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Information on EC 2.8.2.1 - aryl sulfotransferase and Organism(s) Homo sapiens and UniProt Accession O75897

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.1 aryl sulfotransferase
IUBMB Comments
A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase).
Specify your search results
Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: O75897
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The taxonomic range for the selected organisms is: Homo sapiens
Synonyms
1-naphthol phenol sulfotransferase, 2-naphtholsulfotransferase, 4-nitrocatechol sulfokinase, aryl sulfotransferase IV, aryl SULT, ArylST, arylsulfotransferase, ASST, AST, ASTIV, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-naphthol phenol sulfotransferase
-
-
-
-
2-naphtholsulfotransferase
-
-
-
-
4-nitrocatechol sulfokinase
-
-
-
-
arylsulfotransferase
-
-
-
-
ASTIV
-
-
-
-
catecholamine-sulfating phenol sulfotransferase
-
-
-
-
cytosolic sulfotransferase
DOPA/tyrosine sulfotransferase
-
-
-
-
dopamine sulfotransferase
H-PST
247
i.e. hippocampal phenol sulfotransferase
HAST1/HAST2
-
-
-
-
HAST3
-
-
-
-
hippocampal phenol sulfotransferase
-
-
-
-
M-PST
minoxidil sulfotransferase
-
-
-
-
monoamine sulfotransferase
-
-
-
-
monoamine-form phenol sulfotransferase
247
-
neuronal SULT
281426
-
p-nitrophenol sulfotransferase
-
-
-
-
P-PST
PAPS-sulfotransferase
247
-
phenol sulfokinase
-
-
-
-
phenol sulfotransferase
phenol sulfotransferase 1
247
-
phenol sulfotransferase 1A1
phenol sulfotransferase 1A3
247
-
phenol/aryl sulfotransferase
-
-
-
-
Pst
-
-
-
-
PST-P
247
-
ritodrine sulfotransferase
-
-
-
-
ST1A2
-
-
-
-
ST1A3
-
-
-
-
ST1A4
-
-
-
-
sulfokinase
-
-
-
-
sulfotransferase
247
-
sulfotransferase 1A1
sulfotransferase 1A3
sulfotransferase, aryl
-
-
-
-
sulfotransferase, monoamine-preferring
-
-
-
-
sulphotransferase
272855
-
SULT1A1
SULT1A1*2
247
-
SULT1A2
SULT1A3
SULT1B1
SULT1B2
272865
-
SULT1C*2
272868
-
SULT1C1
247
-
SULT1C2
247
-
SULT1C3
247
-
SULT1E1
247
-
SULT2A1
247
-
SULT4A1
thermolabile phenol sulfotransferase
-
-
-
-
thermostable phenol sulfotransferase
-
-
-
-
TL-PST
-
-
-
-
TS-PST
-
-
-
-
tyrosine-ester sulfotransferase
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:phenol sulfotransferase
A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase).
CAS REGISTRY NUMBER
COMMENTARY hide
9026-09-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
SULT1C2
-
-
?
2 3'-phosphoadenylyl sulfate + 2 dopamine
2 adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + dopamine 4-O-sulfate
show the reaction diagram
SULT1A3
NMR product structure analysis, dopamine 3-O-sulfate is the main product, overview
-
?
3'-phosphoadenosine 5'-phosphosulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 2,3,3',5,5',6-hexachlorobiphenyl-4'-yl
adenosine 3',5'-bisphosphate + 2,2',3,3',5,5'-hexachlorobiphenyl-4'-yl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 2,3,5,5',6-pentachlorobiphenyl-4'-yl
adenosine 3',5'-bisphosphate + 2,2',3,3',5'-pentachlorobiphenyl-4'-yl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 2,6-dichloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2,6-dichloro-4-nitrophenyl sulfate
show the reaction diagram
low activity, inhibitory
-
-
?
3'-phosphoadenylyl sulfate + 2-aminophenol
adenosine 3',5'-bisphosphate + 2-aminophenyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 2-methoxyestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 3',4',5-trichlorobiphenyl-2-yl
adenosine 3',5'-bisphosphate + 3',4',5-trichlorobiphenyl-2-yl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine
adenosine 3',5'-bisphosphate + 3-nitro-O-sulfo-L-tyrosine
show the reaction diagram
specific reaction of SULT1A3, not performed by other SULT isozymes
-
-
?
