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Information on EC 2.7.7.6 - DNA-directed RNA polymerase
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2.7.7.6 DNA-directed RNA polymeraseIUBMB Comments
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
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Word Map
- 2.7.7.6
- chromatin
- histone
- rrna
- strand
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rnaps
- nucleosome
- tata
- drosophila
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pausing
- pre-mrnas
- tbp
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nucleolar
- bacteriophage
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polyadenylation
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single-stranded
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cyclin-dependent
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holoenzyme
- cyclin
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spacers
- helicase
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fidelity
- polya
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coactivator
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protein-coding
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transactivation
- adenovirus
- xenopus
- ribonucleoproteins
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sequence-specific
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stall
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pause
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chip-seq
- vaccinia
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multisubunit
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ribozyme
- heptapeptide
- duplex
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h3k4me3
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spliceosome
- nucleoplasm
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run-on
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supercoiled
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trimethylation
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subcomplexes
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exonuclease
- heterochromatin
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translesion
- medicine
- primase
- molecular biology
- analysis
- diagnostics
- drug development
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misincorporation
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proofread
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
rna polymerase ii, pol ii, t7 rna polymerase, rna polymerase i, pol iii, rna polymerase iii, pol i, rnapii, rnap ii, dna-dependent rna polymerase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C RNA formation factors
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chloroplast soluble RNA polymerase
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deoxyribonucleic acid-dependent ribonucleic acid polymerase
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DNA-dependent ribonucleate nucleotidyltransferase
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DNA-dependent RNA nucleotidyltransferase
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DNA-dependent RNA polymerase
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nucleotidyltransferase, ribonucleate
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Pol II
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ribonucleate nucleotidyltransferase
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ribonucleate polymerase
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ribonucleic acid formation factors, C
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ribonucleic acid nucleotidyltransferase
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ribonucleic acid polymerase
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ribonucleic acid transcriptase
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ribonucleic polymerase
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ribonucleic transcriptase
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RNA formation factors, C
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RNA nucleotidyltransferase
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RNA nucleotidyltransferase (DNA-directed)
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RNA polymerase
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RNA polymerase I
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RNA polymerase II
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RNA polymerase III
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RNA transcriptase
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RNAP
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RNAP I
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RNAP II
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RNAP III
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transcriptase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
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CAS REGISTRY NUMBER
COMMENTARY
9014-24-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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in vitro transcriptional activity of recombinant assembled Xcc RNAP, overview
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?
additional information
?
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in vitro transcriptional activity of recombinant assembled Xcc RNAP, overview
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?
additional information
?
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in vitro transcriptional activity of recombinant assembled Xcc RNAP, overview
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?
additional information
?
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in vitro transcriptional activity of recombinant assembled Xcc RNAP, overview
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?
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death.
Acquired Immunodeficiency Syndrome
A small post-translocation energy bias AIDS nucleotide selection in t7 RNA polymerase transcription.
Acquired Immunodeficiency Syndrome
TEFM is a potent stimulator of mitochondrial transcription elongation in vitro.
Acquired Immunodeficiency Syndrome
Transcription blockage by bulky end termini at single-strand breaks in the DNA template: differential effects of 5' and 3' adducts.
Acute Kidney Injury
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Acute Kidney Injury
Endotoxin mediates recruitment of RNA polymerase II to target genes in acute renal failure.
Adenocarcinoma
AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.
Adenocarcinoma
Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription.
Adenocarcinoma of Lung
BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.
Adenocarcinoma of Lung
Cytoplasmic expression of a reporter gene by co-delivery of T7 RNA polymerase and T7 promoter sequence with cationic liposomes.
Adenocarcinoma of Lung
OverGeneDB: a database of 5' end protein coding overlapping genes in human and mouse genomes.
Adenoma
Relationship between nuclear ADP-ribosylation and RNA transcription in calf and human thyroid.
Adenoviridae Infections
Adenovirus type 2 preferentially stimulates polymerase III transcription of Alu elements by relieving repression: a potential role for chromatin.
African Swine Fever
An Optimized Reverse Genetics System Suitable for Efficient Recovery of Simian, Human, and Murine-Like Rotaviruses.
African Swine Fever
Effect of inhibitors of the host cell RNA polymerase II on African swine fever virus multiplication.
African Swine Fever
Effect of rifamycin derivatives and coumermycin A1 on in vitro RNA synthesis by African swine fever virus. Brief report.
African Swine Fever
High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.
African Swine Fever
Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II.
Alzheimer Disease
Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.
Alzheimer Disease
fISHing with immunohistochemistry for housekeeping gene changes in Alzheimer's disease using an automated quantitative analysis workflow.
Alzheimer Disease
Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease.
Alzheimer Disease
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
Alzheimer Disease
RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration.
Alzheimer Disease
Run-on gene transcription in human neocortical nuclei. Inhibition by nanomolar aluminum and implications for neurodegenerative disease.
Alzheimer Disease
Study of the Alzheimer's A4 precursor gene promoter region by genomic sequencing using Taq polymerase.
Amebiasis
Identification of critical genes in gastric cancer to predict prognosis using bioinformatics analysis methods.
Amyotrophic Lateral Sclerosis
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Amyotrophic Lateral Sclerosis
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Anemia
Derivation and External Validation of a Prediction Rule for Five-Year Mortality in Patients With Early Diffuse Cutaneous Systemic Sclerosis.
Anemia
dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification.
Anemia
Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation.
Anemia
Validation of reference genes for real-time polymerase chain reaction studies in atlantic salmon.
Anemia, Hypochromic
Virus-induced gene silencing of the RPC5-like subunit of RNA polymerase III caused pleiotropic effects in Nicotiana benthamiana.
Anodontia
POLR3-related leukodystrophy: How do mutations affecting RNA polymerase III subunits cause hypomyelination?
Anodontia
Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.
Anthrax
Palladium-Triggered Chemical Rescue of Intracellular Proteins via Genetically Encoded Allene-Caged Tyrosine.
Apraxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Arthritis, Rheumatoid
Identification of differentially expressed genes and pathways crosstalk analysis in Rheumatoid and Osteoarthritis using next-generation sequencing and protein-protein networks.
Ataxia
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Ataxia Telangiectasia
Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma.
Autoimmune Diseases
Adenovirus infection induces loss of HLA class I and CD3 antigens, but does not induce cell surface presentation of the La (SS-B) autoantigen.
Autoimmune Diseases
Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease.
Autoimmune Diseases
Association of an RNA polymerase III transcription factor with a ribonucleoprotein complex recognized by autoimmune sera.
Autoimmune Diseases
Autoimmune diseases may result from inappropriate RNA polymerase III transcription: comment on the article by Neidhart et al.
Autoimmune Diseases
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
Autoimmune Diseases
Immunochemical and molecular characterization of anti-RNA polymerase I autoantibodies produced by tight skin mouse.
Autoimmune Diseases
Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I.
Autoimmune Diseases
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
Avian Leukosis
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.
Bacterial Infections
Determination of internal controls for quantitative real time RT-PCR analysis of the effect of Edwardsiella tarda infection on gene expression in turbot (Scophthalmus maximus).
Bacterial Infections
Environmental History Modulates Arabidopsis Pattern-Triggered Immunity in a HISTONE ACETYLTRANSFERASE1-Dependent Manner.
