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Information on EC 2.8.1.15 - tRNA-5-methyluridine54 2-sulfurtransferase

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IUBMB Comments
The enzyme, found in thermophilic bacteria and archaea, modifies the ribothymidine (5-methyluridine) residue at position 54 of tRNAs. Contains zinc and an [4Fe-4S] cluster. Some organisms, such as the archaeon Pyrococcus horikoshii, do not have a TtuB sulfur-carrier protein, and appear to use sulfide as the sulfur source.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Reaction Schemes
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[TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH
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5-methyluracil54 in tRNA
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=
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5-methyl-2-thiouracil54 in tRNA
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[TtuB sulfur-carrier protein]-Gly-Gly
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[TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH
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5-methyuracil54 in tRNA
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=
+
+
5-methyl-2-thiouracil54 in tRNA
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[TtuB sulfur-carrier protein]-Gly-Gly
Synonyms
PH0300, TTC0106, TtuA, TT_C0106, Veg136 protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + 5-methyluracil54 in tRNA + H2O = AMP + diphosphate + 5-methyl-2-thiouracil54 in tRNA + [TtuB sulfur-carrier protein]-Gly-Gly
show the reaction diagram
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ATP + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + 5-methyuracil54 in tRNA + H2O = AMP + diphosphate + 5-methyl-2-thiouracil54 in tRNA + [TtuB sulfur-carrier protein]-Gly-Gly
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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