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Information on EC 2.7.7.7 - DNA-directed DNA polymerase
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2.7.7.7 DNA-directed DNA polymeraseIUBMB Comments
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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Word Map
- 2.7.7.7
- strand
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single-stranded
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fidelity
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holoenzyme
- mismatch
- bacteriophage
- pcna
- fork
- polymerization
- aphidicolin
- duplex
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proofreading
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calf
- endonuclease
- thymus
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clamp
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misincorporation
- helicase
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abasic
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template-primer
- 5'-triphosphate
- dntps
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stall
- thymine
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error-free
- mispairs
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anneal
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sliding
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uv-induced
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incoming
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exonucleolytic
- replisome
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transversions
- deoxyribonucleoside
- xeroderma
- pigmentosum
- ssdna
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deoxynucleotide
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hypermutation
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undamaged
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okazaki
- dtmp
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slippage
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cyclobutane
- transcriptases
- dnab
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watson-crick
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high-fidelity
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myeloblastosis
- aquaticus
- synthesis
- analysis
- drug development
- diagnostics
- biotechnology
- medicine
- molecular biology
The enzyme appears in viruses and cellular organisms
Synonyms
dna polymerase alpha, dna polymerase beta, dna polymerase iii, pol beta, klenow fragment, dna polymerase delta, taq dna polymerase, pol delta, pol alpha, dna polymerase gamma, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
deoxynucleate polymerase
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deoxyribonucleate nucleotidyltransferase
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deoxyribonucleic acid duplicase
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deoxyribonucleic acid polymerase
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deoxyribonucleic duplicase
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deoxyribonucleic polymerase
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deoxyribonucleic polymerase I
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DNA duplicase
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DNA nucleotidyltransferase
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DNA nucleotidyltransferase (DNA-directed)
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DNA polmerase beta
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DNA polymerase
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DNA polymerase alpha
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DNA polymerase gamma
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DNA polymerase I
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DNA polymerase II
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DNA polymerase III
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DNA replicase
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DNA-dependent DNA polymerase
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duplicase
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Klenow fragment
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nucleotidyltransferase, deoxyribonucleate
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Pol gamma
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sequenase
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Taq DNA polymerase
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Taq Pol I
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Tca DNA polymerase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.
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CAS REGISTRY NUMBER
COMMENTARY
9012-90-2
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis, Lactic
Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects.
Acidosis, Lactic
High rate of hypertension in patients with m.3243A>G MELAS mutations and POLG variants.
Acidosis, Lactic
Lack of correlation between length variation in the DNA polymerase gamma gene CAG repeat and lactic acidosis or neuropathy during antiretroviral treatment.
Acidosis, Lactic
Novel mutation of human DNA polymerase gamma associated with mitochondrial toxicity induced by anti-HIV treatment.
Acquired Immunodeficiency Syndrome
Differential utilization of 2',3'-dideoxyguanosine 5'-triphosphate as a substrate for various DNA polymerases.
Acquired Immunodeficiency Syndrome
DNA polymerase gamma in mitochondrial DNA replication and repair.
Acquired Immunodeficiency Syndrome
Genetic Analysis of DinG Family Helicase YoaA and Its Interaction with Replication Clamp Loader Protein HolC in Escherichia coli.
Acquired Immunodeficiency Syndrome
Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine.
Acquired Immunodeficiency Syndrome
Molecular insights into NRTI inhibition and mitochondrial toxicity revealed from a structural model of the human mitochondrial DNA polymerase.
Acquired Immunodeficiency Syndrome
On the early emergence of reverse transcription: theoretical basis and experimental evidence.
Acquired Immunodeficiency Syndrome
Rapid feline immunodeficiency virus provirus quantitation by polymerase chain reaction using the TaqMan fluorogenic real-time detection system.
Acquired Immunodeficiency Syndrome
Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.
Acquired Immunodeficiency Syndrome
Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.
Acquired Immunodeficiency Syndrome
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase.
Acute Kidney Injury
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease.
adenine phosphoribosyltransferase deficiency
Polymerase chain reaction amplification and sequence analysis of human mutant adenine phosphoribosyltransferase genes: the nature and frequency of errors caused by Taq DNA polymerase.
Adenocarcinoma
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
Adenocarcinoma
DNA polymerase alpha as an independent prognostic parameter in non-small cell lung cancer--an immunohistochemical study.
Adenocarcinoma
DNA polymerase beta expression differences in selected human tumors and cell lines.
Adenocarcinoma
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Adenocarcinoma
Effects of estradiol on deoxyribonucleic acid polymerase alpha activity in the Ishikawa human endometrial adenocarcinoma cell line.
Adenocarcinoma
Effects of estradiol on proliferation of endometrial adenocarcinoma cells (Ishikawa line).
Adenocarcinoma
Enucleation of human endometrial cells: nucleo-cytoplasmic distribution of DNA polymerase alpha and estrogen receptor.
Adenocarcinoma
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
Adenocarcinoma
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.
Adenocarcinoma
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines.
Adenocarcinoma
Intranuclear dynamics of DNA polymerase alpha differs between the transplanted R3230AC mammary adenocarcinomas and the host mammary gland depending on lactation cycle.
Adenocarcinoma
Proliferative cell index in endometrial adenocarcinoma of different nuclear grades.
Adenocarcinoma of Lung
4-Nitroquinoline-1-oxide effects human lung adenocarcinoma A549 cells by regulating the expression of POLD4.
Adenocarcinoma of Lung
Nonsynonymous single nucleotide polymorphisms in DNA damage repair pathways and lung cancer risk.
Adenoma
Detection of the growth fraction in colorectal tumours by a monoclonal antibody against DNA polymerase alpha.
Adenoma
Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.
Adenoma
Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.
Adenoma
Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.
Adenoma
[Detection of proliferative cells in colorectal carcinomas and adenomas by monoclonal antibody to DNA polymerase alpha]
Adenomatous Polyposis Coli
Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair.
Adenomatous Polyposis Coli
Structure/function analysis of the interaction of adenomatous polyposis coli with DNA polymerase beta and its implications for base excision repair.
Adenomatous Polyposis Coli
The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots.
Adenoviridae Infections
Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor.
Adenoviridae Infections
Increase in DNA polymerase alpha in nuclei of chicken kidney cells after avian adenovirus infection.
African Swine Fever
Altered order of substrate binding by DNA polymerase X from African Swine Fever virus.
African Swine Fever
ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts.
African Swine Fever
Contributions of an Endonuclease IV Homologue to DNA Repair in the African Swine Fever Virus.
African Swine Fever
DNA polymerase X from African swine fever virus: quantitative analysis of the enzyme-ssDNA interactions and the functional structure of the complex.
African Swine Fever
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA.
African Swine Fever
How a low-fidelity DNA polymerase chooses non-watson-crick from watson-crick incorporation.
African Swine Fever
How DNA polymerase X preferentially accommodates incoming dATP opposite 8-oxoguanine on the template.
African Swine Fever
Human DNA Polymerase ? Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
African Swine Fever
In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanism.
African Swine Fever
Increased deoxyribonucleic acid polymerase activity in African swine fever virus-infected culture cells. Brief report.
African Swine Fever
Interactions of the DNA polymerase X from African swine fever virus with gapped DNA substrates. Quantitative analysis of functional structures of the formed complexes.
African Swine Fever
Interactions of the DNA polymerase X from African Swine Fever Virus with the ssDNA. Properties of the total DNA-binding site and the strong DNA-binding subsite.
African Swine Fever
Interactions of the DNA polymerase X of African swine fever virus with double-stranded DNA. Functional structure of the complex.
African Swine Fever
Involvement of the reparative DNA polymerase pol x of african Swine Fever virus in the maintenance of viral genome stability in vivo.
African Swine Fever
Mismatched base-pair simulations for ASFV Pol X/DNA complexes help interpret frequent G*G misincorporation.
African Swine Fever
Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.
African Swine Fever
Solution structure of a viral DNA polymerase X and evidence for a mutagenic function.
African Swine Fever
Solution structures of 2 : 1 and 1 : 1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle X-ray scattering.
African Swine Fever
Use of damaged DNA and dNTP substrates by the error-prone DNA polymerase X from African swine fever virus.
AIDS-Related Complex
Differential utilization of 2',3'-dideoxyguanosine 5'-triphosphate as a substrate for various DNA polymerases.
Alzheimer Disease
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.
Anemia
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
Anemia, Hemolytic
5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia.
Anemia, Hemolytic
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease.
Anemia, Megaloblastic
5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia.
Antiphospholipid Syndrome
Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review.
Arthralgia
Synovial involvement assessed by power Doppler ultra-sonography in systemic sclerosis: results of a cross-sectional study.
Arthritis
Sensitivity to change of joint count composite indices in 72 patients with systemic sclerosis.
Ataxia
Abundance of the POLG disease mutations in Europe, Australia, New Zealand, and the United States explained by single ancient European founders.
Ataxia
Asymmetric Ataxia, Depression, Memory Loss, Epilepsy, and Axonal Neuropathy Associated with A Heterozygous DNA Polymerase Gamma Variant of Uncertain Significance, c1370G>a (R457Q).
Ataxia
Dimethylarsinic Acid in Drinking Water Changed the Morphology of Urinary Bladder but Not the Expression of DNA Repair Genes of Bladder Transitional Epithelium in F344 Rats.
Ataxia
Genetic and chemical rescue of the Saccharomyces cerevisiae phenotype induced by mitochondrial DNA polymerase mutations associated with progressive external ophthalmoplegia in humans.
Ataxia
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Ataxia
Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin.
Ataxia
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.
Ataxia
Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism.
Ataxia Telangiectasia
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
Ataxia Telangiectasia
Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.
Ataxia Telangiectasia
DNA repair enzyme deficiency and in vitro complementation of the enzyme activity in cell-free extracts from ataxia telangiectasia fibroblasts.
Ataxia Telangiectasia
Measurement of DNA polymerase beta in skin fibroblast cell lines from patients with ataxia telangiectasia.
Ataxia Telangiectasia
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.
Autoimmune Diseases
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
beta-Thalassemia
The use of the amplification refractory mutation system (arms) in the detection of rare beta-thalassemia mutations in the Malays and Chinese in Malaysia.
Blast Crisis
Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.
Bloom Syndrome
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Brain Diseases
A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.
Brain Diseases
Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects.
Brain Diseases
High rate of hypertension in patients with m.3243A>G MELAS mutations and POLG variants.
Brain Injuries, Traumatic
Detection of single- and double-strand DNA breaks after traumatic brain injury in rats: comparison of in situ labeling techniques using DNA polymerase I, the Klenow fragment of DNA polymerase I, and terminal deoxynucleotidyl transferase.
Brain Ischemia
In situ detection of neuronal DNA strand breaks using the Klenow fragment of DNA polymerase I reveals different mechanisms of neuron death after global cerebral ischemia.
Brain Neoplasms
Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.
Brain Neoplasms
Immunohistochemical demonstration of DNA polymerase alpha in human brain-tumor cells.
Brain Neoplasms
Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.
Brain Neoplasms
Measurement of labeling index of DNA polymerase alpha in human brain tumors. Comparative study with labeling indices of BUdR in vitro and Ki-67.
Breast Diseases
Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas.
Breast Neoplasms
Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas.
Breast Neoplasms
Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis.
Breast Neoplasms
An Evaluation of DNA Polymerase alpha as a Prognostic Predictor in Early Breast Cancers Smaller than 2 cm.
Breast Neoplasms
Analysis by DNA polymerase alpha activity of human breast tumour proliferation and the effect of endocrine therapy.
Breast Neoplasms
Antiproliferative effect of DNA polymerase alpha antisense oligodeoxynucleotides on breast cancer cells.
Breast Neoplasms
Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
Breast Neoplasms
Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review.
Breast Neoplasms
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Breast Neoplasms
DNA polymerase iota (Pol ?) promotes the migration and invasion of breast cancer cell via EGFR-ERK-mediated epithelial to mesenchymal transition.
Breast Neoplasms
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Breast Neoplasms
Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer.
Breast Neoplasms
Effects of estrogen and antiestrogen on DNA polymerase in human breast cancer.
Breast Neoplasms
Erratum: Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study: Erratum.
Breast Neoplasms
Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-associated R438W DNA Polymerase Lambda Protein.
Breast Neoplasms
Evaluation of cancer-associated myositis and scleroderma autoantibodies in breast cancer patients without rheumatic disease.
Breast Neoplasms
Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer.
Breast Neoplasms
Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk.
Breast Neoplasms
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines.
Breast Neoplasms
Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.
Breast Neoplasms
Inhibition of DNA polymerase alpha expression and cell growth, a possible triple helix mechanism.
Breast Neoplasms
Mutations in DNA-polymerase-Beta occur in breast, prostate and colorectal tumors.
Breast Neoplasms
Proliferating cell nuclear antigen in breast lesions: correlation of c-erbB-2 oncoprotein and EGF receptor and its clinicopathological significance in breast cancer.
Breast Neoplasms
Rapidly progressive systemic sclerosis associated with breast carcinoma: Report of a case with anti-RNA polymerase III antibody.
Breast Neoplasms
Reduced DNA repair capacity in breast cancer patients and unaffected individuals from breast cancer families.
Breast Neoplasms
RNA-directed DNA polymerase activity in human breast cancer biopsy specimens. Relation to estrogen receptor protein.
Breast Neoplasms
The effect of medroxyprogesterone acetate on aromatase and DNA polymerase alpha activities in breast tumours.
Breast Neoplasms
The response of human breast tumour cell lines with altered polymerase beta levels to cisplatin and radiation.
Breast Neoplasms
Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer.
Breast Neoplasms
Universal molecular beacon-based tracer system for real-time polymerase chain reaction.
Breast Neoplasms
[A study of the proliferative activity of DNA polymerase alpha immunoreactivity in breast cancer]
Burkitt Lymphoma
High terminal deoxynucleotidyl transferase activity in pediatric patients with acute lymphocytic and acute myelocytic leukemias.
Burkitt Lymphoma
Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.
Burkitt Lymphoma
Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.
Burkitt Lymphoma
Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.
Calcinosis
Calcinosis is associated with digital ischaemia in systemic sclerosis-a longitudinal study.
Carcinogenesis
Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice.
Carcinogenesis
Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals.
Carcinogenesis
Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene.
Carcinogenesis
Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta.
Carcinogenesis
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Carcinogenesis
Deregulated expression of DNA polymerase ? is involved in the progression of genomic instability.
Carcinogenesis
DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis.
Carcinogenesis
DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line.
Carcinogenesis
DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.
Carcinogenesis
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Carcinogenesis
DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.
Carcinogenesis
Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach.
Carcinogenesis
Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.
Carcinogenesis
Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1.
Carcinogenesis
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues.
Carcinogenesis
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.
Carcinogenesis
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
Carcinogenesis
Induction of a low level of microsatellite instability by overexpression of DNA polymerase Beta.
Carcinogenesis
Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors.
Carcinogenesis
Involvement of DNA polymerase iota in hypermutagenesis and tumorigenesis: an improper model can lead to inaccurate results.
Carcinogenesis
Mammary carcinogenesis in transgenic mice expressing a dominant-negative mutant of DNA polymerase beta in their mammary glands.
