Reference on EC 2.7.7.8 - polyribonucleotide nucleotidyltransferase and Organism(s) Homo sapiens and UniProt Accession Q8TCS8
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Godefroy-Colburn, T.; Grunenberg-Manago, M.
Polynucleotide phosphorylase
The Enzymes, 3rd. Ed. (Boyer, P. D. , ed. )
7
533-574
1972
Ascaris lumbricoides, Auxenochlorella pyrenoidosa, Cavia porcellus, Escherichia coli, Halobacterium salinarum, Homo sapiens, Lactiplantibacillus plantarum, Micrococcus luteus, Neisseria meningitidis, Pseudomonas aeruginosa, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Spinacia oleracea, Synechococcus elongatus PCC 7942 = FACHB-805, Triticum aestivum
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Leszczyniecka, M.; Kang, D.C.; Sarkar, D.; Su, Z.Z.; Holmes, M.; Valerie, K.; Fisher, P.B.
Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence
Proc. Natl. Acad. Sci. USA
99
16636-16641
2002
Homo sapiens (Q8TCS8), Homo sapiens
Sarkar, D.; Lebedeva, I.V.; Emdad, L.; Kang, D.C.; Baldwin, A.S.; Fisher, P.B.
Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation
Cancer Res.
64
7473-7478
2004
Homo sapiens
Nagaike, T.; Suzuki, T.; Katoh, T.; Ueda, T.
Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase
J. Biol. Chem.
280
19721-19727
2005
Homo sapiens
Hayakawa, H.; Sekiguchi, M.
Human polynucleotide phosphorylase protein in response to oxidative stress
Biochemistry
45
6749-6755
2006
Homo sapiens
French, S.W.; Dawson, D.W.; Chen, H.; Rainey, R.N.; Sievers, S.A.; Balatoni, C.E.; Wong, L.; Troke, J.J.; Nguyen, M.T.; Koehler, C.M.; Teitell, M.A.
The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity
Cancer Lett.
248
198-210
2007
Homo sapiens (Q8TCS8)
Sarkar, D.; Park, E.S.; Fisher, P.B.
Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35)
Cell Death Differ.
13
1541-1553
2006
Homo sapiens
Chen, H.W.; Rainey, R.N.; Balatoni, C.E.; Dawson, D.W.; Troke, J.J.; Wasiak, S.; Hong, J.S.; McBride, H.M.; Koehler, C.M.; Teitell, M.A.; French, S.W.
Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis
Mol. Cell. Biol.
26
8475-8487
2006
Homo sapiens
Wu, J.; Li, Z.
Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress
Biochem. Biophys. Res. Commun.
372
288-292
2008
Homo sapiens
Sarkar, D.; Park, E.S.; Barber, G.N.; Fisher, P.B.
Activation of double-stranded RNA dependent protein kinase, a new pathway by which human polynucleotide phosphorylase (hPNPase(old-35)) induces apoptosis
Cancer Res.
67
7948-7953
2007
Homo sapiens
Chan, I.; Lebedeva, I.V.; Su, Z.Z.; Sarkar, D.; Valerie, K.; Fisher, P.B.
Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression
J. Cell. Physiol.
215
401-409
2008
Homo sapiens
Portnoy, V.; Palnizky, G.; Yehudai-Resheff, S.; Glaser, F.; Schuster, G.
Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts
RNA
14
297-309
2008
Homo sapiens
Slomovic, S.; Schuster, G.
Stable PNPase RNAi silencing: its effect on the processing and adenylation of human mitochondrial RNA
RNA
14
310-323
2008
Homo sapiens
Wang, D.D.; Shu, Z.; Lieser, S.A.; Chen, P.L.; Lee, W.H.
Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality
J. Biol. Chem.
284
20812-20821
2009
Homo sapiens
Lin, C.L.; Wang, Y.T.; Yang, W.Z.; Hsiao, Y.Y.; Yuan, H.S.
Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation
Nucleic Acids Res.
40
4146-4157
2012
Homo sapiens (G8TCS8), Homo sapiens
Das, S.K.; Bhutia, S.K.; Sokhi, U.K.; Dash, R.; Azab, B.; Sarkar, D.; Fisher, P.B.
Human polynucleotide phosphorylase (hPNPase(old-35)): an evolutionary conserved gene with an expanding repertoire of RNA degradation functions
Oncogene
30
1733-1743
2011
Homo sapiens, Mus musculus
Das, S.K.; Sokhi, U.K.; Bhutia, S.K.; Azab, B.; Su, Z.Z.; Sarkar, D.; Fisher, P.B.
Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells
Proc. Natl. Acad. Sci. USA
107
11948-11953
2010
Homo sapiens
Malla, S.; Li, Z.
Functions of conserved domains of human polynucleotide phosphorylase on RNA oxidation
Insights Biomed. Res.
3
62-67
2019
Homo sapiens (Q8TCS8), Homo sapiens
Shepherd, D.L.; Hathaway, Q.A.; Pinti, M.V.; Nichols, C.E.; Durr, A.J.; Sreekumar, S.; Hughes, K.M.; Stine, S.M.; Martinez, I.; Hollander, J.M.
Exploring the mitochondrial microRNA import pathway through polynucleotide phosphorylase (PNPase)
J. Mol. Cell. Cardiol.
110
15-25
2017
Mus musculus (Q8K1R3), Mus musculus, Homo sapiens (Q8TCS8), Homo sapiens