The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.
The expected taxonomic range for this enzyme is: Streptomyces viridochromogenes
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SYSTEMATIC NAME
IUBMB Comments
CTP:phosphonoformate cytidylyltransferase
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.
Substrates: - Products: the enzyme catalyzes the displacement of the beta- and gamma-phosphates of CTP (as diphosphate) by phosphonoformate to produce the intermediate CMP-5'-phosphonoformate
Substrates: - Products: the enzyme catalyzes the displacement of the beta- and gamma-phosphates of CTP (as diphosphate) by phosphonoformate to produce the intermediate CMP-5'-phosphonoformate
a PhpF deletion mutant fails to produce phosphinothricin after growth in malt-yeast-glucose broth. Culture supernatants from this mutant reveal two unique peaks, which correspond to phosphonoformate and phosphite, respectively
a PhpF deletion mutant fails to produce phosphinothricin after growth in malt-yeast-glucose broth. Culture supernatants from this mutant reveal two unique peaks, which correspond to phosphonoformate and phosphite, respectively
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