Information on EC 2.7.7.B21 - N-acetylglucosamine 1-phosphate thymidylyltransferase and Organism(s) Sulfurisphaera tokodaii and UniProt Accession Q975F9for references in articles please use BRENDA:EC2.7.7.B21
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The expected taxonomic range for this enzyme is: Sulfurisphaera tokodaii
The taxonomic range for the selected organisms is: Sulfurisphaera tokodaii
dTTP + N-acetyl-alpha-D-glucosamine 1-phosphate
diphosphate + dTDP-N-acetyl-alpha-D-glucosamine
maximal velocity of the reverse reaction is 11.4fold of the maximal velocity of the forward reaction. The multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 188.8.131.52, UTP-glucose-1-phosphate uridylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 184.108.40.206, UDP-N-acetylglucosamine diphosphorylase), dTTP + alpha-D-glucose 1-phosphate (EC 220.127.116.11, glucose-1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
pH 7.5, 80°C, substrates: dTTP + N-acetyl-alpha-D-glucosamine 1-phosphate
expression in Escherichia coli, wild-type and truncated enzyme form lacking the 170-residues C-terminal domain
Zhang, Z.; Tsujimura, M.; Akutsu, J.; Sasaki, M.; Tajima, H.; Kawarabayasi, Y.
Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7
J. Biol. Chem.
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii 7 (Q975F9)
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