Blister
Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.
Blister
The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.
Bloom Syndrome
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
Bluetongue
Expression of the non-structural protein NS1 of bluetongue virus in bacteria and yeast: identification of two antigenic sites at the amino terminus.
Borna Disease
Development of a novel Borna disease virus reverse genetics system using RNA polymerase II promoter and SV40 nuclear import signal.
Breast Neoplasms
A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors.
Breast Neoplasms
A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.
Breast Neoplasms
A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology.
Breast Neoplasms
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.
Breast Neoplasms
Analysis of paired end Pol II ChIP-seq and short capped RNA-seq in MCF-7 cells.
Breast Neoplasms
Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.
Breast Neoplasms
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Breast Neoplasms
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Breast Neoplasms
Bioinformatic analysis of changes in RNA polymerase II transcription stimulated by estradiol in MCF7 cells.
Breast Neoplasms
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
Breast Neoplasms
Breast Cancer Suppression by Progesterone Receptors Is Mediated by Their Modulation of Estrogen Receptors and RNA Polymerase III.
Breast Neoplasms
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.
Breast Neoplasms
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors.
Breast Neoplasms
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
Breast Neoplasms
Coactivator Function Defines the Active Estrogen Receptor-{alpha} Cistrome.
Breast Neoplasms
CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer.
Breast Neoplasms
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
Breast Neoplasms
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
Breast Neoplasms
ER? mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.
Breast Neoplasms
Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells.
Breast Neoplasms
HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis.
Breast Neoplasms
High levels of ?-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer.
Breast Neoplasms
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery.
Breast Neoplasms
Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells.
Breast Neoplasms
Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction.
Breast Neoplasms
Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis.
Breast Neoplasms
Nuclear localization of cytokeratin 8 and the O-linked N-acetylglucosamine-containing epitope H in epithelial cells of infiltrating ductal breast carcinomas: a combination of immunogold and EDTA regressive staining methods.
Breast Neoplasms
PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor ?-Positive Breast Cancer Cells.
Breast Neoplasms
Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer.
Breast Neoplasms
Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells.
Breast Neoplasms
Prognostic Value of the Expression of DNA Repair-Related Biomarkers Mediated by Alcohol in Gastric Cancer Patients.
Breast Neoplasms
Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity.
Breast Neoplasms
RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition.
Breast Neoplasms
Role of betaine in inhibiting the induction of RNA Pol III gene transcription and cell growth caused by alcohol.
Breast Neoplasms
Role of Brf1 interaction with ER?, and significance of its overexpression, in human breast cancer.
Breast Neoplasms
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Breast Neoplasms
The evolution of cyclin dependent kinase inhibitors in the treatment of cancer.
Breast Neoplasms
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Breast Neoplasms
The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.
Breast Neoplasms
Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data.
Breast Neoplasms
Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.
Breast Neoplasms
Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.
Breast Neoplasms
ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.
Carcinogenesis
Activation of RNA polymerase I transcription by hepatitis C virus core protein.
Carcinogenesis
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Carcinogenesis
Author Correction: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Carcinogenesis
Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals.
Carcinogenesis
BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.
Carcinogenesis
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
Carcinogenesis
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
Carcinogenesis
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
Carcinogenesis
CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the ?-catenin·TCF4 transcriptional activity in response to Wnt signaling.
Carcinogenesis
DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation.
Carcinogenesis
Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.
Carcinogenesis
Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.
Carcinogenesis
Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis.
Carcinogenesis
Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.
Carcinogenesis
Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis.
Carcinogenesis
Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Carcinogenesis
Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis.
Carcinogenesis
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Carcinogenesis
Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.
Carcinogenesis
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling.
Carcinogenesis
RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma.
Carcinogenesis
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Carcinogenesis
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
Carcinogenesis
The prognostic signature of the somatic mutations in Ewing sarcoma: from a network view.
Carcinogenesis
The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II.
Carcinogenesis
Tissue, sex, and animal species specificity of aflatoxin B1 inhibition of nuclear RNA polymerase II activity.
Carcinoma
B2 RNA and 7SK RNA, RNA polymerase III transcripts, have a cap-like structure at their 5' end.
Carcinoma
Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma.
Carcinoma
CUT&RUN detects distinct DNA footprints of RNA polymerase II near the transcription start sites.
Carcinoma
Differential Incorporation of ?-actin as A Component of RNA Polymerase II into Regulatory Regions of Stemness/Differentiation Genes in Retinoic Acid-Induced Differentiated Human Embryonic Carcinoma Cells.
Carcinoma
DNA-dependent RNA polymerases of Ehrlich carcinoma, other murine ascites tumors, and murine normal tissues.
Carcinoma
Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.
Carcinoma
Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.
Carcinoma
Inclusion of a matrix-attached region in a 7SK pol III vector increases the efficiency of shRNA-mediated gene silencing in embryonic carcinoma cells.
Carcinoma
Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2.
Carcinoma
Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.
Carcinoma
The most abundant nascent poly(A) + RNAs are transcribed by RNA polymerase III in murine tumor cells.
Carcinoma
The preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
Carcinoma
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
Carcinoma
von Hippel-Lindau-Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas.
Carcinoma
[B2 RNA and 7SK RNA, transcripts of RNA-polymerase III, have a cap-like structure at the 5'-end]
Carcinoma
[Synthesis by RNA polymerase III of high-molecular weight of polyadenylated RNA in Ehrlich carcinoma cells]
Carcinoma, Ehrlich Tumor
Accurate transcription initiation in an Ehrlich ascites tumor cell lysate.
Carcinoma, Ehrlich Tumor
Conformational change of DNA binding subunit of RNA polymerase II on binding to DNA.
Carcinoma, Ehrlich Tumor
Daunorubicin inhibition of DNA-dependent RNA polymerases from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Difference in phosphorylation of two factors stimulating RNA polymerase II of Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II.
Carcinoma, Ehrlich Tumor
DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.
Carcinoma, Ehrlich Tumor
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. V. Characterization of a factor repressing RNA polymerase II as a ribonucleoprotein.
Carcinoma, Ehrlich Tumor
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. 3. Ribonuclease H and elongating activity of stimulatory factor S-II.
Carcinoma, Ehrlich Tumor
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. I. Partial purification and characterization of RNA polymerase II.
Carcinoma, Ehrlich Tumor
Enhancement of ormation of the initiation complex by factor stimulating RNA polymerase II from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Evidence that stimulatory factor(s) of RNA polymerase II participates in accurate transcription in a HeLa cell lysate.
Carcinoma, Ehrlich Tumor
Identification of subunits of RNA polymerase II from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Identification of the DNA binding subunit of RNA polymerase II from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Protein which interacts with a stimulatory factor of RNA polymerase II of Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Purification and preparation of antibody to RNA polymerase II stimulatory factors from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II.
Carcinoma, Ehrlich Tumor
Purification of a new protein stimulating RNA polymerase II from Ehrlich ascites tumor cells: comparison with proteins purified before.
Carcinoma, Ehrlich Tumor
Regulation of nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Regulation of the nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Regulation of the Nucleolar DNA-Dependent RNA Polymerase by Amino Acids in Ehrlich Ascites Tumor Cells.
Carcinoma, Ehrlich Tumor
Retrostatin, a new specific enzyme inhibitor against avian myeloblastosis virus reverse transcriptase.
