Reference on EC 2.7.7.85 - diadenylate cyclase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zheng, C.; Wang, J.; Luo, Y.; Fu, Y.; Su, J.; He, J.
Highly efficient enzymatic preparation of c-di-AMP using the diadenylate cyclase DisA from Bacillus thuringiensis
Enzyme Microb. Technol.
52
319-324
2013
Bacillus thuringiensis (D5TM67), Bacillus thuringiensis, Bacillus thuringiensis BMB171 (D5TM67)
Mehne, F.M.; Gunka, K.; Eilers, H.; Herzberg, C.; Kaever, V.; Stuelke, J.
Cyclic di-AMP homeostasis in Bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth
J. Biol. Chem.
288
2004-2017
2013
Bacillus subtilis, Bacillus subtilis 168
Witte, C.E.; Whiteley, A.T.; Burke, T.P.; Sauer, J.D.; Portnoy, D.A.; Woodward, J.J.
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection
mBio
4
e00282-13
2013
Listeria monocytogenes
Witte, G.; Hartung, S.; Buettner, K.; Hopfner, K.P.
Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates
Mol. Cell
30
167-178
2008
Bacillus subtilis (P37573), Bacillus subtilis, Thermotoga maritima (Q9WY43)
Woodward, J.; Lavarone, A.; Portnoy, D.
C-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response
Science
328
1703-1705
2010
Listeria monocytogenes (Q8Y5E4)
Mueller, M.; Deimling, T.; Hopfner, K.P.; Witte, G.
Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3-dATP
Biochem. J.
469
367-374
2015
Thermotoga maritima (Q9WY43), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WY43)
Cheng, X.; Zheng, X.; Zhou, X.; Zeng, J.; Ren, Z.; Xu, X.; Cheng, L.; Li, M.; Li, J.; Li, Y.
Regulation of oxidative response and extracellular polysaccharide synthesis by a diadenylate cyclase in Streptococcus mutans
Environ. Microbiol.
18
904-922
2016
Streptococcus mutans (Q8DTC4), Streptococcus mutans, Streptococcus mutans UA159 (Q8DTC4)
Zheng, C.; Ma, Y.; Wang, X.; Xie, Y.; Ali, M.K.; He, J.
Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis
Front. Microbiol.
6
908
2015
Bacillus thuringiensis (D5TM67), Bacillus thuringiensis, Bacillus thuringiensis BMB171 (D5TM67)
Gundlach, J.; Mehne, F.M.; Herzberg, C.; Kampf, J.; Valerius, O.; Kaever, V.; Stuelke, J.
An essential poison: synthesis and degradation of cyclic di-AMP in Bacillus subtilis
J. Bacteriol.
197
3265-3274
2015
Bacillus subtilis (Q45589), Bacillus subtilis, Bacillus subtilis 168 (Q45589)
Rismondo, J.; Gibhardt, J.; Rosenberg, J.; Kaever, V.; Halbedel, S.; Commichau, F.M.
Phenotypes associated with the essential diadenylate cyclase CdaA and its potential regulator CdaR in the human pathogen Listeria monocytogenes
J. Bacteriol.
198
416-426
2016
Listeria monocytogenes (Q8Y5E4), Listeria monocytogenes, Listeria monocytogenes ATCC BAA-679 (Q8Y5E4)
Mehne, F.M.; Schroeder-Tittmann, K.; Eijlander, R.T.; Herzberg, C.; Hewitt, L.; Kaever, V.; Lewis, R.J.; Kuipers, O.P.; Tittmann, K.; Stuelke, J.
Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production
J. Biol. Chem.
289
21098-21107
2014
Bacillus subtilis (O31854), Bacillus subtilis, Bacillus subtilis 168 (O31854)
Rosenberg, J.; Dickmanns, A.; Neumann, P.; Gunka, K.; Arens, J.; Kaever, V.; Stuelke, J.; Ficner, R.; Commichau, F.M.
Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes
J. Biol. Chem.
290
6596-6606
2015
Listeria monocytogenes (Q8Y5E4), Listeria monocytogenes, Listeria monocytogenes ATCC BAA-679 (Q8Y5E4)
Zhu, Y.; Pham, T.H.; Nhiep, T.H.; Vu, N.M.; Marcellin, E.; Chakrabortti, A.; Wang, Y.; Waanders, J.; Lo, R.; Huston, W.M.; Bansal, N.; Nielsen, L.K.; Liang, Z.X.; Turner, M.S.
Cyclic-di-AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in Lactococcus lactis
Mol. Microbiol.
99
1015-1027
2016
Lactococcus lactis
Dengler, V.; McCallum, N.; Kiefer, P.; Christen, P.; Patrignani, A.; Vorholt, J.A.; Berger-Baechi, B.; Senn, M.M.
Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus
PLoS ONE
8
e73512
2013
Staphylococcus aureus (Q2FW92), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FW92)
Opoku-Temeng, C.; Sintim, H.O.
Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols
Sci. Rep.
6
25445
2016
Bacillus subtilis
Pham, T.H.; Liang, Z.X.; Marcellin, E.; Turner, M.S.
Replenishing the cyclic-di-AMP pool regulation of diadenylate cyclase activity in bacteria
Curr. Genet.
62
731-738
2016
Streptococcus pneumoniae (A0A0B7L730), Clostridium botulinum (A0A0C2N691), Bacillus amyloliquefaciens (A0A0D7XMK3), Clostridium perfringens (A0A0H2YU52), Lacticaseibacillus rhamnosus (A0A2A5L6R6), Bacillus anthracis (A0A2A8KZ47), Streptococcus equi subsp. zooepidemicus (A0A2X3T317), Enterococcus faecalis (A0A2Z6BU13), Clostridium novyi (A0PXZ3), Lactococcus cremoris (A2RIF7), Lactococcus cremoris (Q031P4), Clostridium ljungdahlii (D8GIJ7), Tetragenococcus halophilus (G4L7W3), Streptococcus pyogenes serotype M2 (Q1JH51), Staphylococcus aureus (Q2FW92), Bacillus subtilis (Q45589), Lactobacillus acidophilus (Q5FL37), Bacillus licheniformis (Q65P49), Geobacter sulfurreducens (Q74EU1), Streptococcus mutans serotype c (Q8DTC4), Listeria monocytogenes EGD (Q8Y5E4), Tetragenococcus halophilus JCM 20259 (G4L7W3), Listeria monocytogenes EGD EGD-e (Q8Y5E4), Lactococcus cremoris Sk11 (Q031P4), Staphylococcus aureus NCTC 8325 (Q2FW92), Bacillus subtilis 168 (Q45589), Tetragenococcus halophilus DSM 20338 (G4L7W3), Tetragenococcus halophilus NCIMB 9735 (G4L7W3), Clostridium ljungdahlii DSM 13528 (D8GIJ7), Bacillus licheniformis NCIMB 9375 (Q65P49), Enterococcus faecalis ERV62 (A0A2Z6BU13), Bacillus licheniformis Gibson 46 (Q65P49), Clostridium novyi NT (A0PXZ3), Clostridium perfringens NCIMB 6125 (A0A0H2YU52), Clostridium perfringens NCTC 8237 (A0A0H2YU52), Clostridium perfringens JCM 1290 (A0A0H2YU52), Bacillus licheniformis JCM 2505 (Q65P49), Streptococcus mutans serotype c ATCC 700610 (Q8DTC4), Tetragenococcus halophilus NBRC 12172 (G4L7W3), Lactococcus cremoris MG1363 (A2RIF7), Lactobacillus acidophilus NCFM (Q5FL37), Streptococcus pyogenes serotype M2 MGAS10270 (Q1JH51), Bacillus licheniformis NRRL NRS-1264 (Q65P49), Clostridium perfringens type A (A0A0H2YU52), Lacticaseibacillus