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Information on EC 2.7.8.38 - archaetidylserine synthase
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EC Tree
2.7.8.38 archaetidylserine synthaseIUBMB Comments
Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Reaction Schemes
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Synonyms
archaetidylserine synthase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine O-archaetidyltransferase
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine O-archaetidyltransferase
-
-
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine O-archaetidyltransferase
-
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine O-archaetidyltransferase
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine
(2)
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-
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CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
(1)
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
(1)
-
-
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-O-(geranylgeranyl)-sn-glycerol phosphotransferase
Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phospho-L-serine
-
91% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
-
-
?
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phosphoserine
CDP-1,2-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(oleoyl)-sn-glycero-3-phospho-L-serine
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
CDP-2,3-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 2,3-dioleoyl-sn-glycero-1-phospho-L-serine
280% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
CDP-2,3-dioleoyl-sn-glycerol + L-serine
CMP + 2,3-bis-O-(oleoyl)-sn-glycero-1-phospho-L-serine
-
143% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
-
-
?
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phosphoserine
149% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(geranylgeranyl)-sn-glycero-3-phosphoserine
149% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(oleoyl)-sn-glycero-3-phospho-L-serine
-
102% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
-
-
?
CDP-1,2-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(oleoyl)-sn-glycero-3-phospho-L-serine
64% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-bis-O-(oleoyl)-sn-glycerol + L-serine
CMP + 1,2-bis-O-(oleoyl)-sn-glycero-3-phospho-L-serine
64% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-diacylglycerol + L-serine
CMP + 1,2-diacyl-sn-glycero-3-phospho-L-serine
-
fatty acids from lecithin
-
-
?
CDP-1,2-diacylglycerol + L-serine
CMP + 1,2-diacyl-sn-glycero-3-phospho-L-serine
fatty acids from lecithin. 199% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-1,2-diacylglycerol + L-serine
CMP + 1,2-diacyl-sn-glycero-3-phospho-L-serine
fatty acids from lecithin. 199% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
-
i.e. CDP-unsaturated archaeol. 80% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
the enzyme is involved in the biosynthesis of polar lipids in archaea
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
i.e. CDP-unsaturated archaeol. The activity of D-serine with the enzyme is 30% of that observed for L-serine. Among various synthetic substrate analogs, both enantiomers of CDP-unsaturated archaeols with ether-linked geranylgeranyl chains and CDP-saturated archaeol with ether-linked phytanyl chains are similarly active toward the archaetidylserine synthase
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
the enzyme is involved in the biosynthesis of polar lipids in archaea
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
i.e. CDP-unsaturated archaeol. The activity of D-serine with the enzyme is 30% of that observed for L-serine. Among various synthetic substrate analogs, both enantiomers of CDP-unsaturated archaeols with ether-linked geranylgeranyl chains and CDP-saturated archaeol with ether-linked phytanyl chains are similarly active toward the archaetidylserine synthase
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
-
120% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
-
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
86% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
the enzyme is involved in the biosynthesis of polar lipids in archaea
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serine
the enzyme is involved in the biosynthesis of polar lipids in archaea
i.e. unsaturated archaetidylserine
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
-
120% of the activity compared to CDP-1,2-diacylglycerol with fatty acids from lecithin
-
-
?
CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine
CMP + 2,3-bis-O-(phytanyl)-sn-glycero-1-phospho-L-serine
86% of the activity compared to CDP-2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mn2+
stimulates, maximal activity in presence of 10 mM Mn2+. Mg2+ is much less effective
additional information
additional information
the enzyme does not require the addition of K+. The enzyme activity is lowered to about 70% of its maximum at 0.6 M K+, which corresponds to the intracellular concentration found in Methanothermobacter thermautotrophicus
additional information
-
the enzyme does not require the addition of K+. The enzyme activity is lowered to about 70% of its maximum at 0.6 M K+, which corresponds to the intracellular concentration found in Methanothermobacter thermautotrophicus
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Triton X-100
activity is dependent on TRiton X-100
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50 - 70
50°C: about 50% of maximal activity, 70°C: about 65% of maximal activity
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ARSS_METTH
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
233
6
24618
Swiss-Prot
-
A0A151AD97_9EURY
235
5
23953
TrEMBL
-
A0A3B1CYM5_9ZZZZ
245
8
27140
TrEMBL
Secretory Pathway (Reliability: 3)
A0A6J4RT08_9SPHN
275
0
29369
TrEMBL
-
A0A284VS75_9EURY
226
6
24326
TrEMBL
-
A0A3B0W6A7_9ZZZZ
249
8
27242
TrEMBL
Secretory Pathway (Reliability: 2)
M1Y0Q5_NATM8
Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 / 8.8.11)
227
5
22929
TrEMBL
-
A0A6J4IQ42_9PROT
310
0
32580
TrEMBL
-
A0A3B1CSD5_9ZZZZ
245
8
27110
TrEMBL
Secretory Pathway (Reliability: 1)
A0A1V4YFY0_9EURY
232
6
24824
TrEMBL
-
A0A7G9YZZ9_9EURY
182
4
20798
TrEMBL
-
A0A1V4YEK6_9EURY
240
6
26238
TrEMBL
-
Q3IQ90_NATPD
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)
231
6
23724
TrEMBL
-
Q18HQ9_HALWD
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
232
4
24011
TrEMBL
-
A0A5B9DD23_9ARCH
261
8
29417
TrEMBL
-
Q9HRA7_HALSA
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
225
6
22426
TrEMBL
-
A0A1V6ILP6_9EURY
218
6
24412
TrEMBL
-
A0A1L9C628_9EURY
227
4
25174
TrEMBL
-
D4GWA0_HALVD
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
223
5
22806
TrEMBL
-
A0A150J1A1_9EURY
218
6
24717
TrEMBL
-
A0A4D6GS09_HALS9
Halobacterium salinarum (strain ATCC 33171 / DSM 3754 / JCM 8978 / NBRC 102687 / NCIMB 764 / 91-R6)
225
6
22392
TrEMBL
-
A0A3B1CK42_9ZZZZ
280
7
31425
TrEMBL
other Location (Reliability: 2)
A0A150JF57_9EURY
218
6
24412
TrEMBL
-
A0A3B0RIM6_9ZZZZ
266
8
29472
TrEMBL
other Location (Reliability: 3)
A0A1Q9NAF3_HEILC
Heimdallarchaeota archaeon (strain LC_2)
255
6
28600
TrEMBL
-
D3SXN7_NATMM
Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3)
243
6
25317
TrEMBL
-
A0A1V4TJ58_9EURY
239
6
26159
TrEMBL
-
B0R455_HALS3
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
225
6
22426
TrEMBL
-
G0LL00_HALWC
Haloquadratum walsbyi (strain DSM 16854 / JCM 12705 / C23)
232
4
24011
TrEMBL
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morii, H.; Koga, Y.
CDP-2,3-di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus
J. Bacteriol.
185
1181-1189
2003
Bacillus subtilis, Methanothermobacter thermautotrophicus (O27106), Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus DSM 1053 (O27106)
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Release 2023.1 (January 2023)
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