Carcinoma, Ehrlich Tumor
Separation of a stimulatory factor of RNA polymerase II from protein kinase activity of Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Stimulation of messenger ribonucleic acid synthesis in isolated nuclei by a protein that stimulates RNA polymerase II.
Carcinoma, Ehrlich Tumor
Stimulatory proteins of RNA polymerase II from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Structural relationships of the three stimulatory factors of RNA polymerase II from Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Transcription factor(s) of Ehrlich ascites tumor cells having affinity to the 'TATA' box and a further upstream region of the adenovirus 2 major late gene.
Carcinoma, Ehrlich Tumor
Transcription in vitro of Ehrlich ascites tumor DNA and chromatin by purified homologous RNA polymerase II (or B).
Carcinoma, Ehrlich Tumor
Transcription of globin genes in murine erythroleukemic cell chromatin by RNA polymerase II from mouse cells.
Carcinoma, Ehrlich Tumor
[A protein stimulating the activity of RNA polymerase II of Ehrlich ascites tumor cells (author's transl)]
Carcinoma, Embryonal
Regulation of a TATA-binding protein-associated factor during cellular differentiation.
Carcinoma, Embryonal
Regulation of RNA polymerase I transcription in response to F9 embryonal carcinoma stem cell differentiation.
Carcinoma, Embryonal
Regulation of RNA polymerase III transcription in response to F9 embryonal carcinoma stem cell differentiation.
Carcinoma, Hepatocellular
A comparative study of DNA-dependent RNA polymerases from rat ascites hepatoma cell nuclei and from rat liver nuclei.
Carcinoma, Hepatocellular
Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII.
Carcinoma, Hepatocellular
Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase.
Carcinoma, Hepatocellular
Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription.
Carcinoma, Hepatocellular
Baculovirus mediated production of infectious hepatitis C virus in human hepatoma cells stably expressing t7 RNA polymerase.
Carcinoma, Hepatocellular
Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma.
Carcinoma, Hepatocellular
Comparison of the multiple deoxyribonucleic acid-dependent ribonucleic acid polymerase forms of whole rat liver and a minimal-deviation rat hepatoma cell line.
Carcinoma, Hepatocellular
Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.
Carcinoma, Hepatocellular
DNA-dependent RNA polymerase I from hepatomas: comparison of activity levels and properties.
Carcinoma, Hepatocellular
Fluctuations of DNA-dependent RNA polymerase and synthesis of macromolecules during the growth cycle of Novikoff rat hepatoma cells in suspension culture.
Carcinoma, Hepatocellular
Formation of transcribing mononucleosome-eukaryotic RNA polymerase II complexes in vitro as a simple model of active chromatin.
Carcinoma, Hepatocellular
Glucocorticoid-induced stimulation of ribosomal gene transcription in rat hepatoma cells is mediated by modification of RNA polymerase I or an associated factor.
Carcinoma, Hepatocellular
Glycerol inhibition of purified and chromatin-associated mouse liver hepatoma RNA polymerase II activity.
Carcinoma, Hepatocellular
HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Inhibition of EGFP expression by siRNA in EGFP-stably expressing Huh-7 cells.
Carcinoma, Hepatocellular
Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect.
Carcinoma, Hepatocellular
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.
Carcinoma, Hepatocellular
Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry.
Carcinoma, Hepatocellular
Monoclonal antibodies directed against mammalian RNA polymerase I. Identification of the catalytic center.
Carcinoma, Hepatocellular
Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection.
Carcinoma, Hepatocellular
Phosphorylation of deoxyribonucleic acid dependent RNA polymerase II by nuclear protein kinase NII: mechanism of enhanced ribonucleic acid synthesis.
Carcinoma, Hepatocellular
Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides.
Carcinoma, Hepatocellular
Protein kinase NII. Interaction with RNA polymerase II and contribution to immunological cross-reactivity of RNA polymerases I and II.
Carcinoma, Hepatocellular
Reduction in RNA synthesis following red cell-mediated microinjection of antibodies to RNA polymerase I.
Carcinoma, Hepatocellular
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
Carcinoma, Hepatocellular
RNA polymerase I in hepatoma 3924A: mechanism of enhanced activity relative to liver.
Carcinoma, Hepatocellular
RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma.
Carcinoma, Hepatocellular
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Carcinoma, Hepatocellular
shRNA driven by Pol II/T7 dual-promoter system effectively induce cell-specific RNA interference in mammalian cells.
Carcinoma, Hepatocellular
The effect of hydroxycamptothecin in the activity of RNA and DNA polymerases prepared from murine hepatoma cells.
Carcinoma, Hepatocellular
The relationship between the activity of DNA-dependent RNA polymerase I and the rate of synthesis of rRNA in hepatoma cells in culture.
Carcinoma, Hepatocellular
The significance of Brf1 overexpression in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Carcinoma, Hepatocellular
Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV.
Carcinoma, Lewis Lung
The preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
Carcinoma, Non-Small-Cell Lung
Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
RPB5-mediating protein promotes the progression of non-small cell lung cancer by regulating the proliferation and invasion.
Carcinoma, Non-Small-Cell Lung
The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth.
Carcinoma, Renal Cell
Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma.
Carcinoma, Squamous Cell
Small stable RNA level depends on the physiological state of the cell.
Carcinoma, Squamous Cell
[Dynamic phosphorylation of RNA polymerase III holoenzyme subunits from human epidermoid carcinoma cells A431 cultivated under different conditions]
Carcinoma, Squamous Cell
[Subunits of human holoenzyme of DNA dependent RNA polymerase III phosphorylated in vivo]
Carcinoma, Squamous Cell
[SUBUNITS OF MAMMAL DNA DEPENDENT RNA POLYMERASE III MODIFIED IN VIVO].
Cardiomegaly
A Ras-dependent pathway regulates RNA polymerase II phosphorylation in cardiac myocytes: implications for cardiac hypertrophy.
Cardiomegaly
Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription.
Cardiomegaly
Control of histone H3 phosphorylation by CaMKII? in response to haemodynamic cardiac stress.
Cardiomegaly
Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.
Cardiomegaly
Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II.
Cardiomegaly
Maf1 ameliorates cardiac hypertrophy by inhibiting RNA polymerase III through ERK1/2.
Cardiomegaly
Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9.
Cardiomegaly
Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy.
Cardiomyopathy, Dilated
POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.
Cardiovascular Diseases
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
Cataract
Comprehensive Profiling of Proteome and Ubiquitome Changes in Human Lens Epithelial Cell Line after Ultraviolet-B Irradiation.
Cataract
Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome.
Cataract
Recessive Mutations in POLR3B Encoding RNA Polymerase III Subunit Causing Diffuse Hypomyelination in Patients with 4H Leukodystrophy with Polymicrogyria and Cataracts.
Central Nervous System Infections
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.
Cerebellar Diseases
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.
Chickenpox
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Chickenpox
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
Chickenpox
The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.
Chordoma
Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067.
Classical Swine Fever
Development of a novel single-step reverse genetics system for the generation of classical swine fever virus.
Classical Swine Fever
Efficient and stable rescue of classical swine fever virus from cloned cDNA using an RNA polymerase II system.
Classical Swine Fever
Membrane-anchored incorporation of a foreign protein in recombinant influenza virions.
