Reference on EC 2.7.7.86 - cyclic GMP-AMP synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sun, L.; Wu, J.; Du, F.; Chen, X.; Chen, Z.J.
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
Science
339
786-791
2013
Mus musculus (Q8C6L5), Homo sapiens (Q8N884)
Gao, P.; Ascano, M.; Wu, Y.; Barchet, W.; Gaffney, B.L.; Zillinger, T.; Serganov, A.A.; Liu, Y.; Jones, R.A.; Hartmann, G.; Tuschl, T.; Patel, D.J.
Cyclic [G(2,5)pA(3,5)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
Cell
153
1094-1107
2013
Mus musculus (Q8C6L5)
Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z.J.
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
Mol. Cell
51
226-235
2013
Homo sapiens (Q8N884)
Ablasser, A.; Schmid-Burgk, J.L.; Hemmerling, I.; Horvath, G.L.; Schmidt, T.; Latz, E.; Hornung, V.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Nature
503
530-534
2013
Homo sapiens (Q8N884)
Kato, K.; Ishii, R.; Goto, E.; Ishitani, R.; Tokunaga, F.; Nureki, O.
Structural and functional analyses of dna-sensing and immune activation by human cGAS
PLoS ONE
8
e76983
2013
Homo sapiens (Q8N884), Homo sapiens
Gao, D.; Wu, J.; Wu, Y.; Du, F.; Aroh, C.; Yan, N.; Sun, L.; Chen, Z.
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
Science
341
903-906
2013
Homo sapiens (Q8N884), Homo sapiens
Collins, A.C.; Cai, H.; Li, T.; Franco, L.H.; Li, X.D.; Nair, V.R.; Scharn, C.R.; Stamm, C.E.; Levine, B.; Chen, Z.J.; Shiloh, M.U.
Cyclic GMP-AMP synthase is an innate immune DNA sensor for Mycobacterium tuberculosis
Cell Host Microbe
17
820-828
2015
Mus musculus (Q8C6L5), Mus musculus, Homo sapiens (Q8N884), Homo sapiens
Andrade, W.A.; Agarwal, S.; Mo, S.; Shaffer, S.A.; Dillard, J.P.; Schmidt, T.; Hornung, V.; Fitzgerald, K.A.; Kurt-Jones, E.A.; Golenbock, D.T.
Type I interferon induction by Neisseria gonorrhoeae: dual Requirement of cyclic GMP-AMP synthase and toll-like receptor 4
Cell Rep.
15
2438-2448
2016
Homo sapiens (Q8N884)
Li, X.; Shu, C.; Yi, G.; Chaton, C.T.; Shelton, C.L.; Diao, J.; Zuo, X.; Kao, C.C.; Herr, A.B.; Li, P.
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
Immunity
39
1019-1031
2013
Mus musculus (Q8C6L5), Mus musculus, Homo sapiens (Q8N884)
Zhang, Y.; Yeruva, L.; Marinov, A.; Prantner, D.; Wyrick, P.B.; Lupashin, V.; Nagarajan, U.M.
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during Chlamydia trachomatis infection
J. Immunol.
193
2394-2404
2014
Homo sapiens (Q8N884)
Storek, K.M.; Gertsvolf, N.A.; Ohlson, M.B.; Monack, D.M.
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
J. Immunol.
194
3236-3245
2015
Mus musculus
An, J.; Woodward, J.J.; Sasaki, T.; Minie, M.; Elkon, K.B.
Cutting edge: Antimalarial drugs inhibit IFN-beta production through blockade of cyclic GMP-AMP synthase-DNA interaction
J. Immunol.
194
4089-4093
2015
Homo sapiens
Motani, K.; Ito, S.; Nagata, S.
DNA-mediated cyclic GMP-AMP synthase-dependent and -independent regulation of innate immune responses
J. Immunol.
194
4914-4923
2015
Mus musculus (Q8C6L5), Mus musculus
Lio, C.W.; McDonald, B.; Takahashi, M.; Dhanwani, R.; Sharma, N.; Huang, J.; Pham, E.; Benedict, C.A.; Sharma, S.
cGAS-STING signaling regulates initial innate control of cytomegalovirus infection
J. Virol.
90
7789-7797
2016
Homo sapiens (Q8N884), Homo sapiens
Wang, Y.; Su, G.H.; Zhang, F.; Chu, J.X.; Wang, Y.S.
Cyclic GMP-AMP synthase is required for cell proliferation and inflammatory responses in rheumatoid arthritis synoviocytes
Mediators Inflamm.