rhamnosus ATCC 8530 (A0A2A5L6R6), Geobacter sulfurreducens PCA (Q74EU1), Clostridium ljungdahlii PETC (D8GIJ7), Streptococcus pneumoniae ATCC 700669 (A0A0B7L730), Listeria monocytogenes EGD ATCC BAA-679 (Q8Y5E4), Lactobacillus acidophilus ATCC 700396 (Q5FL37), Geobacter sulfurreducens ATCC 51573 (Q74EU1), Lactobacillus acidophilus NCK56 (Q5FL37), Clostridium perfringens DSM 756 (A0A0H2YU52), Bacillus licheniformis NBRC 12200 (Q65P49), Staphylococcus aureus PS 47 (Q2FW92), Bacillus licheniformis ATCC 14580 (Q65P49), Lactobacillus acidophilus N2 (Q5FL37), Streptococcus mutans serotype c UA159 (Q8DTC4), Bacillus licheniformis DSM 13 (Q65P49), Clostridium ljungdahlii ATCC 55383 (D8GIJ7), Geobacter sulfurreducens DSM 12127 (Q74EU1)
Gibhardt, J.; Heidemann, J.L.; Bremenkamp, R.; Rosenberg, J.; Seifert, R.; Kaever, V.; Ficner, R.; Commichau, F.M.
An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes
Environ. Microbiol.
22
2771-2791
2020
Listeria monocytogenes EGD (Q8Y5E4), Listeria monocytogenes EGD ATCC BAA-679 (Q8Y5E4)
Commichau, F.M.; Heidemann, J.L.; Ficner, R.; Stuelke, J.
Making and breaking of an essential poison the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in bacteria
J. Bacteriol.
201
e00462-18
2019
Streptococcus pneumoniae (A0A0B7L730), Bacillus subtilis (A0A6M3Z9Z6), Bacillus subtilis (O31854), Bacillus subtilis (P37573), Mycoplasma pneumoniae (P75528), Listeria monocytogenes EGD (Q8Y5E4), Staphylococcus aureus (Q9RL70), Listeria monocytogenes EGD EGD-e (Q8Y5E4), Bacillus subtilis 168 (A0A6M3Z9Z6), Bacillus subtilis 168 (O31854), Bacillus subtilis 168 (P37573), Mycoplasma pneumoniae M129 (P75528), Listeria monocytogenes EGD ATCC BAA-679 (Q8Y5E4), Mycoplasma pneumoniae ATCC 29342 (P75528)
Zarrella, T.M.; Yang, J.; Metzger, D.W.; Bai, G.
Bacterial second messenger cyclic di-AMP modulates the competence state in Streptococcus pneumoniae
J. Bacteriol.
202
e00691-19
2020
Streptococcus pneumoniae serotype 2 D39 (A0A0H2ZPG9), Streptococcus pneumoniae serotype 2 D39 NCTC 7466 (A0A0H2ZPG9)
Heidemann, J.L.; Neumann, P.; Dickmanns, A.; Ficner, R.
Crystal structures of the c-di-AMP-synthesizing enzyme CdaA
J. Biol. Chem.
294
10463-10470
2019
Listeria monocytogenes EGD (Q8Y5E4), Listeria monocytogenes EGD ATCC BAA-679 (Q8Y5E4)
Braun, F.; Thomalla, L.; van der Does, C.; Quax, T.E.F.; Allers, T.; Kaever, V.; Albers, S.V.
Cyclic nucleotides in archaea cyclic di-AMP in the archaeon Haloferax volcanii and its putative role
MicrobiologyOpen
8
e00829
2019
Haloferax volcanii (D4GZM5), Haloferax volcanii, Haloferax volcanii NCIMB 2012 (D4GZM5), Haloferax volcanii JCM 8879 (D4GZM5), Haloferax volcanii DS2 (D4GZM5), Haloferax volcanii DSM 3757 (D4GZM5), Haloferax volcanii ATCC 29605 (D4GZM5), Haloferax volcanii NBRC 14742 (D4GZM5), Haloferax volcanii VKM B-1768 (D4GZM5)
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