Classical Swine Fever
Recovery of infectious classical swine fever virus (CSFV) from full-length genomic cDNA clones by a swine kidney cell line expressing bacteriophage T7 RNA polymerase.
Cockayne Syndrome
A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair.
Cockayne Syndrome
A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription.
Cockayne Syndrome
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a.
Cockayne Syndrome
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.
Cockayne Syndrome
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.
Cockayne Syndrome
Cockayne syndrome group B protein enhances elongation by RNA polymerase II.
Cockayne Syndrome
Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth.
Cockayne Syndrome
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.
Cockayne Syndrome
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality.
Cockayne Syndrome
DNA damage stabilizes interaction of CSB with the transcription elongation machinery.
Cockayne Syndrome
FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.
Cockayne Syndrome
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Cockayne Syndrome
Involvement of mismatch repair in transcription-coupled nucleotide excision repair.
Cockayne Syndrome
Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair.
Cockayne Syndrome
Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.
Cockayne Syndrome
Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
Cockayne Syndrome
Modulation of Rad26- and Rpb9-mediated DNA repair by different promoter elements.
Cockayne Syndrome
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Cockayne Syndrome
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
Cockayne Syndrome
Rad26, the yeast homolog of the cockayne syndrome B gene product, counteracts inhibition of DNA repair due to RNA polymerase II transcription.
Cockayne Syndrome
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
Cockayne Syndrome
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells.
Cockayne Syndrome
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells.
Cockayne Syndrome
Requirement of yeast RAD2, a homolog of human XPG gene, for efficient RNA polymerase II transcription. implications for Cockayne syndrome.
Cockayne Syndrome
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
Cockayne Syndrome
RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells.
Cockayne Syndrome
Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair.
Cockayne Syndrome
Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.
Cockayne Syndrome
Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair.
Cockayne Syndrome
Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast.
Cockayne Syndrome
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.
Cockayne Syndrome
The Winged Helix Domain of CSB Regulates RNAPII Occupancy at Promoter Proximal Pause Sites.
Cockayne Syndrome
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro.
Cockayne Syndrome
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches.
Cockayne Syndrome
Truncated Cockayne syndrome B protein represses elongation by RNA polymerase I.
Cockayne Syndrome
UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein.
Cockayne Syndrome
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.
Cockayne Syndrome
UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.
Cockayne Syndrome
Von Hippel-Lindau-Coupled and Transcription-Coupled Nucleotide Excision Repair-Dependent Degradation of RNA Polymerase II in Response to Trabectedin.
Cockayne Syndrome
What happens at the lesion does not stay at the lesion: Transcription-coupled nucleotide excision repair and the effects of DNA damage on transcription in cis and trans.
Cockayne Syndrome
XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population.
Coinfection
Expression of cDNA encoding the Sendai virus hemagglutinin-neuraminidase gene: characterization of wild-type and mutant gene products.
Coinfection
Expression of functional Bunyamwera virus L protein by recombinant vaccinia viruses.
Coinfection
Expression of target genes by coinfection with replication-deficient viral vectors.
Coinfection
Feline calicivirus capsid protein expression and capsid assembly in cultured feline cells.
Coinfection
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Coinfection
Optimization of plasmid-only rescue of highly attenuated and temperature-sensitive respiratory syncytial virus (RSV) vaccine candidates for human trials.
Colonic Neoplasms
Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors.
Colonic Neoplasms
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
Colonic Neoplasms
Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.
Colonic Neoplasms
RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells.
Colorectal Neoplasms
Association Between Germline Mutations in BRF1, a subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.
Colorectal Neoplasms
Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.
Colorectal Neoplasms
Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers.
Colorectal Neoplasms
Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis.
Colorectal Neoplasms
Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment.
Connective Tissue Diseases
Analysis of anti-RNA polymerase III antibodies in Chinese Han systemic sclerosis patients.
COVID-19
Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors.
COVID-19
Cardioembolic Stroke in a Patient with Coronavirus Disease of 2019 (COVID-19) Myocarditis: A Case Report.
COVID-19
Epidemiological and Clinical Findings of Short-Term Recurrence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid Polymerase Chain Reaction Positivity in 1282 Discharged Coronavirus Disease 2019 Cases: A Multicenter, Retrospective, Observational Study.
Cowpox
Recombinant protein synthesis in Chinese hamster ovary cells using a vaccinia virus/bacteriophage T7 hybrid expression system.
Cowpox
The vaccinia virus fusion inhibitor proteins SPI-3 (K2) and HA (A56) expressed by infected cells reduce the entry of superinfecting virus.
Cystic Fibrosis
Detection of Pseudomonas aeruginosa in sputum from cystic fibrosis patients by the polymerase chain reaction.
Cystic Fibrosis
Expression in Escherichia coli of cytoplasmic portions of the cystic fibrosis transmembrane conductance regulator: apparent bacterial toxicity of peptides containing R-domain sequences.
Cysts
Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage.
Cysts
DNA-dependent RNA polymerase I from Acanthamoeba castellanii: comparison of the catalytic properties and subunit architectures of the trophozoite and cyst enzymes.
Cysts
DNA-dependent RNA polymerase II from Acanthamoeba castellanii. Comparison of the catalytic properties and subunit architectures of the trophozoite and cyst enzymes.
Cysts
DNA-dependent RNA polymerase III from Acanthamoeba castellanii: comparison of the catalytic properties of the trophozoite and cyst enzymes.
Cytomegalovirus Infections
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Cytomegalovirus Infections
Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome.
De Lange Syndrome
Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome.
Dengue
A quantitative luciferase-based cell-cell fusion assay to measure four-serotype dengue virus E protein-triggered membrane fusion.
Dengue
Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity.
Dengue
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.
Diabetes Mellitus, Type 1
Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes.
dna topoisomerase deficiency
Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes.
DNA Virus Infections
Alteration of the Premature tRNA Landscape by Gammaherpesvirus Infection.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Dyskinesias
Striatal NELF-mediated RNA polymerase II stalling controls L-dopa induced dyskinesia.
Encephalitis
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response.
Encephalitis
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Encephalitis, Japanese
Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA.
Encephalitis, Tick-Borne
T7 DNA-dependent RNA polymerase can transcribe RNA from tick-borne encephalitis virus (TBEV) cDNA with SP6 promoter.
Encephalitis, Tick-Borne
[New Genetic Marker of Human Predisposition to Severe Forms of Tick-Borne Encephalitis].
Encephalomyelitis, Venezuelan Equine
RNA-polymerase, type I: activity in rat brain cell nuclei and peripheral blood mononuclear cells after Venezuelan equine encephalomyelitis virus infection.
Encephalomyelitis, Venezuelan Equine
[Expression of fragments of Venezuelan equine encephalomyelitis virus E2 protein in a system based on phage T7 RNA polymerase]
Endocarditis
Clonal structure of Streptococcus sanguinis strains isolated from endocarditis cases and the oral cavity.
Endometrial Neoplasms
Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ER? in Tamoxifen-Associated Endometrial Carcinomas.
Endophthalmitis
Reliability of nested polymerase chain reaction in the diagnosis of bacterial endophthalmitis.
Enzootic Bovine Leukosis
An avian retrovirus uses canonical expression and processing mechanisms to generate viral microRNA.
