Disease on EC 2.7.7.6 - DNA-directed RNA polymerase

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DISEASE
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Acidosis
Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death.
Restriction of rRNA synthesis by VHL maintains energy equilibrium under hypoxia.
Acute Kidney Injury
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Endotoxin mediates recruitment of RNA polymerase II to target genes in acute renal failure.
Adenocarcinoma
Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription.
Gender Specific Differences in RNA Polymerase III Transcription.
Inhibition of nuclear DNA-dependent RNA polymerases from mouse ascites tumors and liver by glycerol.
RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells.
Adenocarcinoma of Lung
Cytoplasmic expression of a reporter gene by co-delivery of T7 RNA polymerase and T7 promoter sequence with cationic liposomes.
OverGeneDB: a database of 5' end protein coding overlapping genes in human and mouse genomes.
Adenoma
Relationship between nuclear ADP-ribosylation and RNA transcription in calf and human thyroid.
Adenoviridae Infections
Adenovirus type 2 preferentially stimulates polymerase III transcription of Alu elements by relieving repression: a potential role for chromatin.
African Swine Fever
African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases.
DNA-dependent RNA polymerase in African swine fever virus.
Effect of inhibitors of the host cell RNA polymerase II on African swine fever virus multiplication.
Effect of rifamycin derivatives and coumermycin A1 on in vitro RNA synthesis by African swine fever virus. Brief report.
High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.
Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II.
alpha-Thalassemia
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alzheimer Disease
Expression of Alu and 7SL RNA in Alzheimer's and control brains.
Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease.
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration.
Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease.
Study of the Alzheimer's A4 precursor gene promoter region by genomic sequencing using Taq polymerase.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Amyotrophic Lateral Sclerosis
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Anemia
Derivation and External Validation of a Prediction Rule for Five-Year Mortality in Patients With Early Diffuse Cutaneous Systemic Sclerosis.
dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification.
Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation.
Validation of reference genes for real-time polymerase chain reaction studies in atlantic salmon.
Anemia, Hypochromic
Virus-induced gene silencing of the RPC5-like subunit of RNA polymerase III caused pleiotropic effects in Nicotiana benthamiana.
Anodontia
Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.
Anthrax
Palladium-Triggered Chemical Rescue of Intracellular Proteins via Genetically Encoded Allene-Caged Tyrosine.
Autoimmune Diseases
Adenovirus infection induces loss of HLA class I and CD3 antigens, but does not induce cell surface presentation of the La (SS-B) autoantigen.
Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease.
Association of an RNA polymerase III transcription factor with a ribonucleoprotein complex recognized by autoimmune sera.
Autoantibody to RNA polymerase I in scleroderma sera.
Autoimmune diseases may result from inappropriate RNA polymerase III transcription: comment on the article by Neidhart et al.
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
Immunochemical and molecular characterization of anti-RNA polymerase I autoantibodies produced by tight skin mouse.
New nuclear functions for calmodulin.
Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I.
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
Avian Leukosis
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.
Bacterial Infections
Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus).
Environmental History Modulates Arabidopsis Pattern-Triggered Immunity in a HISTONE ACETYLTRANSFERASE1-Dependent Manner.
Blister
Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.
The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.
Bloom Syndrome
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
Bluetongue
Expression of the non-structural protein NS1 of bluetongue virus in bacteria and yeast: identification of two antigenic sites at the amino terminus.
Borna Disease
Development of a novel Borna disease virus reverse genetics system using RNA polymerase II promoter and SV40 nuclear import signal.
Brain Ischemia
Experimental stroke in gerbils: effect on translation and transcription.
Breast Neoplasms
A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors.
A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.
A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology.
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.
Analysis of HP1? regulation in human breast cancer cells.
Analysis of paired end Pol II ChIP-seq and short capped RNA-seq in MCF-7 cells.
Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Bioinformatic analysis of changes in RNA polymerase II transcription stimulated by estradiol in MCF7 cells.
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
Breast Cancer Suppression by Progesterone Receptors Is Mediated by Their Modulation of Estrogen Receptors and RNA Polymerase III.
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
Coactivator Function Defines the Active Estrogen Receptor-{alpha} Cistrome.
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
ER? mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.
Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells.
Genome-wide analysis of estrogen receptor binding sites.
High levels of ?-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer.
Incidence, risk factors and outcomes of cancer in systemic sclerosis.
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery.
Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells.
Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction.
Nuclear localization of cytokeratin 8 and the O-linked N-acetylglucosamine-containing epitope H in epithelial cells of infiltrating ductal breast carcinomas: a combination of immunogold and EDTA regressive staining methods.
Problem-solving test: Real-time polymerase chain reaction.
Prognostic Value of the Expression of DNA Repair-Related Biomarkers Mediated by Alcohol in Gastric Cancer Patients.
RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition.
Role of Brf1 interaction with ER?, and significance of its overexpression, in human breast cancer.
Systematic identification of Ctr9 regulome in ER?-positive breast cancer.
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data.
Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.
Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.
ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.
Carcinogenesis
A tRNA with oncogenic capacity.
Activation of RNA polymerase I transcription by hepatitis C virus core protein.
Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Author Correction: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals.
BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the ?-catenin·TCF4 transcriptional activity in response to Wnt signaling.
Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.
Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.
Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis.
Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.
Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis.
Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis.
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Regulation and regulatory parameters of histone modifications.
Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling.
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
The prognostic signature of the somatic mutations in Ewing sarcoma: from a network view.
The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II.
Tissue, sex, and animal species specificity of aflatoxin B1 inhibition of nuclear RNA polymerase II activity.
Carcinoma
B2 RNA and 7SK RNA, RNA polymerase III transcripts, have a cap-like structure at their 5' end.
Differential Incorporation of ?-actin as A Component of RNA Polymerase II into Regulatory Regions of Stemness/Differentiation Genes in Retinoic Acid-Induced Differentiated Human Embryonic Carcinoma Cells.
DNA-dependent RNA polymerases of Ehrlich carcinoma, other murine ascites tumors, and murine normal tissues.
Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.
Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.
Inclusion of a matrix-attached region in a 7SK pol III vector increases the efficiency of shRNA-mediated gene silencing in embryonic carcinoma cells.
Inhibition of nuclear DNA-dependent RNA polymerases from mouse ascites tumors and liver by glycerol.
Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2.
Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.
RNA polymerase III transcription in cancer: the BRF2 connection.
The green tea component EGCG inhibits RNA polymerase III transcription.
The most abundant nascent poly(A) + RNAs are transcribed by RNA polymerase III in murine tumor cells.
The preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
von Hippel-Lindau-Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas.
[B2 RNA and 7SK RNA, transcripts of RNA-polymerase III, have a cap-like structure at the 5'-end]
[Synthesis by RNA polymerase III of high-molecular weight of polyadenylated RNA in Ehrlich carcinoma cells]
Carcinoma, Ehrlich Tumor
Accurate transcription initiation in an Ehrlich ascites tumor cell lysate.
Conformational change of DNA binding subunit of RNA polymerase II on binding to DNA.
Daunorubicin inhibition of DNA-dependent RNA polymerases from Ehrlich ascites tumor cells.
Difference in phosphorylation of two factors stimulating RNA polymerase II of Ehrlich ascites tumor cells.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II.
DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. V. Characterization of a factor repressing RNA polymerase II as a ribonucleoprotein.
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. 3. Ribonuclease H and elongating activity of stimulatory factor S-II.
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. I. Partial purification and characterization of RNA polymerase II.
Enhancement of ormation of the initiation complex by factor stimulating RNA polymerase II from Ehrlich ascites tumor cells.
Evidence that stimulatory factor(s) of RNA polymerase II participates in accurate transcription in a HeLa cell lysate.
Identification of subunits of RNA polymerase II from Ehrlich ascites tumor cells.
Identification of the DNA binding subunit of RNA polymerase II from Ehrlich ascites tumor cells.
Nuclear DNA-dependent RNA polymerases of Ehrlich ascites tumor cells: two discrete -amanitin-sensitive forms.
Protein which interacts with a stimulatory factor of RNA polymerase II of Ehrlich ascites tumor cells.
Purification and preparation of antibody to RNA polymerase II stimulatory factors from Ehrlich ascites tumor cells.
Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II.
Purification of a new protein stimulating RNA polymerase II from Ehrlich ascites tumor cells: comparison with proteins purified before.
Regulation of nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Regulation of the nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Retrostatin, a new specific enzyme inhibitor against avian myeloblastosis virus reverse transcriptase.
Separation of a stimulatory factor of RNA polymerase II from protein kinase activity of Ehrlich ascites tumor cells.
Stimulation of messenger ribonucleic acid synthesis in isolated nuclei by a protein that stimulates RNA polymerase II.
Stimulatory proteins of RNA polymerase II from Ehrlich ascites tumor cells.
Structural relationships of the three stimulatory factors of RNA polymerase II from Ehrlich ascites tumor cells.
Transcription factor(s) of Ehrlich ascites tumor cells having affinity to the 'TATA' box and a further upstream region of the adenovirus 2 major late gene.
Transcription in vitro of Ehrlich ascites tumor DNA and chromatin by purified homologous RNA polymerase II (or B).
Transcription of globin genes in murine erythroleukemic cell chromatin by RNA polymerase II from mouse cells.
[A protein stimulating the activity of RNA polymerase II of Ehrlich ascites tumor cells (author's transl)]
Carcinoma, Embryonal
Regulation of a TATA-binding protein-associated factor during cellular differentiation.
Regulation of RNA polymerase I transcription in response to F9 embryonal carcinoma stem cell differentiation.
Regulation of RNA polymerase III transcription in response to F9 embryonal carcinoma stem cell differentiation.
Carcinoma, Hepatocellular
A comparative study of DNA-dependent RNA polymerases from rat ascites hepatoma cell nuclei and from rat liver nuclei.
Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.
Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII.
Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase.
Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription.
Baculovirus mediated production of infectious hepatitis C virus in human hepatoma cells stably expressing t7 RNA polymerase.
Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma.
Comparison of the multiple deoxyribonucleic acid-dependent ribonucleic acid polymerase forms of whole rat liver and a minimal-deviation rat hepatoma cell line.
Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.
DNA-dependent RNA polymerase I from hepatomas: comparison of activity levels and properties.
DNA-dependent RNA polymerases from Morris hepatomas 3924A and 7800 and from liver treated with thioacetamide.
Fluctuations of DNA-dependent RNA polymerase and synthesis of macromolecules during the growth cycle of Novikoff rat hepatoma cells in suspension culture.
Formation of transcribing mononucleosome-eukaryotic RNA polymerase II complexes in vitro as a simple model of active chromatin.
Glucocorticoid-induced stimulation of ribosomal gene transcription in rat hepatoma cells is mediated by modification of RNA polymerase I or an associated factor.
Glycerol inhibition of purified and chromatin-associated mouse liver hepatoma RNA polymerase II activity.
Inhibition of EGFP expression by siRNA in EGFP-stably expressing Huh-7 cells.
Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect.
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.
Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry.
Monoclonal antibodies directed against mammalian RNA polymerase I. Identification of the catalytic center.
Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection.
Phosphorylation of deoxyribonucleic acid dependent RNA polymerase II by nuclear protein kinase NII: mechanism of enhanced ribonucleic acid synthesis.
Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides.
Protein kinase NII. Interaction with RNA polymerase II and contribution to immunological cross-reactivity of RNA polymerases I and II.
Reduction in RNA synthesis following red cell-mediated microinjection of antibodies to RNA polymerase I.
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
RNA polymerase I in hepatoma 3924A: mechanism of enhanced activity relative to liver.
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Rpb3 promotes hepatocellular carcinoma through its N-terminus.
shRNA driven by Pol II/T7 dual-promoter system effectively induce cell-specific RNA interference in mammalian cells.
The effect of hydroxycamptothecin in the activity of RNA and DNA polymerases prepared from murine hepatoma cells.
The relationship between the activity of DNA-dependent RNA polymerase I and the rate of synthesis of rRNA in hepatoma cells in culture.
The significance of Brf1 overexpression in human hepatocellular carcinoma.
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV.
Carcinoma, Lewis Lung
The preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
Carcinoma, Non-Small-Cell Lung
Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Carcinoma, Renal Cell
Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.
Carcinoma, Squamous Cell
RNA polymerase III transcription in cancer: the BRF2 connection.
Small stable RNA level depends on the physiological state of the cell.
[Dynamic phosphorylation of RNA polymerase III holoenzyme subunits from human epidermoid carcinoma cells A431 cultivated under different conditions]
[Subunits of human holoenzyme of DNA dependent RNA polymerase III phosphorylated in vivo]
[SUBUNITS OF MAMMAL DNA DEPENDENT RNA POLYMERASE III MODIFIED IN VIVO].
Cardiomegaly
A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy.
Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription.
Control of histone H3 phosphorylation by CaMKII? in response to haemodynamic cardiac stress.
Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.
Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II.
Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9.
Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy.
Cardiomyopathy, Dilated
POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.
Cardiovascular Diseases
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
Cataract
Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome.
Recessive Mutations in POLR3B Encoding RNA Polymerase III Subunit Causing Diffuse Hypomyelination in Patients with 4H Leukodystrophy with Polymicrogyria and Cataracts.
Central Nervous System Infections
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.
Cerebellar Diseases
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.
Chickenpox
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.
Classical Swine Fever
Development of a novel single-step reverse genetics system for the generation of classical swine fever virus.
Efficient and stable rescue of classical swine fever virus from cloned cDNA using an RNA polymerase II system.
