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Synonyms
hcls1, crls1, cls_cap, cls1p, cardiolipin synthase 1, sco1389, crcls1, cls 1, ydl142c, cardiolipin synthase-1,
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CDP-dimyristoylglycerol + 1,2-dioleoylphosphatidylglycerol
1-(1-myristoyl-2-myristoyl-sn-glycero-3-phospho)-3-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
competition experiments with [14C]-CDP-dioleoylglycerol show that the enzyme has similar activity with CDP-dimyristoylglycerol, CDP-diacylglycerol from egg yolk and CDP-dioleoylglycerol. CDP-dipalmitoylglycerol shows considerably less activity
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CDP-dioleoylglycerol + 1,2-dilinoleoylphosphatidylglycerol
1-(1-linoleoyl-2-linoleoyl-sn-glycero-3-phospho)-3-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
the enzyme is more active with dioleoyl and dilinoleoyl species of phosphatidylglycerol than with species with one or two palmitoyl groups
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CDP-dioleoylglycerol + 1,2-dimyristoylphosphatidylglycerol
1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-myristoyl-2-oleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
dimyristoyl phosphatidylglycerol is a very poor substrate
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CDP-dioleoylglycerol + 1,2-dioleoylphosphatidylglycerol
1,3-bis(1,2-dioleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
the enzyme is more active with dioleoyl and dilinoleoyl species of phosphatidylglycerol than with species with one or two palmitoyl groups. Competition experiments with [14C]-CDP-dioleoylglycerol show that the enzyme has similar activity with CDP-dimyristoylglycerol, CDP-diacylglycerol from egg yolk and CDP-dioleoylglycerol. CDP-dipalmitoylglycerol shows considerably less activity
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CDP-dioleoylglycerol + 1,2-dipalmitoylphosphatidylglycerol
1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-palmitoyl-2-palmitoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
the enzyme is more active with dioleoyl and dilinoleoyl species of phosphatidylglycerol than with species with one or two palmitoyl groups
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?
CDP-dioleoylglycerol + 1-oleoyl-2-linoleoyl phosphatidylglycerol
1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-oleoyl-2-linoleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
the enzyme is more active with dioleoyl and dilinoleoyl species of phosphatidylglycerol than with species with one or two palmitoyl groups
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?
CDP-dioleoylglycerol + 1-palmitoyl-2-oleoyl phosphatidylglycerol
1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-palmitoyl-2-oleoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
the enzyme is more active with dioleoyl and dilinoleoyl species of phosphatidylglycerol than with species with one or two palmitoyl groups
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?
CDP-dipalmitoylglycerol + 1,2-dioleoylphosphatidylglycerol
1-(1-oleoyl-2-oleoyl-sn-glycero-3-phospho)-3-(1-palmitoyl-2-palmitoyl-sn-glycero-3-phospho)-sn-glycerol + CMP
competition experiments with [14C]-CDP-dioleoylglycerol show that the enzyme has similar activity with CDP-dimyristoylglycerol, CDP-diacylglycerol from egg yolk and CDP-dioleoylglycerol. CDP-dipalmitoylglycerol shows considerably less activity
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egg yolk CDP-diacylglycerol + 1,2-dioleoylphosphatidylglycerol
a cardiolipin + CMP
CDP-diacylglycerol from egg lecithin is primarily CDP-1-palmitoyl-2-oleoylglycerol. Competition experiments with [14C]-CDP-dioleoylglycerol show that the enzyme has similar activity with CDP-dimyristoylglycerol, CDP-diacylglycerol from egg yolk and CDP-dioleoylglycerol. CDP-dipalmitoylglycerol shows considerably less activity
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Adenocarcinoma of Lung
Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer.
Carcinogenesis
Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer.
Carcinoma, Hepatocellular
Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1.
Carcinoma, Non-Small-Cell Lung
Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer.
cardiolipin synthase (cmp-forming) deficiency
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.
Cystic Fibrosis
Disease-associated mutations in cytoplasmic loops 1 and 2 of cystic fibrosis transmembrane conductance regulator impede processing or opening of the channel.
Essential Tremor
DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease.
Insulin Resistance
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis.
Insulin Resistance
CRLS1 ameliorates nonalcoholic steatohepatitis through ATF3 transcriptional inactivation.
Leukemia, Myeloid, Acute
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Lung Neoplasms
Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer.
Neoplasms
Exome sequencing reveals recurrent germline variants in patients with familial Waldenstrom's macroglobulinemia.
Neoplasms
Expression and potential mechanism of metabolism-related genes and CRLS1 in non-small cell lung cancer.