Enzootic Bovine Leukosis
Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo.
Enzootic Bovine Leukosis
Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome.
Enzootic Bovine Leukosis
Deep sequencing reveals abundant noncanonical retroviral microRNAs in B-cell leukemia/lymphoma.
Enzootic Bovine Leukosis
Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs.
Enzootic Bovine Leukosis
In vitro accurate transcription from the cap site of bovine leukemia virus (BLV) dependent on the BLV-infected cell nuclear lysate.
Epstein-Barr Virus Infections
Identification of novel biomarkers and small-molecule compounds for nasopharyngeal carcinoma with metastasis.
Epstein-Barr Virus Infections
RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus.
Equine Infectious Anemia
dUTPase from the retrovirus equine infectious anemia virus: high-level expression in Escherichia coli and purification.
Esophageal Motility Disorders
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis.
Esophageal Neoplasms
Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9.
Esophageal Neoplasms
[Establishment of cDNA microarray technology and analysis of gene expression profiles in human esophageal cancer cell line ECa109]
exodeoxyribonuclease (lambda-induced) deficiency
Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli.
Fatty Liver
Study of the protective effect of an anabolic steroid, 19-nortestosterone phenylpropionate (19-NTPP) on the fatty liver induced by high doses of rifampicin in the rat.
Foot-and-Mouth Disease
Development of a hamster kidney cell line expressing stably T7 RNA polymerase using retroviral gene transfer technology for efficient rescue of infectious foot-and-mouth disease virus.
Foot-and-Mouth Disease
Effect of actinomycin D on virus-induced ribonucleic acid polymerase formation in foot-and-mouth disease virus-infected baby hamster kidney cells.
Foot-and-Mouth Disease
Effect of foot-and-mouth disease virus on protein synthesis and ribonucleic acid polymerase activity at various temperatures.
Foot-and-Mouth Disease
Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus.
Foot-and-Mouth Disease
Foot-and-mouth disease virus-induced ribonucleic acid polymerase in baby hamster kidney cells.
Foot-and-Mouth Disease
In vitro products of a membrane-free foot-and-mouth disease virus ribonucleic acid polymerase.
Foot-and-Mouth Disease
Recovery of infectious foot-and-mouth disease virus from full-length genomic cDNA clones using an RNA polymerase I system.
Fowlpox
Efficient rescue of infectious bursal disease virus from cloned cDNA: evidence for involvement of the 3'-terminal sequence in genome replication.
Fowlpox
Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus.
Fowlpox
Presence of an encephalomyocarditis virus internal ribosome entry site sequence in avian infectious bronchitis virus defective RNAs abolishes rescue by helper virus.
Fowlpox
Recovery and characterization of a chimeric rinderpest virus with the glycoproteins of peste-des-petits-ruminants virus: homologous F and H proteins are required for virus viability.
Fowlpox
Recovery of genetically defined murine norovirus in tissue culture by using a fowlpox virus expressing T7 RNA polymerase.
Fowlpox
Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses.
Fowlpox
Transient Dominant Selection for the Modification and Generation of Recombinant Infectious Bronchitis Coronaviruses.
Friedreich Ataxia
A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro.
Friedreich Ataxia
The GAA*TTC triplet repeat expanded in Friedreich's ataxia impedes transcription elongation by T7 RNA polymerase in a length and supercoil dependent manner.
Frontotemporal Dementia
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Gastric Antral Vascular Ectasia
Evaluation and management of gastrointestinal manifestations in scleroderma.
Gastric Antral Vascular Ectasia
Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis.
Gastric Antral Vascular Ectasia
Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement.
Genetic Diseases, Inborn
Dynamics of the RNA polymerase I TFIIF/TFIIE-like subcomplex: a mini-review.
Genetic Diseases, Inborn
Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III.
Genetic Diseases, Inborn
The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same.
Glioma
C/EBP? mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas.
Glioma
Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II.
Glioma
Interferon-? sensitizes human glioblastoma cells to the cyclin-dependent kinase inhibitor, TG02.
Glioma
Isoproterenol-induced selective phosphorylation in vivo of the 214,000 dalton subunit of rat C6 glioma cell RNA polymerase II.
Glioma
Phosphorylation of rat C6 glioma cell DNA-dependent RNA polymerase II in vivo. Identification of phosphorylated subunits and modulation of phosphorylation by isoproterenol and N6,O2'-dibutyryl cyclic AMP.
Glioma
RNA polymerase II in C6 glioma cells. Alpha-amanitin blockade of cAMP phosphodiesterase induction by beta-adrenergic stimulation.
Glomerulonephritis
Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma.
Hantavirus Infections
Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein.
Hearing Loss
Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
Heart Defects, Congenital
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hematologic Neoplasms
The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer.
Hematologic Neoplasms
The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers.
Hemorrhagic Septicemia, Viral
An RNA-binding domain in the viral haemorrhagic septicaemia virus nucleoprotein.
Hepatic Insufficiency
[Prognostic use of the determination of serum AFP in acute hepatic insufficiency caused by the blockade of hepatocyte RNA polymerase II]
Hepatitis
A Reverse Genetics System for Cypovirus Based on a Bacmid Expressing T7 RNA Polymerase.
Hepatitis
Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II.
Hepatitis
Conserved features of an RNA promoter for RNA polymerase II determined from sequence heterogeneity of a hepatitis delta virus population.
Hepatitis
Development of a novel Borna disease virus reverse genetics system using RNA polymerase II promoter and SV40 nuclear import signal.
Hepatitis
Efficient and stable rescue of classical swine fever virus from cloned cDNA using an RNA polymerase II system.
Hepatitis
Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs.
Hepatitis
Endogenous promoters can direct the transcription of hepatitis delta virus RNA from a recircularized cDNA template.
Hepatitis
Establishment of an entirely plasmid-based reverse genetics system for Bluetongue virus.
Hepatitis
Formation of an RNA polymerase II preinitiation complex on an RNA promoter derived from the hepatitis delta virus RNA genome.
Hepatitis
Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity.
Hepatitis
High-frequency leader sequence switching during coronavirus defective interfering RNA replication.
Hepatitis
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Hepatitis
Identification and characterization of a hepatitis delta virus RNA transcriptional promoter.
Hepatitis
Inhibition of Cellular RNA polymerase II transcription by delta antigen of hepatitis delta virus.
Hepatitis
Multiple genomic sequences of hepatitis delta virus are associated with cDNA promoter activity and RNA double rolling-circle replication.
Hepatitis
Phosphorylation of serine 177 of the small hepatitis delta antigen regulates viral antigenomic RNA replication by interacting with the processive RNA polymerase II.
Hepatitis
Recovery of a virulent strain of newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation.
Hepatitis
Recovery of avian metapneumovirus subgroup C from cDNA: cross-recognition of avian and human metapneumovirus support proteins.
Hepatitis
Recovery of infectious type Asia1 foot-and-mouth disease virus from suckling mice directly inoculated with an RNA polymerase I/II-driven unidirectional transcription plasmid.
Hepatitis
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Hepatitis
Replication of flock house virus RNAs from primary transcripts made in cells by RNA polymerase II.
Hepatitis
Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence.
Hepatitis
Ribonucleic acid synthesis and nuclear ribonucleic acid polymerase activity in livers of mice infected with mouse hepatitis virus (MHV-3).
