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Information on EC 2.7.7.86 - cyclic GMP-AMP synthase and Organism(s) Sus scrofa and UniProt Accession I3LM39

for references in articles please use BRENDA:EC2.7.7.86
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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.86 cyclic GMP-AMP synthase
IUBMB Comments
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
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This record set is specific for:
Sus scrofa
UNIPROT: I3LM39
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Word Map
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  • 2.7.7.86
  • sting
  • cgas-sting
  • autoimmune
  • dsdna
  • adaptor
  • self-dna
  • cgas-dependent
  • sting-dependent
  • cgas-stimulator
  • dna-sensing
  • dna-induced
  • tank-binding
  • cgas-mediated
  • dna-triggered
  • pattern-recognition
  • autoinflammatory
  • mavs
  • medicine
  • sting-mediated
  • interferonopathy
  • rig-i-like
  • ifn-stimulated
The taxonomic range for the selected organisms is: Sus scrofa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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ATP
+
GTP
=
2
diphosphate
+
cyclic Gp(2'-5')Ap(3'-5')
+
=
2
+
Synonyms
cyclic gmp-amp synthase, cyclic guanosine monophosphate-adenosine monophosphate synthase, cgamp synthase, hcgas, mb21d1, chcgas, h-cgas, mab-21 domain-containing protein, c6orf150, more
SYSTEMATIC NAME
IUBMB Comments
ATP:GTP adenylyltransferase (cyclizing)
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
mRNA is abundant in the spleen, duodenum, jejunum, and ileum
Manually annotated by BRENDA team
mRNA is abundant in the spleen, duodenum, jejunum, and ileum
Manually annotated by BRENDA team
mRNA is abundant in the spleen, duodenum, jejunum, and ileum
Manually annotated by BRENDA team
mRNA is abundant in the spleen, duodenum, jejunum, and ileum
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
membrane of endoplasmic reticulum
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the overexpression of wild-type cGAS in porcine kidney epithelial cells, but not its catalytically inactive mutants, induces IFN-beta expression, which is dependent on STING and IRF3. The downregulation of cGAS by RNAi markedly reduces IFN-beta expression after pseudorabies virus infection or poly(dA:dT) transfection
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CGAS_PIG
495
0
55809
Swiss-Prot
Mitochondrion (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, J.; Chu, B.; Du, L.; Han, Y.; Zhang, X.; Fan, S.; Wang, Y.; Yang, G.
Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase
Mol. Immunol.
65
436-445
2015
Sus scrofa (I3LM39), Sus scrofa
Manually annotated by BRENDA team