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Information on EC 2.7.8.26 - adenosylcobinamide-GDP ribazoletransferase

for references in articles please use BRENDA:EC2.7.8.26

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IUBMB Comments

In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. CobS catalyses the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with α-ribazole to yield adenosylcobalamin.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
cobalamin synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, 4-methylphenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, 5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, 5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, 5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, 5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I, adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II, benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, phenyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP, superpathway of adenosylcobalamin salvage from cobinamide I, superpathway of adenosylcobalamin salvage from cobinamide II
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