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine
adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine
show the reaction diagram
sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-3'-ol
adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-3-yl sulfate
show the reaction diagram
low activity
-
-
?
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-4'-ol
adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-4-yl sulfate
show the reaction diagram
low activity
-
-
?
3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
show the reaction diagram
3'-phosphoadenylyl sulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + 4-methylumbelliferyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 5-chloro-7-iodo-8-quinolinol
adenosine 3',5'-bisphosphate + 5-chloro-7-iodo-8-quinolinyl sulfate
show the reaction diagram
-
isoform SULT1A3 is responsible for the 5-chloro-7-iodo-8-quinolinol sulfation in human jejunum
-
-
?
3'-phosphoadenylyl sulfate + 6-hydroxydopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + acetaminophen
adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + butylparaben
adenosine 3',5'-bisphosphate + butylparaben sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
substrate of allozyme SULT1A1*1
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + DL-3-hydroxyphenylalanine
adenosine 3',5'-bisphosphate + DL-3-(sulfooxy)phenylalanine
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopaminyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity
-
-
?
3'-phosphoadenylyl sulfate + fenoterol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
as fenoterol hydrobromide
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
as isoproterenol hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
adenosine 3',5'-bisphosphate + isoproterenol sulfate
show the reaction diagram
as isoproterenol hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + L-DOPA
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + L-tyrosine
adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine
show the reaction diagram
low activity
-
-
?
3'-phosphoadenylyl sulfate + minoxidil
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl-4-amine
show the reaction diagram
SULT1C*2
-
-
?
3'-phosphoadenylyl sulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + pentachlorophenol
adenosine 3',5'-bisphosphate + pentachlorophenyl sulfate
show the reaction diagram
low activity, inhibitory
-
-
?
3'-phosphoadenylyl sulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
allozyme SULT1A1*1
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + trans-resveratrol-3-O sulfate
show the reaction diagram
-
3,4',5-trihydroxy-trans-stilbene
-
-
?
3'-phosphoadenylyl sulfate + ritodrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
as ritodrine hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + salbutamol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
as salbutamol hemisulfate
-
-
?
3'-phosphoadenylyl sulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + terbutaline
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
as terbutaline hemisulfate
-
-
?
3'-phosphoadenylyl sulfate + trans-4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + trans-4-(sulfooxy)tamoxifen
show the reaction diagram
substrate of the allozymes SULT1A1*2 and SULT1A1*1
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + (+/-)isoproterenol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + (+/-)metoprolol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + (+/-)salbutamol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + (+/-)sotalol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 2-amino-4'-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 2-ethylphenol
adenosine 3',5'-bisphosphate + 2-ethylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 2-methylphenol
adenosine 3',5'-bisphosphate + 2-methylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthylsulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylacetate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 3,5-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 3-ethylphenol
adenosine 3',5'-bisphosphate + 3-ethylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 3-methylphenol
adenosine 3',5'-bisphosphate + 3-methylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-chlorocatechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 4-ethylphenol
adenosine 3',5'-bisphosphate + 4-ethylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-hydroxy-3-methoxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 4-isopropylcatechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 4-methoxytyramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylcatechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 4-methylphenol
adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + 4-n-amylphenol
adenosine 3',5'-bisphosphate + 4-n-amylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-n-butylphenol
adenosine 3',5'-bisphosphate + 4-n-butylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-n-propylphenol
adenosine 3',5'-bisphosphate + 4-n-propylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 4-nonylphenol
adenosine 3',5'-bisphosphate + 4-nonylphenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 4-octylphenol
adenosine 3',5'-bisphosphate + 4-octylphenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + 5,7-dihydroxyflavanone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-(hydroxyphenyl)-5-(p-tolyl)-hydantoin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxyindole
adenosine 3',5'-bisphosphate + 5-indoxyl sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + acebutolol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + acetaminophen
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST and P-PST
-
-
?
3'-phosphoadenylylsulfate + benzyl alcohol
adenosine 3',5'-bisphosphate + benzyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + bisphenol A
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + bupivacaine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + D-tyrosine
adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
show the reaction diagram
M-PST
-
-
?
