Disease on EC 2.7.7.86 - cyclic GMP-AMP synthase
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Arthritis, Rheumatoid
Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes.
Asthma
Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation.
Autoimmune Diseases
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
Autoimmune Diseases
Comparative Study of Interactions between Human cGAS and Inhibitors: Insights from Molecular Dynamics and MM/PBSA Studies.
Autoimmune Diseases
Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations.
Autoimmune Diseases
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Autoimmune Diseases
Synthesis and Pharmacological Evaluation of Tetrahydro-?-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase.
Autoimmune Diseases
The catalytic mechanism of cyclic gmp-amp synthase (cGAS) and implications for innate immunity and inhibition.
Autoimmune Diseases
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Bacterial Infections
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Breast Neoplasms
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
Cardiovascular Diseases
Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-?-AP-1 Signal Pathway.
Colitis
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Communicable Diseases
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Communicable Diseases
Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
DNA Virus Infections
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-? Production.
DNA Virus Infections
Inhibition of the DNA-Sensing pathway by pseudorabies virus UL24 protein via degradation of interferon regulatory factor 7.
Hepatitis B
Hepatitis B virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes.
Herpes Simplex
Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-?B Activation.
Herpes Simplex
Relative Contributions of the cGAS-STING and TLR3 Signaling Pathways to Attenuation of Herpes Simplex Virus 1 Replication.
Herpes Simplex
The intracellular DNA sensors cGAS and IFI16 do not mediate effective antiviral immune responses to HSV-1 in human microglial cells.
Herpesviridae Infections
Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection.
Huntington Disease
Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.
Infections
A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms.
Infections
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection.
Infections
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
Infections
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.
Infections
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Infections
Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations.
Infections
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Infections
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Infections
Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure.
Infections
Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
Infections
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.
Infections
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.
Infections
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.
Infections
Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression.
Infections
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Infections
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
Infections
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
Infections
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-? during Chlamydia trachomatis infection.
Infections
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Liver Diseases
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liver Neoplasms
Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lupus Erythematosus, Systemic
Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
VDAC oligomer pores: A mechanism in disease triggered by mtDNA release.
Malaria
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.
Marek Disease
Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation.
Melanoma
Cell-free DNA beyond a biomarker for rejection: Biological trigger of tissue injury and potential therapeutics.
Melanoma
Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins.
Melanoma
Type I Interferons and Malaria: A Double-Edge Sword Against a Complex Parasitic Disease.
Neoplasms
A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2'3'-cGAMP.
Neoplasms
Association of homozygous variants of STING1 with outcome in human cervical cancer.
Neoplasms
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
Neoplasms
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Neoplasms
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Neoplasms
HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.
Neoplasms
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Neoplasms
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Neoplasms
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.
Neuralgia
Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain.
Neurodegenerative Diseases
Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice.
Neuroinflammatory Diseases
HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.
Neuroinflammatory Diseases
Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Non-alcoholic Fatty Liver Disease
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Ovarian Neoplasms
Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis.
Pancreatic Neoplasms
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Pneumonia
Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway.
Porcine Reproductive and Respiratory Syndrome
Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS.
Porcine Reproductive and Respiratory Syndrome
Interferon-Inducible Protein 16 (IFI16) Has a Broad-Spectrum Binding Ability Against ssDNA Targets: An Evolutionary Hypothesis for Antiretroviral Checkpoint.
Porcine Reproductive and Respiratory Syndrome
Mitochondria-Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses.
Porcine Reproductive and Respiratory Syndrome
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.
Porcine Reproductive and Respiratory Syndrome
The microbiome and cytosolic innate immune receptors.
Porcine Reproductive and Respiratory Syndrome
The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways.
Sepsis
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
Tuberculosis
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.
Tuberculosis
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
Vesicular Stomatitis
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.
Virus Diseases
A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2'3'-cGAMP.
Virus Diseases
Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase.
Virus Diseases
Development of novel highly sensitive methods to detect endogenous cGAMP in cells and tissue.
Virus Diseases
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Virus Diseases
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.
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