Carcinogenesis
Mechanism of carcinogenesis by RNA tumour viruses: the RNA-and DNA-dependent DNA polymerase activities of feline sarcoma virus.
Carcinogenesis
Mutation at the Polymerase Active Site of Mouse DNA Polymerase {delta} Increases Genomic Instability and Accelerates Tumorigenesis.
Carcinogenesis
Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice.
Carcinogenesis
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Carcinogenesis
Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
Carcinogenesis
Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.
Carcinogenesis
Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer.
Carcinogenesis
Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues.
Carcinogenesis
The error-prone DNA polymerase ? provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.
Carcinogenesis
The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin.
Carcinogenesis
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
Carcinogenesis
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
Carcinogenesis
[Complex of repair DNA polymerase beta with autonomous 3'-->5'-exonuclease shows increased accuracy of DNA synthesis]
Carcinogenesis
[Preliminary study of DNA polymerase beta gene silencing by small interfering RNA in human gastric cancer BGC-823 cells]
Carcinoma
Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice.
Carcinoma
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling.
Carcinoma
Association of a Newly Identified Variant of DNA Polymerase Beta (pol?63-123, 208-304) with the Risk Factor of Ovarian Carcinoma in India.
Carcinoma
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
Carcinoma
Association of two polymorphisms of DNA polymerase beta in exon-9 and exon-11 with ovarian carcinoma in India.
Carcinoma
Characterization of chromosome aberrations induced by incubation at a restrictive temperature in the mouse temperature-sensitive mutant tsFT20 strain containing heat-labile DNA polymerase alpha.
Carcinoma
Characterization of DNA replication at a restrictive temperature in a mouse DNA temperature-sensitive mutant, tsFT20 strain, containing heat-labile DNA polymerase alpha activity.
Carcinoma
Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma.
Carcinoma
Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines.
Carcinoma
Detection of proliferative cells in dysplasia, carcinoma in situ, and invasive carcinoma of the uterine cervix by monoclonal antibody against DNA polymerase alpha.
Carcinoma
Difference in expression level and localization of DNA polymerase beta among human esophageal cancer focus, adjacent and corresponding normal tissues.
Carcinoma
Differential oncogene amplification in tumor cells from a patient treated with cisplatin and 5-fluorouracil.
Carcinoma
DNA polymerase iota (Pol ?) promotes invasion and metastasis of esophageal squamous cell carcinoma.
Carcinoma
DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.
Carcinoma
DNA polymerase zeta accounts for the reduced cytotoxicity and enhanced mutagenicity of cisplatin in human colon carcinoma cells that have lost DNA mismatch repair.
Carcinoma
Exon 8-9 mutations of DNA polymerase ? in ovarian carcinoma patients from Haldia, India.
Carcinoma
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines.
Carcinoma
Identification of a point mutation in the cDNA of the catalytic subunit of DNA polymerase alpha from a temperature-sensitive mouse FM3A cell line.
Carcinoma
Lack of significant modulation of the formation and removal of platinum-DNA adducts by aphidicolin glycinate in two logarithmically-growing ovarian tumour cell lines in vitro.
Carcinoma
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.
Carcinoma
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Carcinoma
Overexpression of DNA polymerase iota (Pol?) in esophageal squamous cell carcinoma.
Carcinoma
Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1.
Carcinoma
The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions.
Carcinoma
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.
Carcinoma
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
Carcinoma
The relationship between the antitumor activity and the ribonucleotide reductase inhibitory activity of (E)-2'-deoxy-2'-(fluoromethylene) cytidine, MDL 101,731.
Carcinoma
[Detection of drug resistant-gene in cisplatin-resistant colon carcinoma cells by RT-PCR assay. I]
Carcinoma
[Expression of p53 gene with DNA polbeta and CMV promoter in salivary adenoid cystic carcinoma cells]
Carcinoma
[Expression of proliferating cell nuclear antigen (PCNA) in premalignant lesions of laryngeal epithelium]
Carcinoma in Situ
Detection of proliferative cells in dysplasia, carcinoma in situ, and invasive carcinoma of the uterine cervix by monoclonal antibody against DNA polymerase alpha.
Carcinoma, Adenoid Cystic
[Expression of p53 gene with DNA polbeta and CMV promoter in salivary adenoid cystic carcinoma cells]
Carcinoma, Adenosquamous
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Carcinoma, Ductal
The frequency and clinical significance of DNA polymerase beta (POL?) expression in breast ductal carcinoma in situ (DCIS).
Carcinoma, Ehrlich Tumor
Effect of Ehrlich ascites cell chalone on nascent DNA synthesis in isolated nuclei.
Carcinoma, Ehrlich Tumor
Ehrlich ascites tumor (EAT) chalone effects on nascent DNA synthesis and DNA polymerase alpha and beta.
Carcinoma, Ehrlich Tumor
In vitro conversion of MVM parvovirus single-stranded DNA to the replicative form by DNA polymerase alpha from Ehrlich ascites tumour cells.
Carcinoma, Ehrlich Tumor
Retrostatin, a new specific enzyme inhibitor against avian myeloblastosis virus reverse transcriptase.
Carcinoma, Ehrlich Tumor
Studies on deoxyribonucleic acid polymerase from Ehrlich ascites tumor cells. I. Isolation and purification of the polymerase and some general properties of the enzyme catalyzed reaction.
Carcinoma, Ehrlich Tumor
Studies on deoxyribonucleic acid polymerase from Ehrlich ascites tumor cells. II. Factors influencing primer and template requirement of deoxyribonucleic acid polymerase.
Carcinoma, Hepatocellular
A new form of high molecular weight DNA polymerase in the nuclei of rat ascites hepatoma cells.
Carcinoma, Hepatocellular
An analysis of proliferating cells in biopsy specimens from patients with small hepatocellular carcinoma.
Carcinoma, Hepatocellular
Antitemplate effect of polynucleotides and their hybrid complexes.
Carcinoma, Hepatocellular
Chick embryo DNA polymerase beta. Purified enzyme consists of a single Mr = 40,000 polypeptide.
Carcinoma, Hepatocellular
Cloning, expression and characterization of human tissue-specific DNA polymerase lambda2.
Carcinoma, Hepatocellular
Detection of the preneoplastic lesions of small hepatocellular carcinoma in cirrhotic livers.
Carcinoma, Hepatocellular
DNA polymerase alpha from normal rat liver is different than DNA polymerases alpha from Morris hepatoma strains.
Carcinoma, Hepatocellular
High molecular weight deoxyribonucleic acid polymerase of LF hepatoma. Purification and properties.
Carcinoma, Hepatocellular
Identification and fine structure of proliferating hepatocytes in malignant and nonmalignant liver diseases by use of a monoclonal antibody against DNA polymerase alpha.
Carcinoma, Hepatocellular
Immunohistochemical analysis of retinoblastoma gene product (pRB) expression in malignant and non-malignant liver diseases.
Carcinoma, Hepatocellular
Incorporation of nucleotides into DNA by mammalian DNA polymerase in the presence of a single deoxynucleoside triphosphate.
Carcinoma, Hepatocellular
Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue.
Carcinoma, Hepatocellular
Knockdown of POLQ interferes the development and progression of hepatocellular carcinoma through regulating cell proliferation, apoptosis and migration.
Carcinoma, Hepatocellular
Nude mice bearing human primary hepatocellular carcinoma that produces hepatitis B surface, core, and e antigens, as well as deoxyribonucleic acid polymerase.
Carcinoma, Hepatocellular
Significance of DNA Polymerase Delta Catalytic Subunit p125 Induced by Mutant p53 in the Invasive Potential of Human Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Structural homology of DNA polymerase beta from various mammalian cells.
Carcinoma, Hepatocellular
Studies on the molecular species of DNA polymerase extracted from rat ascites hepatoma cells.
Carcinoma, Hepatocellular
The inhibitory effect of 4-hydroxy-nonenal on DNA-polymerases alpha and beta from rat liver and rapidly dividing Yoshida ascites hepatoma.
Carcinoma, Hepatocellular
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Carcinoma, Hepatocellular
Unique requirements for template primers of DNA polymerase beta from rat ascites hepatoma AH130 cells.
Carcinoma, Hepatocellular
[Establishment of AFP promoter operated murine IL-1beta recombinant vector and its expression in H22 cells.]
Carcinoma, Hepatocellular
[The radiobiologic characteristics of DNA polymerase beta in hepatomas]
Carcinoma, Intraductal, Noninfiltrating
The frequency and clinical significance of DNA polymerase beta (POL?) expression in breast ductal carcinoma in situ (DCIS).
Carcinoma, Non-Small-Cell Lung
DNA polymerase alpha as an independent prognostic parameter in non-small cell lung cancer--an immunohistochemical study.
Carcinoma, Non-Small-Cell Lung
DNA Polymerase Alpha Subunit B Is a Binding Protein for Erlotinib Resistance in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking.
Carcinoma, Non-Small-Cell Lung
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Carcinoma, Non-Small-Cell Lung
Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy.
Carcinoma, Renal Cell
A novel role of XRCC1 in the functions of a DNA polymerase beta variant.
Carcinoma, Renal Cell
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines.
Carcinoma, Renal Cell
Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1.
Carcinoma, Squamous Cell
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling.
Carcinoma, Squamous Cell
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
Carcinoma, Squamous Cell
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.
Carcinoma, Squamous Cell
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.
Carcinosarcoma
Exceptional Response of Cryoablation Followed by Pembrolizumab in a Patient with Metastatic Cervical Carcinosarcoma with High Tumor Mutational Burden: A Case Report.
Cardiotoxicity
Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library.
Cardiovascular Diseases
Comparative study of cardiovascular function and ventricular premature complexes in smokers and nonsmokers during maximal treadmill exercise.
Cataract
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.
Cerebellar Ataxia
Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patients with adult-onset ataxia on Taiwan.
Chagas Disease
Cloning and characterization of DNA polymerase eta from Trypanosoma cruzi: Roles for translesion bypass of oxidative damage.
Cockayne Syndrome
Contributions of nucleotide excision repair, DNA polymerase eta, and homologous recombination to replication of UV-irradiated herpes simplex virus type 1.
Coinfection
Assembly of functional replication factor C expressed using recombinant baculoviruses.
Coinfection
Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.
Colonic Neoplasms
A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.
Colonic Neoplasms
Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
Colonic Neoplasms
Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines.
Colonic Neoplasms
DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.
Colonic Neoplasms
Mutation analysis of replicative genes encoding the large subunits of DNA polymerase alpha and replication factors A and C in human sporadic colorectal cancers.
Colonic Neoplasms
Quantification of somatic mutation flow across individual cell division events by lineage sequencing.
Colonic Neoplasms
The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots.
Colorectal Neoplasms
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.
Colorectal Neoplasms
A DNA polymerase beta mutant from colon cancer cells induces mutations.
Colorectal Neoplasms
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
Colorectal Neoplasms
Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer.
Colorectal Neoplasms
Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines.
Colorectal Neoplasms
Detection of the growth fraction in colorectal tumours by a monoclonal antibody against DNA polymerase alpha.
Colorectal Neoplasms
DNA polymerase alpha positive-cell rate in colorectal cancer and its relationship to prognosis.
Colorectal Neoplasms
Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers.
Colorectal Neoplasms
Evaluation of DNA polymerase beta gene mutation as a genetic marker for colorectal carcinoma.
Colorectal Neoplasms
Finding the hot spot: identifying immune sensitive gastrointestinal tumors.
Colorectal Neoplasms
Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.
Colorectal Neoplasms
Mitochondrial DNA Polymerase ? Mutations and Their Implications in mtDNA Alterations in Colorectal Cancer.
Colorectal Neoplasms
Mutation analysis of replicative genes encoding the large subunits of DNA polymerase alpha and replication factors A and C in human sporadic colorectal cancers.
Colorectal Neoplasms
Mutations in DNA-polymerase-Beta occur in breast, prostate and colorectal tumors.
Colorectal Neoplasms
Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer.
Colorectal Neoplasms
Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer.
Colorectal Neoplasms
Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer.
Colorectal Neoplasms
[Detection of proliferative cells in colorectal carcinomas and adenomas by monoclonal antibody to DNA polymerase alpha]
Connective Tissue Diseases
Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis.
Contracture
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.
Cryptorchidism
Changes of enzymes involved in DNA synthesis in the testes of cryptorchid rats.
Cysts
DNA polymerases alpha and gamma during pre-emergence and early larval development of Artemia.
Decompression Sickness
Conformation of DNA GG intrastrand cross-link of antitumor oxaliplatin and its enantiomeric analog.
Decompression Sickness
O-helix mutant T664P of Thermus aquaticus DNA polymerase I: altered catalytic properties for incorporation of incorrect nucleotides but not correct nucleotides.
Dehydration
Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis.
Dengue
A simple reverse transcription-polymerase chain reaction for dengue type 2 virus identification.
Dermatomyositis
Evaluation of cancer-associated myositis and scleroderma autoantibodies in breast cancer patients without rheumatic disease.
Dermatomyositis
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
Diabetes Mellitus, Type 2
Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes.
Diffuse Cerebral Sclerosis of Schilder
A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.
Diffuse Cerebral Sclerosis of Schilder
Abnormalities in Glycogen Metabolism in a Patient with Alpers' Syndrome Presenting with Hypoglycemia.
Diffuse Cerebral Sclerosis of Schilder
Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanisms.
Diffuse Cerebral Sclerosis of Schilder
Alpers syndrome with prominent white matter changes.
Diffuse Cerebral Sclerosis of Schilder
Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol {gamma}
Diffuse Cerebral Sclerosis of Schilder
Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication.
Diffuse Cerebral Sclerosis of Schilder
Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo.
Diffuse Cerebral Sclerosis of Schilder
Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers' syndrome.
Diffuse Cerebral Sclerosis of Schilder
Polymerase ? gene POLG determines the risk of sodium valproate-induced liver toxicity.
Diffuse Cerebral Sclerosis of Schilder
Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.
Diffuse Cerebral Sclerosis of Schilder
Rapidly progressive neurological deterioration in a child with Alpers syndrome exhibiting a previously unremarkable brain MRI.
Diffuse Cerebral Sclerosis of Schilder
Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism.
Diffuse Cerebral Sclerosis of Schilder
Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening dependent apoptotic sensitivity in an induced pluripotent stem cell model.
Diffuse Cerebral Sclerosis of Schilder
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
dna-directed dna polymerase deficiency
A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.
dna-directed dna polymerase deficiency
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.
dna-directed dna polymerase deficiency
Decreased mutant frequency in embryonic brain of DNA polymerase {beta} null mice.
dna-directed dna polymerase deficiency
DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.
dna-directed dna polymerase deficiency
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice.
dna-directed dna polymerase deficiency
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
dna-directed dna polymerase deficiency
Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.
dna-directed dna polymerase deficiency
Involvement of DNA polymerase beta in repairing oxidative damages induced by antitumor drug adriamycin.
dna-directed dna polymerase deficiency
Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers' syndrome.
dna-directed dna polymerase deficiency
Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice.
dna-directed dna polymerase deficiency
p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice.
dna-directed dna polymerase deficiency
p53 suppression overwhelms DNA polymerase eta deficiency in determining the cellular UV DNA damage response.
dna-directed dna polymerase deficiency
Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.
dna-directed dna polymerase deficiency
Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.
dna-directed dna polymerase deficiency
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
Down Syndrome
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging.