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein 4'-sulfate
show the reaction diagram
-
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + daidzein 4'-sulfate
adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
show the reaction diagram
3'-phosphoadenylylsulfate + daidzein 7-sulfate
adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
show the reaction diagram
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + dexamethasone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + DL-propanolol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + dobutamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 4'-sulfate
show the reaction diagram
-
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + genistein 4'-sulfate
adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
show the reaction diagram
3'-phosphoadenylylsulfate + genistein 7-sulfate
adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
show the reaction diagram
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + L-thyroxine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + L-tyrosine
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
show the reaction diagram
M-PST
-
-
?
3'-phosphoadenylylsulfate + lidocaine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + naringenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + normetanephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + phentolamine
adenosine 3',5'-bisphosphate + phentolamine sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + ritodrine
adenosine 3',5'-bisphosphate + ritodrine sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + sakuranetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + salicylamide
adenosine 3',5'-bisphosphate + 2-sulfooxybenzamide
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
3'-phosphoadenylylsulfate + troglitazone
adenosine 3',5'-bisphosphate + troglitazone sulfate
show the reaction diagram
-
ST1A3, not ST1A5
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + umbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
adenosine 3',5'-bisphosphate + 4-methylumbelliferyl sulfate
3'-phosphoadenylyl sulfate + 4-methylumbelliferone
show the reaction diagram
-
-
-
-
r
adenosine 3',5'-bisphosphate + dopamine sulfate
3'-phosphoadenylyl sulfate + dopamine
show the reaction diagram
-
-
-
-
r
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 3'-phosphoadenylyl sulfate + 2 dopamine
2 adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + dopamine 4-O-sulfate
show the reaction diagram
P0DMM9
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methoxyestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine
adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine
show the reaction diagram
P0DMM9
sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
show the reaction diagram
-
a potent inducer of apoptosis in breast tumor cell lines
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
i.e. aminoflavone, diaminoflavone analogues with potent growth-inhibitory activity against human breast and renal cancer cells in vitro and antitumor activity in mice bearing human tumor xenografts, aminoflavone binds to DNA in tumor cells and induces DNA-protein cross-links
-
-
?
3'-phosphoadenylyl sulfate + 5-chloro-7-iodo-8-quinolinol
adenosine 3',5'-bisphosphate + 5-chloro-7-iodo-8-quinolinyl sulfate
show the reaction diagram
-
isoform SULT1A3 is responsible for the 5-chloro-7-iodo-8-quinolinol sulfation in human jejunum
-
-
?
3'-phosphoadenylyl sulfate + 6-hydroxydopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + acetaminophen
adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + desipramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopaminyl sulfate
show the reaction diagram
-
specific substrate for isoform SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + minoxidil
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
accounts for approximately 10% of the enzymic activity directed towards catabolism of dopamine
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
adenosine 3',5'-bisphosphate + dopamine sulfate
3'-phosphoadenylyl sulfate + dopamine
show the reaction diagram
-
-
-
-
r
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
activates
NaCl
-
activates
additional information
-
no effect: Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-catechin
-
(-)-epicatechin
(-)-epicatechin gallate
(-)-epigallocatechin
(-)-epigallocatechin gallate
1-hydroxy-4-ethylbenzene
-
-
17alpha-ethinylestradiol
