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Information on EC 2.7.8.44 - teichoic acid glycerol-phosphate primase and Organism(s) Staphylococcus aureus and UniProt Accession Q2G2X4

for references in articles please use BRENDA:EC2.7.8.44
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IUBMB Comments
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. This enzyme adds the first glycerol unit to the disaccharide linker of the teichoic acid.
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This record set is specific for:
Staphylococcus aureus
UNIPROT: Q2G2X4
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The taxonomic range for the selected organisms is: Staphylococcus aureus
The enzyme appears in selected viruses and cellular organisms
Synonyms
cdp-glycerol:n-acetyl-beta-d-mannosaminyl-1,4-n-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CDP-glycerol:glycerophosphate glycerophosphotransferase
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Tag primase
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
CDP-glycerol:N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. This enzyme adds the first glycerol unit to the disaccharide linker of the teichoic acid.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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enzyme mutations inhibit growth
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brown, S.; Zhang, Y.; Walker, S.
a revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps
Chem. Biol.
15
12-21
2008
Staphylococcus aureus (Q2G2X4), Staphylococcus aureus NCTC 8325 (Q2G2X4)
Manually annotated by BRENDA team
DElia, M.A.; Pereira, M.P.; Chung, Y.S.; Zhao, W.; Chau, A.; Kenney, T.J.; Sulavik, M.C.; Black, T.A.; Brown, E.D.
Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway
J. Bacteriol.
188
4183-4189
2006
Staphylococcus aureus, Staphylococcus aureus SA178RI
Manually annotated by BRENDA team
Chan, Y.G.; Frankel, M.B.; Dengler, V.; Schneewind, O.; Missiakas, D.
Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium
J. Bacteriol.
195
4650-4659
2013
Staphylococcus aureus, Staphylococcus aureus RN4220
Manually annotated by BRENDA team