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IUBMB Comments The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
The enzyme appears in viruses and cellular organisms
Synonyms
C10F3.4 ,
C15orf58 ,
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GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP
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-
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GDP:alpha-D-glucose 1-phosphate guanylyltransferase
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
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GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
the enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose
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-
?
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose
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-
?
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
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-
-
?
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose
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-
?
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
-
-
-
?
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GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
the enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose
-
-
?
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
-
-
-
?
GDP-alpha-D-glucose + phosphate
alpha-D-glucose 1-phosphate + GDP
-
-
-
?
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0.002 - 0.01
GDP-alpha-D-glucose
0.002
GDP-alpha-D-glucose
pH 7.5, 31°C
0.01
GDP-alpha-D-glucose
pH 7.5, 26°C
1.2
phosphate
pH 7.5, 26°C
2.9
phosphate
pH 7.5, 31°C
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26 - 265
GDP-alpha-D-glucose
26
GDP-alpha-D-glucose
pH 7.5, 31°C
265
GDP-alpha-D-glucose
pH 7.5, 26°C
28.1
phosphate
pH 7.5, 31°C
380
phosphate
pH 7.5, 26°C
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1300 - 26500
GDP-alpha-D-glucose
1300
GDP-alpha-D-glucose
pH 7.5, 31°C
26500
GDP-alpha-D-glucose
pH 7.5, 26°C
9.7
phosphate
pH 7.5, 31°C
317
phosphate
pH 7.5, 26°C
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SwissProt
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SwissProt
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SwissProt
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highest levels measured in brain and testis (4-8 times higher than in the remaining tissues)
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developing
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highest levels measured in brain and testis (4-8 times higher than in the remaining tissues)
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highest levels measured in brain and testis (4-8 times higher than in the remaining tissues)
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expressed in all the normal larval stages observed
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highest levels measured in brain and testis (4-8 times higher than in the remaining tissues)
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highest levels measured in brain and testis (4-8 times higher than in the remaining tissues)
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highest levels measured in brain and testis (4-8 times higher than in the remaining tissues)
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-80°C, 10% glycerol
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expression in Escherichia coli
expression in Escherichia coli
expression in Escherichia coli
expression in Escherichia coli
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Adler, L.N.; Gomez, T.A.; Clarke, S.G.; Linster, C.L.
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals
J. Biol. Chem.
286
21511-21523
2011
Mus musculus (Q3TLS3), Mus musculus, Caenorhabditis elegans (Q5ZR76), Caenorhabditis elegans, Homo sapiens (Q6ZNW5), Homo sapiens
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