2015
192329
2015
Homo sapiens (Q8N884), Homo sapiens
Wang, J.; Chu, B.; Du, L.; Han, Y.; Zhang, X.; Fan, S.; Wang, Y.; Yang, G.
Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase
Mol. Immunol.
65
436-445
2015
Sus scrofa (I3LM39), Sus scrofa
Xia, P.; Ye, B.; Wang, S.; Zhu, X.; Du, Y.; Xiong, Z.; Tian, Y.; Fan, Z.
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
Nat. Immunol.
17
369-378
2016
Mus musculus (Q8C6L5)
Gao, D.; Li, T.; Li, X.D.; Chen, X.; Li, Q.Z.; Wight-Carter, M.; Chen, Z.J.
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Proc. Natl. Acad. Sci. USA
112
E5699-E5705
2015
Mus musculus (Q8C6L5), Mus musculus
Chen, H.Y.; Pang, X.Y.; Xu, Y.Y.; Zhou, G.P.; Xu, H.G.
Transcriptional regulation of human cyclic GMP-AMP synthase gene
Cell. Signal.
62
109355
2019
Homo sapiens (Q8N884), Homo sapiens
Wang, J.; Ba, G.; Han, Y.Q.; Ming, S.L.; Wang, M.D.; Fu, P.F.; Zhao, Q.Q.; Zhang, S.; Wu, Y.N.; Yang, G.Y.; Chu, B.B.
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens
Int. J. Biol. Macromol.
146
497-507
2020
Gallus gallus (F1NVJ8), Gallus gallus
Abdisalaam, S.; Bhattacharya, S.; Mukherjee, S.; Sinha, D.; Srinivasan, K.; Zhu, M.; Akbay, E.A.; Sadek, H.A.; Shay, J.W.; Asaithamby, A.
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase
J. Biol. Chem.
295
11144-11160
2020
Homo sapiens (Q8N884)
Zhao, W.; Xiong, M.; Yuan, X.; Li, M.; Sun, H.; Xu, Y.
In silico screening-based discovery of novel inhibitors of human cyclic GMP-AMP synthase a cross-validation study of molecular docking and experimental testing
J. Chem. Inf. Model.
60
3265-3276
2020
Homo sapiens (Q8N884), Homo sapiens
Gallego-Marin, C.; Schrum, J.E.; Andrade, W.A.; Shaffer, S.A.; Giraldo, L.F.; Lasso, A.M.; Kurt-Jones, E.A.; Fitzgerald, K.A.; Golenbock, D.T.
Cyclic GMP-AMP synthase is the cytosolic sensor of Plasmodium falciparum genomic DNA and activates type I IFN in malaria
J. Immunol.
200
768-774
2018
Homo sapiens (Q8N884)
Padilla-Salinas, R.; Sun, L.; Anderson, R.; Yang, X.; Zhang, S.; Chen, Z.J.; Yin, H.
Discovery of small-molecule cyclic GMP-AMP synthase inhibitors
J. Org. Chem.
85
1579-1600
2020
Homo sapiens (Q8N884), Homo sapiens
Xu, Q.; Xiong, H.; Zhu, W.; Liu, Y.; Du, Y.
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice
Life Sci.
260
118315
2020
Mus musculus (Q8C6L5)
Diner, B.A.; Lum, K.K.; Toettcher, J.E.; Cristea, I.M.
Viral DNA sensors IFI16 and cyclic GMP-AMP synthase possess distinct functions in regulating viral gene expression, immune defenses, and apoptotic responses during herpesvirus infection
mBio
7
e01553-16
2016
Homo sapiens (Q8N884), Homo sapiens
Sharma, M.; Rajendrarao, S.; Shahani, N.; Ramirez-Jarquin, U.N.; Subramaniam, S.
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease
Proc. Natl. Acad. Sci. USA
117
15989-15999
2020
Mus musculus (Q8C6L5), Homo sapiens (Q8N884), Homo sapiens, Mus musculus C57BL/6J (Q8C6L5)
Hall, J.; Ralph, E.C.; Shanker, S.; Wang, H.; Byrnes, L.J.; Horst, R.; Wong, J.; Brault, A.; Dumlao, D.; Smith, J.F.; Dakin, L.A.; Schmitt, D.C.; Trujillo, J.; Vincent, F.; Griffor, M.; Aulabaugh, A.E.
The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition
Protein Sci.
26
2367-2380
2017
Homo sapiens (Q8N884)
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