Membrane-anchored incorporation of a foreign protein in recombinant influenza virions.
Recovery of infectious classical swine fever virus (CSFV) from full-length genomic cDNA clones by a swine kidney cell line expressing bacteriophage T7 RNA polymerase.
Cockayne Syndrome
A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair.
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a.
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.
Cockayne syndrome group B protein enhances elongation by RNA polymerase II.
Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth.
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality.
DNA damage stabilizes interaction of CSB with the transcription elongation machinery.
FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Involvement of mismatch repair in transcription-coupled nucleotide excision repair.
Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.
Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.
Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome.
Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
Modulation of Rad26- and Rpb9-mediated DNA repair by different promoter elements.
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
Rad26, the yeast homolog of the cockayne syndrome B gene product, counteracts inhibition of DNA repair due to RNA polymerase II transcription.
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells.
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells.
Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome.
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells.
Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair.
Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair.
Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast.
TFIIH is an elongation factor of RNA polymerase I.
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.
Transcription elongation and human disease.
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro.
Truncated Cockayne syndrome B protein represses elongation by RNA polymerase I.
UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein.
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.
UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.
Von Hippel-Lindau-Coupled and Transcription-Coupled Nucleotide Excision Repair-Dependent Degradation of RNA Polymerase II in Response to Trabectedin.
What happens at the lesion does not stay at the lesion: Transcription-coupled nucleotide excision repair and the effects of DNA damage on transcription in cis and trans.
XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population.
Coinfection
Detection of Norwalk virus in the UK by the polymerase chain reaction.
Expression of cDNA encoding the Sendai virus hemagglutinin-neuraminidase gene: characterization of wild-type and mutant gene products.
Expression of functional Bunyamwera virus L protein by recombinant vaccinia viruses.
Expression of target genes by coinfection with replication-deficient viral vectors.
Feline calicivirus capsid protein expression and capsid assembly in cultured feline cells.
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Optimization of plasmid-only rescue of highly attenuated and temperature-sensitive respiratory syncytial virus (RSV) vaccine candidates for human trials.
Recombinant decorin glycoforms. Purification and structure.
Colonic Neoplasms
Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors.
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.
Colorectal Neoplasms
Association Between Germline Mutations in BRF1, a subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.
Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.
Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers.
Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis.
Connective Tissue Diseases
Effects of antinuclear autoantibodies on RNA polymerase.
Cowpox
Recombinant protein synthesis in Chinese hamster ovary cells using a vaccinia virus/bacteriophage T7 hybrid expression system.
The vaccinia virus fusion inhibitor proteins SPI-3 (K2) and HA (A56) expressed by infected cells reduce the entry of superinfecting virus.
Cystic Fibrosis
Detection of Pseudomonas aeruginosa in sputum from cystic fibrosis patients by the polymerase chain reaction.
Expression in Escherichia coli of cytoplasmic portions of the cystic fibrosis transmembrane conductance regulator: apparent bacterial toxicity of peptides containing R-domain sequences.
Cysts
Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage.
DNA-dependent RNA polymerase from trophozoites and cysts of Acanthamoeba castellanii.
DNA-dependent RNA polymerase I from Acanthamoeba castellanii: comparison of the catalytic properties and subunit architectures of the trophozoite and cyst enzymes.
DNA-dependent RNA polymerase II from Acanthamoeba castellanii. Comparison of the catalytic properties and subunit architectures of the trophozoite and cyst enzymes.
DNA-dependent RNA polymerase III from Acanthamoeba castellanii: comparison of the catalytic properties of the trophozoite and cyst enzymes.
Cytomegalovirus Infections
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome.
De Lange Syndrome
Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Deafness
A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1.
Decompression Sickness
Evidence for DNA bending at the T7 RNA polymerase promoter.
Structure of human mitochondrial RNA polymerase.
Structure of Taq ploymerase with DNA at the polymerase active site.
Dengue
Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity.
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.
Diabetes Mellitus, Type 1
Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes.
DiGeorge Syndrome
Argonaute-bound small RNAs from promoter-proximal RNA polymerase II.
dna topoisomerase deficiency
Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Dyskinesias
Striatal NELF-mediated RNA polymerase II stalling controls L-dopa induced dyskinesia.
Dystonia
Dystonia in RNA Polymerase III-Related Leukodystrophy.
Encephalitis
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response.
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Encephalitis, Japanese
Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA.
Encephalitis, Tick-Borne
T7 DNA-dependent RNA polymerase can transcribe RNA from tick-borne encephalitis virus (TBEV) cDNA with SP6 promoter.
[New Genetic Marker of Human Predisposition to Severe Forms of Tick-Borne Encephalitis].
Encephalomyelitis, Venezuelan Equine
RNA-polymerase, type I: activity in rat brain cell nuclei and peripheral blood mononuclear cells after Venezuelan equine encephalomyelitis virus infection.
[Expression of fragments of Venezuelan equine encephalomyelitis virus E2 protein in a system based on phage T7 RNA polymerase]
Endocarditis
Clonal structure of Streptococcus sanguinis strains isolated from endocarditis cases and the oral cavity.
Endometrial Neoplasms
Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ER? in Tamoxifen-Associated Endometrial Carcinomas.
Endophthalmitis
Reliability of nested polymerase chain reaction in the diagnosis of bacterial endophthalmitis.
Enzootic Bovine Leukosis
An avian retrovirus uses canonical expression and processing mechanisms to generate viral microRNA.
Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo.
Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome.
Deep sequencing reveals abundant noncanonical retroviral microRNAs in B-cell leukemia/lymphoma.
Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs.
In vitro accurate transcription from the cap site of bovine leukemia virus (BLV) dependent on the BLV-infected cell nuclear lysate.
RNA virus microRNA that mimics a B-cell oncomiR.
Epstein-Barr Virus Infections
RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus.
Equine Infectious Anemia
dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification.
Esophageal Motility Disorders
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis.
Esophageal Neoplasms
Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9.
[Establishment of cDNA microarray technology and analysis of gene expression profiles in human esophageal cancer cell line ECa109]
exodeoxyribonuclease (lambda-induced) deficiency
Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli.
Fatty Liver
Study of the protective effect of an anabolic steroid, 19-nortestosterone phenylpropionate (19-NTPP) on the fatty liver induced by high doses of rifampicin in the rat.
Fibrosarcoma
Separation of replication and transcription domains in nucleoli.
Telomerase activity in melanoma and non-melanoma skin cancer.
Foot-and-Mouth Disease
Development of a hamster kidney cell line expressing stably T7 RNA polymerase using retroviral gene transfer technology for efficient rescue of infectious foot-and-mouth disease virus.
Effect of actinomycin D on virus-induced ribonucleic acid polymerase formation in foot-and-mouth disease virus-infected baby hamster kidney cells.
Effect of foot-and-mouth disease virus on protein synthesis and ribonucleic acid polymerase activity at various temperatures.
Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus.
Foot-and-mouth disease virus-induced ribonucleic acid polymerase in baby hamster kidney cells.
In vitro products of a membrane-free foot-and-mouth disease virus ribonucleic acid polymerase.
Recovery of infectious foot-and-mouth disease virus from full-length genomic cDNA clones using an RNA polymerase I system.
Fowlpox
Efficient rescue of infectious bursal disease virus from cloned cDNA: evidence for involvement of the 3'-terminal sequence in genome replication.
Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus.
Presence of an encephalomyocarditis virus internal ribosome entry site sequence in avian infectious bronchitis virus defective RNAs abolishes rescue by helper virus.
Recovery and characterization of a chimeric rinderpest virus with the glycoproteins of peste-des-petits-ruminants virus: homologous F and H proteins are required for virus viability.
Recovery of genetically defined murine norovirus in tissue culture by using a fowlpox virus expressing T7 RNA polymerase.
Reverse genetics system for the avian coronavirus infectious bronchitis virus.
Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses.
Friedreich Ataxia
A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro.
The GAA*TTC triplet repeat expanded in Friedreich's ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent manner.
Frontotemporal Dementia
Distinct pathways leading to TDP-43-induced cellular dysfunctions.
Gastric Antral Vascular Ectasia
Evaluation and management of gastrointestinal manifestations in scleroderma.
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis.
Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement.
Genetic Diseases, Inborn
Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
Glioblastoma
Inhibition of U6 snRNA Transcription by PTEN.
Glioma
C/EBP? mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas.
Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II.
Isoproterenol-induced selective phosphorylation in vivo of the 214,000 dalton subunit of rat C6 glioma cell RNA polymerase II.
Phosphorylation of rat C6 glioma cell DNA-dependent RNA polymerase II in vivo. Identification of phosphorylated subunits and modulation of phosphorylation by isoproterenol and N6,O2'-dibutyryl cyclic AMP.
RNA polymerase II in C6 glioma cells. Alpha-amanitin blockade of cAMP phosphodiesterase induction by beta-adrenergic stimulation.
Glomerulonephritis
Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma.
Hantavirus Infections
Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein.
Hearing Loss
Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
Heart Diseases
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hematologic Neoplasms
The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer.
Hemorrhagic Septicemia, Viral
An RNA-binding domain in the viral haemorrhagic septicaemia virus nucleoprotein.
Hepatic Insufficiency
[Prognostic use of the determination of serum AFP in acute hepatic insufficiency caused by the blockade of hepatocyte RNA polymerase II]
Hepatitis
A Reverse Genetics System for Cypovirus Based on a Bacmid Expressing T7 RNA Polymerase.
A reverse-genetics system for Influenza A virus using T7 RNA polymerase.
Capped small RNAs and MOV10 in human hepatitis delta virus replication.
Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II.
Conserved features of an RNA promoter for RNA polymerase II determined from sequence heterogeneity of a hepatitis delta virus population.
CRISPR-Cas9 mediated gene deletions in lager yeast Saccharomyces pastorianus.
Development of a novel Borna disease virus reverse genetics system using RNA polymerase II promoter and SV40 nuclear import signal.
Efficient and stable rescue of classical swine fever virus from cloned cDNA using an RNA polymerase II system.
Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs.
Endogenous promoters can direct the transcription of hepatitis delta virus RNA from a recircularized cDNA template.
Establishment of an entirely plasmid-based reverse genetics system for Bluetongue virus.
Formation of an RNA polymerase II preinitiation complex on an RNA promoter derived from the hepatitis delta virus RNA genome.
Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity.
High-frequency leader sequence switching during coronavirus defective interfering RNA replication.
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
ICTV Virus Taxonomy Profile: Deltavirus.
Identification and characterization of a hepatitis delta virus RNA transcriptional promoter.
Inhibition of Cellular RNA polymerase II transcription by delta antigen of hepatitis delta virus.
Molecular basis of RNA-dependent RNA polymerase II activity.
Multiple genomic sequences of hepatitis delta virus are associated with cDNA promoter activity and RNA double rolling-circle replication.
Phosphorylation of serine 177 of the small hepatitis delta antigen regulates viral antigenomic RNA replication by interacting with the processive RNA polymerase II.
Plant Gene Knockout and Knockdown by CRISPR-Cpf1 (Cas12a) Systems.
Recovery of a virulent strain of newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation.
Recovery of avian metapneumovirus subgroup C from cDNA: cross-recognition of avian and human metapneumovirus support proteins.
Recovery of infectious SV5 from cloned DNA and expression of a foreign gene.
Recovery of infectious type Asia1 foot-and-mouth disease virus from suckling mice directly inoculated with an RNA polymerase I/II-driven unidirectional transcription plasmid.
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Replication of flock house virus RNAs from primary transcripts made in cells by RNA polymerase II.
Rescue of influenza A virus from recombinant DNA.
Rescue of mumps virus from cDNA.
Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence.
Ribonucleic acid synthesis and nuclear ribonucleic acid polymerase activity in livers of mice infected with mouse hepatitis virus (MHV-3).
RNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases.
RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies.
Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells.
Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases.
Significantly improved rescue of rabies virus from cDNA plasmids.
Specific HDV RNA-templated transcription by pol II in vitro.
Stimulation of RNA polymerase II elongation by hepatitis delta antigen.
The human RNA polymerase II interacts with the terminal stem-loop regions of the hepatitis delta virus RNA genome.
The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza-virus-like RNAs with precise 3' ends in a plasmid-only-based virus rescue system.
The RNAs of hepatitis delta virus are copied by RNA polymerase II in nuclear homogenates.
Transcription of hepatitis delta virus RNA by RNA polymerase II.
Viroids: self-replicating, mobile, and fast-evolving noncoding regulatory RNAs.
Hepatitis A
Baculovirus mediated production of infectious hepatitis C virus in human hepatoma cells stably expressing t7 RNA polymerase.
Characterization of replication-competent hepatitis A virus constructs containing insertions at the N terminus of the polyprotein.
Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells.
The 5'-terminal nucleotides of hepatitis A virus RNA, but not poliovirus RNA, are required for infectivity.
Hepatitis B
A positive regulatory sequence of hepatitis B viral small X promoter.
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver.
Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II.
Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice.
Hepatitis B virus encodes an RNA polymerase III transcript.
Hepatitis B virus pX targets TFIIB in transcription coactivation.
Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway.
Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5.
Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein.
RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.
Rpb5, a subunit shared by eukaryotic RNA polymerases, cooperates with prefoldin-like Bud27/URI.
The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF.
The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.
The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.
The new core promoter element XCPE1 (X Core Promoter Element 1) directs activator-, mediator-, and TATA-binding protein-dependent but TFIID-independent RNA polymerase II transcription from TATA-less promoters.
