Information on EC 2.7.7.66 - malonate decarboxylase holo-[acyl-carrier protein] synthase

for references in articles please use BRENDA:EC2.7.7.66
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The expected taxonomic range for this enzyme is: Klebsiella pneumoniae

EC NUMBER
COMMENTARY hide
2.7.7.66
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RECOMMENDED NAME
GeneOntology No.
malonate decarboxylase holo-[acyl-carrier protein] synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2'-(5-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein] = malonate decarboxylase holo-[acyl-carrier protein] + diphosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
malonate decarboxylase activation
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SYSTEMATIC NAME
IUBMB Comments
2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase
The delta subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the prosthetic group 2-(5-triphosphoribosyl)-3-dephospho-CoA. Two reactions are involved in the production of the holo-ACP form of this enzyme. The first reaction is catalysed by EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase. The resulting prosthetic group is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase.
CAS REGISTRY NUMBER
COMMENTARY hide
312492-44-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein]
malonate decarboxylase holo-[acyl-carrier protein] + diphosphate
show the reaction diagram
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D134A
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mutation abolishes the transfer of the prosthetic group to apo acyl carrier protein, but the binding of triphosphoribosyl-dephospho-CoA to MdcG is not affected
D134A/D136A
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mutation abolishes the transfer of the prosthetic group to apo acyl carrier protein, but the binding of triphosphoribosyl-dephospho-CoA to MdcG is not affected
D136A
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mutation abolishes the transfer of the prosthetic group to apo acyl carrier protein, but the binding of triphosphoribosyl-dephospho-CoA to MdcG is not affected
Show AA Sequence (622 entries)
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