Down Syndrome
Studies on deoxyribonucleic acid polymerase from normal and Down's syndrome skin fibroblasts in vitro.
Drug Resistant Epilepsy
Prospective study of POLG mutations presenting in children with intractable epilepsy-prevalence and clinical features.
Drug-Related Side Effects and Adverse Reactions
A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease.
Drug-Related Side Effects and Adverse Reactions
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase.
Drug-Related Side Effects and Adverse Reactions
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Dysarthria
Clinical and Molecular Features of POLG-Related Sensory Ataxic Neuropathy with Dysarthria and Ophthalmoparesis.
Dysarthria
Protein molecular modeling shows residue T599 is critical to wild-type function of POLG and description of a novel variant associated with the SANDO phenotype.
Encephalitis, Tick-Borne
Reverse Genetics of RNA Viruses: ISA-Based Approach to Control Viral Population Diversity without Modifying Virus Phenotype.
Endocarditis
Clonal structure of Streptococcus sanguinis strains isolated from endocarditis cases and the oral cavity.
Endometrial Neoplasms
Detection of POLE Subtypes in High-Grade Endometrioid Carcinoma by BaseScope-ISH Assay.
Endometrial Neoplasms
Effects of estradiol on deoxyribonucleic acid polymerase alpha activity in the Ishikawa human endometrial adenocarcinoma cell line.
Endometrial Neoplasms
Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis.
Endometrial Neoplasms
Expression of the cancer-associated DNA polymerase ? P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Endometrial Neoplasms
Immunohistochemical study of p53 expression in endometrial carcinomas: correlation with markers of proliferating cells and clinicopathologic features.
Endometrial Neoplasms
Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer.
Endometrial Neoplasms
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Endometrial Neoplasms
TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
Endometrial Neoplasms
The frequency of POLE-mutation in endometrial carcinoma and prognostic implications: a systemic review and meta-analysis.
Endometrial Neoplasms
Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa.
Epilepsy
Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects.
Epilepsy
Asymmetric Ataxia, Depression, Memory Loss, Epilepsy, and Axonal Neuropathy Associated with A Heterozygous DNA Polymerase Gamma Variant of Uncertain Significance, c1370G>a (R457Q).
Epilepsy
Elevated cerebrospinal fluid protein in POLG-related epilepsy: Diagnostic and prognostic implications.
Epilepsy
Genetic and chemical rescue of the Saccharomyces cerevisiae phenotype induced by mitochondrial DNA polymerase mutations associated with progressive external ophthalmoplegia in humans.
Epilepsy
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Epilepsy
Mitochondrial DNA damage and impaired base excision repair during epileptogenesis.
Epilepsy
Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism.
Epilepsy
Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy.
Esophageal Neoplasms
Difference in expression level and localization of DNA polymerase beta among human esophageal cancer focus, adjacent and corresponding normal tissues.
Esophageal Neoplasms
DNA polymerase beta promoter mutations affect gene transcription, translation and the sensitivity of esophageal cancer cells to cisplatin treatment.
Esophageal Neoplasms
NRAGE promotes cell proliferation by stabilizing PCNA in a ubiquitin-proteasome pathway in esophageal carcinomas.
Esophageal Squamous Cell Carcinoma
Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
DNA polymerase iota (Pol ?) promotes invasion and metastasis of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.
Esophageal Squamous Cell Carcinoma
Overexpression of DNA polymerase iota (Pol?) in esophageal squamous cell carcinoma.
Fanconi Anemia
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand.
Fatty Liver
Regulation of mitochondrial morphology and cell survival by Mitogenin I and mitochondrial single-stranded DNA binding protein.
Fibroadenoma
Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas.
Fibrosarcoma
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Fragile X Syndrome
Assignment of the human gene for DNA polymerase alpha to the X chromosome.
Fragile X Syndrome
Human DNA polymerase alpha. Compensation for heat-labile mouse DNA polymerase alpha and its gene localization on the X chromosome.
Gastric Antral Vascular Ectasia
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.
Gastric Antral Vascular Ectasia
An update on biomarker discovery and use in systemic sclerosis.
Gastric Antral Vascular Ectasia
Anti-RNA polymerase III antibodies as a risk marker for early gastric antral vascular ectasia (GAVE) in systemic sclerosis.
Gastric Antral Vascular Ectasia
Gastric antral vascular ectasia in systemic sclerosis: Association with anti-RNA polymerase III and negative anti-nuclear antibodies.
Gastric Antral Vascular Ectasia
Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement.
Gastritis, Atrophic
Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach.
Genetic Diseases, Inborn
Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa.
Genetic Diseases, Inborn
Alternative splicing of DNA polymerase beta mRNA is not tumor-specific.
Genetic Diseases, Inborn
DNA polymerase eta, a key protein in translesion synthesis in human cells.
Genetic Diseases, Inborn
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.
Genetic Diseases, Inborn
Functional human mitochondrial DNA polymerase gamma forms a heterotrimer.
Genetic Diseases, Inborn
Replication of damaged DNA by translesion synthesis in human cells.
Genetic Diseases, Inborn
[DNA polymerase eta: from a DNA repair-deficient genetic disease to the discovery of a novel DNA polymerase]
Gingival Overgrowth
Immunohistochemical analysis of effects of cyclosporin A on gingival epithelium.
Glioblastoma
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms.
Glioblastoma
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
Glioblastoma
The error-prone DNA polymerase ? promotes temozolomide resistance in glioblastoma through Rad17-dependent activation of ATR-Chk1 signaling.
Glioma
A comparison of the enhancement of radiation sensitivity and DNA polymerase inactivation by hyperthermia in human glioma cells.
Glioma
Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance.
Glioma
Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea.
Glioma
Immunohistochemical demonstration of DNA polymerase alpha in human brain-tumor cells.
Glioma
The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case-control study.
Hearing Loss
Effects of mitochondrial mutations on hearing and cochlear pathology with age.
Hearing Loss
The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.
Hepatitis
Analysis of proliferating biliary epithelial cells in human liver disease using a monoclonal antibody against DNA polymerase alpha.
Hepatitis
Effect of short-term prednisone therapy on aminotransferase levels and hepatitis B virus markers in chronic type B hepatitis.
Hepatitis
Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis.
Hepatitis
Inhibition of human hepatitis B virus DNA polymerase and duck hepatitis B virus DNA polymerase by triphosphates of thymidine analogs and pharmacokinetic properties of the corresponding nucleosides.
Hepatitis B
A second gene (qutH) within the Aspergillus nidulans-quinic-acid utilisation gene cluster encodes a protein with a putative zinc-cluster motif.
Hepatitis B
Case report: lactic acidosis and rhabdomyolysis during telbivudine and tenofovir treatment for chronic hepatitis B.
Hepatitis B
DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA.
Hepatitis B
Effect of short-term prednisone therapy on aminotransferase levels and hepatitis B virus markers in chronic type B hepatitis.
Hepatitis B
Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition.
Hepatitis B
Expression of hepatitis B virus-specific markers in asymptomatic hepatitis B surface antigen carriers.
Hepatitis B
Factors influencing postexposure immunoprophylaxis of hepatitis B virus infection with hepatitis B immune globulin. High deoxyribonucleic acid polymerase activity in the inocula of unsuccessful cases.
Hepatitis B
Failure to detect naturally occurring serum inhibitors of hepatitis B virus deoxyribonucleic acid polymerase.
Hepatitis B
Hepatitis B antigen-associated deoxyribonucleic acid polymerase activity and e antigen/anti-e system.
Hepatitis B
Hepatitis B virus replication and mutation are autoregulated by interactions between surface antigen and HBeAg and the HBV DNA polymerase: a functional model with therapeutic implications.
Hepatitis B
Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis.
Hepatitis B
Immunological and biophysical alteration of hepatitis B virus antigens by sodium hypochlorite disinfection.
Hepatitis B
Improvement of proteinuria in a case of hepatitis B-associated glomerulonephritis after treatment with interferon.
Hepatitis B
Inhibition of duck hepatitis B virus replication by 2',3'-dideoxycytidine. A potent inhibitor of reverse transcriptase.
Hepatitis B
Inhibition of hepatitis B virus deoxyribonucleic acid polymerase by the 5'-triphosphates of 9-beta-D-arabinofuranosyladenine and 1-beta-D-arabinofuranosylcytosine.
Hepatitis B
Inhibition of human hepatitis B virus DNA polymerase and duck hepatitis B virus DNA polymerase by triphosphates of thymidine analogs and pharmacokinetic properties of the corresponding nucleosides.
Hepatitis B
Nude mice bearing human primary hepatocellular carcinoma that produces hepatitis B surface, core, and e antigens, as well as deoxyribonucleic acid polymerase.
Hepatitis B
On the early emergence of reverse transcription: theoretical basis and experimental evidence.
Hepatitis B
Randomized controlled trial of adenine arabinoside monophosphate for chronic type B hepatitis.
Hepatitis B
Randomized, controlled trial of recombinant human alpha-interferon in patients with chronic hepatitis B.
Hepatitis B
Recombinant leukocyte a interferon treatment in patients with chronic hepatitis B virus infection. Pharmacokinetics, tolerance, and biologic effects.
Hepatitis B
Stable inhibition of hepatitis B virus expression and replication in HepG2.2.15 cells by RNA interference based on retrovirus delivery.
Hepatitis B
The mechanism of inhibition of hepatitis B virus replication by the carbocyclic analog of 2'-deoxyguanosine.
Hepatitis B
Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine.
Hepatitis B
[The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases]
Hepatitis C
[Detection of Hepatitis C Virus by Reverse Transcription-loop Mediated Isothermal Amplification].
Hepatitis, Chronic
Analysis of proliferating biliary epithelial cells in human liver disease using a monoclonal antibody against DNA polymerase alpha.
Hepatitis, Chronic
Expression of hepatitis B virus-specific markers in asymptomatic hepatitis B surface antigen carriers.
Herpes Simplex
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.
Herpes Simplex
A monoclonal antibody that neutralizes Epstein-Barr virus, human cytomegalovirus, human herpesvirus 6, and bacteriophage T4 DNA polymerases.
Herpes Simplex
Activation of RNA polymerase II by topologically linked DNA-tracking proteins.
Herpes Simplex
Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase.
Herpes Simplex
Allosteric interaction of a herpes simplex viral thymidine kinase with host DNA polymerase alpha in mouse LP1-1 cells.
Herpes Simplex
Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha.
Herpes Simplex
Characterization of herpes simplex virus-induced deoxyribonucleic acid polymerase.
Herpes Simplex
Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2).
Herpes Simplex
Cloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit.
Herpes Simplex
Contributions of nucleotide excision repair, DNA polymerase eta, and homologous recombination to replication of UV-irradiated herpes simplex virus type 1.
Herpes Simplex
Demonstration of a stimulatory protein for virus-specified DNA polymerase in phorbol ester-treated Epstein-Barr virus-carrying cells.
Herpes Simplex
Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.
Herpes Simplex
Deoxyribonucleic acid-binding properties of the deoxyribonucleic acid-dependent deoxyribonucleic acid polymerase induced in baby-hamster kidney cells after infection with herpes simplex virus type I [proceedings]
Herpes Simplex
Differential incorporation of thymidylate analogues into DNA by DNA polymerase alpha and by DNA polymerases specified by two herpes simplex viruses.
Herpes Simplex
Differential substrate specificity of DNA polymerase beta and of a DNA polymerase induced by herpes simplex virus type 2 towards thymidine triphosphate analogues.
Herpes Simplex
Effect of manganese on in vitro replication of damaged DNA catalyzed by the herpes simplex virus type-1 DNA polymerase.
Herpes Simplex
Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.
Herpes Simplex
Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
Herpes Simplex
Herpes simplex virus replication in the presence of DNA polymerase alpha inhibitors.
Herpes Simplex
Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus.
Herpes Simplex
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Herpes Simplex
Induction of deoxyribonucleic acid polymerase and deoxyribonuclease activities in cells infected with herpes simplex virus type II.
Herpes Simplex
Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.
Herpes Simplex
Inhibition of cellular and virus-associated nucleotide polymerases by, and anti-herpes simplex virus activity of, streptovaricin derivatives.
Herpes Simplex
Inhibition of herpes simplex virus-induced DNA polymerase, cellular DNA polymerase alpha, and virus production by aphidicolin.
Herpes Simplex
Inhibition of herpes simplex virus-induced DNA polymerases and cellular DNA polymerase alpha by triphosphates of acyclic guanosine analogs.
Herpes Simplex
Inhibition of herpesvirus DNA synthesis by 9-beta-D-arabinofuranosyladenine in cellular and cell-free systems.
Herpes Simplex
Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha.
Herpes Simplex
Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha.
Herpes Simplex
Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.
Herpes Simplex
Intermolecular Complementation between Two Varicella-Zoster Virus pORF30 Terminase Domains Essential for DNA Encapsidation.
Herpes Simplex
Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.
Herpes Simplex
Involvement of DNA polymerase alpha in host cell reactivation of UV-irradiated herpes simplex virus.
Herpes Simplex
Involvement of eucaryotic deoxyribonucleic acid polymerases alpha and gamma in the replication of cellular and viral deoxyribonucleic acid.
Herpes Simplex
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).
Herpes Simplex
Lithium chloride suppresses the synthesis of messenger RNA for infected cell protein-4 and viral deoxyribonucleic acid polymerase in herpes simplex virus-1 infected endothelial cells.
Herpes Simplex
Mechanism of inhibition of human cytomegalovirus replication by oxetanocin G.
Herpes Simplex
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Herpes Simplex
Potent inhibitory effects of the 5'-triphosphates of (E)-5-(2-bromovinyl)-2'-deoxyuridine and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on DNA polymerase gamma.
Herpes Simplex
Pyrophosphate analogues as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin.
Herpes Simplex
Rescue of the adeno-associated virus genome from a plasmid vector: evidence for rescue by replication.
Herpes Simplex
Structural and functional properties of DNA polymerase delta from rabbit bone marrow.
Herpes Simplex
Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.
Herpes Simplex
The replicative DNA polymerase of herpes simplex virus 1 exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activities.
Herpes Simplex
Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.
Herpes Simplex
[The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerases]
HIV Infections
Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy.
HIV Infections
Incident HIV infection and perinatal transmission rates among HIV negative pregnant women who retested in labor in a tertiary health centre, South East Nigeria.
HIV Infections
Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol.
Hypersensitivity
'Knock down' of DNA polymerase beta by RNA interference: recapitulation of null phenotype.
Hypersensitivity
Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice.
Hypersensitivity
DNA repair by polymerase delta in Saccharomyces cerevisiae is not controlled by the proliferating cell nuclear antigen-like Rad17/Mec3/Ddc1 complex.
Hypersensitivity
Expression of collateral sensitivity to cisplatin, methotrexate, and fluorouracil in a human ovarian carcinoma cell line following exposure to fractionated x-irradiation in vitro.