Transcription of hepatitis B virus by RNA polymerase II.
Transcriptional regulation of the TATA-binding protein by Ras cellular signaling.
tRNA Lys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs.
Hepatitis C
Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1.
Activation of RNA polymerase I transcription by hepatitis C virus core protein.
Bacteriophage T7 RNA polymerase-based expression in Pichia pastoris.
Baculovirus mediated production of infectious hepatitis C virus in human hepatoma cells stably expressing t7 RNA polymerase.
ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver.
Hepatitis C viral proteins affect cell viability and membrane permeability.
Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons.
Interferon alpha-2b inhibits negative-strand RNA and protein expression from full-length HCV1a infectious clone.
Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription.
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
Systematic and large-scale two-hybrid screens.
Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV.
Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation.
Hepatitis, Chronic
Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice.
Herpes Simplex
A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.
A murine RNA polymerase I promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection.
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Activation of expression of multiple subfamilies of human Alu elements by adenovirus type 5 and herpes simplex virus type 1.
Activation of RNA polymerase II by topologically linked DNA-tracking proteins.
Activation of RNA polymerase III transcription of human Alu elements by herpes simplex virus.
An amplification-promoting sequence from mouse genomic DNA: interaction with a trans-acting factor that also affects gene expression.
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.
Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme.
Binding of ICP4, TATA-binding protein, and RNA polymerase II to herpes simplex virus type 1 immediate-early, early, and late promoters in virus-infected cells.
Characterization of RNA polymerase II-dependent transcription in Xenopus extracts.
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Cooperation between herpes simplex virus specific alpha protein and host cell RNA polymerase II in the transcription of viral deoxypyrimidine kinase.
Correction for Abrisch et al., Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
dUTPase from herpes simplex virus type 1; purification from infected green monkey kidney (Vero) cells and from an overproducing Escherichia coli strain.
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation.
Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation.
Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection.
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program.
Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II.
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Herpes simplex virus type 1 infection leads to loss of serine-2 phosphorylation on the carboxyl-terminal domain of RNA polymerase II.
Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes.
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II.
ICP27 Interacts with the C-Terminal Domain of RNA Polymerase II and Facilitates Its Recruitment to Herpes Simplex Virus 1 Transcription Sites, Where It Undergoes Proteasomal Degradation during Infection.
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.
Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.
Identification of transcription factories in nuclei of HeLa cells transiently expressing the Us11 gene of herpes simplex virus type 1.
In vitro transcription of herpes simplex virus genes. Partial purification and properties of RNA polymerase II from uninfected and infected Hep-2 cells.
In vitro transcription of herpes simplex virus genes: identification of a new initiation site and second intervening sequence in the immediate-early RNA-5 gene.
Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Inhibition of cdk9 during herpes simplex virus 1 infection impedes viral transcription.
Inhibition of cellular and virus-associated nucleotide polymerases by, and anti-herpes simplex virus activity of, streptovaricin derivatives.
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).
Levels of DNA-dependent RNA polymerases in herpes simplex virus-infected BHK21 C13 cells.
Mitotic transcription repression in vivo in the absence of nucleosomal chromatin condensation.
Protease footprinting reveals a surface on transcription factor TFIIB that serves as an interface for activators and coactivators.
Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit.
Purification and characterization of the herpes simplex virus type 1 ribonucleotide reductase small subunit following expression in Escherichia coli.
Regulation of herpes simplex virus gene transcription in vitro.
Repression of host RNA polymerase II transcription by herpes simplex virus type 1.
Requirement of host cell RNA polymerase II in the replication of herpes simplex virus in alpha-amanitin-sensitive and -resistant cell lines.
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.
Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.
Synthesis of herpes simplex virus-specified RNA by an RNA polymerase II in isolated nuclei in vitro.
TATA-binding protein and TBP-associated factors during herpes simplex virus type 1 infection: localization at viral DNA replication sites.
The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
The effects of herpes simplex virus type 1 on cellular DNA-dependent RNA polymerase activities.
The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae.
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.
Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters.
Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
Herpes Zoster
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.
HIV Infections
Continuation of postpartum antiretroviral therapy in a cohort of women infected with human immunodeficiency virus.
Huntington Disease
Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.
Hyperglycemia
Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney.
Hypersensitivity
Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae.
Conservation of major nuclease S1-sensitive sites in the non-conserved spacer region of ribosomal DNA in Drosophila species.
Defects in yeast RNA polymerase II transcription elicit hypersensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.
DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.
Escape from X inactivation varies in mouse tissues.
Identification and Characterization of Human snoRNA Core Promoters.
RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF.
Role of Mediator in Regulating Pol II Elongation and Nucleosome Displacement in Saccharomyces cerevisiae.
Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.
Site-specific silencing of regulatory elements as a mechanism of X inactivation.
Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Specificity in transcriptional regulation in the absence of specific DNA binding sites: the case of T7 lysozyme.
The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.
The role of transcriptional activator GATA-1 at human beta-globin HS2.
The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model.
Topoisomerase II? Deficiency Enhances Camptothecin-induced Apoptosis.
Transcription elongation factors repress transcription initiation from cryptic sites.
Transcriptional regulatory logic of the diurnal cycle in the mouse liver.
Underproduction of the largest subunit of RNA polymerase II causes temperature sensitivity, slow growth, and inositol auxotrophy in Saccharomyces cerevisiae.
Hypertrophy, Left Ventricular
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Hypogonadism
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.
Hypothyroidism
Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos.
Ichthyosis
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells.
Infections
A hybrid baculovirus-T7 RNA polymerase system for recovery of an infectious virus from cDNA.
A murine RNA polymerase I promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection.
A mutation in the yeast mitochondrial core RNA polymerase, Rpo41, confers defects in both specificity factor interaction and promoter utilization.
A NEW RIBONUCLEIC ACID POLYMERASE APPEARING AFTER MENGOVIRUS INFECTION OF L-CELLS.
A transcriptionally active form of TFIIIC is modified in poliovirus-infected HeLa cells.
Accumulation of poliovirus proteins in uninfected isolated HEp-2 cell nuclei in vitro.
Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1.
Activation of RNA polymerase I transcription by hepatitis C virus core protein.
Activation of RNA polymerase III transcription of human Alu elements by herpes simplex virus.
Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.
alpha-Amanitin-Resistant Viral RNA Synthesis in Nuclei Isolated from Nuclear Polyhedrosis Virus-Infected Heliothis zea Larvae and Spodoptera frugiperda Cells.
An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development.
An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4.
An inhibitor of host sigma-stimulated core enzyme activity that purifies with DNA-dependent RNA polymerase of E. coli following T4 phage infection.
An isotopic study of DNA-dependent RNA polymerase of E. coli following T4 phage infection.
Arabidopsis Histone Reader EMSY-LIKE 1 Binds H3K36 and Suppresses Geminivirus Infection.
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.
Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme.
Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.
Bacterial expression of immunoglobulin VH proteins.
Bacteriophage T7 DNA ejection into cells is initiated by an enzyme-like mechanism.
Bacteriophage T7 DNA packaging. I. Plasmids containing a T7 replication origin and the T7 concatemer junction are packaged into transducing particles during phage infection.
Baculovirus infection raises the level of TATA-binding protein that colocalizes with viral DNA replication sites.
Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma brucei.
Chemical structure of a modification of the Escherichia coli ribonucleic acid polymerase alpha polypeptides induced by bacteriophage T4 infection.
Cleavage of transcriptional activator Oct-1 by poliovirus encoded protease 3Cpro.
Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors.
Cloning and expression of a recombinant CagA -gene fragment of Helicobacter pylori and its preliminary evaluation in serodiagnosis.
Coding sequences enhance internal initiation of translation by hepatitis A virus RNA in vitro.
Construction of infectious cDNA clones for RNA viruses: Turnip crinkle virus.
Control of promoter utilization by bacteriophage T4-induced modification of RNA polymerase alpha subunit.
Correction for Abrisch et al., Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease. A retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children.
Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells.
Deletion mapping of a mouse hepatitis virus defective interfering RNA reveals the requirement of an internal and discontiguous sequence for replication.
Delivery and expression of heterologous genes in mammalian cells using self-replicating alphavirus vectors.
Detection of a subunit of cellular Pol II within highly purified preparations of RNA polymerase isolated from rabbit poxvirus virions.
Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitro.
Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.
Disruption of Nuclear Organization during the Initial Phase of African Swine Fever Virus Infection.
DNA-dependent RNA polymerases from Schneider 2-L cells of Drosophila. II. Response to infection by an endogenous picorna-like virus.
Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III.
Effects of poliovirus 2A(pro) on vaccinia virus gene expression.
Efficiency of VIGS and gene expression in a novel bipartite potexvirus vector delivery system as a function of strength of TGB1 silencing suppression.
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.
Efficient silencing of hepatitis B virus by helper-dependent adenovirus vector-mediated delivery of artificial antiviral primary micro RNAs.
ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver.
Enhancement of RNA polymerase III transcription by the E1A gene product of adenovirus.
Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA.
Establishment of a Nipah virus rescue system.
Evidence for direct involvement of T7 RNA polymerase bacteriophage DNA replication.
Evolution of bacteriophage T7 in a growing plaque.
Expression and nuclear localization of the TATA-binding protein during baculovirus infection.
Expression of cDNA encoding the Sendai virus hemagglutinin-neuraminidase gene: characterization of wild-type and mutant gene products.
Expression of hepatitis A virus precursor protein P3 in vivo and in vitro: polyprotein processing of the 3CD cleavage site.
Expression of poliovirus 2Apro in mammalian cells: effects on translation.
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Genome characterization, infectivity assays of in vitro and in vivo infectious transcripts of soybean yellow mottle mosaic virus from India reveals a novel short mild genotype.
Genome-wide mapping of infection-induced SINE RNAs reveals a role in selective mRNA export.
Genome-wide profiling of chicken dendritic cell response to infectious bursal disease.
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.
Hepatitis B virus X protein partially substitutes for E1A transcriptional function during adenovirus infection.
Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection.
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program.
Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II.
Herpes simplex virus type 1 infection leads to loss of serine-2 phosphorylation on the carboxyl-terminal domain of RNA polymerase II.
High level expression and purification of HhaI methyltransferase.
Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression.
Hsc70 Focus Formation at the Periphery of HSV-1 Transcription Sites Requires ICP27.
HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III.
Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes.
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II.
ICP27 Interacts with the C-Terminal Domain of RNA Polymerase II and Facilitates Its Recruitment to Herpes Simplex Virus 1 Transcription Sites, Where It Undergoes Proteasomal Degradation during Infection.
ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expression.
Identification of upstream promoter elements mediating early transcription from the 35,000-molecular-weight protein gene of Autographa californica nuclear polyhedrosis virus.
Identifying the RNA polymerases that synthesize specific transcripts of the Autographa californica nuclear polyhedrosis virus.
IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications.
Impairment of host cell ribonucleic acid polymerase II after infection with frog virus 3.
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter.
Influence of RNA polymerase II upon vaccinia virus-related translation examined by means of alpha-amanitin.
Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle.
Influenza virus infection causes global RNAPII termination defects.
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.
Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro.
Inhibition of cdk9 during herpes simplex virus 1 infection impedes viral transcription.
INHIBITION OF DEOXYRIBONUCLEIC ACID-DIRECTED RIBONUCLEIC ACID POLYMERASE IN ESCHERICHIA COLI AFTER INFECTION WITH BACTERIOPHAGE T4.
Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.
Inhibition of host cell RNA polymerase III-mediated transcription by poliovirus: inactivation of specific transcription factors.
Inhibition of rRNA synthesis by poliovirus: specific inactivation of transcription factors.
Inhibition of transcription factor activity by poliovirus.
Insight into DNA and protein transport in double-stranded DNA viruses: the structure of bacteriophage N4.
Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites.
Intracellular hepatitis C virus RNA-dependent RNA polymerase activity.
Low molecular weight viral RNAs transcribed by RNA polymerase III during adenovirus 2 infection.
Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection.
Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription.
Modulatory effect of rRNA synthesis and ppUL83 nucleolar compartmentalization on human cytomegalovirus gene expression in vitro.
Molecular Pathways: Involvement of Helicobacter pylori-Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers.
Multiple roles of T7 RNA polymerase and T7 lysozyme during bacteriophage T7 infection.
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.
New small polypeptides associated with DNA-dependent RNA polymerase of Escherichia coli after infection with bacteriophage T4.
New small proteins associated with DNA-dependent RNA polymerase of Escherichia coli after infection with T4 phage.
Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis.
Occupancy of chromatin organizers in the Epstein-Barr virus genome.
ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68.
Overproduction of the toxic protein, bovine pancreatic DNaseI, in Escherichia coli using a tightly controlled T7-promoter-based vector.
Poliovirus 3C protease-mediated degradation of transcriptional activator p53 requires a cellular activity.
Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus.
Production of pro-opiomelanocortin (POMC) by a vaccinia virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme.
Purification and characterization of bacteriophage gh-I-induced deoxyribonucleic acid-dependent ribonucleic acid polymerase from Pseudomonas putida.
Quantitative real time RT-PCR study of pathogen-induced gene expression in rock bream (Oplegnathus fasciatus): Internal controls for data normalization.
Recognition properties of the beta subunit of Escherichia coli ribonucleic acid polymerase.
Recovery of DNA-dependent RNA polymerase activities from L cells after mengovirus infection.
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Recruitment to the cytoplasm of a cellular lamin-like protein from the nucleus during a poxvirus infection.