Hepatitis
RNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases.
Hepatitis
RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies.
Hepatitis
Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells.
Hepatitis
Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases.
Hepatitis
Single-Round Infectious Particle Production by DNA-Launched Infectious Clones of Bungowannah Pestivirus.
Hepatitis
The human RNA polymerase II interacts with the terminal stem-loop regions of the hepatitis delta virus RNA genome.
Hepatitis
The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza-virus-like RNAs with precise 3' ends in a plasmid-only-based virus rescue system.
Hepatitis
The RNAs of hepatitis delta virus are copied by RNA polymerase II in nuclear homogenates.
Hepatitis A
Baculovirus mediated production of infectious hepatitis C virus in human hepatoma cells stably expressing t7 RNA polymerase.
Hepatitis A
Characterization of replication-competent hepatitis A virus constructs containing insertions at the N terminus of the polyprotein.
Hepatitis A
Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells.
Hepatitis A
The 5'-terminal nucleotides of hepatitis A virus RNA, but not poliovirus RNA, are required for infectivity.
Hepatitis B
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver.
Hepatitis B
Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II.
Hepatitis B
Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice.
Hepatitis B
Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway.
Hepatitis B
Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5.
Hepatitis B
Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein.
Hepatitis B
RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein.
Hepatitis B
Rpb5, a subunit shared by eukaryotic RNA polymerases, cooperates with prefoldin-like Bud27/URI.
Hepatitis B
The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF.
Hepatitis B
The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.
Hepatitis B
The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters.
Hepatitis B
The new core promoter element XCPE1 (X Core Promoter Element 1) directs activator-, mediator-, and TATA-binding protein-dependent but TFIID-independent RNA polymerase II transcription from TATA-less promoters.
Hepatitis B
Transcriptional regulation of the TATA-binding protein by Ras cellular signaling.
Hepatitis B
tRNA Lys3 promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs.
Hepatitis C
Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1.
Hepatitis C
Activation of RNA polymerase I transcription by hepatitis C virus core protein.
Hepatitis C
Baculovirus mediated production of infectious hepatitis C virus in human hepatoma cells stably expressing t7 RNA polymerase.
Hepatitis C
ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver.
Hepatitis C
Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons.
Hepatitis C
Interferon alpha-2b inhibits negative-strand RNA and protein expression from full-length HCV1a infectious clone.
Hepatitis C
Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
Hepatitis C
Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription.
Hepatitis C
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.
Hepatitis C
Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV.
Hepatitis C
Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation.
Hepatitis, Chronic
Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice.
Herpes Simplex
A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.
Herpes Simplex
A murine RNA polymerase I promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection.
Herpes Simplex
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Herpes Simplex
Activation of expression of multiple subfamilies of human Alu elements by adenovirus type 5 and herpes simplex virus type 1.
Herpes Simplex
Activation of RNA polymerase II by topologically linked DNA-tracking proteins.
Herpes Simplex
Activation of RNA polymerase III transcription of human Alu elements by herpes simplex virus.
Herpes Simplex
An amplification-promoting sequence from mouse genomic DNA: interaction with a trans-acting factor that also affects gene expression.
Herpes Simplex
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.
Herpes Simplex
Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme.
Herpes Simplex
Binding of ICP4, TATA-binding protein, and RNA polymerase II to herpes simplex virus type 1 immediate-early, early, and late promoters in virus-infected cells.
Herpes Simplex
Characterization of RNA polymerase II-dependent transcription in Xenopus extracts.
Herpes Simplex
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Herpes Simplex
Cooperation between herpes simplex virus specific alpha protein and host cell RNA polymerase II in the transcription of viral deoxypyrimidine kinase.
Herpes Simplex
Correction for Abrisch et al., Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Herpes Simplex
dUTPase from herpes simplex virus type 1; purification from infected green monkey kidney (Vero) cells and from an overproducing Escherichia coli strain.
Herpes Simplex
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation.
Herpes Simplex
Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off.
Herpes Simplex
Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation.
Herpes Simplex
Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection.
Herpes Simplex
Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27.
Herpes Simplex
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program.
Herpes Simplex
Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II.
Herpes Simplex
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Herpes Simplex
Herpes simplex virus type 1 infection leads to loss of serine-2 phosphorylation on the carboxyl-terminal domain of RNA polymerase II.
Herpes Simplex
Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes.
Herpes Simplex
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II.
Herpes Simplex
ICP27 Interacts with the C-Terminal Domain of RNA Polymerase II and Facilitates Its Recruitment to Herpes Simplex Virus 1 Transcription Sites, Where It Undergoes Proteasomal Degradation during Infection.
Herpes Simplex
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.
Herpes Simplex
Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.
Herpes Simplex
Identification of transcription factories in nuclei of HeLa cells transiently expressing the Us11 gene of herpes simplex virus type 1.
Herpes Simplex
In vitro transcription of herpes simplex virus genes. Partial purification and properties of RNA polymerase II from uninfected and infected Hep-2 cells.
Herpes Simplex
In vitro transcription of herpes simplex virus genes: identification of a new initiation site and second intervening sequence in the immediate-early RNA-5 gene.
Herpes Simplex
Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Herpes Simplex
Inhibition of cdk9 during herpes simplex virus 1 infection impedes viral transcription.
Herpes Simplex
Inhibition of cellular and virus-associated nucleotide polymerases by, and anti-herpes simplex virus activity of, streptovaricin derivatives.
Herpes Simplex
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).
Herpes Simplex
Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation.
Herpes Simplex
Mitotic transcription repression in vivo in the absence of nucleosomal chromatin condensation.
Herpes Simplex
Protease footprinting reveals a surface on transcription factor TFIIB that serves as an interface for activators and coactivators.
Herpes Simplex
Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit.
Herpes Simplex
Purification and characterization of the herpes simplex virus type 1 ribonucleotide reductase small subunit following expression in Escherichia coli.
Herpes Simplex
Repression of host RNA polymerase II transcription by herpes simplex virus type 1.
Herpes Simplex
Requirement of host cell RNA polymerase II in the replication of herpes simplex virus in alpha-amanitin-sensitive and -resistant cell lines.
Herpes Simplex
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
Herpes Simplex
RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.
Herpes Simplex
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.
Herpes Simplex
RNA Polymerase II Promoter-Proximal Pausing and Release to Elongation Are Key Steps Regulating Herpes Simplex Virus 1 Transcription.
Herpes Simplex
Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.
Herpes Simplex
Synthesis of herpes simplex virus-specified RNA by an RNA polymerase II in isolated nuclei in vitro.
Herpes Simplex
TATA-binding protein and TBP-associated factors during herpes simplex virus type 1 infection: localization at viral DNA replication sites.
Herpes Simplex
The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
Herpes Simplex
The effects of herpes simplex virus type 1 on cellular DNA-dependent RNA polymerase activities.
Herpes Simplex
The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae.
Herpes Simplex
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.
Herpes Simplex
Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters.
Herpes Simplex
Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
Herpes Zoster
Computer-assisted primary and secondary structure analyses of DNA polymerases of herpes simplex, Epstein-Barr and varicella zoster viruses reveal conserved domains with some homology to DNA-binding domain in E. coli DNA pol I.
Herpes Zoster
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
Herpes Zoster
The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.
Histiocytosis
A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.