Hypersensitivity
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions.
Hypersensitivity
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.
Hypersensitivity
Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells.
Hypersensitivity
Involvement of DNA polymerase beta in repairing oxidative damages induced by antitumor drug adriamycin.
Hypersensitivity
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.
Hypersensitivity
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
Hypersensitivity
Structure of chromatin at deoxyribonucleic acid replication forks: nuclease hypersensitivity results from both prenucleosomal deoxyribonucleic acid and an immature chromatin structure.
Hypersensitivity
The stabilized Pol31-Pol3 interface counteracts Pol32 ablation with differential effects on repair.
Hypertension
An anti-RNA polymerase III antibody-positive systemic sclerosis patient with thymic carcinoma whose digital ulcers healed during treatment with macitentan and sildenafil for pulmonary arterial hypertension.
Hypertension
Anti-RNA Polymerase III Antibodies in Systemic Sclerosis: Multicentric Study from Argentina.
Hypertension
Anti-RNA polymerase III antibodies in systemic sclerosis: Multicentric study from Argentina.
Hypertension, Pulmonary
Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study.
Hypertriglyceridemia
Sequencing of Lipoprotein Lipase Gene in 11 Cases of Chinese Patients with Severe Endogenous Hypertriglyceridemia.
Hypoglycemia
Abnormalities in Glycogen Metabolism in a Patient with Alpers' Syndrome Presenting with Hypoglycemia.
Ichthyosis
A role for polymerase eta in the cellular tolerance to cisplatin-induced damage.
Ichthyosis
DNA polymerase eta reduces the gamma-H2AX response to psoralen interstrand crosslinks in human cells.
Ichthyosis
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.
Immunoblastic Lymphadenopathy
Phenotyping of proliferating lymphocytes in angioimmunoblastic lymphadenopathy and related lesions by the double immunoenzymatic staining technique.
Infections
A novel primase-free form of murine DNA polymerase alpha induced by infection with minute virus of mice.
Infections
A STUDY OF THE DEOXYRIBONUCLEASES AND DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI K12S AFTER INFECTION WITH THE BACTERIOPHAGE T4R.
Infections
Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice.
Infections
Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.
Infections
Adenovirus type 2 preferentially stimulates polymerase III transcription of Alu elements by relieving repression: a potential role for chromatin.
Infections
Altered properties of deoxyribonucleic acid polymerase I isolated from the membrane of bacteriophage T4-infected Escherichia coli.
Infections
Application of Phi29 DNA polymerase in identification and full-length clone inoculation of tomato yellow leaf curl Thailand virus and tobacco leaf curl Thailand virus.
Infections
CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early protein.
Infections
Contributions of nucleotide excision repair, DNA polymerase eta, and homologous recombination to replication of UV-irradiated herpes simplex virus type 1.
Infections
Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.
Infections
Deoxyribonucleic acid synthesis in bacteriophage SP01-infected Bacillus subtilis. II. Purification and catalytic properties of a deoxyribonucleic acid polymerase induced after infection.
Infections
Deoxyribonucleic acid-binding properties of the deoxyribonucleic acid-dependent deoxyribonucleic acid polymerase induced in baby-hamster kidney cells after infection with herpes simplex virus type I [proceedings]
Infections
Development of DNA mismatch repair gene, MutS, as a diagnostic marker for detection and phylogenetic analysis of algal Megaviruses.
Infections
Differential effect of aphidicolin on adenovirus DNA synthesis and cellular DNA synthesis.
Infections
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA.
Infections
Efficient cloning of hepatitis B virus DNA from single-stranded replicative intermediates and its application to S1 mapping of viral RNA in human liver tissue.
Infections
Elimination of bacterial DNA from Taq DNA polymerases by restriction endonuclease digestion.
Infections
Enzymatic synthesis of deoxyribonucleic acid. XXV. Purification and properties of deoxyribonucleic acid polymerase induced by infection with phage T4.
Infections
Factors influencing postexposure immunoprophylaxis of hepatitis B virus infection with hepatitis B immune globulin. High deoxyribonucleic acid polymerase activity in the inocula of unsuccessful cases.
Infections
Fluctuation in activity of the molecular forms of cellular DNA polymerase during infection by SV40.
Infections
Genetic analysis of the interaction between bacteriophage T7 DNA polymerase and Escherichia coli thioredoxin.
Infections
Involvement of the reparative DNA polymerase pol x of african Swine Fever virus in the maintenance of viral genome stability in vivo.
Infections
Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice.
Infections
Productive HIV-1 infection of macrophages restricted to the cell fraction with proliferative capacity.
Infections
Prosthetic infection: improvement of diagnostic procedures using 16S ribosomal deoxyribonucleic acid polymerase chain reaction.
Infections
Simultaneous initiation of synthesis of bacteriophage T4 DNA and of deoxyribonucleotides.
Infections
Studies on the synthesis of deoxyribonucleic acid. I. Further purification and properties of the deoxyribonucleic acid polymerase induced by infection of Escherichia coli with bacteriophage T5.
Infections
Urinary tract infection drives genome instability in uropathogenic Escherichia coli and necessitates translesion synthesis DNA polymerase IV for virulence.
Infertility
Association of the CAG repeat polymorphism in mitochondrial polymerase gamma (POLG1) with male infertility: a case-control study in an Algerian population.
Infertility
Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility.
Infertility, Male
CAG repeat variation in the mtDNA polymerase gamma is not associated with oligoasthenozoospermia.
Infertility, Male
Mitochondrial DNA polymerase gamma gene polymorphism is not associated with male infertility.
Infertility, Male
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.
Infertility, Male
The CAG repeat polymorphism of mitochondrial polymerase gamma (POLG) is associated with male infertility in Tunisia.
Infertility, Male
[CAG repeats of DNA polymerase gamma in Chinese males and relationship of idiopathic male infertility to CAG repeats]
Influenza in Birds
Human H1 promoter expressed short hairpin RNAs (shRNAs) suppress avian influenza virus replication in chicken CH-SAH and canine MDCK cells.
Influenza, Human
Evaluation of PCR assays in presence of antibody to thermostable DNA polymerases for detection of microbial agents: avoiding false negative results for specimen containing low-titer agent.
Influenza, Human
In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery.
Influenza, Human
Reverse misreading of a GC doublet by the modified T7 DNA polymerase, Sequenase.
Intervertebral Disc Degeneration
Iron deficiency accelerates intervertebral disc degeneration through affecting the stability of DNA polymerase epsilon complex.
Intervertebral Disc Degeneration
Upregulation of the long noncoding RNA lncPolE contributes to intervertebral disc degeneration by negatively regulating DNA polymerase epsilon.
Iron Deficiencies
Iron deficiency accelerates intervertebral disc degeneration through affecting the stability of DNA polymerase epsilon complex.
Iron Deficiencies
Upregulation of the long noncoding RNA lncPolE contributes to intervertebral disc degeneration by negatively regulating DNA polymerase epsilon.
Keratosis, Actinic
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling.
Keratosis, Actinic
Human polymerase alpha inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives.
Leishmaniasis
Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.
Leukemia
A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.
Leukemia
A non-radioactive assay system for screening for inhibitors of RNA-dependent reverse transcriptase activity; an analysis using aurintricarboxylic acid and plant flavonoids.
Leukemia
Altered sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate of DNA polymerase alpha from leukemic blasts of acute lymphoblastic leukemia.
Leukemia
An aptamer biosensor for leukemia marker mRNA detection based on polymerase-assisted signal amplification and aggregation of illuminator.
Leukemia
Analysis of interactions of DNA polymerase beta and reverse transcriptases of human immunodeficiency and mouse leukemia viruses with dNTP analogs containing a modified sugar residue.
Leukemia
Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines.
Leukemia
Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma.
Leukemia
Cytotoxicity and mode of action of vanada- and niobatricarbadecaboranyl monohalide complexes in human HL-60 promyelocytic leukemia cells.
Leukemia
Differential inhibition of the activities of reverse transcriptase and various cellular DNA polymerases by a traditional Kampo drug, sho-saiko-to.
Leukemia
Differential inhibition of various deoxyribonucleic and ribonucleic acid polymerases by suramin.
Leukemia
Effect of morpholinyladriamycin analogs and adriamycin on the activities of DNA polymerase alpha and RNA polymerase II of chicken leukemia cells.
Leukemia
Effect of pH on the base-mispairing properties of 5-bromouracil during DNA synthesis.
Leukemia
Effects of exogenous polyamine and trypanocides on the DNA polymerase activities from Trypanosoma brucei brucei, mouse thymus and murine leukemia virus.
Leukemia
Effects of streptovaricins and their degradation products on RNA-directed DNA polymerase of Rauscher leukemia virus.
Leukemia
Elevated DNA polymerase beta activity in a cis-diamminedichloroplatinum(II) resistant P388 murine leukemia cell line.
Leukemia
Enhanced detection of RNA by MMLV reverse transcriptase coupled with thermostable DNA polymerase and DNA/RNA helicase.
Leukemia
Escherichia coli DNA polymerase III epsilon subunit increases Moloney murine leukemia virus reverse transcriptase fidelity and accuracy of RT-PCR procedures.
Leukemia
Evaluation of 2,2'-anhydro-1-(3'-Ok-acetyl-beta-D-arabinofuranosyl)-5-iodocytosine hydrochloride and related compounds as antineoplastic and antiviral agents.
Leukemia
Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.
Leukemia
In vitro production of Rauscher murine leukemia virus: influence of culture age on biological properties.
Leukemia
Inhibition of DNA polymerase from L1210 murine leukemia by a sulfhydryl reagent from agaricus bisporus.
Leukemia
Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework.
Leukemia
Inhibition of T-cell proliferation by a MYB antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression.
Leukemia
Inhibition of the 3' --> 5' exonuclease of human DNA polymerase epsilon by fludarabine-terminated DNA.
Leukemia
Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.
Leukemia
One-tube and one-buffer system of RT-PCR amplification of 1D gene of foot-and-mouth disease virus field isolates.
Leukemia
Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.
Leukemia
Reversible inactivation of the deoxyribonucleic acid polymerase of Rauscher leukemia virus.
Leukemia
Template primer inactivation by cis- and trans-dichlorodiammine platinum for human DNA polymerase alpha, beta, and Rauscher murine leukemia virus reverse transcriptase, as a mechanism of cytotoxicity.
Leukemia
The ability of a variety of polymerases to synthesize past site-specific cis-syn, trans-syn-II, (6-4), and Dewar photoproducts of thymidylyl-(3'-->5')-thymidine.
Leukemia
The mechanism of inorganic phosphate-mediated inhibition of calf thymus DNA polymerase beta and Rauscher leukemia virus dna polymerase.
Leukemia
Two novel real-time reverse transcriptase PCR assays for rapid detection of bacterial contamination in platelet concentrates.
Leukemia
[Activity of DNA polymerase alpha in acute leukemia: comparative analysis of the catalytic unit of the enzyme based on SDS polyacrylamide electrophoresis]
Leukemia
[Biochemical mechanisms of resistance to a new antineoplastic drug CRC 680578 from the nitrosourea class]
Leukemia L1210
Studies on the structure--activity relationship among aliphatic and aromatic bisguanylhydrazones and some related compounds.
Leukemia, Erythroblastic, Acute
Absence of high levels of DNA polymerase alpha activity in the nuclear matrix prepared from mouse erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Effect of aphidicolin on Friend erythroleukemia cell maturation.
Leukemia, Erythroblastic, Acute
Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation.
Leukemia, Feline
Deoxyribonucleic acid polymerase associated with feline leukemia and sarcoma viruses: properties of the enzyme and its product.
Leukemia, Lymphocytic, Chronic, B-Cell
Deoxyribonucleic acid polymerase activity associated with a plasma particulate fraction from patients with chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.
Leukemia, Lymphoid
The inhibition of P338 lymphocytic leukemia DNA polymerase alpha activity by cis-diamminedichloroplatinum(II) and related derivatives.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.
Leukemia, Myeloid
[Terminal DNA nucleotidyltransferase in blastic crisis in myelocytic leukemia]
Leukemia, Myeloid, Acute
Altered sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate of DNA polymerase alpha from leukemic blasts of acute lymphoblastic leukemia.
Leukemia, Myeloid, Acute
The thymidine dideoxynucleoside analogue, alovudine, inhibits the mitochondrial DNA polymerase ?, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.
Liver Cirrhosis
Analysis of proliferating biliary epithelial cells in human liver disease using a monoclonal antibody against DNA polymerase alpha.
Liver Diseases
Analysis of proliferating biliary epithelial cells in human liver disease using a monoclonal antibody against DNA polymerase alpha.
Liver Diseases
Identification and fine structure of proliferating hepatocytes in malignant and nonmalignant liver diseases by use of a monoclonal antibody against DNA polymerase alpha.
Liver Diseases
Immunohistochemical analysis of retinoblastoma gene product (pRB) expression in malignant and non-malignant liver diseases.
Liver Diseases
POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion.
Liver Diseases
[A cell kinetic study of liver cells in various liver diseases by the detection of DNA polymerase alpha]
Liver Failure
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation.
Liver Failure
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.
Liver Failure, Acute
Detection of proliferating hepatocytes in patients with acute hepatic failure by mitotic figures and a monoclonal antibody against DNA polymerase alpha.
Liver Neoplasms, Experimental
A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme.
Liver Neoplasms, Experimental
A novel single-stranded DNA-binding protein from the Novikoff hepatoma which stimulates DNA polymerase beta. Purification and general characterization.
Liver Neoplasms, Experimental
A role for DNA polymerase in the specificity of nucleotide incorporation opposite N-acetyl-2-aminofluorene adducts.
Liver Neoplasms, Experimental
Characterization of DNA metabolizing enzymes in situ following polyacrylamide gel electrophoresis.
Liver Neoplasms, Experimental
Deoxyribonucleic acid dependent adenosinetriphosphatases from the Novikoff hepatoma. Characterization of a homogeneous adenosinetriphosphatase that stimulates DNA polymerase beta.
Liver Neoplasms, Experimental
DNA polymerase alpha from normal rat liver is different than DNA polymerases alpha from Morris hepatoma strains.
Liver Neoplasms, Experimental
Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.
Liver Neoplasms, Experimental
Interaction of DNA accessory proteins with DNA polymerase beta of the Novikoff hepatoma.
Liver Neoplasms, Experimental
Novikoff hepatoma deoxyribonucleic acid polymerase. Identification of a stimulatory protein bound to the beta-polymerase.
Liver Neoplasms, Experimental
Novikoff hepatoma deoxyribonucleic acid polymerase. Purification and properties of a homogeneous beta polymerase.
Liver Neoplasms, Experimental
Novikoff hepatoma deoxyribonucleic acid polymerase. Sensitivity of the beta-polymerase to sulfhydryl blocking agents.
Liver Neoplasms, Experimental
Stimulation of calf thymus DNA polymerase alpha activity by nucleolar protein B23.
Lung Diseases, Interstitial
Mortality in systemic sclerosis-a single centre study from the UK.