-
potent inhibitor, 17alpha-ethinylestradiol binds and inhibits isoform SULT1A1 activity toward 4-nitrophenol and 2-naphthol at low nanomolar concentrations, whereas the compound is not sulfated until significantly higher concentrations are reached
2,3',4,6-tetrachlorobiphenyl-4'-ol
i.e. 4'-OH-CB69
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor
2,3,3',5,6-pentachlorobiphenyl-4'-ol
i.e. 4'-OH-CB112
2,3-Butanedione
Arg-specific modification reagent; SULT1A1, inactivation
2,6-Dichloro-4-nitrophenol
2,6-dichloro-4-nitrophenyl phosphate
-
i.e. DCNP
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol
2-Aminophenol
substrate inhibition of SULT1A1
2-Ethylphenol
-
inhibits SULT1A1/2 and SULT1A3
2-n-propylphenol
-
inhibits SULT1A1/2, but not SULT1A3
2-sec-Butylphenol
-
inhibits SULT1A1/2, but not SULT1A3
2-sec-propylphenol
-
inhibits SULT1A1/2 and SULT1A3
2-tert-butylphenol
-
inhibits SULT1A1/2, but not SULT1A3
3',4,5'-trichlorobiphenyl-4'-ol
i.e. 4'-OH-CB39
3'-phosphoadenylylsulfate
-
substrate inhibition
3,3',4-trichlorobiphenyl-6'-ol
i.e. 6'-OH-CB35
3,3',5',6-tetrachlorobiphenyl-4'-ol
i.e. 4'-OH-CB72
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide
-
DBHM
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide
-
DBHD
4-aminobiphenyl
i.e. 4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol
4-chlorobiphenyl-3'-ol
i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview
4-chlorobiphenyl-4'-ol
i.e. 4'-OH-CB3
4-n-amylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-n-heptylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-n-nonylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-n-octylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-nitrophenol
5,7-dichlorokynurenic acid
-
-
5-chloro-7-iodo-8-quinolinol
-
inhibits isoform SULT1A3-mediated sulfation of dopamine in a dose-dependent manner
6',7'-dihydroxybergamottin
6-Hydroxydopamine
-
competiitve versus dopamine, complete inhibition at about 1 mM
7-hydroxyserotonin
-
competitive versus serotonin, complete inhibition at about 1 mM
Acetylsalicylate
-
binds near enough to the substrate site to prevent catalysis but does not affect dissociation of the substrate-enzyme complex
adenosine 3',5'-bisphosphate
adenosine 5'-(beta,gamma-imido) triphosphate
-
i.e. AMP-PNP, a non-hydrolysable ATP analogue
apigenin
-
antagonizes aminoflavone by inhibiting SULT1A1
bergamottin
caffeic acid
-
inhibition of P-PST and M-PST
chlorogenic acid
-
inhibition of P-PST and M-PST
Co2+
-
P-PST, not M-PST; P-PST, slightly inhibiting with minoxidil as substrate
Cu2+
-
M-PST and P-PST, strong inhibition
daidzein
diethyldicarbonate
-
His108 is critical for activity
dopamine
dopamine 3-O-sulfate
-
35-85% product inhibition of SULT1A3
dopamine 4-O-sulfate
-
40-80% product inhibition of SULT1A3
epigallocatechin gallate
-
highly specific inhibitor of isoform SULT1A1
Fe2+
-
M-PST, not P-PST
gavestinel
-
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
genistein
Hg2+
-
M-PST and P-PST, strong inhibition
Ibuprofen
-
-
indomethacin
-
-
Kynurenic acid
-
-
L689,560
-
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
-
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
meclofenamate
-
binds near enough to the substrate site to prevent catalysis but does not affect dissociation of the substrate-enzyme complex
Mefenamic acid
-
-
N-Hydroxy-4-aminobiphenyl
i.e. N-OH-4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol
naproxen
-
-
naringenin
naringin
inhibition of SULT1A3
nimesulide
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
nobiletin
Pentachlorophenol
Phenylglyoxal
-
-
piroxicam
-
-
protocatechuic acid
-
inhibition of P-PST and M-PST
punicalagin
-
-
pyridoxal 5'-phosphate
-
a competitive inhibitor for sulfotransferases
quercetin
resveratrol
-
substrate inhibition
salicylate
-
-
Sinapic acid
-
inhibition of P-PST and M-PST
sulindac
-
-
syringic acid
-
inhibition of P-PST and M-PST
tangeretin
theaflavin
thearubigin
vanillic acid
-
inhibition of P-PST and M-PST
Zn2+
-
P-PST and M-PST
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ferulic acid
-
activation of M-PST
gallic acid
-
activation of P-PST and M-PST
gentisic acid
-
activation of P-PST and M-PST
m-coumaric acid
-
activation of P-PST
morpholinosydnonimine
-
i.e. SIN-1, a peroxynitrite generator, activates SULT1A3 in vivo in Hep-G2 cells
o-coumaric acid
-
activation of P-PST
p-coumaric acid
-
activation of P-PST
p-hydroxybenzoic acid
-
activation of P-PST and M-PST
additional information
-