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Information on EC 2.7.9.6 - rifampicin phosphotransferase

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IUBMB Comments
The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21. The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate-carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis.
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The enzyme appears in viruses and cellular organisms
Synonyms
rifampin phosphotransferase, RPH, rph4747, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + rifampicin + H2O = AMP + 21-phosphorifampicin + phosphate
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