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Information on EC 2.7.8.2 - diacylglycerol cholinephosphotransferase
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2.7.8.2 diacylglycerol cholinephosphotransferaseIUBMB Comments
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
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Word Map
- 2.7.8.2
- diacylglycerols
- acyltransferase
- phosphatidylethanolamine
- cytidylyltransferase
- phospholipase
- phosphatidate
- cdpcholine
-
platelet-activating
-
ctp:phosphocholine
- 1,2-diacylglycerols
-
cholinephosphate
- cmp
- cdp-ethanolamine
- lysophosphatidylcholine
- glycerolipids
- glycerophospholipids
-
14ccholine
- 1,2-diacyl-sn-glycerols
-
ptdcho
-
acetylhydrolase
-
disaturated
- lysolecithin
-
lyso-paf
-
kennedy
- paf-ah
-
phosphotransferases
-
2.7.7.15
-
3hcholine
-
cdp-alcohol
-
methyl-3hcholine
-
alkylacylglycerols
- glycerolphosphate
-
methyl-14ccholine
- 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine
-
phosphatidyltransferase
- paf-acetylhydrolase
- phosphoglycerides
- synthesis
- analysis
- biotechnology
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
cholinephosphotransferase, choline phosphotransferase, cept1, paf-cpt, dtt-insensitive cholinephosphotransferase, diacylglycerol cholinephosphotransferase, phosphorylcholine glyceride transferase, 1,2-diacylglycerol cholinephosphotransferase, aapt1, phosphatidylcholine:diacylglycerol cholinephosphotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-alkyl-2-acetyl-m-glycerol:CDP-choline choline phosphotransferase
-
-
-
-
1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase
-
-
-
-
1-alkyl-2-acetylglycerol cholinephosphotransferase
-
-
-
-
AAPT
-
-
-
-
alkylacylglycerol choline phosphotransferase
-
-
-
-
alkylacylglycerol cholinephosphotransferase
-
-
-
-
aminoalcoholphosphotransferase
CDP-choline diglyceride phosphotransferase
-
-
-
-
CEPT
CEPT1
choline phosphotransferase
cholinephosphotransferase
cholinephosphotransferase, 1-alkyl-2-acetylglycerol
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-
-
-
cholinephosphotransferase, diacylglycerol
-
-
-
-
CPT
CPT1
cytidine diphosphocholine glyceride transferase
-
-
-
-
cytidine diphosphorylcholine diglyceride transferase
-
-
-
-
diacylglycerol choline phosphotransferase
-
-
-
-
DTT-insensitive CDP-choline: 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase
-
-
EC 2.7.8.16
-
-
formerly
-
PAF-CPT
-
PAF: platelet activating factor, to be distinguished from PC-CPT, PC: phosphatidylcholine
PDCT
PDCT1
PDCT2
phosphatidylcholine diacylglycerol cholinephosphotransferase
phosphatidylcholine:diacylglycerol cholinephosphotransferase
-
-
phosphocholine diacylglyceroltransferase
-
-
-
-
phospholipid:diacylglycerol choline phosphotransferase
-
phosphorylcholine-glyceride transferase
-
-
-
-
sn-1,2-diacylglycerol cholinephosphotransferase
-
-
-
-
TDE0021
aminoalcoholphosphotransferase
-
-
-
-
CEPT
-
-
-
-
cholinephosphotransferase
-
-
-
-
CPT
-
-
-
-
phosphatidylcholine diacylglycerol cholinephosphotransferase
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
sequential kinetic mechanism
-
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
chimeric constructs of cholinephosphotransferase and choline/ethanolaminephosphotransferase, study on mechanism of cation activation
-
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
1-alkyl-2-acylglycerol can act as acceptor, this activity was previously listed as EC 2.7.8.16, 1-alkyl-2-acylglycerol choline phosphotransferase
-
-
-
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
mechanism of regulation by thyroid hormone T3
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CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine
bi-bi sequential mechanism involving a direct nucleophilic attack of diacylglycerol on CDP-choline during the reaction
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
substituted phospho group transfer
substituted phospho group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.
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CAS REGISTRY NUMBER
COMMENTARY
77237-98-0
formerly, EC 2.7.8.16
9026-13-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
CDP-choline + 1,2-dilinolenoyl-sn-glycerol
CMP + 1,2-dilinolenoylphosphatidylcholine
-
-
-
-
?
CDP-choline + 1,2-dioleoyl-sn-glycerol
?
-
the most preferred diacylglycerol substrate is 18:0/20:4 diacylglycerol, followed by 18:0/22:6 diacylglycerol. The specific activities for 18:0/20:4 diacylglycerol and 18:0/22:6 diacylglycerol are 26 and 14fold higher than those of other diacylglycerol species
-
-
?
CDP-choline + 1,2-dioleoyl-sn-glycerol
CMP + 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
CDP-choline + 1-arachidoyl-2-oleoyl-sn-glycerol
CMP + 1-arachidoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-batyl-2-acetyl-sn-glycerol
CMP + 1-batyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-chimyl-2-acetyl-sn-glycerol
CMP + 1-chimyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-heptadecanoyl-2-oleoyl-sn-glycerol
CMP + 1-heptadecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecanoyl-2-octadecanoyl-sn-glycerol
CMP + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecyl-2-acetyl-sn-glycerol
CMP + 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecyl-2-octadecanoyl-sn-glycerol
CMP + 1-hexadecyl-2-octadecanoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-hexadecyl-2-octadecenoyl-sn-glycerol
CMP + 1-hexadecyl-2-octadecenoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-lauroyl-2-oleoyl-sn-glycerol
CMP + 1-lauroyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-myristoyl-2-oleoyl-sn-glycerol
CMP + 1-myristoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-nonadecanoyl-2-oleoyl-sn-glycerol
CMP + 1-nonadecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
CDP-choline + 1-O-hexadecyl-2-acetyl-sn-glycerol
CMP + 1-O-hexadecyl-2-acetyl-sn-glycero-phosphocholine
-
-
-
-
?