Histiocytosis, Langerhans-Cell
A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.
HIV Infections
Continuation of postpartum antiretroviral therapy in a cohort of women infected with human immunodeficiency virus.
Huntington Disease
Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.
Hyperglycemia
Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney.
Hyperostosis
A variant of neonatal progeroid syndrome, or Wiedemann-Rautenstrauch syndrome, is associated with a nonsense variant in POLR3GL.
Hypersensitivity
Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae.
Hypersensitivity
Conservation of major nuclease S1-sensitive sites in the non-conserved spacer region of ribosomal DNA in Drosophila species.
Hypersensitivity
Defects in yeast RNA polymerase II transcription elicit hypersensitivity to G1 arrest induced by Kluyveromyces lactis zymocin.
Hypersensitivity
DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.
Hypersensitivity
RBPJ binds to consensus and methylated cis elements within phased nucleosomes and controls gene expression in human aortic smooth muscle cells in cooperation with SRF.
Hypersensitivity
Role of Mediator in Regulating Pol II Elongation and Nucleosome Displacement in Saccharomyces cerevisiae.
Hypersensitivity
Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.
Hypersensitivity
Site-specific silencing of regulatory elements as a mechanism of X inactivation.
Hypersensitivity
Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Hypersensitivity
Specificity in transcriptional regulation in the absence of specific DNA binding sites: the case of T7 lysozyme.
Hypersensitivity
The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.
Hypersensitivity
The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model.
Hypersensitivity
Transcription elongation factors repress transcription initiation from cryptic sites.
Hypersensitivity
Underproduction of the largest subunit of RNA polymerase II causes temperature sensitivity, slow growth, and inositol auxotrophy in Saccharomyces cerevisiae.
Hypertension
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodelling.
Hypertrophy, Left Ventricular
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Hypogonadism
Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.
Hypothyroidism
Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos.
Ichthyosis
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells.
Infections
A hybrid baculovirus-T7 RNA polymerase system for recovery of an infectious virus from cDNA.
Infections
A murine RNA polymerase I promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection.
Infections
A mutation in the yeast mitochondrial core RNA polymerase, Rpo41, confers defects in both specificity factor interaction and promoter utilization.
Infections
A NEW RIBONUCLEIC ACID POLYMERASE APPEARING AFTER MENGOVIRUS INFECTION OF L-CELLS.
Infections
A transcriptionally active form of TFIIIC is modified in poliovirus-infected HeLa cells.
Infections
Accumulation of poliovirus proteins in uninfected isolated HEp-2 cell nuclei in vitro.
Infections
Activation of RNA polymerase III transcription of human Alu elements by herpes simplex virus.
Infections
Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.
Infections
alpha-Amanitin-Resistant Viral RNA Synthesis in Nuclei Isolated from Nuclear Polyhedrosis Virus-Infected Heliothis zea Larvae and Spodoptera frugiperda Cells.
Infections
An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development.
Infections
An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4.
Infections
An inhibitor of host sigma-stimulated core enzyme activity that purifies with DNA-dependent RNA polymerase of E. coli following T4 phage infection.
Infections
An isotopic study of DNA-dependent RNA polymerase of E. coli following T4 phage infection.
Infections
Arabidopsis Histone Reader EMSY-LIKE 1 Binds H3K36 and Suppresses Geminivirus Infection.
Infections
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.
Infections
Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme.
Infections
Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.
Infections
Bacteriophage T7 DNA ejection into cells is initiated by an enzyme-like mechanism.
Infections
Bacteriophage T7 DNA packaging. I. Plasmids containing a T7 replication origin and the T7 concatemer junction are packaged into transducing particles during phage infection.
Infections
Baculovirus infection raises the level of TATA-binding protein that colocalizes with viral DNA replication sites.
Infections
Cardioembolic Stroke in a Patient with Coronavirus Disease of 2019 (COVID-19) Myocarditis: A Case Report.
Infections
Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma brucei.
Infections
Chemical structure of a modification of the Escherichia coli ribonucleic acid polymerase alpha polypeptides induced by bacteriophage T4 infection.
Infections
Cleavage of transcriptional activator Oct-1 by poliovirus encoded protease 3Cpro.
Infections
Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors.
Infections
Cloning and expression of a recombinant CagA -gene fragment of Helicobacter pylori and its preliminary evaluation in serodiagnosis.
Infections
Coding sequences enhance internal initiation of translation by hepatitis A virus RNA in vitro.
Infections
Control of promoter utilization by bacteriophage T4-induced modification of RNA polymerase alpha subunit.
Infections
Correction for Abrisch et al., Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Infections
Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease. A retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children.
Infections
Cytomegalovirus late transcription factor target sequence diversity orchestrates viral early to late transcription.
Infections
Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells.
Infections
Deletion mapping of a mouse hepatitis virus defective interfering RNA reveals the requirement of an internal and discontiguous sequence for replication.
Infections
Delivery and expression of heterologous genes in mammalian cells using self-replicating alphavirus vectors.
Infections
Detection of a subunit of cellular Pol II within highly purified preparations of RNA polymerase isolated from rabbit poxvirus virions.
Infections
DING Protein Inhibits Transcription of HIV-1 Gene through Suppression of Phosphorylation of NF-?B p65.
Infections
Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitro.
Infections
Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes.
Infections
Disruption of Nuclear Organization during the Initial Phase of African Swine Fever Virus Infection.
Infections
Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III.
Infections
Efficiency of VIGS and gene expression in a novel bipartite potexvirus vector delivery system as a function of strength of TGB1 silencing suppression.
Infections
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.
Infections
ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver.
Infections
Enhancement of RNA polymerase III transcription by the E1A gene product of adenovirus.
Infections
Epigenetic reprogramming of host and viral genes by Human Cytomegalovirus infection in Kasumi-3 myeloid progenitor cells at early times post-infection.
Infections
Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA.
Infections
Evidence for direct involvement of T7 RNA polymerase bacteriophage DNA replication.
Infections
Expression and nuclear localization of the TATA-binding protein during baculovirus infection.
Infections
Expression of cDNA encoding the Sendai virus hemagglutinin-neuraminidase gene: characterization of wild-type and mutant gene products.
Infections
Expression of hepatitis A virus precursor protein P3 in vivo and in vitro: polyprotein processing of the 3CD cleavage site.
Infections
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Infections
Genome characterization, infectivity assays of in vitro and in vivo infectious transcripts of soybean yellow mottle mosaic virus from India reveals a novel short mild genotype.
Infections
Genome-wide mapping of infection-induced SINE RNAs reveals a role in selective mRNA export.
Infections
Genome-wide profiling of chicken dendritic cell response to infectious bursal disease.
Infections
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.
Infections
Hepatitis B virus X protein partially substitutes for E1A transcriptional function during adenovirus infection.
Infections
Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection.
Infections
Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27.
Infections
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program.
Infections
Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II.
Infections
Herpes simplex virus type 1 infection leads to loss of serine-2 phosphorylation on the carboxyl-terminal domain of RNA polymerase II.
Infections
Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression.
Infections
Hsc70 Focus Formation at the Periphery of HSV-1 Transcription Sites Requires ICP27.
Infections
HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III.
Infections
Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes.
Infections
Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II.
Infections
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Infections
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
Infections
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II.
