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ATP + selenide + H2O
AMP + selenophosphate + phosphate
ATP + selenide + H2O
AMP + selenophosphate + phosphate
additional information
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
required for synthesis of selenocysteine and seleno-tRNAs
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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the Sps1-encoded enzyme depends on a selenium salvage system that recycles L-selenocysteine
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ATP + selenide + H2O
AMP + selenophosphate + phosphate
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the Sps2-encoded can function with a selenite assimilation system
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SPS2 is involved in the synthesis of selenophosphate for Sel synthesis, selen and selenoprotien metabolism, physiological functions, detailed overview
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development of a non-radioactive assay for detection of selenophosphate synthetase activity using recombinant pyruvate diphosphate dikinase, PPDK, from Thermus thermophilus strain HB8 in an enzyme-coupled reaction system, overview
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Adenocarcinoma of Lung
Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.
Adenoma
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Breast Neoplasms
Selenium detoxification is required for cancer-cell survival.
Breast Neoplasms
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer.
Carcinogenesis
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer.
Dehydration
Selenocysteine synthase from Escherichia coli. Analysis of the reaction sequence.
Epilepsy
Application of Trio-Whole Exome Sequencing in Genetic Diagnosis and Therapy in Chinese Children With Epilepsy.
Hypersensitivity
Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster.
Infections
Identification and cloning of a selenophosphate synthetase (SPS) from tiger shrimp, Penaeus monodon, and its transcription in relation to molt stages and following pathogen infection.
Insulin Resistance
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Neoplasms
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Neoplasms
p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression.
Neoplasms
Selenium detoxification is required for cancer-cell survival.
Neoplasms
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer.
Obesity
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Scimitar Syndrome
Standardized Approach to Intervention for Intestinal Malrotation in Single Ventricle Patients with Heterotaxy Syndrome: Impact on Interstage Attrition and Time to Superior Cavopulmonary Connection.
Starvation
Functional expression in Escherichia coli of the Haemophilus influenzae gene coding for selenocysteine-containing selenophosphate synthetase.
Triple Negative Breast Neoplasms
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer.
Wiskott-Aldrich Syndrome
Cellular gene expression survey of vaccinia virus infection of human HeLa cells.
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Low, S.C.; Harney, J.W.; Berry, M.J.
Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis
J. Biol. Chem.
270
21659-21664
1995
Homo sapiens (P49903), Homo sapiens
brenda
Guimaraes, M.J.; Peterson, D.; Vicari, A.; Cocks, B.G.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Ferrick, D.A.; Kastelein, R.A.; Bazan, J.F.; Zlotnik, A.
Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: Is there an autoregulatory mechanism in selenocysteine metabolism?
Proc. Natl. Acad. Sci. USA
93
15086-15091
1996
Haemophilus influenzae, Homo sapiens (Q99611), Homo sapiens, Methanocaldococcus jannaschii, Mus musculus (P97364), Mus musculus
brenda
Tamura, T.; Yamamoto, S.; Takahata, M.; Sakaguchi, H.; Tanaka, H.; Stadtman, T.C.; Inagaki, K.
Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation
Proc. Natl. Acad. Sci. USA
101
16162-16167
2004
Homo sapiens
brenda
Chung, H.J.; Yoon, S.I.; Shin, S.H.; Koh, Y.A.; Lee, S.J.; Lee, Y.S.; Bae, S.
p53-mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression
J. Cell. Physiol.
209
131-141
2006
Homo sapiens
brenda
Pappas, A.C.; Zoidis, E.; Surai, P.F.; Zervas, G.
Selenoproteins and maternal nutrition
Comp. Biochem. Physiol. B
151
361-372
2008
Homo sapiens (Q99611)
brenda
Wang, K.T.; Wang, J.; Li, L.F.; Su, X.D.
Crystal structures of catalytic intermediates of human selenophosphate synthetase 1
J. Mol. Biol.
390
747-759
2009
Homo sapiens (P49903), Homo sapiens
brenda
Kim, J.Y.; Lee, K.H.; Shim, M.S.; Shin, H.; Xu, X.M.; Carlson, B.A.; Hatfield, D.L.; Lee, B.J.
Human selenophosphate synthetase 1 has five splice variants with unique interactions, subcellular localizations and expression patterns
Biochem. Biophys. Res. Commun.
397
53-58
2010
Homo sapiens
brenda
Kamada, S.; Okugochi, T.; Asano, K.; Tobe, R.; Mihara, H.; Nemoto, M.; Inagaki, K.; Tamura, T.
A non-radioactive assay for selenophosphate synthetase activity using recombinant pyruvate pyrophosphate dikinase from Thermus thermophilus HB8
Biosci. Biotechnol. Biochem.
80
1970-1972
2016
Homo sapiens (Q99611)
brenda
Mariotti, M.; Santesmasses, D.; Capella-Gutierrez, S.; Mateo, A.; Arnan, C.; Johnson, R.; D'Aniello, S.; Yim, S.H.; Gladyshev, V.N.; Serras, F.; Corominas, M.; Gabaldon, T.; Guigo, R.
Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization
Genome Res.
25
1256-1267
2015
Ciona intestinalis, Escherichia coli, no activity in Hymenoptera, Oikopleura dioica, Molgula tectiformis, Botryllus schlosseri, no activity in Lepidoptera, no activity in Coleoptera, no activity in Endopterygota, no activity in Acyrthosiphon pisum, no activity in Drosophila willistoni, Drosophila melanogaster (O18373), Caenorhabditis elegans (O62461), Homo sapiens (Q99611)
brenda
Oudouhou, F.; Casu, B.; Dopgwa Puemi, A.S.; Sygusch, J.; Baron, C.
Analysis of Novel interactions between components of the selenocysteine biosynthesis pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43
Biochemistry
56
2261-2270
2017
Homo sapiens (Q99611)
brenda
Na, J.; Jung, J.; Bang, J.; Lu, Q.; Carlson, B.A.; Guo, X.; Gladyshev, V.N.; Kim, J.; Hatfield, D.L.; Lee, B.J.
Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation
Free Radic. Biol. Med.
127
190-197
2018
Escherichia coli, Homo sapiens (Q99611), Homo sapiens
brenda