CDP-choline + 1-palmitoyl-2-linoleoylglycerol
CMP + 1-palmitoyl-2-linoleoylglycero-3-phosphocholine
CDP-choline + 1-palmitoyl-2-oleoyl-sn-glycerol
CMP + 1-palmitoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-pentadecanoyl-2-oleoyl-sn-glycerol
CMP + 1-pentadecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-selachyl-2-acetyl-sn-glycerol
CMP + 1-selachyl-2-acetyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-stearoyl-2-oleoyl-sn-glycerol
CMP + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
-
-
-
-
?
CDP-choline + 1-stearoyl-2-oleoyl-sn-glycerol
CMP + 1-stearoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + 1-tridecanoyl-2-oleoyl-sn-glycerol
CMP + 1-tridecanoyl-2-oleoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + bacterial 1,2-diacyl-sn-glycerol
CMP + phosphatidylethanolamine
-
-
-
-
?
CDP-choline + didodecanoylglycerol
CMP + didodecanoylglycerophosphocholine
-
-
-
-
?
CDP-choline + dimyristoyl-sn-glycerol
CMP + dimyristoyl-sn-glycerophosphocholine
-
-
-
-
?
CDP-choline + dioctanoylglycerol
CMP + dioctanoylglycerophosphocholine
-
at 5-10% of the activity with dioleoylglycerol or egg diglycerides
-
-
?
CMP + a phosphatidylcholine
CDP-choline + 1,2-diacylglycerol
-
-
-
r
dCDP-choline + 1,2-diacylglycerol
CMP + 1,2-diacylglycero-3-phosphocholine
-
-
-
-
?
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
-
-
-
?
3-alpha-D-glucopyranosyl-1,2-di-palmitoylglycerol + CDP-choline
CMP + 3-(6-O-cholinephosphoryl-alpha-D-glucopyranosyl)-1,2-dipalmitoylglycerol
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
enzyme phosphatidylcholine diacylglycerol cholinephosphotransferase catalyzes the interconversion between phosphatidylcholine and diacylglycerol
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-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
preferred substrates in decreasing order: di-10:0 diacylglycerol, di-16:1 diacylglycerol, di-8:0 diacylglycerol, di-18:1 diacylglycerol, 16:0/22:6 diacylglycerol
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
preferred substrates in decreasing order, activation by Mg2+: di18:1-diacylglycerol, 16:0/22:6-diacylglycerol, 16:0/18:1-diacylglycerol, 18:0/20:4-diacylglycerol, di16:0-diacylglycerol, preferred substrates in decreasing order, activation by Mn2+: di10:0-diacylglycerol, 18:1/2:0-diacylglycerol, 16:0/22:6-diacylglycerol, di18:1-diacylglycerol, di16:0-diacylglycerol, di14:1-diacylglycerol, di16:1-diacylglycerol
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
preferred substrates: di-18:1-diacylglycerol, di-16:1-diacylglycerol, 16:0/18:1-diacylglycerol, 16:0/22:6-diacylglycerol
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
r
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-diacylglycerol
CMP + a phosphatidylcholine
-
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
preferred substrate over other disaturated species
-
-
?
CDP-choline + 1,2-dipalmitoyl-sn-glycerol
CMP + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
-
poor substrate
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
-
platelet activating factor (PAF) de novo biosynthesis
-
-
?
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol
CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
-
37°C, 20 min, pH 8, in presence of 15 mM dithiothreitol, 5 mM EDTA, 20 mM MgCl2, 1 mg/ml bovine serum albumin
analysis by thin-layer chromatography
-
?
CDP-choline + 1-palmitoyl-2-linoleoylglycerol
CMP + 1-palmitoyl-2-linoleoylglycero-3-phosphocholine
-
preferred substrate
-
-
?
CDP-choline + 1-palmitoyl-2-linoleoylglycerol
CMP + 1-palmitoyl-2-linoleoylglycero-3-phosphocholine
-
preferred substrate
-
-
?
CDP-choline + didecanoylglycerol
CMP + didecanoylglycerophosphocholine
-
-
-
-
?
CDP-choline + didecanoylglycerol
CMP + didecanoylglycerophosphocholine
-
at 5-10% of the activity with dioleoylglycerol or egg diglycerides
-
-
?
CDP-choline + dihexanoylglycerol
CMP + dihexanoylglycerophosphocholine
-
-
-
-
?
CDP-choline + dihexanoylglycerol
CMP + dihexanoylglycerophosphocholine
-
at 5-10% of the activity with dioleoylglycerol or egg diglycerides
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
dithiothreitol-sensitive activity
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
?
CDP-choline + sn-1,2-diacylglycerol
?
-
final reaction in synthesis of phosphatidylcholine
-
-
r
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacyl-sn-glycerol
CMP + a phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
-
-
-
r
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine
-
preferred substrates in decreasing order: di-18:1 diacylglycerol, di-16:1 diacylglycerol, 16:0/18:1 diacylglycerol, 16:0/22:6 diacylglycerol
-
-
?
CDP-ethanolamine + 1,2-diacylglycerol
CMP + phosphatidylethanolamine