Information on EC 2.7.7.88 - GDP polyribonucleotidyltransferase

for references in articles please use BRENDA:EC2.7.7.88
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EC Tree
IUBMB Comments
The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses and lyssaviruses) is specific for mRNAs with sequences starting with AACA. cf. EC 2.7.7.50, mRNA guanylyltransferase.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
(5')pppAACA-[mRNA]
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=
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G(5')pppAACA-[mRNA]
(5')pppAACA-[mRNA]
+
[protein L]-L-histidine
=
+
[protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA]
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[protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA]
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+
=
[protein L]-L-histidine
+
G(5')pppAACA-[mRNA]
Synonyms
gdp polyribonucleotidyltransferase, rna:gdp polyribonucleotidyltransferase, l-prna complex, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(5')pppAACA-[mRNA] + GDP = diphosphate + G(5')pppAACA-[mRNA]
show the reaction diagram
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(5')pppAACA-[mRNA] + [protein L]-L-histidine = diphosphate + [protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA] + H2O
show the reaction diagram
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[protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA] + GDP + H2O = [protein L]-L-histidine + G(5')pppAACA-[mRNA]
show the reaction diagram
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