Regulation of herpes simplex virus gene transcription in vitro.
Regulation of histone deposition on the herpes simplex virus type 1 genome during lytic infection.
Reorganization of RNA polymerase II on the SV40 genome occurs coordinately with the early to late transcriptional switch.
Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells.
RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.
RNA Polymerase III as a Gatekeeper to Prevent Severe VZV Infections.
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
RNA-polymerase, type I: activity in rat brain cell nuclei and peripheral blood mononuclear cells after Venezuelan equine encephalomyelitis virus infection.
Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection.
Role of Viral Hemorrhagic Septicemia Virus Matrix (M) Protein in Suppressing Host Transcription.
Roles of vaccinia virus ribonucleotide reductase and glutaredoxin in DNA precursor biosynthesis.
rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus.
Sarcocysts of an unidentified species of Sarcocystis in the sea otter (Enhydra lutris).
Scaffold attachment factor B suppresses HIV-1 infection of CD4+ T cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat.
Selective transcription of vaccinia virus genes in template dependent soluble extracts of infected cells.
Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice.
Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells.
Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.
Synthesis of a eukaryotic virus protein in a prokaryotic viral-cell system: production of the adenovirus type 2 fiber shaft fragment by a tightly regulated T7POL-M13 expression system.
T7 infection-dependent selective expression of cloned genes in P1-lysogenic Escherichia coli.
T7 lysozyme inhibits transcription by T7 RNA polymerase.
T7-promoter-based Escherichia coli expression system induced with bacteriophage M13HEP.
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
Temporal studies of factors associated with changes in transcription during Q fever.
The 19S proteasome activator promotes human cytomegalovirus immediate early gene expression through proteolytic and nonproteolytic mechanisms.
The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes.
The effect of Mengovirus infection on the activity of the DNA-dependent RNA polymerase of L-cells.
The effect of mengovirus infection on the activity of the DNA-dependent RNA polymerase of L-cells. II. Preliminary data on the inhibitory factor.
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
The N-terminus of Bunyamwera virus NSs protein is essential for interferon antagonism.
The protamine-like DNA-binding protein P6.9 epigenetically up-regulates Autographa californica multiple nucleopolyhedrovirus gene transcription in the late infection phase.
The simian immunodeficiency virus targets central cell cycle functions through transcriptional repression in vivo.
The transcriptional role of host DNA-dependent RNA polymerases in adenovirus-infected KB cells.
The use of adenovirus-infected HeLa cells for the detection of low titer autoantibodies.
Transcription of methylated viral DNA by eukaryotic RNA polymerase II.
Transcription of the bovine parvovirus genome in isolated nuclei.
Transcription unit mapping in adenovirus: regions of termination.
Trichinella spiralis-infected muscle cells: abundant RNA polymerase II in nuclear speckle domains colocalizes with nuclear antigens.
Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A.
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.
Vaccinia virus-bacteriophage T7 expression vector for complementation analysis of late gene processes.
Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins.
VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.
Wide range of quasispecies diversity during primary hepatitis C virus infection.
[Construction of minigenome of Newcastle disease virus of goose origin and its preliminary application]
[Effect of the attenuated strain (TC-83) of Venezuelan equine encephalitis virus on nuclear transcription in rat brain cells]
Infertility
KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth.
Infertility, Male
DSP1 and DSP4 Act Synergistically in Small Nuclear RNA 3' End Maturation and Pollen Growth.
Influenza in Birds
Avian Influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection.
Influenza, Human
A Mechanism for the Activation of the Influenza Virus Transcriptase.
A reverse-genetics system for Influenza A virus using T7 RNA polymerase.
An efficient screening system for influenza virus cap-dependent endonuclease inhibitors.
Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II.
Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.
Characterization of the ribonucleic acid product synthesized by on influenza A2 virus-induced ribonucleic acid polymerase in vitro.
CHD6, a Cellular Repressor of Influenza Virus Replication, Is Degraded in Human Alveolar Epithelial Cells and Mice Lungs during Infection.
Cloning of the canine RNA polymerase I promoter and establishment of reverse genetics for influenza A and B in MDCK cells.
Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells.
Cloning the Horse RNA Polymerase I Promoter and Its Application to Studying Influenza Virus Polymerase Activity.
Comparison of vRNA and cRNA based reporters for detection of influenza replication.
Cyclin T1/CDK9 interacts with influenza A viral polymerase and facilitates its association with cellular RNA Polymerase II.
Deoxyribonucleic acid-dependent ribonucleic acid polymerase activity in cells infected with influenza virus.
Detection and identification of human influenza viruses by the polymerase chain reaction.
DNA intercalator stimulates influenza transcription and virus replication.
Efficient translation of mRNAs in influenza A virus-infected cells is independent of the viral 5' untranslated region.
Establishment and characterization of a Madin-Darby canine kidney reporter cell line for influenza A virus assays.
Fluorometric detection of influenza viral RNA using graphene oxide.
Functional association between viral and cellular transcription during influenza virus infection.
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.
Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.
Human RNA polymerase I-driven reverse genetics for influenza a virus in canine cells.
Imaging and characterizing influenza A virus mRNA transport in living cells.
Improved and simplified recombineering approach for influenza virus reverse genetics.
In vitro product of a ribonucleic acid polymerase induced by influenza virus.
In vivo activity of an inhibitor of influenza virus-induced ribonucleic acid polymerase.
Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export.
Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection.
Influenza A virus preferentially snatches noncoding RNA caps.
Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle.
Influenza virus infection causes global RNAPII termination defects.
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.
Influenza virus inhibits RNA polymerase II elongation.
Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription.
Influenza virus-induced ribonucleic acid nucleotidyltransferase and the effect of actinomycin D on its formation.
Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.
Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate.
Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery.
Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells.
Membrane-anchored incorporation of a foreign protein in recombinant influenza virions.
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.
Mutational analysis of influenza virus promoter elements in vivo.
Mutations in influenza virus replication and transcription: detection of amino acid substitutions in hemagglutinin of an avian influenza virus (H1N1).
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response.
Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies.
Nuclear export of influenza A virus mRNAs requires ongoing RNA polymerase II activity.
Partial and full PCR-based reverse genetics strategy for influenza viruses.
Participation of DNA-dependent RNA polymerase II in replication of influenza viruses.
Plasmid-driven formation of influenza virus-like particles.
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex.
Rescue of a synthetic chloramphenicol acetyltransferase RNA into influenza virus-like particles obtained from recombinant plasmids.
Rescue of influenza B virus from eight plasmids.
Reverse genetics of influenza virus.
Reverse genetics of the avian influenza virus.
Reverse genetics system for Uukuniemi virus (Bunyaviridae): RNA polymerase I-catalyzed expression of chimeric viral RNAs.
RNA polymerase I catalysed transcription of insert viral cDNA.
RNA polymerase I-mediated expression of influenza viral RNA molecules.
RNA Polymerase II Inhibitors Dissociate Antigenic Peptide Generation from Normal Viral Protein Synthesis: A Role for Nuclear Translation in Defective Ribosomal Product Synthesis?
RNA primers and the role of host nuclear RNA polymerase II in influenza viral RNA transcription.
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
Selection of the 5'-proximal translation initiation site is influenced by mRNA and eIF-2 concentrations.
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein.
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Specific inhibition of influenza virus-induced ribonucleic acid polymerase by gliotoxin.
Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice.
Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins.
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Synthesis of influenza virus polypeptides in cells resistant to alpha-amanitin: evidence for the involvement of cellular RNA polymerase II in virus replication.
Synthesis of influenza virus: new impetus from an old enzyme, RNA polymerase I.
T7 RNA polymerase can direct expression of influenza virus cap-binding protein (PB2) in Escherichia coli.
The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins.
The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza-virus-like RNAs with precise 3' ends in a plasmid-only-based virus rescue system.
The role of the influenza virus RNA polymerase in host shut-off.
The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template.
The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative- and positive-strand RNA viruses.
Thogoto and Dhori virus replication is blocked by inhibitors of cellular polymerase II activity but does not cause shutoff of host cell protein synthesis.
Transcription of the influenza ribonucleic acid genome by a virion polymerase. I. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymerase.
Virus-inducible reporter genes as a tool for detecting and quantifying influenza A virus replication.
[Inhibitory effect of 3'-azido-3'-azido-3'-deoxy- ribavirin-5'-triphosphate on RNA synthesis catalyzed by RNA polymerase from influenza A virus and by cellular DNA-dependent RNA polymerase II]
[The reverse genetics systems for human and animal RNA viruses]
Insulin Resistance
Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.
Insulinoma
Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme.
Intellectual Disability
Dysregulations of sonic hedgehog signaling in MED12-related X-linked intellectual disability disorders.
Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling.
Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.
Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Keratitis
Phylogenetic diversity and microsphere array-based genotyping of human pathogenic Fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006.
Kidney Failure, Chronic
Increase in deoxyribonuclease activity in uraemic lymphocytes is caused by the cleavage of the largest polymerase I subunit.
Leiomyoma
Screening of potential biomarkers in uterine leiomyomas disease via gene expression profiling analysis.
Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells.
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
Leiomyosarcoma
miRNA deregulation targets specific pathways in leiomyosarcoma development: an in silico analysis.
Leprosy
Polymerase chain reaction for the detection of Mycobacterium leprae.
Leukemia
A novel CDK9 inhibitor shows potent anti-tumor efficacy in preclinical hematological tumor models.
A Phase I Trial of Vorinostat and Alvocidib in Patients with Relapsed, Refractory, or Poor Prognosis Acute Leukemia, or Refractory Anemia with Excess Blasts-2.
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus.
Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma.
Decontamination of polymerase chain reaction reagents using DEAE-cellulose.
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.
Dual coding potential of a 2',5'-branched ribonucleotide in DNA.
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC).
Effect of morpholinyladriamycin analogs and adriamycin on the activities of DNA polymerase alpha and RNA polymerase II of chicken leukemia cells.
Effects of streptovaricins and their degradation products on RNA-directed DNA polymerase of Rauscher leukemia virus.
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Identification of a RNA polymerase II initiation site in the long terminal repeat of Moloney murine leukemia viral DNA.
In vitro transcription of Moloney leukemia virus genes in infected cell nuclei and chromatin: elongation of chromatin associated ribonucleic acid by Escherichia coli ribonucleic acid polymerase.
Inhibition of human immunodeficiency virus-1 reverse transcriptase by heme and synthetic heme analogs.
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Interaction of N-trifluoroacetyladriamycin-14-O-hemiadipate with chicken leukemia RNA polymerase. Formation of drug-enzyme complex.
Isolation and purification of protein kinase C from human leukemia ML-1 cells phosphorylation of human leukemia RNA polymerase II in vitro.
Liver-directed gene therapy: quantitative evaluation of promoter elements by using in vivo retroviral transduction.
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Multiple DNA-dependent RNA polymerases from mouse leukemia L 1210 ascites cells.
Novel approaches to reversing anti-cancer drug resistance using gene-specific therapeutics.
Novel Real-Time Simultaneous Amplification and Testing Method To Accurately and Rapidly Detect Mycobacterium tuberculosis Complex.
Optimization of in vitro transcription and full-length cDNA synthesis using the T4 bacteriophage gene 32 protein.
Proteasomes degrade proteins in focal subdomains of the human cell nucleus.
Protein kinase C phosphorylates leukemia RNA polymerase II.
RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies.
Role of divalent ion complex formation in pyran--inhibition of nucleic acid biosynthesis.
Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1.
Specific transcriptional initiation in vitro on murine type C retrovirus promoters.
Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.
Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.
The 24,000 Da subunit is not required for the RNA synthesis activity of chicken leukemia RNA polymerase II.
The ability of a variety of polymerases to synthesize past site-specific cis-syn, trans-syn-II, (6-4), and Dewar photoproducts of thymidylyl-(3'-->5')-thymidine.
The elongation factor ELL (eleven-nineteen lysine-rich leukemia) is a selective coregulator for steroid receptor functions.
The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.
The little elongation complex regulates small nuclear RNA transcription.
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.
The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription.
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins.
Transcription elongation and human disease.
[Activity of DNA-dependent RNA polymerases A and B in spleen nuclei of mice infected with Rauscher leukemia virus]
[Application of transcription mediated amplification and real-time reverse transcription polymerase chain reaction in detection of human immunodeficiency virus RNA].
[Detection of serum HCV RNA in patients with chronic hepatitis C by transcription mediated amplification and real-time reverse transcription polymerase chain reaction].
[DNA-dependent RNA polymerases in human leukocytes. II different specific activities of the polymerases A and B in acute and chronic leukemia and their prognostic relevance (author's transl)]
[Effect of methotrexate on the activity of DNA-dependent RNA polymerases (A and B) in the spleen of mice infected with Rauscher leukemia virus and on the development of virus-induced leukemia]
Leukemia L1210
Multiple DNA-dependent RNA polymerases from mouse leukemia L 1210 ascites cells.
Purification and properties of RNA polymerase II from mouse leukemia L1210 ascites cells.
[RNA-polymerase of murine leukemia L1210 cells]
Leukemia, Erythroblastic, Acute
Accurate in vitro initiation of beta-globin gene transcription in induced Friend-cell nuclei.
Assembly of nuclear ribonucleoprotein particles during in vitro transcription.
Characterization of an unique RNA initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro: polymerase II-dependence, tissue specificity, and subcellular location.
RNA polymerase II transcripts as targets for 5-fluorouridine cytotoxicity: antagonism of 5-fluorouridine actions by alpha-amanitin.
USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the {beta}-globin gene locus.
Leukemia, Lymphocytic, Chronic, B-Cell
Template properties of human DNA-dependent RNA polymerase II.
[Free and template-bound RNA polymerase in normal and leukaemic human lymphocytes (author's transl)]
Leukemia, Myeloid
Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival.
Inhibition of RNA polymerase I transcription in differentiated myeloid leukemia cells by inactivation of selectivity factor 1.
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
Leukemia, Myeloid, Acute
Aberrant hypomethylated STAT3 was identified as a biomarker of chronic benzene poisoning through integrating DNA methylation and mRNA expression data.
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II.
CX-5461 inhibits RNA Pol I in blood cancers.
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
ELL2, a new member of an ELL family of RNA polymerase II elongation factors.
Expression and Role of the ErbB3 Binding Protein 1 in Acute Myelogenous Leukemic Cells.
Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3.
Targeting mitochondrial RNA polymerase in acute myeloid leukemia.
Leukemia, T-Cell
Host range of human T-cell leukemia virus type I analyzed by a cell fusion-dependent reporter gene activation assay.
Human T-cell leukemia virus type I Tax protein transactivates RNA polymerase III promoter in vitro and in vivo.
In vitro transcription of human T-cell leukemia virus type 1 is RNA polymerase II dependent.
Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.
Leukoencephalopathies
Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy.
Leukoplakia
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Leukoplakia, Oral
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Li-Fraumeni Syndrome
RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.
Lipodystrophy
Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction.
Liposarcoma
Localization and characterization of the RNA binding protein TLS in skin and stratified mucosa.
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.
Liposarcoma, Myxoid
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.
Liver Cirrhosis
Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1.
Liver Failure, Acute
Benzylpenicyllin and acetylcysteine protection from alpha-amanitin-induced apoptosis in human hepatocyte cultures.
Liver Neoplasms
Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis.
Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA binding protein MBD2.
Liver Neoplasms, Experimental
Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII.
Characterization of factors that direct transcription of rat ribosomal DNA.
Identification of a La protein binding site in a RNA polymerase III transcript (4.5 I RNA).
Phosphorylation of deoxyribonucleic acid dependent RNA polymerase II by nuclear protein kinase NII: mechanism of enhanced ribonucleic acid synthesis.
Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I.
Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides.
Protein kinase NII. Interaction with RNA polymerase II and contribution to immunological cross-reactivity of RNA polymerases I and II.
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Lung Neoplasms
A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network.
Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824.
CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells.
Gender Specific Differences in RNA Polymerase III Transcription.
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Incidence, risk factors and outcomes of cancer in systemic sclerosis.
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Lupus Erythematosus, Systemic
Association of autoantibodies to topoisomerase I and the phosphorylated (IIO) form of RNA polymerase II in Japanese scleroderma patients.
Autoantibodies and autoantigens in the urine of SLE patients.
Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.
Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma.
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
Immunization of rabbits with purified RNA polymerase I induces a distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic lupus erythematosus.
Phosphorylation of RNA polymerase I augments its interaction with autoantibodies of systemic lupus erythematosus patients.
Production of monoclonal antibodies against RNA polymerase I from nonimmunized autoimmune MRL/lpr mice and their use in rDNA transcription analysis.
Lymphocytic Choriomeningitis
Rescue of the prototypic Arenavirus LCMV entirely from plasmid.
Lymphoma
Detection of t(8;14)(q24;q32) by polymerase chain reaction for long DNA targets: a report of two patients with B-cell non-Hodgkin's lymphoma.
Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.
Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate.
Lymphoma, B-Cell, Marginal Zone
Increased sensitivity of B-cell clonality analysis in formalin-fixed and paraffin-embedded B-cell lymphoma samples using an enzyme blend with both 5'-->3' DNA polymerase and 3'-->5' exonuclease activity.
Lymphoma, Non-Hodgkin
Heat shock selectively inhibits ribosomal RNA gene transcription and down-regulates E1BF/Ku in mouse lymphosarcoma cells.
Malaria
An unusual recent expansion of the C-terminal domain of RNA polymerase II in primate malaria parasites features a motif otherwise found only in mammalian polymerases.
The C-terminal domain of RNA polymerase II of the malaria parasite Plasmodium berghei.
The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites.
Malnutrition
Ribonucleic acid metabolism in rat liver during long-term adaptation to malnutrition.
Mandibulofacial Dysostosis
The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome.
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity.
Marfan Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Measles
Measles virus prevalence in otosclerotic foci.
Rescue system for measles virus from cloned cDNA driven by vaccinia virus Lister vaccine strain.
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
[Rescue of minireplicon by using the cell line stably expressing the T7 RNA polymerase]
Melanoma
Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.
BRAF inhibition sensitizes melanoma cells to ?-amanitin via decreased RNA polymerase II assembly.
Cytoskeletal Filamin A Differentially Modulates RNA Polymerase III Gene Transcription in Transformed Cell Lines.
Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response.
Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.
Incidence, risk factors and outcomes of cancer in systemic sclerosis.
Lentivirus-mediated bifunctional cell labeling for in vivo melanoma study.
Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.
Therapeutic interventions to disrupt the protein synthetic machinery in melanoma.
Meningioma
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas.
Meningitis, Bacterial
Can Broad-Range 16S Ribosomal Ribonucleic Acid Gene Polymerase Chain Reactions Improve the Diagnosis of Bacterial Meningitis? A Systematic Review and Meta-analysis.
Mesothelioma
In Vivo Imaging of Human Malignant Mesothelioma Grown Orthotopically in the Peritoneal Cavity of Nude Mice.
Mixed Connective Tissue Disease
Class II ribonuclease H comigrates with, but is distinct from, the third largest subunit of calf thymus RNA polymerase I.
Molluscum Contagiosum
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.
Molluscum contagiosum -- a defective poxvirus?
Mouth Neoplasms
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Laser capture microdissection-generated target sample for high-density oligonucleotide array hybridization.
Multiple Myeloma
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
CX-5461 inhibits RNA Pol I in blood cancers.
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.
RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.
The Covalent CDK7 Inhibitor THZ1 Potently Induces Apoptosis in Multiple Myeloma Cells In Vitro and In Vivo.
Mumps
Rescue of mumps virus from cDNA.
Myelodysplastic Syndromes
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1.
Myositis
Inclusion body myositis in a patient with RNA polymerase III antibody-positive systemic sclerosis.
Novel cytoplasmic immunolocalization of RNA polymerase II in inclusion-body myositis muscle.
Myositis, Inclusion Body
Inclusion body myositis in a patient with RNA polymerase III antibody-positive systemic sclerosis.
Myotonic Dystrophy
Transcriptional properties of RNA polymerase II within triplet repeat-containing DNA from the human myotonic dystrophy and fragile X loci.
Neoplasm Metastasis
Mediator of RNA polymerase II transcription subunit 19 promotes osteosarcoma growth and metastasis and associates with prognosis.
Neoplasms
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
A novel CDK9 inhibitor shows potent anti-tumor efficacy in preclinical hematological tumor models.
A novel sensing platform using aptamer and RNA polymerase-based amplification for detection of cancer cells.
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression.
A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network.
A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries.
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
A tRNA with oncogenic capacity.
A wave of nascent transcription on activated human genes.
Accurate transcription initiation in an Ehrlich ascites tumor cell lysate.
Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.
Activation of putative transposition intermediate formation in tumor cells.
Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo.
Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells.
Alcohol-associated cancer and deregulation of Pol III genes.
Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A.
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription.
An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA.
Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities.
Analysis of the mechanisms mediating tumor-specific changes in gene expression in human liver tumors.
Analyzing RNA polymerase III by electron cryomicroscopy.
Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.
Association Between Germline Mutations in BRF1, a subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer.
AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes.
Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer.
Bias in detection of instability of the (C)8 mononucleotide repeat of MSH6 in tumours from HNPCC patients.
Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts.
BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.
BRCA1 associates with processive RNA polymerase II.
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
BRCA1 is a component of the RNA polymerase II holoenzyme.
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator.
BRCA1-dependent and independent functions of BARD1.
BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.
BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity.
BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.
Broad targeting of triptolide to resistance and sensitization for cancer therapy.
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.
Cancer and systemic sclerosis: novel insights into pathogenesis and clinical implications.
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
Cell cycle dependent oscillatory expression of estrogen receptor-? links Pol II elongation to neoplastic transformation.
Characterization of hampin/MSL1 as a node in the nuclear interactome.
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals constitutive expression in tumors and transcriptional interaction with viral microRNAs.
Characterizing functional consequences of DNA copy number alterations in breast and ovarian tumors by spaceMap.
Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation.
Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01).
Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.
Comparison of nuclear DNA-dependent RNA polymerases from mouse tumors and tissues of normal Swiss mice.
Comparison of the effects of polyamines on the activities of RNA polymerases from murine normal tissues and transplantable tumors.
Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate.
Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.
Conformational change of DNA binding subunit of RNA polymerase II on binding to DNA.
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ER?-positive breast tumorigenesis.
CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma.
CX-5461 inhibits RNA Pol I in blood cancers.
Cyclin D1 activation in B-cell malignancy: association with changes in histone acetylation, DNA methylation, and RNA polymerase II binding to both promoter and distal sequences.
Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.
Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma.
Cytoplasmic steroid effects on nuclear RNA polymerase activity in canine mammary carcinomas.
Daunorubicin inhibition of DNA-dependent RNA polymerases from Ehrlich ascites tumor cells.
Deletion mapping of tumor promotion-susceptibility gene pro1 implicates an RNA polymerase III transcription unit.
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Dexamethasone increases the number of RNA polymerase II molecules transcribing integrated mouse mammary tumor virus DNA and flanking mouse sequences.
Difference in phosphorylation of two factors stimulating RNA polymerase II of Ehrlich ascites tumor cells.
Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.
Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.
Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas.
Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini.
Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9.
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics.
Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.
DNA binding preferences of S. cerevisiae RNA polymerase I Core Factor reveal a preference for the GC-minor groove and a conserved binding mechanism.
DNA damage and the DNA-activated protein kinase.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II.
DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. V. Characterization of a factor repressing RNA polymerase II as a ribonucleoprotein.
DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer.
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. 3. Ribonuclease H and elongating activity of stimulatory factor S-II.
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. I. Partial purification and characterization of RNA polymerase II.
DNA-dependent RNA polymerase from T8 Guerin tumor.
DNA-dependent RNA polymerase I from hepatomas: comparison of activity levels and properties.
DNA-dependent RNA polymerases of Ehrlich carcinoma, other murine ascites tumors, and murine normal tissues.
Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ER?-negative Breast Cancers to Tamoxifen through ER? Reexpression.
Dysregulation of RNA polymerase I transcription during disease.
Early increases in ribonucleic acid polymerase activities of dimethylbenzanthracene-induced mammary tumour nuclei in response to oestradiol-17beta and tamoxifen.
eEF1A is a novel component of the mammalian nuclear protein export machinery.
Effect of sex hormones on RNA synthesis of androgen-dependent mouse mammary tumor (Shionogi carcinoma).
Effect of tumour growth on hepatic neutral ribonuclease and its inhibitor and on RNA polymerase activity of liver nuclei.
Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.
Effects on prostate cancer cells of targeting RNA polymerase III.
Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells.
ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
Elevated RNA polymerase III transcription drives proliferation and oncogenic transformation.
Elevated snoRNA biogenesis is essential in breast cancer.
Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes.
Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis.
Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
Enhancement of ormation of the initiation complex by factor stimulating RNA polymerase II from Ehrlich ascites tumor cells.
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III.
Epigenetics and microRNAs.
Epitope mapping by phage display: random versus gene-fragment libraries.
ER? mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.
Estrogen Receptor-? Modulation of the ER?-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer.
Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.
Evidence that mouse promotion-sensitivity gene pro1 is transcribed by RNA polymerase III.
Evidence that stimulatory factor(s) of RNA polymerase II participates in accurate transcription in a HeLa cell lysate.
Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma.
Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells.
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Fluorescent conjugated polymer-based FRET technique for detection of DNA methylation of cancer cells.
Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Gene expression analysis of EpiDerm following exposure to SLS using cDNA microarrays.
Generation of antigen-presenting cells using cultured dendritic cells and amplified autologous tumor mRNA.
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative.
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.
Histone methyltransferase Smyd3 regulates early embryonic lineage commitment in mice.
Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells.
Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.
Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis.
Identification of subunits of RNA polymerase II from Ehrlich ascites tumor cells.
Identification of the DNA binding subunit of RNA polymerase II from Ehrlich ascites tumor cells.
In vitro effect of androgen on RNA synthesis in nuclei from androgen-independent subline of Shionogi carcinoma (CS 2).
In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.
Incidence, risk factors and outcomes of cancer in systemic sclerosis.
Inhibition of DNA-dependent RNA polymerase from sarcoma-180 ascites tumour cells by DNA-binding antitumor antibiotics.
Inhibition of Human Carcinoma and Neuroblastoma Cell Proliferation by Anti-c-myc siRNA.
Inhibition of nuclear DNA-dependent RNA polymerases from mouse ascites tumors and liver by glycerol.
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Inhibition of U6 snRNA Transcription by PTEN.
INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Integrative Bioinformatics Analysis Reveals Potential Long Non-Coding RNA Biomarkers and Analysis of Function in Non-Smoking Females with Lung Cancer.
Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers.
Intragenic DNA methylation prevents spurious transcription initiation.
