzyme solution can be stored for at least 3 months without serious decrease in activity
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in HepG2 cells or CaCo-2 cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
medicine
-
assay for bile salt sulfotransferase renders it possible to estimate this enzyme in percutaneous liver biopsy specimens. By application of this technique it will be possible to study this enzyme in patients with various liver diseases
medicine
-
aging does not influence the response to the hormonal and xenobiotic signaling for enzyme Sult2A1 induction
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, L.J.; Bolt, R.J.; Admirand, W.H.
Enzymatic sulfation of bile salts. Partial purification and characterization of an enzyme from rat liver that catalyzes the sulfation of bile salts
Biochim. Biophys. Acta
480
219-227
1977
Rattus norvegicus
brenda
Chen, L.J.; Imperato, T.J.; Bolt, R.J.
Enzymatic sulfation of bile salts. II. Studies on bile salt sulfotranferase from rat kidney
Biochim. Biophys. Acta
522
443-451
1978
Rattus norvegicus
brenda
Loeoef, L.; Wengle, B.
Enzymatic sulphation of bile salts in human liver
Biochim. Biophys. Acta
530
451-460
1978
Homo sapiens
brenda
Loeoef, L.; Hjerten, S.
Partial purification of a human liver sulphotransferase active towards bile salts
Biochim. Biophys. Acta
617
192-204
1980
Homo sapiens
brenda
Chen, L.J.
Bile salt sulfotransferase
Methods Enzymol.
77
213-218
1981
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Rattus norvegicus, Sus scrofa
brenda
Barnes, S.; Spenney, J.G.
Evidence for heterogeneity of hepatic bile salt sulfotransferases in female hamsters and rats
Biochim. Biophys. Acta
704
353-360
1982
Mesocricetus auratus, Rattus norvegicus, Rattus norvegicus Wistar
brenda
Chen, L.J.
Bile salt sulfotransferase in guinea pig liver
Biochim. Biophys. Acta
717
316-321
1982
Cavia porcellus
brenda
Chen, L.J.; Segel, I.H.
Purification and characterization of bile salt sulfotransferase from human liver
Arch. Biochem. Biophys.
241
371-379
1985
Homo sapiens
brenda
Barnes, S.; Waldrop, R.; Crenshaw, J.; King, R.J.; Taylor, K.B.
Evidence for an ordered reaction mechanism for bile salt:3phosphoadenosine-5-phosphosulfate:sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate
J. Lipid Res.
27
1111-1123
1986
Macaca mulatta
brenda
Kane, R.E.; Chen, L.J.
Hepatic bile salt sulfotransferases in the rat: sulfation of 3beta-hydroxy-5-cholenoate during development
J. Ped. Gastroent. Nutri.
12
260-268
1991
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Obinata, K.; Carlstroem, K.; Hjelte, L.; Strandvik, B.
The effect of essential fatty acid deficiency on hepatic bile salt sulfotransferase in rats
J. Steroid Biochem. Mol. Biol.
42
625-627
1992
Rattus norvegicus
brenda
Singer, S.S.; Dravis, D.; Henkels, K.; Trulzsch, D.V.
Fatty acid binding protein inhibits glycolithocholate sulfation
Biochem. Int.
27
373-383
1992
Rattus norvegicus
brenda
Macrides, T.A.; Faktor, D.A.; Kalafatis, N.; Amiet, R.G
Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyzes the sulfation of the shark bile steroid 5beta-scymnol
Comp. Biochem. Physiol. B
107
461-469
1994
Heterodontus portusjacksoni
brenda
Obinata, K.; Nemeth, A.; Ellin, A.; Strandvik, B.
Bile salt sulphotransferase activity in the liver of cholestatic infants
Scand. J. Clin. Lab. Invest.
54
285-290
1994
Homo sapiens
brenda
Chen, W.T.; Liu, M.C.; Yang, Y.S.
Fluorometric assay for alcohol sulfotransferase
Anal. Biochem.
339
54-60
2005
Homo sapiens
brenda
Seely, J.; Amigh, K.S.; Suzuki, T.; Mayhew, B.; Sasano, H.; Giguere, V.; Laganiere, J.; Carr, B.R.; Rainey, W.E.
Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha
Endocrinology
146
3605-3613
2005
Homo sapiens
brenda
Stanley, E.L.; Hume, R.; Coughtrie, M.W.H.
Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification
Mol. Cell. Endocrinol.
240
32-42
2005
Homo sapiens
brenda
Echchgadda, I.; Song, C.S.; Roy, A.K.; Chatterjee, B.
Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor
Mol. Pharmacol.
65
720-729
2004
Homo sapiens, Rattus norvegicus
brenda
Seo, Y.K.; Chung, Y.T.; Kim, S.; Echchgadda, I.; Song, C.S.; Chatterjee, B.
Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin
Gene
386
218-223
2007
Mus musculus
brenda
Echchgadda, I.; Song, C.S.; Oh, T.; Ahmed, M.; De La Cruz, I.J.; Chatterjee, B.
The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase
Mol. Endocrinol.
21
2099-2111
2007
Homo sapiens (Q06520), Homo sapiens
brenda
Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases
Biochem. J.
422
455-462
2009
Homo sapiens (Q06520)
brenda
Kurogi, K.; Krasowski, M.D.; Injeti, E.; Liu, M.Y.; Williams, F.E.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs)
J. Steroid Biochem. Mol. Biol.
127
307-314
2011
Homo sapiens
brenda
Huang, J.; Bathena, S.P.; Tong, J.; Roth, M.; Hagenbuch, B.; Alnouti, Y.
Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)
Xenobiotica
40
184-194
2010
Homo sapiens, Homo sapiens (Q06520)
brenda
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