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Information on EC 2.7.7.78 - GDP-D-glucose phosphorylase and Organism(s) Homo sapiens and UniProt Accession Q6ZNW5

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IUBMB Comments
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
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This record set is specific for:
Homo sapiens
UNIPROT: Q6ZNW5
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
c10f3.4, gdp-d-glucose phosphorylase, c15orf58, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
GDP:alpha-D-glucose 1-phosphate guanylyltransferase
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.002
GDP-alpha-D-glucose
pH 7.5, 31°C
2.9
phosphate
pH 7.5, 31°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
26
GDP-alpha-D-glucose
pH 7.5, 31°C
28.1
phosphate
pH 7.5, 31°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1300
GDP-alpha-D-glucose
pH 7.5, 31°C
9.7
phosphate
pH 7.5, 31°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GDPP1_HUMAN
385
0
42362
Swiss-Prot
other Location (Reliability: 1)
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, 10% glycerol
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adler, L.N.; Gomez, T.A.; Clarke, S.G.; Linster, C.L.
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals
J. Biol. Chem.
286
21511-21523
2011
Caenorhabditis elegans (Q5ZR76), Caenorhabditis elegans, Homo sapiens (Q6ZNW5), Homo sapiens, Mus musculus (Q3TLS3), Mus musculus
Manually annotated by BRENDA team