Information on EC 2.7.7.76 - molybdenum cofactor cytidylyltransferase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
2.7.7.76
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RECOMMENDED NAME
GeneOntology No.
molybdenum cofactor cytidylyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
cytidylyl molybdenum cofactor biosynthesis
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molybdenum cofactor biosynthesis
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Folate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
CTP:molybdenum cofactor cytidylyltransferase
Catalyses the cytidylation of the molybdenum cofactor. This modification occurs only in prokaryotes. Divalent cations such as Mg2+ or Mn2+ are required for activity. ATP or GTP cannot replace CTP.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
K-12
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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molybdenum cofactor biosynthesis
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP + molybdenum cofactor
diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
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-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP + molybdenum cofactor
diphosphate + cytidylyl molybdenum cofactor
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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required
Mn2+
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required
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0034 - 0.0046
CTP
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003 - 0.0062
CTP
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L79P/T81A/S82G
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increased Km for CTP, decreased kcat
T9L/A11G
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increased Km for CTP, decreased kcat
T9L/A11G/L79P/T81A/S82G
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increased Km for CTP, decreased kcat, low activity with GTP instead of CTP
Show AA Sequence (165 entries)
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