Neoplasms
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
Neoplasms
Identification Hub Genes in Colorectal Cancer by Integrating Weighted Gene Co-Expression Network Analysis and Clinical Validation in vivo and vitro.
Neoplasms
Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator.
Neutropenia
Defective G-CSFR signaling pathways in congenital neutropenia.
Neutropenia
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Non-alcoholic Fatty Liver Disease
CRLS1 ameliorates nonalcoholic steatohepatitis through ATF3 transcriptional inactivation.
Osteosarcoma
Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture.
Osteosarcoma
Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9.
Pneumonia
E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia.
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physiological function
cardiolipin synthase is involved in maintaining physiologic membrane structure and function even under metabolic stress
physiological function
the enzyme catalyzes the terminal step in cardiolipin biosynthesis. Cardiolipin is essential for mitochondrial structure and function
physiological function
knockdown of cardiolipin synthase induces mitochondrial elongation in human cells. In cardiolipin synthase-knocked down cells a decreased amount of cardiolipin and an accumulation of phosphatidylglycerol is observed. Knockdown of other genes involved in cardiolipin synthesis does not influence mitochondrial morphology
physiological function
phosphatidylglycerophosphate synthase PGS1 and CLS1 are constituents of large protein complexes. PGS1 forms oligomers and associates with CLS1 and phosphatidylglycerophosphate phosphatase PTPMT1. Cardiolipin and CLS1 are not required for PGS1 to assemble in the complex. PGS1 and CLS1 interact with multiple cardiolipin-binding mitochondrial membrane proteins, including prohibitins, stomatin-like protein 2 and the MICOS components MIC60 and MIC19
physiological function
synthesis of cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Overexpression of cardiolipin synthase Crls1 enhances energy consumption in adipocytes, and adipose Crls1 levels positively correlate with insulin sensitivity
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Chen, D.; Zhang, X.Y.; Shi, Y.
Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria
Biochem. J.
398
169-176
2006
Homo sapiens (Q9UJA2), Homo sapiens
brenda
Houtkooper, R.H.; Akbari, H.; van Lenthe, H.; Kulik, W.; Wanders, R.J.; Frentzen, M.; Vaz, F.M.
Identification and characterization of human cardiolipin synthase
FEBS Lett.
580
3059-3064
2006
Homo sapiens (Q9UJA2), Homo sapiens
brenda
Lu, B.; Xu, F.Y.; Taylor, W.A.; Feingold, K.R.; Hatch, G.M.
Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation
Inflammation
34
247-254
2011
Homo sapiens (Q9UJA2), Homo sapiens, Mus musculus (Q80ZM8), Mus musculus
brenda
Kiebish, M.A.; Yang, K.; Sims, H.F.; Jenkins, C.M.; Liu, X.; Mancuso, D.J.; Zhao, Z.; Guan, S.; Abendschein, D.R.; Han, X.; Gross, R.W.
Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency
J. Biol. Chem.
287
25086-25097
2012
Homo sapiens (Q9UJA2)
brenda
Lu, B.; Xu, F.Y.; Jiang, Y.J.; Choy, P.C.; Hatch, G.M.; Grunfeld, C.; Feingold, K.R.
Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)
J. Lipid Res.
47
1140-1145
2006
Homo sapiens (Q9UJA2), Homo sapiens
brenda
Serricchio, M.; Vissa, A.; Kim, P.; Yip, C.; McQuibban, G.
Cardiolipin synthesizing enzymes form a complex that interacts with cardiolipin-dependent membrane organizing proteins
Biochim. Biophys. Acta
1863
447-457
2018
Homo sapiens (Q9UJA2)
brenda
Sustarsic, E.; Ma, T.; Lynes, M.; Larsen, M.; Karavaeva, I.; Havelund, J.; Nielsen, C.; Jedrychowski, M.; Moreno-Torres, M.; Lundh, M.; Plucinska, K.; Jespersen, N.; Grevengoed, T.; Kramar, B.; Peics, J.; Hansen, J.; Shamsi, F.; Forss, I.; Neess, D.
Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis
Cell Metab.
28
159-174.e11
2018
Homo sapiens (Q9UJA2), Homo sapiens, Mus musculus (Q80ZM8), Mus musculus
brenda
Matsumura, A.; Higuchi, J.; Watanabe, Y.; Kato, M.; Aoki, K.; Akabane, S.; Endo, T.; Oka, T.
Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology
FEBS Lett.
592
209-218
2018
Caenorhabditis elegans (O01916), Homo sapiens (Q9UJA2)
brenda