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Information on EC 2.7.8.15 - UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
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EC Tree
2.7.8.15 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferaseSpecify your search results
Word Map
- 2.7.8.15
- lysosomal
- mucolipidosis
- tunicamycin
- i-cell
-
myasthenic
- gnptg
-
tunicamycin-resistant
-
udp-n-acetylglucosamine:lysosomal
- glcnac-1-phosphotransferase
- polydystrophy
-
dolichol-linked
-
nagts
- mliii
- alpha-methylmannoside
- uteroferrin
-
pseudo-hurler
-
man-6-p
- medicine
- biotechnology
- molecular biology
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
dpagt1, n-acetylglucosamine-1-phosphotransferase, glcnac-phosphotransferase, n-acetylglucosamine-1-phosphate transferase, glcnac-1-p transferase, gnpta, l-g1pt, dolichyl-phosphate n-acetylglucosaminephosphotransferase, dolichol-p-dependent n-acetylglucosamine-1-p transferase, udp-glcnac:dolichol phosphate glcnac-1-phosphate transferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetylglucosamine-1-phosphotransferase, uridine diphosphoacetylglucosamine-dolichyl phosphate
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-
-
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AglH
chitobiosylpyrophosphoryldolichol synthase
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-
-
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dolichol phosphate N-acetylglucosamine-1-phosphotransferase
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-
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dolichol-P-dependent N-acetylglucosamine-1-P transferase
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-
-
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dolichol-P-dependent N-acetylglucosamine-1-phosphate transferase
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-
-
-
DPAGT1
G1PT
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-
-
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GlcNAc-1-P transferase
GlcNAc-phosphotransferase
-
encoded by genes GNPTAB and GNPTG, deficiency causes mucolipidosis II
GnpTA
GPT
L-G1PT
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-
-
-
N-acetylglucosamine-1-phosphate transferase
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-
-
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saci0093
SACI_RS00435
UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase
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-
-
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UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase
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-
-
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UDP-GlcNAc:dolichol phosphate GlcNAc-1-phosphate transferase
UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase
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-
-
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UDP-GlcNAc:dolichyl-P GlcNAc1P transferase
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UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase
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-
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UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase
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UDP-N-acetylglucosamine-dolichylphosphate N-acetylglucosamine phosphotransferase
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UDP-N-acetylglucosamine:dolichol phosphate-N-acetylglucosamine-phosphotransferase
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UDPGlcNAc:dolichol phosphate N-acetylglucosamine 1-phosphate transferase
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-
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DPAGT1
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-
-
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GlcNAc-1-P transferase
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-
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GPT
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
substituted phospho group transfer
substituted phospho group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY
70431-08-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
initiating subsequent synthesis of Glc3Man9GlcNAc2-diphosphodolichol
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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-
-
?, r
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the first step in the assembly of dolichol-linked oligosaccharides
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the first step in the assembly of dolichol-linked oligosaccharides
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
enzyme initiates the dolichol cycle for the biosynthesis of asparagine-linked glycoproteins
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the committed step for N-linked glycosylation
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the key step in the assembly of oligosaccharide-lipid intermediates in N-linked glycosylation
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme is encoded by ALG7, whose expression affects the extent of N-glycosylation and secretion of proteins
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
first enzyme in the dolichol pathway of protein N-glycosylation. The all-trans-retinoic acid induction of the enzyme has a regulatory impact on the dolichol pathway
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
enzyme activity, immunoreactive GPT, and GPT mRNA are modulated in parallel during development and stimulated to a similar extent by a combination of insulin, hydrocortisone and prolactin in mouse mammary gland
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme initiates the dolichol pathway of protein N-glycosylation. A 2.5- to 4fold reduction in enzyme activity gives rise to distinct phenotypes, whose severity is inversely related to the level of enzyme activity. These phenotypes include hypersensitivity to tunicamycin, enlarged cell size, extensive aggregation, lack of typical stationary arrest and defective spore germination
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
first enzyme of dolichol pathway
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-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
first enzyme of dolichol pathway
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-
?
additional information
?
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-
overexpression of GPT in CHO-K1 cells does not go along with accumulation of intermediate Man5GlcNAc2-diphosphodolichol because of alteration of levels of oligosaccharide-diphosphodolichol and monosaccharide-phosphodolichol or through GPT enzymatic activity and excessive dolichyl phosphate consumption but rather may interfere with utilization of mannose- and glucosephosphodolichol
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-
?
additional information
?
-
the uridine moiety of UDP-GlcNAc is coordinated with eight hydrogen bonds between the one backbone amide (Leu46), seven side chains of the amino acids and two water molecules. The uridine moiety of tunicamycin occupies the identical binding sites of UDP-GlcNAc
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additional information
?
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alg7 mutants show diminished activity of GPT, reduced steady-state levels of lipid-linked oligosaccharides and hypoglycosylated carboxypeptidase Y. Mutants also lack mitochondrial DNA including the genes that encode the components of the respiratory machinery
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
additional information
?