Isolated Hepatic Perfusion with High-Dose Melphalan Results in Immediate Alterations in Tumor Gene Expression in Patients with Metastatic Ocular Melanoma.
Knockdown of MED19 by Short Hairpin RNA-Mediated Gene Silencing Inhibits Pancreatic Cancer Cell Proliferation.
Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation.
Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR.
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Maf1, a new player in the regulation of human RNA polymerase III transcription.
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery.
Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters.
Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative.
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.
Microbial Synthesis of 5-Aminolevulinic Acid and Its Coproduction with Polyhydroxybutyrate.
MicroRNA expression data analysis to identify keymiRNAs associated with Alzheimer's disease.
Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance.
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control.
Myc and mRNA capping: Revised manuscript with changes in green.
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.
New roles for Dicer in the nucleolus and its relevance to cancer.
New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
Non-coding RNA production by RNA polymerase III is implicated in cancer.
Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis.
Novel Assay to Detect RNA Polymerase I Activity in vivo.
Novel roles for elongin C in yeast.
Nuclear and cytoplasmic glycosylation.
Nuclear DNA-dependent RNA polymerases of Ehrlich ascites tumor cells: two discrete -amanitin-sensitive forms.
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.
Nuclear RNA polymerase activity in tumor-host livers.
Nucleolar size indicates the rapidity of cell proliferation in cancer tissues.
O-GlcNAc and the control of gene expression.
p53 localizes to intranucleolar regions distinct from the ribosome production compartments.
p53, a translational regulator: contribution to its tumour-suppressor activity.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease.
Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies.
Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription.
Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I.
POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients.
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Polymorphisms in the large subunit of human RNA polymerase II as target for allele-specific inhibition.
Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.
Problem-solving test: The effect of in vitro bisulfite treatment on genomic DNA.
Protective Effect Against Cancer of Antibodies to the Large Subunits of Both RNA Polymerases I and III in Scleroderma.
Protein which interacts with a stimulatory factor of RNA polymerase II of Ehrlich ascites tumor cells.
PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain.
PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription.
Purification and preparation of antibody to RNA polymerase II stimulatory factors from Ehrlich ascites tumor cells.
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase II from the mouse plasmacytoma, MOPC 315.
Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II.
Purification of a new protein stimulating RNA polymerase II from Ehrlich ascites tumor cells: comparison with proteins purified before.
Recent insights into regulation of transcription by RNA polymerase III and the cellular functions of its transcripts.
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors.
Reciprocal regulation of miR-122 and c-Myc in hepatocellular cancer: Role of E2F1 and TFDP2.
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.
Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei.
Regulation of nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Regulation of rDNA transcription in response to growth factors, nutrients and energy.
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.
Regulation of RNA polymerase III transcription in response to Simian virus 40 transformation.
Regulation of the nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Repression of RNA polymerase I transcription by the tumor suppressor p53.
Repression of RNA polymerase III transcription by the retinoblastoma protein.
Response of skeletal muscle RNA polymerases I and II to tumour growth.
Retrostatin, a new specific enzyme inhibitor against avian myeloblastosis virus reverse transcriptase.
Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro.
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling.
Ribonucleic acid transcriptase acitvity in purified wound tumor virus.
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
RMP promotes the proliferation and radioresistance of esophageal carcinoma.
RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.
RNA Interference Remarkably Suppresses bcl-2 Gene Expression in Cancer Cells in Vitro and in Vivo.
RNA polymerase activity in homotransplanted rat brain tumors initially induced by ethylnitrosourea.
RNA polymerase I in hepatoma 3924A: mechanism of enhanced activity relative to liver.
RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.
RNA polymerase III repression by the retinoblastoma tumor suppressor protein.
RNA polymerase III transcription and cancer.
RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.
RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.
RNA polymerase III transcription in cancer: the BRF2 connection.
RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.
RNA polymerase III transcription--a battleground for tumour suppressors and oncogenes.
RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents.
RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes.
Role of Brf1 interaction with ER?, and significance of its overexpression, in human breast cancer.
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice.
Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3'-ethynylcytidine treatment of human cancer cells.
Rpb3 promotes hepatocellular carcinoma through its N-terminus.
S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation.
Sensitive detection of clonal antigen receptor gene rearrangements for the diagnosis and monitoring of lymphoid neoplasms by a polymerase chain reaction-mediated ribonuclease protection assay.
Sensitivity to alpha-amanitin of multiple DNA-dependent RNA polymerases from experimental tumors.
Separation of a stimulatory factor of RNA polymerase II from protein kinase activity of Ehrlich ascites tumor cells.
Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Small-Molecule Targeting of BET Proteins in Cancer.
Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Smyd3-associated regulatory pathways in cancer.
Solubilized nuclear DNA-dependent RNA polymerases from normal rat mammary glands and from transplantable R-35 rat mammary tumors.
Sources and consequences of oxidative damage from mitochondria and neurotransmitter signaling.
Stimulation of ascites tumor RNA polymerase II by protein kinase.
Stimulation of messenger ribonucleic acid synthesis in isolated nuclei by a protein that stimulates RNA polymerase II.
Stimulatory proteins of RNA polymerase II from Ehrlich ascites tumor cells.
Structural relationships of the three stimulatory factors of RNA polymerase II from Ehrlich ascites tumor cells.
SUV420H2-Mediated H4K20 Trimethylation Enforces RNA Polymerase II Promoter-Proximal Pausing by Blocking hMOF-Dependent H4K16 Acetylation.
Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents.
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.
Targeting Cancer Cells with BET Bromodomain Inhibitors.
Targeting RNA polymerase I to treat MYC-driven cancer.
Targeting RNA polymerase I transcription and the nucleolus for cancer therapy.
Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent.
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth.
TARGETING RNA-POLYMERASE I IN BOTH CHEMOSENSITIVE AND CHEMORESISTANT POPULATIONS IN EPITHELIAL OVARIAN CANCER.
Targeting the nucleolus for cancer intervention.
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression.
Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions.
The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.
The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells.
The basal transcription machinery as a target for cancer therapy.
The complete DNA sequence of lymphocystis disease virus.
The differential effects of low birth weight and Western diet consumption upon early life hepatic fibrosis development in guinea pig.
The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C.
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
The emerging role of RNA polymerase I transcription machinery in human malignancy: a clinical perspective.
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.
The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability.
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.
The influences of red wine in phenotypes of human cancer cells.
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
The most abundant nascent poly(A) + RNAs are transcribed by RNA polymerase III in murine tumor cells.
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
The nucleolus: a paradigm for cell proliferation and aging.
The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.
The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding.
The preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.
The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.
The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II.
The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model.
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains.
Tissue-specific and reversible RNA interference in transgenic mice.
Transcription factor(s) of Ehrlich ascites tumor cells having affinity to the 'TATA' box and a further upstream region of the adenovirus 2 major late gene.
Transcription in vitro of Ehrlich ascites tumor DNA and chromatin by purified homologous RNA polymerase II (or B).
Transcription of globin genes in murine erythroleukemic cell chromatin by RNA polymerase II from mouse cells.
Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.
Transcriptional Responses to IFN-? Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.
Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).
Tumor genotype-specific growth inhibition in vivo by antisense oligonucleotides against a polymorphic site of the large subunit of human RNA polymerase II.
Tumor therapy with Amanita phalloides (death cap): stabilization of B-cell chronic lymphatic leukemia.
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.
Use of chromatin immunoprecipitation to clone novel E2F target promoters.
UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein.
von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.
Von Hippel-Lindau-Coupled and Transcription-Coupled Nucleotide Excision Repair-Dependent Degradation of RNA Polymerase II in Response to Trabectedin.
von Hippel-Lindau-Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas.
Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth.
Yeast Screens Identify the RNA Polymerase II CTD and SPT5 as Relevant Targets of BRCA1 Interaction.
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.
[A protein stimulating the activity of RNA polymerase II of Ehrlich ascites tumor cells (author's transl)]
[Effect of actinomycin D on purified DNA-dependent RNA polymerases from normal and neoplastic tissues]
[Effect of bleomycin on DNA-dependent RNA polymerase purified from normal and neoplastic tissues]
[Establishment of cDNA microarray technology and analysis of gene expression profiles in human esophageal cancer cell line ECa109]
Nephrotic Syndrome
miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome.
Nervous System Diseases
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III.
Neuralgia
Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription.
Neuroblastoma
Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.
Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Neurodegenerative Diseases
Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway.
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases.
Novel POLR1C mutation in RNA polymerase III-related leukodystrophy with severe myoclonus and dystonia.
Newcastle Disease
Development of a reverse genetics system based on RNA polymerase II for Newcastle disease virus genotype VII.
Generation of recombinant lentogenic Newcastle disease virus from cDNA.
Rescue of Newcastle disease virus from cloned cDNA using an RNA polymerase II promoter.
Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence.
Reverse Genetics of Newcastle Disease Virus.
Ribonucleic acid polymerase in virions of Newcastle disease virus: comparison with the vesicular stomatitis virus polymerase.
[Generation of newcastle disease virus strain ZJI isolated from an outbreak in the goose using reverse genetics technique]
Obesity
Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes.
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.
Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Osteosarcoma
Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene.
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Mediator of RNA polymerase II transcription subunit 19 promotes osteosarcoma growth and metastasis and associates with prognosis.
Short exposure to the DNA intercalator DRAQ5 dislocates the transcription machinery and induces cell death.
[Screening of serum marker proteins in osteosarcoma and preliminary bioinformatic analysis on POLR3F].
Ovarian Neoplasms
TARGETING RNA-POLYMERASE I IN BOTH CHEMOSENSITIVE AND CHEMORESISTANT POPULATIONS IN EPITHELIAL OVARIAN CANCER.
Targeting TBP-Associated Factors in Ovarian Cancer.
Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.
Pancreatic Neoplasms
Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
Pancreatitis
Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis.
Papilloma
Efficient ex vivo inhibition of perforin and Fas ligand expression by chimeric tRNA-hammerhead ribozymes.
Transcriptional enhancement by upstream activators is brought about by different molecular mechanisms for class I and II RNA polymerase genes.
Paramyxoviridae Infections
An infectious clone of human parainfluenza virus type 3.
Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion.
Minimum protein requirements for transcription and RNA replication of a minigenome of human parainfluenza virus type 3 and evaluation of the rule of six.
Specific phosphorylated forms of glyceraldehyde 3-phosphate dehydrogenase associate with human parainfluenza virus type 3 and inhibit viral transcription in vitro.
Parasitemia
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Paratuberculosis
Detection and identification of mycobacteria by amplification of mycobacterial DNA.
Pericarditis
Scleroderma renal crisis following pericardial effusion in a Japanese female.
Peritonitis
Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses.
Pituitary Neoplasms
Estrogen-induced changes in rRNA accumulation and RNA polymerase I activity in the rat pituitary: correlation with pituitary tumor susceptibility.
Plasmacytoma
Biochemistry of the amatoxins: preparation and characterization of a stably iodinated alpha-amanitin.
In vitro transcription by mouse plasmocytoma RNA polymerase II supplemented with nuclear protein fractions.
Initiated complexes of RNA polymerase II are concentrated in the nuclear skeleton associated DNA.
Production of monoclonal antibody against electrophoretically purified RNA polymerase II subunits using in vitro immunization.
Purification and characterization of mouse plasmocytoma RNA polymerase II.
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase II from the mouse plasmacytoma, MOPC 315.
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase III from the mouse plasmacytoma, MOPC 315.
The most abundant nascent poly(A) + RNAs are transcribed by RNA polymerase III in murine tumor cells.
Transcription of specific genes in isolated nuclei by exogenous RNA polymerases.
Pneumonia
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response.
Polymicrogyria
Recessive Mutations in POLR3B Encoding RNA Polymerase III Subunit Causing Diffuse Hypomyelination in Patients with 4H Leukodystrophy with Polymicrogyria and Cataracts.
Porcine Reproductive and Respiratory Syndrome
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Prader-Willi Syndrome
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.
Progeria
Hutchinson-Gilford progeria fibroblasts exhibit metabolically normal uridine uptake and RNA synthetic rates.
Prostatic Neoplasms
Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.
Effects on prostate cancer cells of targeting RNA polymerase III.
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.
Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells.
KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.
Molecular determinants for enzalutamide-induced transcription in prostate cancer.
Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms.
p68/DdX5 supports ?-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Pseudorabies
In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein.
The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions.
Transcription of class III genes activated by viral immediate early proteins.
Psoriasis
RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product.
Pulmonary Disease, Chronic Obstructive
miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.
SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD.
Pyelonephritis
Bacterial control of host gene expression through RNA polymerase II.
Rabies
An improved method for recovering rabies virus from cloned cDNA.
Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system.
Infectious rabies viruses from cloned cDNA.
Studies on the conditions required for structural and functional maturation of rabies virus glycoprotein (G) in G cDNA-transfected cells.
Renal Insufficiency
A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.
An effective antidotal combination of polymyxin B and methylprednisolone for ?-amanitin intoxication.
Retinoblastoma
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
BAY 1000394, a Novel Cyclin-Dependent Kinase Inhibitor, with Potent Antitumor Activity in Mono- and in Combination Treatment upon Oral Application.
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase.
Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb.
Growth inhibition by a triple ribozyme targeted to repetitive B2 transcripts.
Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein.
Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein.
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Multiple mechanisms contribute to the activation of RNA polymerase III transcription in cells transformed by papovaviruses.
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1.
Regulation of RNA polymerase III transcription during cell cycle entry.