Lung Diseases, Interstitial
Synovial involvement assessed by power Doppler ultra-sonography in systemic sclerosis: results of a cross-sectional study.
Lung Neoplasms
4-Nitroquinoline-1-oxide effects human lung adenocarcinoma A549 cells by regulating the expression of POLD4.
Lung Neoplasms
Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa.
Lung Neoplasms
Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma.
Lung Neoplasms
DNA polymerase alpha as an independent prognostic parameter in non-small cell lung cancer--an immunohistochemical study.
Lung Neoplasms
DNA Polymerase Alpha Subunit B Is a Binding Protein for Erlotinib Resistance in Non-Small Cell Lung Cancer.
Lung Neoplasms
DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy.
Lung Neoplasms
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Lung Neoplasms
Downregulation of POLD4 in Calu6 cells results in G1-S blockage through suppression of the Akt-Skp2-p27 pathway.
Lung Neoplasms
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
Lung Neoplasms
Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking.
Lung Neoplasms
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
Lung Neoplasms
Nonsynonymous single nucleotide polymorphisms in DNA damage repair pathways and lung cancer risk.
Lung Neoplasms
Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.
Lung Neoplasms
Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy.
Lung Neoplasms
Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer.
Lung Neoplasms
siRNA of DNA polymerase iota inhibits the migration and invasion in the lung cancer cell A549.
Lung Neoplasms
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
Lung Neoplasms
[Genetic variation in DNA polymerase kappa gene is associated with the prognosis after platinum-based chemotherapy in small cell lung cancer patients].
Lupus Erythematosus, Systemic
Analysis of autoantibodies to recombinant La (SS-B) peptides in systemic lupus erythematosus and primary Sjogren's syndrome.
Lupus Erythematosus, Systemic
Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.
Lymphatic Metastasis
Cell proliferation in colorectal adenomas containing invasive carcinoma.
Lymphatic Metastasis
DNA polymerase alpha positive-cell rate in colorectal cancer and its relationship to prognosis.
Lymphoma
A role for DNA polymerase in the specificity of nucleotide incorporation opposite N-acetyl-2-aminofluorene adducts.
Lymphoma
Affinity capture of a mammalian DNA polymerase beta by inhibitors immobilized to resins used in solid-phase organic synthesis.
Lymphoma
Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene.
Lymphoma
Coexistence of mucosa-associated lymphoid tissue lymphoma and systemic sclerosis showing positive for anticentromere antibody and anti-RNA polymerase III antibody: A case report and published work review.
Lymphoma
DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.
Lymphoma
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
Lymphoma
Phenotyping of proliferating lymphocytes in angioimmunoblastic lymphadenopathy and related lesions by the double immunoenzymatic staining technique.
Lymphoma
Reduced fidelity of DNA synthesis in cell extracts from chemically induced primary thymic lymphomas of mice.
Lymphoma
Relation between enzymatic activities and the degree of malignancy of human lymphomas.
Lymphoma
Repair of neocarzinostatin-induced deoxyribonucleic acid damage in human lymphoblastoid cells: possible involvement of apurinic/apyrimidinic sites as intermediates.
Lymphoma
Sites of termination of in vitro DNA synthesis on ultraviolet- and N-acetylaminofluorene-treated phi X174 templates by prokaryotic and eukaryotic DNA polymerases.
Lymphoma
[Establishment of AFP promoter operated murine IL-1beta recombinant vector and its expression in H22 cells.]
Lymphoma, B-Cell
DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.
Lymphoma, B-Cell
Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway.
Lymphoma, B-Cell
Reverse translational strategies for developing animal models of bipolar disorder.
Lymphoma, B-Cell, Marginal Zone
Coexistence of mucosa-associated lymphoid tissue lymphoma and systemic sclerosis showing positive for anticentromere antibody and anti-RNA polymerase III antibody: A case report and published work review.
Lymphoma, Non-Hodgkin
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation.
Lymphoma, T-Cell
Expression of three cell proliferation-associated antigens, DNA polymerase alpha, Ki-67 antigen and transferrin receptor in nodal and cutaneous T-cell lymphomas.
Lymphoma, T-Cell, Cutaneous
Expression of three cell proliferation-associated antigens, DNA polymerase alpha, Ki-67 antigen and transferrin receptor in nodal and cutaneous T-cell lymphomas.
Lymphopenia
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
Malaria
DNA polymerase delta: gene sequences from Plasmodium falciparum indicate that this enzyme is more highly conserved than DNA polymerase alpha.
Malaria
The primary structure of Plasmodium falciparum DNA polymerase delta is similar to drug sensitive delta-like viral DNA polymerases.
Mastocytoma
Aphidicolin: a specific inhibitor of DNA synthesis in synchronous mastocytoma P-815 cells.
Mastocytoma
Control of DNA polymerase alpha, beta and gamma activities in heat- and cold-sensitive mammalian cell-cycle mutants.
Mastocytoma
Molecular heterogeneity of DNA polymerase alpha from P815 mouse mastocytoma cells.
Mastocytoma
Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells.
Melanoma
Aphidicolin inhibits the synthesis and joining of short DNA fragments but not the union of 10-kilobase DNA replication intermediates.
Melanoma
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?.
Melanoma
Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3'-deoxycytidine and 3'-azido-3'-deoxythymidine.
Melanoma
[Association between high activity of DNA polymerase iota and the development of human uveal melanoma]
Melanoma, Experimental
Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta.
Memory Disorders
Asymmetric Ataxia, Depression, Memory Loss, Epilepsy, and Axonal Neuropathy Associated with A Heterozygous DNA Polymerase Gamma Variant of Uncertain Significance, c1370G>a (R457Q).
Menopause, Premature
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.
Mitochondrial Diseases
A diagnostic flow chart for POLG-related diseases based on signs sensitivity and specificity.
Mitochondrial Diseases
A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease.
Mitochondrial Diseases
A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.
Mitochondrial Diseases
Biolayer Interferometry: A Novel Method to Elucidate Protein-Protein and Protein-DNA Interactions in the Mitochondrial DNA Replisome.
Mitochondrial Diseases
Clinical and molecular features of POLG-related mitochondrial disease.
Mitochondrial Diseases
Clinical and Molecular Features of POLG-Related Sensory Ataxic Neuropathy with Dysarthria and Ophthalmoparesis.
Mitochondrial Diseases
Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication.
Mitochondrial Diseases
DNA polymerase gamma and mitochondrial disease: Understanding the consequence of POLG mutations.
Mitochondrial Diseases
Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder.
Mitochondrial Diseases
Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease.
Mitochondrial Diseases
Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors.
Mitochondrial Diseases
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)-like phenotype: an expanded clinical spectrum of POLG1 mutations.
Mitochondrial Diseases
Modeling of pathogenic variants of mitochondrial DNA polymerase: insight into the replication defects and implication for human disease.
Mitochondrial Diseases
Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders.
Mitochondrial Diseases
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
Mitochondrial Diseases
Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders.
Mitochondrial Diseases
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation.
Mitochondrial Diseases
Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia.
Mitochondrial Diseases
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits.
Mitochondrial Encephalomyopathies
Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects.
Mitochondrial Myopathies
Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine.
Mitochondrial Myopathies
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Mouth Neoplasms
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Myositis
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.
Myositis
Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity.
Myositis
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
Myxosarcoma
Interaction of phosphatidylinositol-4-monophosphate with a low activity form of DNA polymerase alpha: a potential mechanism for enzyme activation.
Myxosarcoma
Purification of Norman Murine Sarcoma DNA polymerase alpha forms with different DNA template primer binding affinity and different specific activity.
Neoplasm Metastasis
Cell proliferation in colorectal adenomas containing invasive carcinoma.
Neoplasm Metastasis
Diagnostic problems of evaluating vertebral metastasis from breast carcinoma with a higher degree of malignancy.
Neoplasm Metastasis
DNA polymerase alpha positive-cell rate in colorectal cancer and its relationship to prognosis.
Neoplasm Metastasis
DNA polymerase iota (Pol ?) promotes invasion and metastasis of esophageal squamous cell carcinoma.
Neoplasm Metastasis
Evaluation of DNA polymerase beta gene mutation as a genetic marker for colorectal carcinoma.
Neoplasm Metastasis
Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA.
Neoplasms
2',5'-oligoadenylate synthetase activity in human mammary tumors and its potential correlation with tumor growth or hormonal responsiveness.
Neoplasms
A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.
Neoplasms
A case of interdigitating dendritic cell sarcoma studied by whole-exome sequencing.
Neoplasms
A DNA polymerase alpha accessory protein exhibits structural and functional similarities to SV40 large tumor antigen.
Neoplasms
A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
Neoplasms
A mammalian expression system for rapid production and purification of active MAP kinase phosphatases.
Neoplasms
A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme.
Neoplasms
A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen.
Neoplasms
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.
Neoplasms
Aberrant DNA Polymerase Beta Enhances H. pylori Infection Induced Genomic Instability and Gastric Carcinogenesis in Mice.
Neoplasms
Adenovirus type 12 tumor antigen. I. Separation from DNA polymerase alpha and immunoprecipitation of tumor-antigen polypeptides.
Neoplasms
An accessory protein enhances both DNA binding and activity of DNA polymerase alpha isolated from normal, but not transformed, human fibroblasts.
Neoplasms
An endogenous protein inhibitor of DNA polymerase alpha in normal and neoplastic rat mammary tissues.
Neoplasms
An Evaluation of DNA Polymerase alpha as a Prognostic Predictor in Early Breast Cancers Smaller than 2 cm.
Neoplasms
Analysis by DNA polymerase alpha activity of human breast tumour proliferation and the effect of endocrine therapy.
Neoplasms
Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.
Neoplasms
Anti-Cancer Effect of Spinach Glycoglycerolipids as Angiogenesis Inhibitors Based on the Selective Inhibition of DNA Polymerase Activity.
Neoplasms
Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta.
Neoplasms
Apoptosis in breast cancer and its relationship to clinicopathological characteristics and prognosis.
Neoplasms
Association of a Newly Identified Variant of DNA Polymerase Beta (pol?63-123, 208-304) with the Risk Factor of Ovarian Carcinoma in India.
Neoplasms
Association of anti-RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis.
Neoplasms
Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer.
Neoplasms
ATP(GTP)-dependent conversion of MVM parvovirus single-stranded DNA to its replicative form by a purified 10 S species of mouse DNA polymerase alpha.
Neoplasms
ATR/Chk1 Pathway is Activated by Oxidative Stress in Response to UVA Light in Human Xeroderma Pigmentosum Variant Cells.
Neoplasms
Autoantibody status in systemic sclerosis patients defines both cancer risk and survival with ANA negativity in cases with concomitant cancer having a worse survival.
Neoplasms
Biochemical evidences for ribonucleic acid viral-like characteristics in malignant diseases of gastrointestinal tract and lung in humans.
Neoplasms
Biological Relevance of DNA Polymerase Beta and Translesion Synthesis Polymerases to Cancer and its Treatment.
Neoplasms
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta.
Neoplasms
Case of systemic sclerosis with multiple primary malignancies in whom anti-RNA polymerase III antibody was detected by immunoprecipitation.
Neoplasms
Catalytic mechanism of human DNA polymerase lambda with Mg(2+) and Mn(2+) from ab initio quantum mechanical/molecular mechanical studies.
Neoplasms
Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
Neoplasms
Characterization of DNA polymerase beta splicing variants in gastric cancer: The most frequent exon 2-deleted isoform is a non-coding RNA.
Neoplasms
Characterization of MRP RNA-protein interactions within the perinucleolar compartment.
Neoplasms
Characterization of the effects of cisplatin and carboplatin on cell cycle progression and DNA damage response activation in DNA polymerase eta-deficient human cells.
Neoplasms
Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors.
Neoplasms
Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen.
Neoplasms
Comparative flow cytometric analysis of proliferating cell nuclear antigen (PCNA) antibodies in human solid neoplasms.
Neoplasms
Comparison of the effects of polyamines on the activities of RNA polymerases from murine normal tissues and transplantable tumors.
Neoplasms
Concentrations of oestrone and 4-hydroxyandrostenedione in malignant and normal breast tissues.
Neoplasms
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6.
Neoplasms
Correlation between in vitro DNA synthesis, DNA strand separation and in vivo multiplication of cancer cells.
Neoplasms
Defective Nucleotide Release by DNA Polymerase Beta Mutator Variant E288K is the Basis of Its Low Fidelity.
Neoplasms
Deoxyribonucleic acid of Cancer pagurus. II. Template activity for a DNA-dependent DNA polymerase of eukaryotic cells.
Neoplasms
Deoxyribonucleic acid polymerase activity associated with strain MC29 tumor virus.
Neoplasms
Deoxyribonucleic acid polymerase associated with avian tumor viruses: secondary structure of the deoxyribonucleic acid product.
Neoplasms
Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma.
Neoplasms
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Neoplasms
Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities.
Neoplasms
Detection of DNA polymerase-beta gene expression by competitive polymerase chain reaction in human ovarian carcinoma cells.
Neoplasms
Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines.
Neoplasms
Detection of proliferative cells in dysplasia, carcinoma in situ, and invasive carcinoma of the uterine cervix by monoclonal antibody against DNA polymerase alpha.
Neoplasms
Detection of viral DNA polymerase activity in salmon tumour tissue induced by herpes virus, Oncorhynchus masou virus.
Neoplasms
Diagnostic problems of evaluating vertebral metastasis from breast carcinoma with a higher degree of malignancy.
Neoplasms
Diallyl sulfides: Selective inhibitors of family X DNA polymerases from garlic (Allium sativum L.).
Neoplasms
Difference in expression level and localization of DNA polymerase beta among human esophageal cancer focus, adjacent and corresponding normal tissues.
Neoplasms
Differential expression of DNA polymerase alpha in normal and transformed human fibroblasts.
Neoplasms
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats.
Neoplasms
Differential oncogene amplification in tumor cells from a patient treated with cisplatin and 5-fluorouracil.
Neoplasms
DNA polymerase ? as a potential biomarker of chemoradiation resistance and poor prognosis for cervical cancer.
Neoplasms
DNA polymerase ? relies on a unique domain for efficient replisome assembly and strand synthesis.
Neoplasms
DNA polymerase alpha as an independent prognostic parameter in non-small cell lung cancer--an immunohistochemical study.
Neoplasms
DNA polymerase alpha positive-cell rate in colorectal cancer and its relationship to prognosis.
Neoplasms
DNA polymerase alpha stimulates the ATP-dependent binding of simian virus tumor T antigen to the SV40 origin of replication.
Neoplasms
DNA polymerase alpha. An immunohistochemical marker for proliferating cells in normal and neoplastic human tissues.
Neoplasms
DNA polymerase beta expression differences in selected human tumors and cell lines.
Neoplasms
DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress.
Neoplasms
DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line.
Neoplasms
DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation.
Neoplasms
DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.
Neoplasms
DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.
Neoplasms
DNA Polymerase Eta Prevents Tumor Cell Cycle Arrest And Cell Death During Recovery from Replication Stress.
Neoplasms
DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells.
