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Information on EC 2.7.7.93 - phosphonoformate cytidylyltransferase

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IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.
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The expected taxonomic range for this enzyme is: Streptomyces viridochromogenes
Synonyms
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate
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