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Disease on EC 2.7.7.86 - cyclic GMP-AMP synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
The dark side of ferroptosis in pancreatic cancer.
Amyotrophic Lateral Sclerosis
TDP-43 Puts the STING in ALS.
Arteritis
Coronavirus interactions with the cellular autophagy machinery.
Arthritis, Rheumatoid
Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes.
Asthma
Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation.
Autoimmune Diseases
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Comparative Study of Interactions between Human cGAS and Inhibitors: Insights from Molecular Dynamics and MM/PBSA Studies.
Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations.
miR-23a/b suppress cGAS-mediated innate and autoimmunity.
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Synthesis and Pharmacological Evaluation of Tetrahydro-?-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase.
The catalytic mechanism of cyclic gmp-amp synthase (cGAS) and implications for innate immunity and inhibition.
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Transcriptional regulation of human cyclic GMP-AMP synthase gene.
Bacterial Infections
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Breast Neoplasms
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
[Effect of cyclic GMP-AMP synthase on EMT in breast cancer cells].
Bronchitis
Coronavirus interactions with the cellular autophagy machinery.
Carcinogenesis
Causes and consequences of micronuclei.
Cardiovascular Diseases
Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-?-AP-1 Signal Pathway.
Cholera
Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae.
Colitis
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
How autophagy controls the intestinal epithelial barrier.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colorectal Neoplasms
How autophagy controls the intestinal epithelial barrier.
Communicable Diseases
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway.
Coronavirus Infections
Coronavirus interactions with the cellular autophagy machinery.
COVID-19
Coronavirus interactions with the cellular autophagy machinery.
Crohn Disease
Emerging views of mitophagy in immunity and autoimmune diseases.
How autophagy controls the intestinal epithelial barrier.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Cystic Fibrosis
How autophagy controls the intestinal epithelial barrier.
DNA Virus Infections
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-? Production.
Inhibition of the DNA-Sensing pathway by pseudorabies virus UL24 protein via degradation of interferon regulatory factor 7.
Targeting of the cGAS-STING system by DNA viruses.
Foot-and-Mouth Disease
STING1 is essential for an RNA-virus triggered autophagy.
Hepatitis
Coronavirus interactions with the cellular autophagy machinery.
Hepatitis B
Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes.
Herpes Simplex
Coronavirus interactions with the cellular autophagy machinery.
Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-?B Activation.
Relative Contributions of the cGAS-STING and TLR3 Signaling Pathways to Attenuation of Herpes Simplex Virus 1 Replication.
The intracellular DNA sensors cGAS and IFI16 do not mediate effective antiviral immune responses to HSV-1 in human microglial cells.
Herpesviridae Infections
Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection.
Huntington Disease
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.
Infections
A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms.
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity.
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection.
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations.
Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish.
Conserved strategies for pathogen evasion of cGAS-STING immunity.
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure.
Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.
Insight into the dichotomous regulation of STING activation in immunotherapy.
KSHV strategies for host dsDNA sensing machinery.
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.
miR-23a/b suppress cGAS-mediated innate and autoimmunity.
Neuroinflammation and the cGAS-STING pathway.
Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression.
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
STING directly activates autophagy to tune the innate immune response.
STING1 is essential for an RNA-virus triggered autophagy.
Structural basis for nucleosome-mediated inhibition of cGAS activity.
Structural basis of nucleosome-dependent cGAS inhibition.
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
How autophagy controls the intestinal epithelial barrier.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Liver Diseases
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liver Neoplasms
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus.
VDAC oligomer pores: A mechanism in disease triggered by mtDNA release.
Malaria
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.
Marek Disease
Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation.
Melanoma
Cell-free DNA beyond a biomarker for rejection: Biological trigger of tissue injury and potential therapeutics.
Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins.
DNA Sensing across the Tree of Life.
DNA Sensing in the Innate Immune Response.
Emerging views of mitophagy in immunity and autoimmune diseases.
Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity.
TBK1, a central kinase in innate immune sensing of nucleic acids and beyond.
Type I Interferons and Malaria: A Double-Edge Sword Against a Complex Parasitic Disease.
Neoplasm Metastasis
Causes and consequences of micronuclei.
Neoplasms
A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2'3'-cGAMP.
Association of homozygous variants of STING1 with outcome in human cervical cancer.
Causes and consequences of micronuclei.
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response.
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
DNA sensing and immune responses in cancer therapy.
Emerging views of mitophagy in immunity and autoimmune diseases.
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.
How autophagy controls the intestinal epithelial barrier.
Inflammatory microenvironment remodelling by tumour cells after radiotherapy.
Neuroinflammation and the cGAS-STING pathway.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Regulation and repurposing of nutrient sensing and autophagy in innate immunity.
STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.
Structural basis of nucleosome-dependent cGAS inhibition.
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
The dark side of ferroptosis in pancreatic cancer.
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
Neuralgia
Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain.
Neurodegenerative Diseases
Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice.
Neuroinflammatory Diseases
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.
Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Non-alcoholic Fatty Liver Disease
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Ovarian Neoplasms
Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis.
Pancreatic Neoplasms
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Pneumonia
Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway.
Porcine Reproductive and Respiratory Syndrome
Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS.
Interferon-Inducible Protein 16 (IFI16) Has a Broad-Spectrum Binding Ability Against ssDNA Targets: An Evolutionary Hypothesis for Antiretroviral Checkpoint.
Mitochondria-Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses.
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.
The microbiome and cytosolic innate immune receptors.
The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways.
Sepsis
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
Tuberculosis
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
Vesicular Stomatitis
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.
Virus Diseases
A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2'3'-cGAMP.
Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase.
Development of novel highly sensitive methods to detect endogenous cGAMP in cells and tissue.
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Inside Job: Viruses Transfer cGAMP between Cells.
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.
Viruses transfer the antiviral second messenger cGAMP between cells.