Neoplasms
DNA Polymerase Iota Promotes Esophageal Squamous Cell Carcinoma Proliferation Through Erk-OGT-Induced G6PD Overactivation.
Neoplasms
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Neoplasms
DNA polymerase mu gene expression in B-cell non-Hodgkin's lymphomas: an analysis utilizing in situ hybridization.
Neoplasms
DNA polymerase theta (Pol?) - an error-prone polymerase necessary for genome stability.
Neoplasms
DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.
Neoplasms
DNA polymerase theta repression enhances the docetaxel responsiveness in metastatic castration-resistant prostate cancer.
Neoplasms
DNA polymerase zeta accounts for the reduced cytotoxicity and enhanced mutagenicity of cisplatin in human colon carcinoma cells that have lost DNA mismatch repair.
Neoplasms
DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes.
Neoplasms
Does a p53 "Wild-type" Immunophenotype Exclude a Diagnosis of Endometrial Serous Carcinoma?
Neoplasms
Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers.
Neoplasms
Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in end-stage disease.
Neoplasms
Effect of adriamycin on the cell kinetics of 13762 rat mammary tumors and implications for therapy.
Neoplasms
Effect of Ehrlich ascites cell chalone on nascent DNA synthesis in isolated nuclei.
Neoplasms
Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer.
Neoplasms
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.
Neoplasms
Ehrlich ascites tumor (EAT) chalone effects on nascent DNA synthesis and DNA polymerase alpha and beta.
Neoplasms
Elevated DNA polymerase iota (Poli) is involved in the acquisition of aggressive phenotypes of human esophageal squamous cell cancer.
Neoplasms
EMT transcription factor ZEB1 represses the mutagenic POL?-mediated end-joining pathway in breast cancers.
Neoplasms
Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents.
Neoplasms
Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.
Neoplasms
Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors.
Neoplasms
Estimation of tumor growth fraction in murine tumors by the primer-available DNA-dependent DNA polymerase assay.
Neoplasms
Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-associated R438W DNA Polymerase Lambda Protein.
Neoplasms
Evaluation of DNA polymerase beta gene mutation as a genetic marker for colorectal carcinoma.
Neoplasms
Evolution of DNA polymerase alpha, beta and terminal deoxynucleotidyl transferase in hamster lymphoid populations during the development of different types of tumors.
Neoplasms
Exceptional Response of Cryoablation Followed by Pembrolizumab in a Patient with Metastatic Cervical Carcinosarcoma with High Tumor Mutational Burden: A Case Report.
Neoplasms
Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication.
Neoplasms
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand.
Neoplasms
Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking.
Neoplasms
Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.
Neoplasms
Expression of p53 protein in colorectal cancer and its relationship to short-term prognosis.
Neoplasms
Expression of the cancer-associated DNA polymerase ? P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Neoplasms
Expression of the proliferation-associated Ki-67 antigen of transferrin receptors and of DNA polymerase alpha in human tumour lines: implications for in vitro chemoresistance.
Neoplasms
Fidelity and damage bypass ability of Schizosaccharomyces pombe Eso1 protein, comprised of DNA polymerase eta and sister chromatid cohesion protein Ctf7.
Neoplasms
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
Neoplasms
Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach.
Neoplasms
Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing.
Neoplasms
Functional interactions between SV40 T antigen and other replication proteins at the replication fork.
Neoplasms
Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.
Neoplasms
Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.
Neoplasms
Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene.
Neoplasms
Growth inhibition of synchronized trigeminal neurinoma cells by nerve growth factor.
Neoplasms
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.
Neoplasms
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines.
Neoplasms
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.
Neoplasms
High molecular weight deoxyribonucleic acid polymerase from crown gall tumor cells of periwinkle (Vinca rosea).
Neoplasms
High terminal deoxynucleotidyl transferase activity in pediatric patients with acute lymphocytic and acute myelocytic leukemias.
Neoplasms
Histochemical study of pituitary adenomas with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nucleolar organizer region counts.
Neoplasms
Human DNA polymerase eta activity and translocation is regulated by phosphorylation.
Neoplasms
Human DNA polymerase {beta} polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.
Neoplasms
Human replication protein A: global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker.
Neoplasms
Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine.
Neoplasms
Hypoxia-inducible factor-1 mediates the expression of DNA polymerase iota in human tumor cells.
Neoplasms
Identification of an endoplasmic reticulum membrane protein interacting with DNA polymerase beta by a yeast two-hybrid screen.
Neoplasms
Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer.
Neoplasms
Immunohistochemical analysis of plasminogen activator expression in human colorectal carcinomas: correlation with CEA distribution and tumor cell kinetics.
Neoplasms
In situ oestrone synthesis in normal breast and breast tumour tissues: effect of treatment with 4-hydroxyandrostenedione.
Neoplasms
In vitro conversion of MVM parvovirus single-stranded DNA to the replicative form by DNA polymerase alpha from Ehrlich ascites tumour cells.
Neoplasms
In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach.
Neoplasms
Induction of a low level of microsatellite instability by overexpression of DNA polymerase Beta.
Neoplasms
Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors.
Neoplasms
Inhibition of calf thymus DNA polymerase alpha and of normal and cancer cell growth by butylanilinouracil and butylphenylguanine.
Neoplasms
Inhibition of DNA polymerase alpha from leukemic and normal human cells by partially thiolated human deoxyribonucleic acids.
Neoplasms
Inhibitor of the DNA-dependent DNA polymerase of some RNA tumour viruses in feline sera.
Neoplasms
Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line.
Neoplasms
Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation.
Neoplasms
Intranuclear dynamics of DNA polymerase alpha differs between the transplanted R3230AC mammary adenocarcinomas and the host mammary gland depending on lactation cycle.
Neoplasms
Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.
Neoplasms
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
Neoplasms
Involvement of DNA polymerase beta in DNA replication and mutagenic consequences.
Neoplasms
Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA.
Neoplasms
Lithocholic acid, a putative tumor promoter, inhibits mammalian DNA polymerase beta.
Neoplasms
Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase alpha holoenzyme: first results with new thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters.
Neoplasms
Malignancies in Italian Patients with Systemic Sclerosis Positive for Anti-RNA Polymerase III Antibodies.
Neoplasms
Malignancies in Patients with Anti-RNA Polymerase III Antibodies and Systemic Sclerosis: Analysis of the EULAR Scleroderma Trials and Research Cohort and Possible Recommendations for Screening.
Neoplasms
Mammary carcinogenesis in transgenic mice expressing a dominant-negative mutant of DNA polymerase beta in their mammary glands.
Neoplasms
Mechanism of carcinogenesis by RNA tumour viruses: the RNA-and DNA-dependent DNA polymerase activities of feline sarcoma virus.
Neoplasms
Metaplastic potential of p53 down-regulation in ovarian surface epithelial cells affected by ovulation.
Neoplasms
Mode of inhibition of HIV-1 reverse transcriptase by polyacetylenetriol, a novel inhibitor of RNA- and DNA-directed DNA polymerases.
Neoplasms
Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta.
Neoplasms
Molecular evidence of viral-like biochemical activities in human genitourinary malignancies.
Neoplasms
Monoclonal antibody that blocks phosphoinositide-dependent activation of mouse tumor DNA polymerase alpha.
Neoplasms
Murine DNA polymerase alpha fills gaps to completion in a direct assay. Altered kinetics of de novo DNA synthesis at single nucleotide gaps.
Neoplasms
Mutation at the Polymerase Active Site of Mouse DNA Polymerase {delta} Increases Genomic Instability and Accelerates Tumorigenesis.
Neoplasms
Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy.
Neoplasms
Mutations in DNA polymerase beta mRNA of stilbene estrogen-induced kidney tumors in Syrian hamster.
Neoplasms
Mutations in DNA-polymerase-Beta occur in breast, prostate and colorectal tumors.
Neoplasms
Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer.
Neoplasms
Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta.
Neoplasms
Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells.
Neoplasms
Nude mice bearing human primary hepatocellular carcinoma that produces hepatitis B surface, core, and e antigens, as well as deoxyribonucleic acid polymerase.
Neoplasms
Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs.
Neoplasms
Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.
Neoplasms
Overexpression of proliferating cell nuclear antigen in mammalian cells negates growth arrest by serum starvation and cell contact.
Neoplasms
Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.
Neoplasms
Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.
Neoplasms
Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia.
Neoplasms
Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.
Neoplasms
PolG Inhibits Gastric Cancer Glycolysis and Viability by Suppressing PKM2 Phosphorylation.
Neoplasms
Poly(2'-O-methylcytidylate)-oligodeoxyguanylate as a template for the ribonucleic acid directed deoxyribonucleic acid polymerase in ribonucleic acid tumor virus particles and a specific probe for the ribonucleic acid directed enzyme in transformed murine cells.
Neoplasms
Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy.
Neoplasms
Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.
Neoplasms
Polyribonucleotide inhibition of ribonucleic acid directed deoxyribonucleic acid polymerase of mouse mammary tumor (type B) virus and simian sarcoma (type C) virus.
Neoplasms
Population-specific variation in haplotype composition and heterozygosity at the POLB locus.
Neoplasms
Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer.
Neoplasms
Proliferating cell nuclear antigen in breast lesions: correlation of c-erbB-2 oncoprotein and EGF receptor and its clinicopathological significance in breast cancer.
Neoplasms
Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator.
Neoplasms
Protective Effect Against Cancer of Antibodies to the Large Subunits of Both RNA Polymerases I and III in Scleroderma.
Neoplasms
Pyridoxal 5'-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon.
Neoplasms
Quantitative estimation of tumor metastasis by measurement of DNA polymerase activity.
Neoplasms
Radiosensitization by a dominant negative to DNA polymerase beta is DNA polymerase beta-independent and XRCC1-dependent.
Neoplasms
Reconstitution of complete SV40 DNA replication with purified replication factors.
Neoplasms
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.
Neoplasms
Regulation of DNA polymerase beta by the LMP1 oncoprotein of EBV through the nuclear factor-kappaB pathway.
Neoplasms
Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer.
Neoplasms
Relation between enzymatic activities and the degree of malignancy of human lymphomas.
Neoplasms
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.
Neoplasms
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Neoplasms
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts.
Neoplasms
Retrostatin, a new specific enzyme inhibitor against avian myeloblastosis virus reverse transcriptase.
Neoplasms
Role of subunits of 60 to 70S avian tumor virus ribonucleic acid in its template activity for the viral deoxyribonucleic acid polymerase.
Neoplasms
Screening and identification of interacting proteins with hepatitis B virus core protein in leukocytes and cloning of new gene C1.
Neoplasms
Sensitive and homogeneous microRNA detection using branched cascade enzymatic amplification.
Neoplasms
Significance of DNA Polymerase Delta Catalytic Subunit p125 Induced by Mutant p53 in the Invasive Potential of Human Hepatocellular Carcinoma.
Neoplasms
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.
Neoplasms
Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase).
Neoplasms
Splice variants but not mutations of DNA polymerase beta are common in bladder cancer.
Neoplasms
Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors.
Neoplasms
Structure and activity relationship of monogalactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth.
Neoplasms
Studies on deoxyribonucleic acid polymerase from Ehrlich ascites tumor cells. I. Isolation and purification of the polymerase and some general properties of the enzyme catalyzed reaction.
Neoplasms
Studies on deoxyribonucleic acid polymerase from Ehrlich ascites tumor cells. II. Factors influencing primer and template requirement of deoxyribonucleic acid polymerase.
Neoplasms
Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system.
Neoplasms
Studies on the initiation of simian virus 40 replication in vitro: RNA primer synthesis and its elongation.
Neoplasms
Synthesis of DNA in oestrogen-induced pituitary tumurs in rats: effect of bromocriptine.
Neoplasms
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
Neoplasms
TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
Neoplasms
The difference in the stimulation by putrescine of DNA synthesis using DNA polymerase extracts of normal rat liver or of tumour tissue or host liver from tumour-bearing rats.
Neoplasms
The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots.
Neoplasms
The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.
Neoplasms
The effect of medroxyprogesterone acetate on aromatase and DNA polymerase alpha activities in breast tumours.
Neoplasms
The effect of the oxic cell sensitizer, beta-ara A on human fibroblasts in plateau and in exponential growth phases.
Neoplasms
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.
Neoplasms
The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin.
Neoplasms
The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.
Neoplasms
The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case-control study.
Neoplasms
The proliferative cell fraction in cytology specimens. A study of human esophageal carcinoma.
Neoplasms
The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells.
Neoplasms
The role of DNA polymerase beta in determining sensitivity to ionizing radiation in human tumor cells.
Neoplasms
The role of the mtDNA set point in differentiation, development and tumorigenesis.
Neoplasms
The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
Neoplasms
Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1.
Neoplasms
Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.
Neoplasms
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
Neoplasms
[An observation of the effect of tanshinone on cancer cell proliferation by Brdu and PCNA labeling]
Neoplasms
[Analysis of proliferative activity in gastric biopsy specimens by combined BrdU and DNA polymerase alpha immunohistochemistry]
Neoplasms
[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].
Neoplasms
[Effect of Mn(II) on the error-prone DNA polymerase iota activity in extracts from human normal and tumor cells].
Neoplasms
[Immunohistochemical detection of p53 in colorectal cancer and its relationship to prognosis]
Neoplasms
[Study on the extent of peritumoral edema in glioma: its correlation with the proliferative potential and tumor-infiltrating mononuclear cells]
Neoplasms, Muscle Tissue
The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase.
Neoplasms, Squamous Cell
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
Neoplasms, Squamous Cell
Elevated DNA polymerase iota (Poli) is involved in the acquisition of aggressive phenotypes of human esophageal squamous cell cancer.
Neurilemmoma
Growth inhibition of synchronized trigeminal neurinoma cells by nerve growth factor.
Neuroblastoma
Differential inhibition of multiple forms of DNA polymerase alpha from IMR-32 human neuroblastoma cells.
Neuroblastoma
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Neuroblastoma
Electron microscopic localization of acridine orange binding to euchromatin in human neuroblastoma cells.
Neuroblastoma
Probable involvement of a glycoconjugate in IMR-32 DNA synthesis: decrease of DNA polymerase alpha 2 activity after tunicamycin treatment.
Neuroblastoma
Stimulation of human neuroblastoma DNA polymerase alpha and primase activities by a protein factor isolated from rat liver chromatin.
Neurodegenerative Diseases
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease.
Neurologic Manifestations
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Neuronal Ceroid-Lipofuscinoses
N-acetylcysteine normalizes the urea cycle and DNA repair in cells from patients with Batten disease.
Obesity
Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction.
Oligospermia
Mitochondrial DNA polymerase gamma gene polymorphism is not associated with male infertility.
Oligospermia
The polymorphic polyglutamine repeat in the mitochondrial DNA polymerase gamma gene is not associated with oligozoospermia.
Ophthalmoplegia
Clinical and Molecular Features of POLG-Related Sensory Ataxic Neuropathy with Dysarthria and Ophthalmoparesis.
Ophthalmoplegia
Protein molecular modeling shows residue T599 is critical to wild-type function of POLG and description of a novel variant associated with the SANDO phenotype.
Ophthalmoplegia, Chronic Progressive External
A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease.
