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Information on EC 2.8.1.16 - L-aspartate semialdehyde sulfurtransferase and Organism(s) Methanosarcina acetivorans and UniProt Accession Q8TPT4

for references in articles please use BRENDA:EC2.8.1.16
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IUBMB Comments
The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.
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Methanosarcina acetivorans
UNIPROT: Q8TPT4
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The taxonomic range for the selected organisms is: Methanosarcina acetivorans
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
=
+
+
2
oxidized ferredoxin [iron-sulfur] cluster
Synonyms
mj0100, ma1821, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MA1821
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase
The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C131A
mutant strain is capable of growth on sulfide-only medium
C54A
mutant strain is incapable of growth on sulfide-only medium
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Allen, K.; Miller, D.; Rauch, B.; Perona, J.; White, R.
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea
Biochemistry
54
3129-3132
2015
Methanocaldococcus jannaschii (Q57564), Methanocaldococcus jannaschii ATCC 43067 (Q57564), Methanosarcina acetivorans (Q8TPT4), Methanosarcina acetivorans DSM 2834 (Q8TPT4)
Manually annotated by BRENDA team
Rauch, B.J.; Klimek, J.; David, L.; Perona, J.J.
Persulfide formation mediates cysteine and homocysteine biosynthesis in Methanosarcina acetivorans
Biochemistry
56
1051-1061
2017
Methanosarcina acetivorans (Q8TPT4), Methanosarcina acetivorans, Methanosarcina acetivorans DSM 2834 (Q8TPT4)
Manually annotated by BRENDA team
Rauch, B.J.; Gustafson, A.; Perona, J.J.
Novel proteins for homocysteine biosynthesis in anaerobic microorganisms
Mol. Microbiol.
94
1330-1342
2014
Methanosarcina acetivorans (Q8TPT4), Methanosarcina acetivorans DSM 2834 (Q8TPT4)
Manually annotated by BRENDA team