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Information on EC 2.7.7.84 - 2'-5' oligoadenylate synthase and Organism(s) Rattus norvegicus and UniProt Accession Q05961

for references in articles please use BRENDA:EC2.7.7.84
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EC Tree
IUBMB Comments
The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity .
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Rattus norvegicus
UNIPROT: Q05961
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
2-5a synthetase, 2',5'-oligoadenylate synthetase, 2'-5'-oligoadenylate synthetase, 2'-5' oligoadenylate synthetase, oas1b, oas1a, 2'-5'-oligoadenylate synthetase 1, 2'-5'oas, 2'5' oligoadenylate synthetase, oligoadenylate synthetase-like, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2'-5' oligoadenylate synthetase
-
2-5A synthetase
-
SYSTEMATIC NAME
IUBMB Comments
ATP:ATP adenylyltransferase (2'-5' linkages-forming)
The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
OAS1A
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
lymphoid cell of spleen
Manually annotated by BRENDA team
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lymphoid cell of thymus, expression increases during inflammatory processes under ulcerogenic conditions caused by stress factors
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
OAS1A_RAT
358
0
41666
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43000
x * 43000, about, OAS1A, sequence calculation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 43000, about, OAS1A, sequence calculation
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in transgenic Solanum tuberosum plants using the Agrobacterium tumefaciens transfection system, the transformed plants show increased resistance against potato virus X, virus concentration is much lower in leaves and tubers compared to wild-type plants, the virus concentrations are almost that low in transgenic plants expressing the potato virus X coat protein
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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in lymphoid cell of thymus, expression increases during inflammatory processes under ulcerogenic conditions caused by stress factors. Omeprazole treatment leads to increase in enzymic activity in thymocytes under stress, but not in the absence of stress. Omeprazole treatment does not increase enzymic activity in lymphoid cells of spleen
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Truve, E.; Aaspollu, A.; Honkanen, J.; Puska, R.; Mehto, M.; Hassi, A.; Teeri, T.; Kelve, M.; Seppaenen, P.; Saarma, M.
Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions
Nat. Biotechnol.
11
1048-1052
1993
Rattus norvegicus (Q05961)
Manually annotated by BRENDA team
Kot, L.; Kompanets, I.; Ostapchenko, L.; Bogdanova, O.
2,5-oligoadenylate-synthetase activity in lymphoid cells of rats with experimental stress-induced gastric ulcer
Russ. J. Biopharm.
7
14-20
2015
Rattus norvegicus
-
Manually annotated by BRENDA team