Ophthalmoplegia, Chronic Progressive External
A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.
Ophthalmoplegia, Chronic Progressive External
Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis.
Ophthalmoplegia, Chronic Progressive External
Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population.
Ophthalmoplegia, Chronic Progressive External
Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene.
Ophthalmoplegia, Chronic Progressive External
Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo.
Ophthalmoplegia, Chronic Progressive External
Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma.
Ophthalmoplegia, Chronic Progressive External
Genetic analysis of two Japanese families with progressive external ophthalmoplegia and parkinsonism.
Ophthalmoplegia, Chronic Progressive External
Genetic and chemical rescue of the Saccharomyces cerevisiae phenotype induced by mitochondrial DNA polymerase mutations associated with progressive external ophthalmoplegia in humans.
Ophthalmoplegia, Chronic Progressive External
Levodopa response in Parkinsonism with multiple mitochondrial DNA deletions.
Ophthalmoplegia, Chronic Progressive External
Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Novel POLG mutations in progressive external ophthalmoplegia mimicking mitochondrial neurogastrointestinal encephalomyopathy.
Ophthalmoplegia, Chronic Progressive External
Patient homozygous for a recessive POLG mutation presents with features of MERRF.
Ophthalmoplegia, Chronic Progressive External
Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.
Ophthalmoplegia, Chronic Progressive External
Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.
Ophthalmoplegia, Chronic Progressive External
Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism.
Ovarian Neoplasms
Activity of aphidicolin glycinate alone or in combination with cisplatin in a murine ovarian tumor resistant to cisplatin.
Ovarian Neoplasms
Association between newly identified variant form of DNA polymerase beta (? 208-304) and ovarian cancer.
Ovarian Neoplasms
Association of a Newly Identified Variant of DNA Polymerase Beta (pol?63-123, 208-304) with the Risk Factor of Ovarian Carcinoma in India.
Ovarian Neoplasms
Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells.
Ovarian Neoplasms
HeLa Cells Containing a Truncated Form of DNA Polymerase Beta are More Sensitized to Alkylating Agents than to Agents Inducing Oxidative Stress.
Pancreatic Neoplasms
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Pancreatic Neoplasms
Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells.
Papilloma
DNA polymerase delta holoenzyme: action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases.
Paraneoplastic Syndromes
Anti-RNA Polymerase III Autoantibody-Positive Scleroderma as a Paraneoplastic Syndrome: Comment on the Article by Stojan et al.
Paraneoplastic Syndromes
Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.
Parkinson Disease
Analysis of the trinucleotide CAG repeat from the DNA polymerase gamma gene (POLG) in patients with Parkinson's disease.
Parkinson Disease
Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models.
Parkinson Disease
Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene.
Parkinson Disease
Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo.
Parkinson Disease
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease.
Parkinson Disease
Variations of mitochondrial DNA polymerase ? in patients with Parkinson's disease.
Parkinson Disease
Variations of the CAG trinucleotide repeat in DNA polymerase gamma (POLG1) is associated with Parkinson's disease in Sweden.
Parkinsonian Disorders
Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms.
Parkinsonian Disorders
Association of mitochondrial DNA polymerase ? gene POLG1 polymorphisms with parkinsonism in Chinese populations.
Parkinsonian Disorders
Do somatic mitochondrial DNA mutations contribute to Parkinson's disease?
Parkinsonian Disorders
Genetic analysis of two Japanese families with progressive external ophthalmoplegia and parkinsonism.
Parkinsonian Disorders
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Parkinsonian Disorders
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.
Peripheral Nervous System Diseases
Effect of 2',3'-dideoxycytidine on oxidative phosphorylation in the PC12 cell, a neuronal model.
Peripheral Nervous System Diseases
Lack of correlation between length variation in the DNA polymerase gamma gene CAG repeat and lactic acidosis or neuropathy during antiretroviral treatment.
Photophobia
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta.
Pituitary Neoplasms
Histochemical study of pituitary adenomas with Ki-67 and anti-DNA polymerase alpha monoclonal antibodies, bromodeoxyuridine labeling, and nucleolar organizer region counts.
Plasmacytoma
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase III from the mouse plasmacytoma, MOPC 315.
Pneumonia, Progressive Interstitial, of Sheep
Properties of maedi nucleic acid and the presence of ribonucleic acid- and deoxyribonucleic acid-dependent deoxyribonucleic acid polymerase in the virions.
Poliomyelitis
Reverse transcription, amplification and sequencing of poliovirus RNA by Taq DNA polymerase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Altered sensitivity to 1-beta-D-arabinofuranosylcytosine 5'-triphosphate of DNA polymerase alpha from leukemic blasts of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Deoxynucleotide-polymerizing enzyme activities in T- and B-cells of acute lymphoblastic leukemia origin.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia.
Primary Ovarian Insufficiency
Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma.
Primary Ovarian Insufficiency
Five mutations of mitochondrial DNA polymerase-gamma (POLG) are not a prevalent etiology for spontaneous 46,XX primary ovarian insufficiency.
Prostatic Neoplasms
DNA polymerase theta repression enhances the docetaxel responsiveness in metastatic castration-resistant prostate cancer.
Prostatic Neoplasms
Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif.
Prostatic Neoplasms
Heterogeneity in expression of DNA polymerase beta and DNA repair activity in human tumor cell lines.
Prostatic Neoplasms
Mutations in DNA-polymerase-Beta occur in breast, prostate and colorectal tumors.
Prostatic Neoplasms
Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis.
Proteinuria
Improvement of proteinuria in a case of hepatitis B-associated glomerulonephritis after treatment with interferon.
Pulmonary Arterial Hypertension
An anti-RNA polymerase III antibody-positive systemic sclerosis patient with thymic carcinoma whose digital ulcers healed during treatment with macitentan and sildenafil for pulmonary arterial hypertension.
Pulmonary Fibrosis
Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study.
Respiratory Insufficiency
Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta.
Retinoblastoma
A DNA polymerase alpha accessory protein exhibits structural and functional similarities to SV40 large tumor antigen.
Retinoblastoma
Biochemical properties of the stimulatory activity of DNA polymerase alpha by the hyper-phosphorylated retinoblastoma protein.
Retinoblastoma
Differential expression of DNA polymerase alpha in normal and transformed human fibroblasts.
Retinoblastoma
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.
Retinoblastoma
Immunohistochemical analysis of retinoblastoma gene product (pRB) expression in malignant and non-malignant liver diseases.
Retinoblastoma
Interaction of the retinoblastoma protein (pRb) with the catalytic subunit of DNA polymerase delta (p125).
Retinoblastoma
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Retinoblastoma
Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activity.
Retinoblastoma
Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase.
Retinoblastoma
Stimulation of DNA polymerase alpha activity by cdk2-phosphorylated Rb protein.
Retinoblastoma
Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1.
Rhabdomyosarcoma
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Rhabdomyosarcoma, Alveolar
Aphidicolin induces myogenic differentiation in the human rhabdomyosarcoma cell line KFR.
Rheumatic Diseases
Evaluation of cancer-associated myositis and scleroderma autoantibodies in breast cancer patients without rheumatic disease.
Rheumatic Diseases
Malignancies in Patients with Anti-RNA Polymerase III Antibodies and Systemic Sclerosis: Analysis of the EULAR Scleroderma Trials and Research Cohort and Possible Recommendations for Screening.
Rheumatic Heart Disease
Paediatric deaths in a tertiary government hospital setting, Malawi.
Sarcoidosis
Clinical characteristics of sarcoidosis patients with systemic sclerosis-specific autoantibody: Possible involvement of thymus and activation-regulated chemokine and a review of the published works.
Sarcoma
An exonuclease possibly involved in the initiation of repair of bleomycin-damaged DNA in mouse ascites sarcoma cells.
Sarcoma
Deficiency of viral ribonucleic acid-dependent deoxyribonucleic acid polymerase in noninfectious virus-like particles released from murine sarcoma virus-transformed hamster cells.
Sarcoma
Deoxyribonucleic acid polymerase associated with feline leukemia and sarcoma viruses: properties of the enzyme and its product.
Sarcoma
Differential effects of heparin on replicative DNA synthesis and unscheduled DNA synthesis.
Sarcoma
Inhibition of cellular and virus-associated nucleotide polymerases by, and anti-herpes simplex virus activity of, streptovaricin derivatives.
Sarcoma
Inhibition of deoxynucleotide-polymerizing enzyme activities of human leukemia lymphoblasts and simian sarcoma virus by tilorone and thirteen of its analogs.
Sarcoma
Mechanism of carcinogenesis by RNA tumour viruses: the RNA-and DNA-dependent DNA polymerase activities of feline sarcoma virus.
Sarcoma
Monoclonal antibody that blocks phosphoinositide-dependent activation of mouse tumor DNA polymerase alpha.
Sarcoma
Polyribonucleotide inhibition of ribonucleic acid directed deoxyribonucleic acid polymerase of mouse mammary tumor (type B) virus and simian sarcoma (type C) virus.
Sarcoma
Properties of 2',3'-dideoxy-2',3'-dehydrothymidine 5'-triphosphate in terminating DNA synthesis catalyzed by several different DNA polymerases.
Sarcoma
Purification of Norman Murine Sarcoma DNA polymerase alpha forms with different DNA template primer binding affinity and different specific activity.
Sarcoma
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
Sarcoma, Avian
Deoxyribonucleic acid polymerase associated with Rous sarcoma virus and avian myeloblastosis virus: properties of the enzyme and its product.
Sarcoma, Avian
Deoxyribonucleic acid polymerase of Rous sarcoma virus: reaction conditions and analysis of the reaction product nucleic acids.
Sarcoma, Avian
Deoxyribonucleic acid polymerase of Rous sarcoma virus: studies on the mechanism of double-stranded deoxyribonucleic acid synthesis.
Sarcoma, Avian
Hybridization of Rous sarcoma virus deoxyribonucleic acid polymerase product and ribonucleic acids from chicken and rat cells infected with Rous sarcoma virus.
Sarcoma, Avian
Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus.
Sarcoma, Avian
Nucleotide sequence and promoter-specific effect of a negative regulatory region located upstream of the mouse proliferating cell nuclear antigen gene.
Sarcoma, Avian
Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus.
Sarcoma, Avian
Ribonuclease-sensitive deoxyribonucleic acid polymerase activity in uninfected rat cells and rat cells infected with Rous sarcoma virus.
Sarcoma, Avian
Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product.
Sarcoma, Avian
RNAase-sensitive DNA-dependent DNA polymerase from rat cells transformed by avian sarcoma virus.
Sarcoma, Avian
Transcription of ribonucleic acid by the ribonucleic acid directed deoxyribonucleic acid polymerase of Rous sarcoma virus and deoxyribonucleic acid polymerase I of Escherichia coli.
Sarcoma, Kaposi
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.
Sarcopenia
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
Scleroderma, Diffuse
Rapidly progressive systemic sclerosis associated with breast carcinoma: Report of a case with anti-RNA polymerase III antibody.
Scleroderma, Localized
Reactivity to anti-RNA polymerase III antibody and nailfold capillary changes in patient with generalized morphea combined with multiple autoimmune disorders.
Scleroderma, Systemic
A longitudinal study of anti-RNA polymerase III antibody levels in systemic sclerosis.
Scleroderma, Systemic
A To-Do List at Diagnosis of Systemic Sclerosis with Positive Anti-RNA Polymerase III Antibodies.
Scleroderma, Systemic
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.
Scleroderma, Systemic
An anti-RNA polymerase III antibody-positive systemic sclerosis patient with thymic carcinoma whose digital ulcers healed during treatment with macitentan and sildenafil for pulmonary arterial hypertension.
Scleroderma, Systemic
Analysis of anti-RNA polymerase III antibodies in Chinese Han systemic sclerosis patients.
Scleroderma, Systemic
Analysis of anti-RNA polymerase III antibody positive systemic sclerosis suggests altered GPATCH2L and CTNND2 expression in scleroderma renal crisis.
Scleroderma, Systemic
Anti-Centromere Antibody Positivity in a Patient with Generalized Morphea.
Scleroderma, Systemic
Anti-RNA polymerase III antibodies as a risk marker for early gastric antral vascular ectasia (GAVE) in systemic sclerosis.
Scleroderma, Systemic
Anti-RNA polymerase III antibodies in patients with systemic sclerosis detected by indirect immunofluorescence and ELISA.
Scleroderma, Systemic
Anti-RNA Polymerase III Antibodies in Systemic Sclerosis: Multicentric Study from Argentina.
Scleroderma, Systemic
Anti-RNA polymerase III antibodies in systemic sclerosis: Multicentric study from Argentina.
Scleroderma, Systemic
Anti-RNA polymerase III antibodies: A marker of Systemic Sclerosis with rapid onset and skin thickening progression.
Scleroderma, Systemic
Anti-RNA polymerase III antibody positive limited cutaneous systemic sclerosis with cryoglobulin-induced digital gangrene.
Scleroderma, Systemic
Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study.
Scleroderma, Systemic
Anti-RNA polymerase III antibody-associated scleroderma renal crisis in a patient with limited cutaneous systemic sclerosis: A case report.
Scleroderma, Systemic
Antibodies to RNA polymerase III in systemic sclerosis detected by ELISA.
Scleroderma, Systemic
Association of anti-RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis.
Scleroderma, Systemic
Association of anti-RNA polymerase III antibody and silicone breast implants in patients with systemic sclerosis.
Scleroderma, Systemic
Association of anti-RNA polymerase III antibody with silicone breast implants rupture in a multicentre series of Italian patients with systemic sclerosis.
Scleroderma, Systemic
Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review.
Scleroderma, Systemic
Cardiopulmonary Disease Development in Anti-RNA Polymerase III-positive Systemic Sclerosis: Comparative Analyses from an Unselected, Prospective Patient Cohort.
Scleroderma, Systemic
Case of systemic sclerosis with multiple primary malignancies in whom anti-RNA polymerase III antibody was detected by immunoprecipitation.
Scleroderma, Systemic
Clinical and immunological predictors of scleroderma renal crisis for Japanese systemic sclerosis patients with anti-RNA polymerase III autoantibodies.
Scleroderma, Systemic
Clinical consequences of the presence of anti-RNA Pol III antibodies in systemic sclerosis.
Scleroderma, Systemic
Clinical features of systemic sclerosis patients with anti-RNA polymerase III antibody in a single centre in Spain.
Scleroderma, Systemic
Coexistence of mucosa-associated lymphoid tissue lymphoma and systemic sclerosis showing positive for anticentromere antibody and anti-RNA polymerase III antibody: A case report and published work review.
Scleroderma, Systemic
Demographic and clinical features of systemic sclerosis patients with anti-RNA polymerase III antibodies.
Scleroderma, Systemic
Demyelinating syndrome in systemic sclerosis and neuromyelitis optica.
Scleroderma, Systemic
Diffuse alveolar haemorrhage in a case with anti-RNA polymerase III antibody-positive systemic sclerosis successfully treated with plasma exchange and corticosteroid therapy.
Scleroderma, Systemic
Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.