Repression of RNA polymerase III transcription by the retinoblastoma protein.
Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription.
Retinoblastoma protein. Pol I gets repressed.
RNA polymerase III repression by the retinoblastoma tumor suppressor protein.
RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130.
RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2.
Specificity of the polycation-stimulated (type-2A) and ATP,Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase.
The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.
Use of chromatin immunoprecipitation to clone novel E2F target promoters.
Rhabdoid Tumor
SNF5 Reexpression in Malignant Rhabdoid Tumors Regulates Transcription of Target Genes by Recruitment of SWI/SNF Complexes and RNAPII to the Transcription Start Site of Their Promoters.
Rheumatic Diseases
Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis.
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen.
Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes.
Rickettsia Infections
Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii.
Rubella
Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing.
Reverse transcription and subsequent DNA amplification of rubella virus RNA.
Sarcoma
Inhibition of cellular and virus-associated nucleotide polymerases by, and anti-herpes simplex virus activity of, streptovaricin derivatives.
Reproduction of the FC/DFC units in nucleoli.
RNA polymerase specificity of mRNA production and enhancer action.
RNA synthesis in the presence of transfer RNa by DNA-dependent RNA polymerase II from mouse ascites sarcoma cells.
Specific transcriptional initiation in vitro on murine type C retrovirus promoters.
Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme.
Sarcoma, Avian
Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system.
Comparative analysis of inducible expression systems in transient transfection studies.
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.
In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase.
Inhibition of rous sarcoma virus by alpha-amanitin: possible role of cell DNA-dependent RNA polymerase form II.
Localization of active promoters for eucaryotic RNA polymerase II in the long terminal repeat of avian sarcoma virus DNA.
Sarcoma, Ewing
Coupled alteration of transcription and splicing by a single oncogene: boosting the effect on cyclin D1 activity.
In vitro interaction between the N-terminus of the Ewing's sarcoma protein and the subunit of RNA polymerase II hsRPB7.
Localization and characterization of the RNA binding protein TLS in skin and stratified mucosa.
Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein.
Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line.
Scleroderma, Diffuse
Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma).
Scleroderma, Systemic
Anti-RNA polymerase antibodies in systemic sclerosis (SSc): association with anti-topoisomerase I antibodies and identification of autoreactive subunits of RNA polymerase II.
Antibodies to fibrillarin, PM-Scl and RNA polymerase III detected by ELISA assays in patients with systemic sclerosis.
Antibodies to RNA polymerase III in systemic sclerosis detected by ELISA.
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Autoantibodies to RNA-polymerases in Italian patients with systemic sclerosis.
Autoantibody reactive with RNA polymerase III in systemic sclerosis.
Clinical and serological associations with anti-RNA polymerase antibodies in systemic sclerosis.
Disappearance of circulating autoantibodies to RNA polymerase III in a patient with systemic sclerosis successfully treated with corticosteroid and methotrexate.
Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.
Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.
Immunochemical and molecular characterization of anti-RNA polymerase I autoantibodies produced by tight skin mouse.
Immunologic aspects of scleroderma.
Inclusion body myositis in a patient with RNA polymerase III antibody-positive systemic sclerosis.
Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort.
RNA polymerase III autoantibodies may indicate renal and more severe skin involvement in systemic sclerosis.
Scleroderma renal crisis in a Swedish systemic sclerosis cohort: survival, renal outcome, and RNA polymerase III antibodies as a risk factor.
Validation of a new immunoenzymatic method to detect antibodies to RNA polymerase III in systemic sclerosis.
Scrub Typhus
[Polymerase chain reaction for the diagnosis of tsutsugamushi disease]
Sepsis
IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis.
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Sjogren's Syndrome
Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies.
Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.
Small Cell Lung Carcinoma
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Smallpox
Evolution of viral DNA-dependent RNA polymerases.
Spinocerebellar Ataxias
Nonapoptotic cell death caused by the inhibition of RNA polymerase disrupts organelle distribution.
Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II.
Starvation
A CxxC Domain That Binds to Unmethylated CpG Is Required for KDM2A to Control rDNA Transcription.
A DNA polymerase V homologue encoded by TOL plasmid pWW0 confers evolutionary fitness on Pseudomonas putida under conditions of environmental stress.
A role for the transcription factor Mca1 in activating the meiosis-specific copper transporter Mfc1.
Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription.
Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells.
Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.
Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.
Identification and characterization of DdRPB4, a subunit of Dictyostelium discoideum RNA polymerase II.
MAF1: a new target of mTORC1.
Modulation of RNA polymerase activities in the intestine of adult rats by dietary sucrose.
Molecular Characterization of Propolis-Induced Cell Death in Saccharomyces cerevisiae.
mTORC1 directly phosphorylates and regulates human MAF1.
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.
Pol II docking and pausing at growth and stress genes in C. elegans.
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.
Reference Gene Validation for Quantitative PCR Under Various Biotic and Abiotic Stress Conditions in Toxoptera citricida (Hemiptera, Aphidiae).
Regulation of RNA polymerase III transcription by Maf1 in mammalian cells.
Regulation of the RNA polymerase I and III transcription systems in response to growth conditions.
Relationship between the expression of estrogen-regulated genes and estrogen-stimulated proliferation of MCF-7 mammary tumor cells.
RNA polymerase I activation and hibernation: unique mechanisms for unique genes.
RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex.
S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.
Transcription rates and transcript stabilities of macronuclear genes in vegetative Euplotes crassus cells.
Stomach Neoplasms
Biogenesis of Epstein-Barr virus microRNAs.
Stuttering
Unusual heterogeneity of the 5'-termini of human adenovirus type 2 early region E2 mRNA.
Subacute Sclerosing Panencephalitis
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Superinfection
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection.
Teratocarcinoma
A conserved organization of transcription during embryonic stem cell differentiation and in cells with high C value.
Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Thymoma
Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing.
Trachoma
Deoxyribonucleic acid-dependent ribonucleic acid polymerase activity in purified trachoma elementary bodies: effect of sodium chloride on ribonucleic acid transcription.
Trypanosomiasis
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Trypanosomiasis, African
An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscape.
Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei.
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Tuberculosis
Association of ? with the C-Terminal Region of the ?' Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis.
Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.
Crystal structure of DNA polymerase III ? sliding clamp from Mycobacterium tuberculosis.
Detection and identification of mycobacteria by amplification of mycobacterial DNA.
Detection and identification of Mycobacterium avium in the blood of AIDS patients by the polymerase chain reaction.
DNA polymerase I of Mycobacterium tuberculosis: functional role of a conserved aspartate in the hinge joining the M and N helices.
Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis.
Identification of Mycobacterium DNA in an Egyptian Pott's disease of 5,400 years old.
Novel Real-Time Simultaneous Amplification and Testing Method To Accurately and Rapidly Detect Mycobacterium tuberculosis Complex.
Purification and properties of DNA-dependent RNA polymerase from Mycobacterium tuberculosis H37RV.
Structural basis for transcription initiation by bacterial ECF ? factors.
Tuberous Sclerosis
The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex.
Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays.
Tularemia
[Comparison of the structural-functional properties of DNA-dependent RNA polymerase of the tularemia microbe and intestinal bacterial]
Tumor Virus Infections
Transcription products synthesized by purified calf thymus DNA-dependent RNA polymerase on Shope papilloma virus DNA.
Urinary Bladder Neoplasms
MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides.
The p63 protein isoform ?Np63? inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205.
Uterine Cervical Neoplasms
Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.
Inhibition of cyclin-dependent kinases by AT7519 is effective to overcome chemoresistance in colon and cervical cancer.
Vaccinia
A Cell-Cell Fusion Assay to Assess Arenavirus Envelope Glycoprotein Membrane-Fusion Activity.
A cellular factor is required for transcription of vaccinia viral intermediate-stage genes.
A functional measles virus replication and transcription machinery encoded by the vaccinia virus genome.
A glycine to alanine substitution in the paramyxovirus SV5 fusion peptide increases the initial rate of fusion.
A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy-back nondefective interfering virus.
A new cationic liposome reagent mediating nearly quantitative transfection of animal cells.
A new vaccinia virus intermediate transcription factor.
A plasmid that improves the efficiency of foreign gene expression by intracellular T7 RNA polymerase.
A plasmid-based reverse genetics system for mammalian orthoreoviruses driven by a plasmid-encoded T7 RNA polymerase.
A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro.
A role for the H4 subunit of vaccinia RNA polymerase in transcription initiation at a viral early promoter.
A vaccinia virus MVA-T7-mediated recovery of infectious hepatitis A virus from full-size cDNA or from two cDNAs, both by themselves unable to complete the virus life cycle.
Adverse effects of MVA-T7 on the transport of Marburg virus glycoprotein.
African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases.
Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce NS2 protein.
An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development.
An infectious clone of human parainfluenza virus type 3.
Antigenic structure of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus.
Assembly of functional Sindbis virus RNA replication complexes: requirement for coexpression of P123 and P34.
Astrovirus ribosomal frameshifting in an infection-transfection transient expression system.
Biogenesis of poxviruses: role for the DNA-dependent RNA polymerase II of the host during expression of late functions.
Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system.
Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells.
Cellular expression of a functional nodavirus RNA replicon from vaccinia virus vectors.
Characterization of a 7-kilodalton subunit of vaccinia virus DNA-dependent RNA polymerase with structural similarities to the smallest subunit of eukaryotic RNA polymerase II.
Characterization of vaccinia virus DNA topoisomerase I expressed in Escherichia coli.
Cloning of the vaccinia virus ribonucleotide reductase small subunit gene. Characterization of the gene product expressed in Escherichia coli.
Coding sequences enhance internal initiation of translation by hepatitis A virus RNA in vitro.
Complementation of a vesicular stomatitis virus glycoprotein G mutant with wild-type protein expressed from either a bovine papilloma virus or a vaccinia virus vector system.
Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells.
Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity.
Deletion mapping of a mouse hepatitis virus defective interfering RNA reveals the requirement of an internal and discontiguous sequence for replication.
Detailed phenotypic characterization of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
DNA-dependent RNA polymerase subunits encoded within the vaccinia virus genome.
Effect of rifamycins and related antibiotics on the deoxyribonucleic acid-dependent ribonucleic acid polymerase of vaccinia virus particles.
Effects of poliovirus 2A(pro) on vaccinia virus gene expression.
Efficient bunyavirus rescue from cloned cDNA.
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.
Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones.
Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells.
Enhanced genetic rescue of negative-strand RNA viruses: use of an MVA-T7 RNA polymerase vector and DNA replication inhibitors.
Enhancement of the vaccinia virus/phage T7 RNA polymerase expression system using encephalomyocarditis virus 5'-untranslated region sequences.
Establishment of a Nipah virus rescue system.
Establishment of a rescue system for canine distemper virus.
Eukaryotic transient expression system dependent on transcription factors and regulatory DNA sequences of vaccinia virus.
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.
Evidence for genetic relationship between RNA and DNA viruses from the sequence homology of a putative polymerase gene of bluetongue virus with that of vaccinia virus: conservation of RNA polymerase genes from diverse species.
Evolution of viral DNA-dependent RNA polymerases.
Expansion of poxvirus RNA polymerase subunits sharing homology with corresponding subunits of RNA polymerase II.
Expression of a cloned gamma-aminobutyric acid transporter in mammalian cells.
Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus.
Expression of cDNA encoding the Sendai virus hemagglutinin-neuraminidase gene: characterization of wild-type and mutant gene products.
Expression of functional Bunyamwera virus L protein by recombinant vaccinia viruses.
Expression of functional parvoviral NS1 from recombinant vaccinia virus: effects of mutations in the nucleotide-binding motif.
Expression of hepatitis A virus precursor protein P3 in vivo and in vitro: polyprotein processing of the 3CD cleavage site.
Expression of mutated glucocerebrosidase alleles in human cells.
Expression of poliovirus 2Apro in mammalian cells: effects on translation.
Expression of structural proteins of hepatitis C virus (HCV) in mammalian cells.
Expression of the Bunyamwera virus M genome segment and intracellular localization of NSm.
Expression of the Japanese encephalitis virus NS3 and NS2b proteins as glutathione S-transferase fusions.
Expression of the M gene of vesicular stomatitis virus cloned in various vaccinia virus vectors.
Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing.
Feline calicivirus capsid protein expression and capsid assembly in cultured feline cells.
Feline calicivirus: recovery of wild-type and recombinant viruses after transfection of cRNA or cDNA constructs.
Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase.
Fine structure mapping of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
Formation of virus-like particles from cloned cDNAs of Thogoto virus.
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion.
Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids.
Further characterization of the rabies virus glycoproteins produced by virus-infected and G cDNA-transfected cells using a monoclonal antibody, #1-30-44, which recognizes an acid-sensitive epitope.
Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation.
Gene expression using the vaccinia virus/ T7 RNA polymerase hybrid system.
Gene expression using the vaccinia virus/T7 RNA polymerase hybrid system.
Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter.
Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus.
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
Heterologous expression systems for studying placental transporters.
High level protein expression in mammalian cells using a safe viral vector: Modified vaccinia virus Ankara.
Homology between RNA polymerases of poxviruses, prokaryotes, and eukaryotes: nucleotide sequence and transcriptional analysis of vaccinia virus genes encoding 147-kDa and 22-kDa subunits.
Hybrid proteins between Pseudomonas exotoxin A and poliovirus protease 2Apro.
Hydrolytic cleavage of nascent RNA in RNA polymerase III ternary transcription complexes.