-
-
alg7 mutants show diminished activity of GPT, reduced steady-state levels of lipid-linked oligosaccharides and hypoglycosylated carboxypeptidase Y. Mutants also lack mitochondrial DNA including the genes that encode the components of the respiratory machinery
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the first step in the assembly of dolichol-linked oligosaccharides
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the first step in the assembly of dolichol-linked oligosaccharides
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
enzyme initiates the dolichol cycle for the biosynthesis of asparagine-linked glycoproteins
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the committed step for N-linked glycosylation
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme catalyzes the key step in the assembly of oligosaccharide-lipid intermediates in N-linked glycosylation
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme is encoded by ALG7, whose expression affects the extent of N-glycosylation and secretion of proteins
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
first enzyme in the dolichol pathway of protein N-glycosylation. The all-trans-retinoic acid induction of the enzyme has a regulatory impact on the dolichol pathway
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
enzyme activity, immunoreactive GPT, and GPT mRNA are modulated in parallel during development and stimulated to a similar extent by a combination of insulin, hydrocortisone and prolactin in mouse mammary gland
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
the enzyme initiates the dolichol pathway of protein N-glycosylation. A 2.5- to 4fold reduction in enzyme activity gives rise to distinct phenotypes, whose severity is inversely related to the level of enzyme activity. These phenotypes include hypersensitivity to tunicamycin, enlarged cell size, extensive aggregation, lack of typical stationary arrest and defective spore germination
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
first enzyme of dolichol pathway
-
-
?
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
?
-
first enzyme of dolichol pathway
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Mn2+
Mg2+
-
divalent cation required for dialyzed enzyme, maximal activity in presence of 8-10 mM
Mg2+
-
divalent metal required, optimal activity in presence of Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
aminouridyl phenoxypiperidinbenzyl butanamide
APPB, APPB shows a strong DPAGT1 inhibitory activity and selectively inhibits growth of the solid tumors at low micromolar concentrations, but does not inhibit growth of a leukemia cell and the healthy cells at these concentrations. Growth inhibition of APPB against the solid cancers is correlated with the expression level of DPAGT1. Docking studies of APPB to DPAGT1, overview
GTP
-
0.4 mM, 25-30% inhibition, enzyme from tunicamycin-resistant cells, no inhibition of wild-type enzyme up to 0.4 mM
NEM
-
protected to the extent of about 50% when all of the substrates, UDP-GlcNAc, dolichyl phosphate and Mn2+ are added before addition of the sulfhydryl reagent
additional information
IC50 of compounds in cytotoxic inhibition of growth of several cancer cell lines, overview. Introduction of pharmacologically benign hydrophobic groups which occupy the proposed Dol-P binding site is essential to exhibit DPAGT1 inhibitory activity. Significant conformational changes are observed in the C-terminal end of TM-9, CL-9 and CL-1 in DPAGT1-ligand bound structures, the other portions of DPAGT1 are subtly changed upon binding
-
PCMB
-
the enzyme from tunicamycin-resistant cells is equally sensitive to tunicamycin as the wilde-type enzyme
PCMB
-
protected to the extent of about 50% when all of the substrates, UDP-GlcNAc, dolichyl phosphate anf Mn2+ are added before addition of the sulfhydryl reagent
tunicamycin
enzyme binding structure analysis, interferes with the first committed enzyme of N-glycan biosynthesis, DPAGT1. A Mg2+ ion is not involved in the binding mode. Arg301, Asn185, and Asp252 residues directly form hydrogen bonding with the C4-OH, C2-NH and C3-OH groups of the GalNAc moiety. The fatty acid chain of tunicamycin is occupied in the hydrophobic tunnel
tunicamycin
-
0.00005-0.0001 mg/ml, 50% inhibition, noncompetitive with respect to UDP-GlcNAc or dolichyl phosphate, both directions
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ATP
-
0.01-0.025 mM, stimulates activity of tunicamycin-resistant cells about 20-30%
cardiolipin
-
stimulates activity of enzyme in endoplasmic membrane vesicles, due to better solubilization of the dolichol phosphate
monogalactosyldiglyceride
-
stimulates activity of enzyme in endoplasmic membrane vesicles
phosphatidylethanolamine
-
stimulates activity of enzyme in endoplasmic membrane vesicles
phosphatidylserine
-
solubilized enzyme is stimulated by exogenously added phospholipids in order of increasing activity: phosphatidylglycerol, phosphatidylinositol, phosphatidylserine
phosphatidylglycerol
-
solubilized enzyme is stimulated by exogenously added phospholipids in order of increasing activity: phosphatidylglycerol, phosphatidylinositol, phosphatidylserine
phosphatidylinositol
-
solubilized enzyme is stimulated by exogenously added phospholipids in order of increasing activity: phosphatidylglycerol, phosphatidylinositol, phosphatidylserine
Phospholipid
-
endogenous microsomal phospholipid is required for reaction to proceed normally in rat lung microsomes
Phospholipid
-
solubilized enzyme is stimulated by exogenously added phospholipids in order of increasing activity: phosphatidylglycerol, phosphatidylinositol, phosphatidylserine
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
Km-value for dolichyl phosphate: 0.005 mg/0.1 ml
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4 - 7.6
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 8.5
-
pH 6.5: about 60% of maximal activity, pH 8.5: about 35% of maximal activity
7 - 8.7
-
pH 6.0: no activity, pH 7.0: 85% of maximal activity, pH 8.7: 64% of maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
60
-
with either dioleoylphosphatidylethanolamine or cardiolipin in the assay mixture
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
25 - 40
-
0°C: no activity, 15°C: 11% of maximal activity, 25°C: 73% of maximal activity, 35°C: 96% of maximal activity, 40°C: 57% of maximal activity
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
