Information on EC 2.7.7.91 - valienol-1-phosphate guanylyltransferase

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The expected taxonomic range for this enzyme is: Streptomyces hygroscopicus

EC NUMBER
COMMENTARY hide
2.7.7.91
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RECOMMENDED NAME
GeneOntology No.
valienol-1-phosphate guanylyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + valienol 1-phosphate = diphosphate + GDP-valienol
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
validamycin biosynthesis
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Acarbose and validamycin biosynthesis
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
GTP:valienol 1-phosphate guanylyltransferase
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + D-glucose 1-phosphate
diphosphate + GDP-D-glucose
show the reaction diagram
ATP + valienol 1-phosphate
diphosphate + ADP-valienol
show the reaction diagram
CTP + valienol 1-phosphate
diphosphate + CDP-valienol
show the reaction diagram
dTTP + valienol 1-phosphate
diphosphate + dTDP-valienol
show the reaction diagram
GTP + valienol 1-phosphate
diphosphate + GDP-valienol
show the reaction diagram
UTP + valienol 1-phosphate
diphosphate + UDP-valienol
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + valienol 1-phosphate
diphosphate + GDP-valienol
show the reaction diagram
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
Q3T6E3;
able to rescue the activity of the EDTA-treated enzyme
Mn2+
Q3T6E3;
able to rescue the activity of the EDTA-treated enzyme
additional information
Q3T6E3;
divalent cation Mg2+, Mn2+, or Co2+ required, Fe2+, Cu2+, Ca2+, Zn2+, and Ni2+ are inactive
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
Q3T6E3;
x * 45000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
Q3T6E3;