Identification and expression of rpo19, a vaccinia virus gene encoding a 19-kilodalton DNA-dependent RNA polymerase subunit.
Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.
Identification of hepatitis A virus non-structural protein 2B and its release by the major virus protease 3C.
Identification of the respiratory syncytial virus proteins required for formation and passage of helper-dependent infectious particles.
Identification of the vaccinia virus gene encoding an 18-kilodalton subunit of RNA polymerase and demonstration of a 5' poly(A) leader on its early transcript.
Identification, sequence, and expression of the gene encoding a Mr 35,000 subunit of the vaccinia virus DNA-dependent RNA polymerase.
Identification, sequence, and expression of the gene encoding the second-largest subunit of the vaccinia virus DNA-dependent RNA polymerase.
In vitro expression analysis of collagen biosynthesis and assembly.
Induction of membrane proliferation by poliovirus proteins 2C and 2BC.
Induction of recombinant gene expression in stably transfected cell lines using attenuated vaccinia virus MVA expressing T7 RNA polymerase with a nuclear localisation signal.
Influence of RNA polymerase II upon vaccinia virus-related translation examined by means of alpha-amanitin.
Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II.
Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites.
Intracellular expression and processing of foot-and-mouth disease virus capsid precursors using vaccinia virus vectors: influence of the L protease.
Intracellular hepatitis C virus RNA-dependent RNA polymerase activity.
Investigation of norovirus replication in a human cell line.
Isolation and properties of the vaccinia virus DNA-dependent RNA polymerase.
Large-scale production and purification of a vaccinia recombinant-derived HIV-1 gp160 and analysis of its immunogenicity.
Localization of Bunyamwera bunyavirus G1 glycoprotein to the Golgi requires association with G2 but not with NSm.
Mammalian cell expression of malaria merozoite surface proteins and experimental DNA and RNA immunisation.
Mechanisms of replication-deficient vaccinia virus/T7 RNA polymerase hybrid expression: effect of T7 RNA polymerase levels and alpha-amanitin.
Membrane permeabilization by poliovirus proteins 2B and 2BC.
Minimum protein requirements for transcription and RNA replication of a minigenome of human parainfluenza virus type 3 and evaluation of the rule of six.
Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase.
Modulation of translation initiation efficiency in classical Swine Fever virus.
Molluscum contagiosum -- a defective poxvirus?
Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure.
Mutagenesis of the L protein encoded by Bunyamwera virus and production of monospecific antibodies.
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.
Nascent RNA cleavage by purified ternary complexes of vaccinia RNA polymerase.
Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase.
Novel approach for transient protein expression in primary cultures of human dental pulp-derived cells.
Novel Nonreplicating Vaccinia Virus Vector Enhances Expression of Heterologous Genes and Suppresses Synthesis of Endogenous Viral Proteins.
NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs.
Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses.
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Optimization of plasmid-only rescue of highly attenuated and temperature-sensitive respiratory syncytial virus (RSV) vaccine candidates for human trials.
Overexpression of human glucocerebrosidase containing different-sized leaders.
Overexpression, purification, and late transcription factor activity of the 17-kilodalton protein encoded by the vaccinia virus A1L gene.
Paramyxovirus mediated cell fusion requires co-expression of both the fusion and hemagglutinin-neuraminidase glycoproteins.
Phenotypic characterization of temperature-sensitive mutants of vaccinia virus with mutations in a 135,000-Mr subunit of the virion-associated DNA-dependent RNA polymerase.
Phosphorylation and modulation of brain glutamate transporters by protein kinase C.
Preparation and characterisation of a subviral particle of vaccinia virus containing the DNA-dependent RNA polymerase activity.
Production of pro-opiomelanocortin (POMC) by a vaccinia virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme.
Purification and characterization of a DNA-dependent RNA polymerase from vaccinia virions.
Purification and characterization of a transcription termination factor from vaccinia virions.
Purification and properties of vaccinia virus DNA-dependent RNA polymerase.
Purification of a factor required for transcription of vaccinia virus early genes.
Recombinant decorin glycoforms. Purification and structure.
Recombinant protein synthesis in Chinese hamster ovary cells using a vaccinia virus/bacteriophage T7 hybrid expression system.
Reconstitution of the human chaperonin CCT by co-expression of the eight distinct subunits in mammalian cells.
Recovery of a virulent strain of newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation.
Recovery of infectious human parainfluenza type 2 virus from cDNA clones and properties of the defective virus without V-specific cysteine-rich domain.
Recovery of infectious human parainfluenza virus type 3 from cDNA.
Recovery of infectious SV5 from cloned DNA and expression of a foreign gene.
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Recovery of pathogenic measles virus from cloned cDNA.
Regulated expression of foreign genes in vaccinia virus under the control of bacteriophage T7 RNA polymerase and the Escherichia coli lac repressor.
Relationship between RNA polymerase II and efficiency of vaccinia virus replication.
Release of non-glycosylated polymeric immunoglobulin receptor protein.
Reovirus protein lambda 3 is a poly(C)-dependent poly(G) polymerase.
Replication and amplification of defective interfering particle RNAs of vesicular stomatitis virus in cells expressing viral proteins from vectors containing cloned cDNAs.
Replication and packaging of Norwalk virus RNA in cultured mammalian cells.
Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells.
Requirements for assembly of poliovirus replication complexes and negative-strand RNA synthesis.
Rescue of a synthetic chloramphenicol acetyltransferase RNA into influenza virus-like particles obtained from recombinant plasmids.
Rescue of bovine respiratory syncytial virus from cloned cDNA: entire genome sequence of BRSV strain A51908.
Rescue of measles virus using a replication-deficient vaccinia-T7 vector.
Rescue of mumps virus from cDNA.
Rescue of recombinant Thogoto virus from cloned cDNA.
Rescue of rinderpest virus from cloned cDNA.
Rescue of Sendai Virus from Cloned cDNA.
Rescue of synthetic genomic RNA analogs of rabies virus by plasmid-encoded proteins.
Rescue of synthetic salmonid rhabdovirus minigenomes.
Rescue system for measles virus from cloned cDNA driven by vaccinia virus Lister vaccine strain.
Reverse genetics for mammalian reovirus.
Reverse Genetics of Newcastle Disease Virus.
Reverse genetics system for the avian coronavirus infectious bronchitis virus.
Ribonucleic acid polymerase induced by vaccinia virus: lack of inhibition by rifampicin and alpha-amanitin.
RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences.
RNA polymerase-associated protein Rap94 confers promoter specificity for initiating transcription of vaccinia virus early stage genes.
RNA polymerase-associated transcription specificity factor encoded by vaccinia virus.
RNA replication by respiratory syncytial virus (RSV) is directed by the N, P, and L proteins; transcription also occurs under these conditions but requires RSV superinfection for efficient synthesis of full-length mRNA.
Role of basic residues in the proteolytic activation of Sendai virus fusion glycoprotein.
Roles of vaccinia virus in the development of new vaccines.
Selective transcription of vaccinia virus genes in template dependent soluble extracts of infected cells.
Self-assembly of sapovirus recombinant virus-like particles from polyprotein in mammalian cells.
Sequence analysis of a functional polymerase (L) gene of bovine respiratory syncytial virus: determination of minimal trans-acting requirements for RNA replication.
Shope fibroma virus. II. Role of the virion-associated nucleases.
Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.
Sodium-dependent GABA-induced currents in GAT1-transfected HeLa cells.
SP6 RNA polymerase containing vaccinia virus for rapid expression of cloned genes in tissue culture.
Structure and stability of mRNA synthesized by vaccinia virus-encoded bacteriophage T7 RNA polymerase in mammalian cells. Importance of the 5' untranslated leader.
Studies of the astrovirus signal that induces (-1) ribosomal frameshifting.
Studies on the conditions required for structural and functional maturation of rabies virus glycoprotein (G) in G cDNA-transfected cells.
Synthesis and intracellular localization of vaccinia virus deoxyribonucleic acid-dependent ribonucleic acid polymerase.
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Systematic and large-scale two-hybrid screens.
Targeted delivery of human neurofibromin and c-Raf-1 mutants to the cytoplasmic membrane by use of the influenza virus hemagglutinin.
Temperature-sensitive mutations in the vaccinia virus H4 gene encoding a component of the virion RNA polymerase.
The A2L intermediate gene product is required for in vitro transcription from a vaccinia virus late promoter.
The alphavirus replicase protein nsP1 is membrane-associated and has affinity to endocytic organelles.
The cellular immune recognition of proteins expressed by an African swine fever virus random genomic library.
The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins.
The H gene of rodent brain-adapted measles virus confers neurovirulence to the Edmonston vaccine strain.
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA.
The role of simian virus 5 V protein on viral RNA synthesis.
The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template.
The vaccinia virus A18R gene product is a DNA-dependent ATPase.
Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes.
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Transcription of a vaccinia virus late promoter template: requirement for the product of the A2L intermediate-stage gene.
Transcripts containing a small anti-HIV hammerhead ribozyme that are active in the cell cytoplasm but inactive in vitro as free RNAs.
Transient and inducible expression of vaccinia/T7 recombinant viruses.
Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses.
Translation of the reovirus M1 gene initiates from the first AUG codon in both infected and transfected cells.
Translational control of Scamper expression via a cell-specific internal ribosome entry site.
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Vaccinia virus A17L open reading frame encodes an essential component of nascent viral membranes that is required to initiate morphogenesis.
Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex.
Vaccinia virus gene D7R encodes a 20,000-dalton subunit of the viral DNA-dependent RNA polymerase.
Vaccinia virus gene encoding a 30-kilodalton subunit of the viral DNA-dependent RNA polymerase.
Vaccinia virus late transcripts generated in vitro have a poly(A) head.
Vaccinia virus-bacteriophage T7 expression vector for complementation analysis of late gene processes.
Viable double vaccinia virus recombinants with the non-inducible phage T7 expression system.
Virus-specific cytotoxic T-lymphocyte activity elicited by coimmunization with human immunodeficiency virus type 1 genes regulated by the bacteriophage T7 promoter and T7 RNA polymerase protein.
[A novel system for producing lentiviral vectors]
[Comparative study of the morphology and antigenic properties of recombinant analogs of a Marburg virus nucleoprotein]
[Construction of minigenome of Newcastle disease virus of goose origin and its preliminary application]
Vasculitis, Central Nervous System
Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins.
Vesicular Stomatitis
Coupled in vitro transcription and translation of vesicular stomatitis virus messenger RNA.
Expression of the vesicular stomatitis virus nucleocapsid protein gene in Escherichia coli: analysis of its biological activity in vitro.
Multigene expression in vivo: Supremacy of large versus small terminators for T7 RNA polymerase.
Recombinant vesicular stomatitis viruses from DNA.
Ribonucleic acid polymerase in virions of Newcastle disease virus: comparison with the vesicular stomatitis virus polymerase.
Ribonucleic acid polymerase induced in L-cells infected with vesicular stomatitis virus.
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
Vesicular stomatitis virus infection reduces the number of active DNA-dependent RNA polymerases in myeloma cells.
Viral ribonucleic acid polymerase: chick-embryo cells infected with vesicular stomatitis virus or Rous-associated virus.
Virus Diseases
A novel effect of adenovirus VA RNA1 on cytoplasmic mRNA abundance.
alpha-Amanitin-Resistant Viral RNA Synthesis in Nuclei Isolated from Nuclear Polyhedrosis Virus-Infected Heliothis zea Larvae and Spodoptera frugiperda Cells.
Disruption of Nuclear Organization during the Initial Phase of African Swine Fever Virus Infection.
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation.
Extensive Cooperation of Immune Master Regulators IRF3 and NF?B in RNA Pol II Recruitment and Pause Release in Human Innate Antiviral Transcription.
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
Influenza virus infection causes global RNAPII termination defects.
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.
Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription.
Inhibition of host cell RNA polymerase III-mediated transcription by poliovirus: inactivation of specific transcription factors.
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.
Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila.
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Relationship between RNA polymerase II and efficiency of vaccinia virus replication.
RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.
RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences.
Simian virus 40 small-t does not transactivate RNA polymerase II promoters in virus infections.
Terminator-specific recycling of a B1-Alu transcription complex by RNA polymerase III is mediated by the RNA terminus-binding protein La.
The role of the influenza virus RNA polymerase in host shut-off.
Vesicular stomatitis virus infection reduces the number of active DNA-dependent RNA polymerases in myeloma cells.
[Effect of the attenuated strain (TC-83) of Venezuelan equine encephalitis virus on nuclear transcription in rat brain cells]
Vitamin A Deficiency
RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient mice.
Werner Syndrome
The transcriptional response to distinct growth factors is impaired in Werner syndrome cells.
The Werner syndrome protein is involved in RNA polymerase II transcription.
Williams Syndrome
De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
Wilms Tumor
Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.
Wiskott-Aldrich Syndrome
Dissection of Pol II trigger loop function and Pol II activity-dependent control of start site selection in vivo.
IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II.
Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation.
Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.
Xeroderma Pigmentosum
Cisplatin induces cytoplasmic to nuclear translocation of nucleotide excision repair factors among spiral ganglion neurons.
Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay.
Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts.
Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA.
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
Transcription-dependent and independent DNA excision repair pathways in human cells.
Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair.
Von Hippel-Lindau-Coupled and Transcription-Coupled Nucleotide Excision Repair-Dependent Degradation of RNA Polymerase II in Response to Trabectedin.
Zika Virus Infection
Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages.