Information on EC 2.7.8.18 - UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase

for references in articles please use BRENDA:EC2.7.8.18
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The expected taxonomic range for this enzyme is: Gallus gallus

EC NUMBER
COMMENTARY hide
2.7.8.18
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RECOMMENDED NAME
GeneOntology No.
UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = UMP + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
substituted phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase
N-Acetylglucosamine end-groups in glycoproteins can also act as acceptors.
CAS REGISTRY NUMBER
COMMENTARY hide
84932-43-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-galactose + N-acetyl-D-glucosaminyl end groups in glycoproteins
?
show the reaction diagram
-
postulated
-
-
?
UDP-galactose + UDP-N-acetyl-D-galactosamine
UMP + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-galactosamine
show the reaction diagram
-
low activity
-
-
?
UDP-galactose + UDP-N-acetyl-D-glucosamine
UMP + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine
show the reaction diagram
-
-
i.e. UDP-N-acetylglucosamine-6-phosphogalactose, i.e. UDP-N-acetyl-D-glucosamine-6-phosphogalactose
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-galactose + UDP-N-acetyl-D-glucosamine
UMP + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine
show the reaction diagram
-
-
i.e. UDP-N-acetyl-D-glucosamine-6-phosphogalactose
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
-
requirement
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Nonidet P-40
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stimulation in presence of Triton X-100 or Triton 20
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2 - 8.1
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60% of maximal activity at pH 7.2, 9% of maximal activity at pH 8.1
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
magnum of oviduct, isthmus region
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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