Scleroderma, Systemic
Enzyme-linked immunosorbent assay for detection of anti-RNA polymerase III antibody: analytical accuracy and clinical associations in systemic sclerosis.
Scleroderma, Systemic
Gastric antral vascular ectasia in systemic sclerosis: Association with anti-RNA polymerase III and negative anti-nuclear antibodies.
Scleroderma, Systemic
Increased apoptosis in circulating lymphocyte cultures of anti-RNA polymerase III positive patients with systemic sclerosis.
Scleroderma, Systemic
Intrarenal arterial stiffness is increased in systemic sclerosis patients with anti-ribonucleic acid polymerase III antibodies.
Scleroderma, Systemic
Low prevalence of anti-RNA polymerase III antibodies in a French scleroderma population: anti-RNA polymerase III scleroderma.
Scleroderma, Systemic
Malignancies in Italian Patients with Systemic Sclerosis Positive for Anti-RNA Polymerase III Antibodies.
Scleroderma, Systemic
Malignancies in Patients with Anti-RNA Polymerase III Antibodies and Systemic Sclerosis: Analysis of the EULAR Scleroderma Trials and Research Cohort and Possible Recommendations for Screening.
Scleroderma, Systemic
Paraneoplastic Systemic Sclerosis: Focus on Anti-RNA Polymerase III Antibodies.
Scleroderma, Systemic
Predictive value of antinuclear autoantibodies: The lessons of the systemic sclerosis autoantibodies.
Scleroderma, Systemic
Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis.
Scleroderma, Systemic
Should we look for anti-RNA polymerase III antibodies in systemic sclerosis patients with anti-centromere or anti-topoisomerase I antibodies?
Scleroderma, Systemic
Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review.
Scleroderma, Systemic
Systemic sclerosis with anti-RNA polymerase III positivity following silicone breast implant rupture: possible role of B-cell depletion and implant removal in the treatment.
Scleroderma, Systemic
Validation of a new immunoenzymatic method to detect antibodies to RNA polymerase III in systemic sclerosis.
Scleroderma, Systemic
[Cancers associated with systemic sclerosis involving anti-RNA polymerase III antibodies].
Seizures
Mitochondrial DNA damage and impaired base excision repair during epileptogenesis.
Seminoma
Low expression of DNA polymerase beta in human testicular germ cell tumours--impact on foetal gonocytic origin theory.
Severe Acute Malnutrition
Paediatric deaths in a tertiary government hospital setting, Malawi.
Sjogren's Syndrome
Analysis of autoantibodies to recombinant La (SS-B) peptides in systemic lupus erythematosus and primary Sjogren's syndrome.
Skin Diseases
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease.
Skin Diseases
Cardiopulmonary Disease Development in Anti-RNA Polymerase III-positive Systemic Sclerosis: Comparative Analyses from an Unselected, Prospective Patient Cohort.
Skin Neoplasms
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.
Skin Neoplasms
ATR/Chk1 Pathway is Activated by Oxidative Stress in Response to UVA Light in Human Xeroderma Pigmentosum Variant Cells.
Skin Neoplasms
DNA polymerase eta participates in the mutagenic bypass of adducts induced by benzo[a]pyrene diol epoxide in mammalian cells.
Skin Neoplasms
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.
Skin Neoplasms
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.
Skin Neoplasms
Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.
Skin Neoplasms
Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.
Skin Neoplasms
Multifaceted activities of DNA polymerase ?: beyond translesion DNA synthesis.
Skin Neoplasms
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.
Skin Neoplasms
Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.
Skin Neoplasms
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
Skin Neoplasms
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.
Skin Neoplasms
Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase eta.
Skin Neoplasms
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts.
Skin Neoplasms
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota.
Skin Neoplasms
The key role of UVA-light induced oxidative stress in human Xeroderma Pigmentosum Variant cells.
Skin Neoplasms
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
Small Cell Lung Carcinoma
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Small Cell Lung Carcinoma
Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer.
Small Cell Lung Carcinoma
[Genetic variation in DNA polymerase kappa gene is associated with the prognosis after platinum-based chemotherapy in small cell lung cancer patients].
Spinocerebellar Ataxias
Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects.
Spinocerebellar Ataxias
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Spinocerebellar Degenerations
Co-occurrence of four nucleotide changes associated with an adult mitochondrial ataxia phenotype.
Squamous Cell Carcinoma of Head and Neck
[Expression of proliferating cell nuclear antigen (PCNA) in premalignant lesions of laryngeal epithelium]
Starvation
Activity levels of mouse DNA polymerase alpha-primase complex (DNA replicase) and DNA polymerase alpha, free from primase activity in synchronized cells, and a comparison of their catalytic properties.
Starvation
Human DNA polymerase eta activity and translocation is regulated by phosphorylation.
Starvation
Threonine starvation of concanavalin A treated lymphocytes impairs DNA polymerase alpha activity.
Stomach Neoplasms
Association between newly identified variant form of DNA polymerase beta (? 208-304) and ovarian cancer.
Stomach Neoplasms
Characterization of DNA polymerase beta splicing variants in gastric cancer: The most frequent exon 2-deleted isoform is a non-coding RNA.
Stomach Neoplasms
Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
Stomach Neoplasms
Clinical significance of a point mutation in DNA polymerase beta (POLB) gene in gastric cancer.
Stomach Neoplasms
Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach.
Stomach Neoplasms
Functional mutation of DNA polymerase beta found in human gastric cancer--inability of the base excision repair in vitro.
Stomach Neoplasms
Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks.
Stomach Neoplasms
Identification of an endoplasmic reticulum membrane protein interacting with DNA polymerase beta by a yeast two-hybrid screen.
Stomach Neoplasms
[Preliminary study of DNA polymerase beta gene silencing by small interfering RNA in human gastric cancer BGC-823 cells]
Stomach Ulcer
Cell proliferation kinetics in the marginal mucosa of gastric ulcer evaluated by immunostaining of DNA polymerase alpha.
Synovitis
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma.
Synovitis
Autoantibody profile and clinical correlation in a group of patients with systemic sclerosis in southern Brazil.
Testicular Neoplasms
CAG repeat polymorphism in the DNA polymerase gamma gene in a Polish population: an association with testicular cancer risk.
Thrombocytopenia
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease.
Thrombotic Microangiopathies
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis sine scleroderma.
Thymoma
An anti-RNA polymerase III antibody-positive systemic sclerosis patient with thymic carcinoma whose digital ulcers healed during treatment with macitentan and sildenafil for pulmonary arterial hypertension.
Thyroid Cancer, Papillary
Immune cell infiltrate-associated dysregulation of DNA repair machinery may predispose to papillary thyroid carcinogenesis.
Thyroid Neoplasms
DNA polymerase beta in human thyroid of Graves' disease and thyroid tumors.
Tuberculosis
Correction: In Silico Screening for Novel Inhibitors of DNA Polymerase III Alpha Subunit of Mycobacterium tuberculosis (MtbDnaE2, H37Rv).
Tuberculosis
Crystal structure of DNA polymerase III ? sliding clamp from Mycobacterium tuberculosis.
Tuberculosis
DNA polymerase III ? subunit from Mycobacterium tuberculosis H37Rv: Homology modeling and molecular docking of its inhibitor.
Tuberculosis
High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center.
Tuberculosis
In silico screening for novel inhibitors of DNA polymerase III alpha subunit of Mycobacterium tuberculosis (MtbDnaE2, H37Rv).
Tuberculosis
The ?2 clamp in the Mycobacterium tuberculosis DNA polymerase III ??2? replicase promotes polymerization and reduces exonuclease activity.
Tuberculosis, Meningeal
Paediatric deaths in a tertiary government hospital setting, Malawi.
Urinary Bladder Neoplasms
Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.
Urinary Bladder Neoplasms
Splice variants but not mutations of DNA polymerase beta are common in bladder cancer.
Urinary Tract Infections
Urinary tract infection drives genome instability in uropathogenic Escherichia coli and necessitates translesion synthesis DNA polymerase IV for virulence.
Uterine Cervical Neoplasms
Cervical cancer isolate PT3, super-permissive for adeno-associated virus replication, over-expresses DNA polymerase delta, PCNA, RFC and RPA.
Uterine Cervical Neoplasms
[Study on DNA polymerase beta gene mutation in human cervical cancer]
Vaccinia
Betalactam antibiotics interfere with eukaryotic DNA-replication by inhibiting DNA polymerase alpha.
Vaccinia
Control of cell division by aphidicolin without adverse effects upon resting cells.
Vaccinia
DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.
Vaccinia
DNA primase-DNA polymerase alpha from simian cells. Modulation of RNA primer synthesis by ribonucleoside triphosphates.
Vaccinia
Expression of the catalytic subunit of human DNA polymerase delta in mammalian cells using a vaccinia virus vector system.
Vaccinia
Human DNA polymerase alpha: predicted functional domains and relationships with viral DNA polymerases.
Vaccinia
Purification and properties of the deoxyribonucleic acid polymerase induced by vaccinia virus.
Varicocele
Deoxyribonucleic acid polymerase activity in the testes of infertile men with varicocele.
Virus Diseases
Cellular and Epstein-Barr virus specific DNA polymerases in virus-producing Burkitt's lymphoma cell lines.
Virus Diseases
Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase.
Virus Diseases
Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase.
Virus Diseases
In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery.
Virus Diseases
Involvement of the reparative DNA polymerase pol x of african Swine Fever virus in the maintenance of viral genome stability in vivo.
Virus Diseases
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase.
Werner Syndrome
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.
Werner Syndrome
Evidence against DNA polymerase beta as a candidate gene for Werner syndrome.
Werner Syndrome
Functional interaction between the Werner Syndrome protein and DNA polymerase delta.
Werner Syndrome
Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome.
Werner Syndrome
Induction of DNA polymerase alpha in senescent cultures of normal and Werner's syndrome cultured skin fibroblasts.
Werner Syndrome
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.
Werner Syndrome
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.
Werner Syndrome
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.
Werner Syndrome
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.
Xeroderma Pigmentosum
A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.
Xeroderma Pigmentosum
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
Xeroderma Pigmentosum
A single (6-4) photoproduct inhibits plasmid DNA replication in xeroderma pigmentosum variant cell extracts.
Xeroderma Pigmentosum
Asymmetry of DNA replication and translesion synthesis of UV-induced thymine dimers.
Xeroderma Pigmentosum
ATR/Chk1 Pathway is Activated by Oxidative Stress in Response to UVA Light in Human Xeroderma Pigmentosum Variant Cells.
Xeroderma Pigmentosum
ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells.
Xeroderma Pigmentosum
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta.
Xeroderma Pigmentosum
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.
Xeroderma Pigmentosum
Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.
Xeroderma Pigmentosum
DNA binding properties of human DNA polymerase eta: implications for fidelity and polymerase switching of translesion synthesis.
Xeroderma Pigmentosum
DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis.
Xeroderma Pigmentosum
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.
Xeroderma Pigmentosum
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.
Xeroderma Pigmentosum
DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation.
Xeroderma Pigmentosum
DNA polymerase eta participates in the mutagenic bypass of adducts induced by benzo[a]pyrene diol epoxide in mammalian cells.
Xeroderma Pigmentosum
DNA polymerase eta, a key protein in translesion synthesis in human cells.
Xeroderma Pigmentosum
DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.
Xeroderma Pigmentosum
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.
Xeroderma Pigmentosum
DNA repair synthesis in human fibroblasts requires DNA polymerase delta.
Xeroderma Pigmentosum
Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.
Xeroderma Pigmentosum
Down-regulation of Pol? expression leads to increased DNA damage, apoptosis and enhanced S phase arrest in L-02 cells exposed to hydroquinone.
Xeroderma Pigmentosum
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.
Xeroderma Pigmentosum
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.
Xeroderma Pigmentosum
Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations.
Xeroderma Pigmentosum
Fidelity and damage bypass ability of Schizosaccharomyces pombe Eso1 protein, comprised of DNA polymerase eta and sister chromatid cohesion protein Ctf7.
Xeroderma Pigmentosum
Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.
Xeroderma Pigmentosum
Human DNA polymerase eta activity and translocation is regulated by phosphorylation.
Xeroderma Pigmentosum
Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.
Xeroderma Pigmentosum
Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.
Xeroderma Pigmentosum
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.
Xeroderma Pigmentosum
Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells.
Xeroderma Pigmentosum
Molecular analysis of DNA polymerase eta gene in Japanese patients diagnosed as xeroderma pigmentosum variant type.
Xeroderma Pigmentosum
Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.
Xeroderma Pigmentosum
Mutation frequencies and spectra in DNA polymerase eta-deficient mice.
Xeroderma Pigmentosum
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.
Xeroderma Pigmentosum
Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.
Xeroderma Pigmentosum
Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.
Xeroderma Pigmentosum
p53 suppression overwhelms DNA polymerase eta deficiency in determining the cellular UV DNA damage response.
Xeroderma Pigmentosum
Physical and functional interactions of human DNA polymerase eta with PCNA.
Xeroderma Pigmentosum
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
Xeroderma Pigmentosum
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins.
Xeroderma Pigmentosum
Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae.
Xeroderma Pigmentosum
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.
Xeroderma Pigmentosum
Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota.
Xeroderma Pigmentosum
Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase eta.
Xeroderma Pigmentosum
Regulation of the specialized DNA polymerase eta: revisiting the biological relevance of its PCNA- and ubiquitin-binding motifs.
Xeroderma Pigmentosum
Replication of damaged DNA in mammalian cells: new solutions to an old problem.
Xeroderma Pigmentosum
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts.
Xeroderma Pigmentosum
Role of DNA polymerase eta in the UV mutation spectrum in human cells.
Xeroderma Pigmentosum
Role of DNA polymerase zeta in the bypass of a (6-4) TT photoproduct.
Xeroderma Pigmentosum
Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota.
Xeroderma Pigmentosum
Structural basis for the suppression of skin cancers by DNA polymerase eta.
Xeroderma Pigmentosum
The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin.
Xeroderma Pigmentosum
The inhibition of DNA repair by aphidicolin or cytosine arabinoside in X-irradiated normal and xeroderma pigmentosum fibroblasts.
Xeroderma Pigmentosum
The key role of UVA-light induced oxidative stress in human Xeroderma Pigmentosum Variant cells.
Xeroderma Pigmentosum
The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme.
Xeroderma Pigmentosum
The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant.
Xeroderma Pigmentosum
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Xeroderma Pigmentosum
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1.
Xeroderma Pigmentosum
UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.
Xeroderma Pigmentosum
UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.
Xeroderma Pigmentosum
Xeroderma pigmentosum variant: Complementary molecular approaches to detect a 13 base pair deletion in the DNA polymerase eta gene.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
localized contact between the catalytic subunit poly gammaA and the accessory subunits
additional information
-
localized contact between the catalytic subunit poly gammaA and the accessory subunits
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yakubovskaya, E.; Lukin, M.; Chen, Z.; Berriman, J.; Wall, J.S.; Kobayashi, R.; Kisker, C.; Bogenhagen, D.F.
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits
EMBO J.
26
4283-4291
2007
Homo sapiens (Q9UHN1), Homo sapiens
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Release 2023.1 (January 2023)
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