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Information on EC 2.7.8.29 - L-serine-phosphatidylethanolamine phosphatidyltransferase and Organism(s) Homo sapiens and UniProt Accession Q9BVG9

for references in articles please use BRENDA:EC2.7.8.29
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IUBMB Comments
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: Q9BVG9
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphatidylserine synthase 1, phosphatidylserine synthase 2, phosphatidylserine synthetase 2, PS synthase 1, PS synthase 2, PSS-2, PSS1, PSS2, pssB, PSSII, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphatidylserine synthase 1
307577
-
phosphatidylserine synthase 2
295006
-
PSS1
307577
-
PSS2
295006
-
PTDSS1
307577
gene name
PTDSS2
295006
gene name
serine-phosphatidylcholine phosphatidyltransferase
307577
-
serine-phosphatidylethanolamine phosphatidyltransferase
295006
-
SYSTEMATIC NAME
IUBMB Comments
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-1-phosphatidylethanolamine + L-serine
L-1-phosphatidylserine + ethanolamine
show the reaction diagram
L-1-phosphatidylcholine + L-serine
L-1-phosphatidylserine + choline
show the reaction diagram
-
isozyme PSS1
-
-
r
additional information
?
-
no substrate: phosphatidylcholine
-
-
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-1-phosphatidylethanolamine + L-serine
L-1-phosphatidylserine + ethanolamine
show the reaction diagram
-
isozyme PSS2
-
-
r
L-1-phosphatidylcholine + L-serine
L-1-phosphatidylserine + choline
show the reaction diagram
-
isozyme PSS1
-
-
r
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3-sn-phosphatidyl)-L-serine
-
end-product inhibition of isozyme PSS1
phosphatidylserine
-
product inhibition
(3-sn-phosphatidyl)-L-serine
-
strong end-product inhibition of isozyme PSS1
additional information
-
addition of phosphatidylcholine instead of phosphatidylserine does not reduce the rate of phosphatidylserine synthesis
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.12
L-serine
-
pH 7.5, 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1
-
pH 7.5, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
integral membrane protein, membrane topology overview
Manually annotated by BRENDA team
-
integral membrane protein, membrane topology overview
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
link between phosphatidylserine synthesis and bone metabolism
malfunction
metabolism
-
link between phosphatidylserine synthesis and bone metabolism
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
PTSS2_HUMAN
487
7
56253
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
-
x * 50000, SDS-PAGE of epitope-tagged recombinant protein
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 50000, SDS-PAGE of epitope-tagged recombinant protein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L265P
-
naturally gain-of-function mutation mutation of PSS1
P269L
-
naturally gain-of-function mutation mutation of PSS1
P269S
-
naturally gain-of-function mutation mutation of PSS1
Q353R
-
naturally gain-of-function mutation mutation of PSS1, which resides in a separate cytosolic domain and has only s slight effect on enzyme activity
W277R
-
naturally occuring mutation in gene PTDSS1 causing Lenz-Majewski hyperostotic dwarfism with hyperphosphoserinuria, the patient shows hyperostosis and osteosclerosis resulting from accelerated bone formation, and increased PTDS biosynthesis caused by the PTDSS1 mutation leading to hyperphosphoserinuria, phenotype
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
epitope-tagged recombinant protein
-
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in HeLa cell
-
gene PTDSS1
-
gene PTDSS1
-
gene PTDSS1, expression analysis
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
docosahexaenoic acid positively modulates phosphatidylserine biosynthesis but does not affect mRNA levels of PSS2
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guo, M.; Stockert, L.; Akbar, M.; Kim, H.Y.
Neuronal specific increase of phosphatidylserine by docosahexaenoic acid
J. Mol. Neurosci.
33
67-73
2007
Cricetulus griseus (O08888), Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Tomohiro, S.; Kawaguti, A.; Kawabe, Y.; Kitada, S.; Kuge, O.
Purification and characterization of human phosphatidylserine synthases 1 and 2
Biochem. J.
418
421-429
2009
Homo sapiens (Q9BVG9)
Manually annotated by BRENDA team
Whyte, M.P.; Blythe, A.; McAlister, W.H.; Nenninger, A.R.; Bijanki, V.N.; Mumm, S.
Lenz-Majewski hyperostotic dwarfism with hyperphosphoserinuria from a novel mutation in PTDSS1 encoding phosphatidylserine synthase 1
J. Bone Miner. Res.
30
606-614
2015
Homo sapiens, Homo sapiens (P48651)
Manually annotated by BRENDA team
Sousa, S.B.; Jenkins, D.; Chanudet, E.; Tasseva, G.; Ishida, M.; Anderson, G.; Docker, J.; Ryten, M.; Sa, J.; Saraiva, J.M.; Barnicoat, A.; Scott, R.; Calder, A.; Wattanasirichaigoon, D.; Chrzanowska, K.; Simandlova, M.; Van Maldergem, L.; Stanier, P.; Beales, P.L.; Vance, J.E.; Moore, G.E.
Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome
Nat. Genet.
46
70-76
2014
Homo sapiens, Homo sapiens (P48651), Homo sapiens (Q9BVG9)
Manually annotated by BRENDA team
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