Infections
ICP27 Interacts with the C-Terminal Domain of RNA Polymerase II and Facilitates Its Recruitment to Herpes Simplex Virus 1 Transcription Sites, Where It Undergoes Proteasomal Degradation during Infection.
Infections
ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expression.
Infections
Identification of upstream promoter elements mediating early transcription from the 35,000-molecular-weight protein gene of Autographa californica nuclear polyhedrosis virus.
Infections
Identifying the RNA polymerases that synthesize specific transcripts of the Autographa californica nuclear polyhedrosis virus.
Infections
IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications.
Infections
Impairment of host cell ribonucleic acid polymerase II after infection with frog virus 3.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infections
Infection by Herpes Simplex Virus 1 Causes Near-Complete Loss of RNA Polymerase II Occupancy on the Host Cell Genome.
Infections
Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter.
Infections
Influence of RNA polymerase II upon vaccinia virus-related translation examined by means of alpha-amanitin.
Infections
Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle.
Infections
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.
Infections
Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro.
Infections
Inhibition of cdk9 during herpes simplex virus 1 infection impedes viral transcription.
Infections
INHIBITION OF DEOXYRIBONUCLEIC ACID-DIRECTED RIBONUCLEIC ACID POLYMERASE IN ESCHERICHIA COLI AFTER INFECTION WITH BACTERIOPHAGE T4.
Infections
Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.
Infections
Inhibition of host cell RNA polymerase III-mediated transcription by poliovirus: inactivation of specific transcription factors.
Infections
Inhibition of rRNA synthesis by poliovirus: specific inactivation of transcription factors.
Infections
Insight into DNA and protein transport in double-stranded DNA viruses: the structure of bacteriophage N4.
Infections
Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites.
Infections
Low molecular weight viral RNAs transcribed by RNA polymerase III during adenovirus 2 infection.
Infections
Lytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression.
Infections
Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection.
Infections
Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription.
Infections
Modulatory effect of rRNA synthesis and ppUL83 nucleolar compartmentalization on human cytomegalovirus gene expression in vitro.
Infections
Molecular Pathways: Involvement of Helicobacter pylori-Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers.
Infections
Multiple roles of T7 RNA polymerase and T7 lysozyme during bacteriophage T7 infection.
Infections
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.
Infections
New small polypeptides associated with DNA-dependent RNA polymerase of Escherichia coli after infection with bacteriophage T4.
Infections
New small proteins associated with DNA-dependent RNA polymerase of Escherichia coli after infection with T4 phage.
Infections
Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis.
Infections
ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68.
Infections
Overproduction of the toxic protein, bovine pancreatic DNaseI, in Escherichia coli using a tightly controlled T7-promoter-based vector.
Infections
Poliovirus 3C protease-mediated degradation of transcriptional activator p53 requires a cellular activity.
Infections
Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus.
Infections
Production of pro-opiomelanocortin (POMC) by a vaccinia virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme.
Infections
Purification and characterization of bacteriophage gh-I-induced deoxyribonucleic acid-dependent ribonucleic acid polymerase from Pseudomonas putida.
Infections
Quantitative real time RT-PCR study of pathogen-induced gene expression in rock bream (Oplegnathus fasciatus): Internal controls for data normalization.
Infections
Recognition properties of the beta subunit of Escherichia coli ribonucleic acid polymerase.
Infections
Recovery of DNA-dependent RNA polymerase activities from L cells after mengovirus infection.
Infections
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Infections
Recruitment to the cytoplasm of a cellular lamin-like protein from the nucleus during a poxvirus infection.
Infections
Regulation of histone deposition on the herpes simplex virus type 1 genome during lytic infection.
Infections
Reorganization of RNA polymerase II on the SV40 genome occurs coordinately with the early to late transcriptional switch.
Infections
Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells.
Infections
RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters.
Infections
RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.
Infections
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.
Infections
RNA Polymerase II Promoter-Proximal Pausing and Release to Elongation Are Key Steps Regulating Herpes Simplex Virus 1 Transcription.
Infections
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
Infections
RNA-polymerase, type I: activity in rat brain cell nuclei and peripheral blood mononuclear cells after Venezuelan equine encephalomyelitis virus infection.
Infections
Role of Viral Hemorrhagic Septicemia Virus Matrix (M) Protein in Suppressing Host Transcription.
Infections
Roles of vaccinia virus ribonucleotide reductase and glutaredoxin in DNA precursor biosynthesis.
Infections
rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus.
Infections
Sarcocysts of an unidentified species of Sarcocystis in the sea otter (Enhydra lutris).
Infections
Scaffold attachment factor B suppresses HIV-1 infection of CD4+ T cells by preventing binding of RNA polymerase II to HIV-1's long terminal repeat.
Infections
Selective transcription of vaccinia virus genes in template dependent soluble extracts of infected cells.
Infections
Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice.
Infections
Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells.
Infections
Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.
Infections
Synthesis of a eukaryotic virus protein in a prokaryotic viral-cell system: production of the adenovirus type 2 fiber shaft fragment by a tightly regulated T7POL-M13 expression system.
Infections
T7 infection-dependent selective expression of cloned genes in P1-lysogenic Escherichia coli.
Infections
T7-promoter-based Escherichia coli expression system induced with bacteriophage M13HEP.
Infections
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
Infections
Temporal studies of factors associated with changes in transcription during Q fever.
Infections
The 19S proteasome activator promotes human cytomegalovirus immediate early gene expression through proteolytic and nonproteolytic mechanisms.
Infections
The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes.
Infections
The effect of Mengovirus infection on the activity of the DNA-dependent RNA polymerase of L-cells.
Infections
The effect of mengovirus infection on the activity of the DNA-dependent RNA polymerase of L-cells. II. Preliminary data on the inhibitory factor.
Infections
The herpes simplex virus 1 protein ICP4 acts as both an activator and repressor of host genome transcription during infection.
Infections
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.
Infections
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Infections
The N-terminus of Bunyamwera virus NSs protein is essential for interferon antagonism.
Infections
The protamine-like DNA-binding protein P6.9 epigenetically up-regulates Autographa californica multiple nucleopolyhedrovirus gene transcription in the late infection phase.
Infections
The simian immunodeficiency virus targets central cell cycle functions through transcriptional repression in vivo.
Infections
The SWI/SNF-Related, Matrix Associated, Actin-Dependent Regulator of Chromatin A4 Core Complex Represses Respiratory Syncytial Virus-Induced Syncytia Formation and Subepithelial Myofibroblast Transition.
Infections
The transcriptional role of host DNA-dependent RNA polymerases in adenovirus-infected KB cells.
Infections
The use of adenovirus-infected HeLa cells for the detection of low titer autoantibodies.
Infections
Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin.
Infections
Trichinella spiralis-infected muscle cells: abundant RNA polymerase II in nuclear speckle domains colocalizes with nuclear antigens.
Infections
Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
Infections
Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A.
Infections
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Infections
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.
Infections
Vaccinia virus-bacteriophage T7 expression vector for complementation analysis of late gene processes.
Infections
Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins.
Infections
VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.
Infections
Wide range of quasispecies diversity during primary hepatitis C virus infection.
Infections
[Construction of minigenome of Newcastle disease virus of goose origin and its preliminary application]
Infections
[Effect of the attenuated strain (TC-83) of Venezuelan equine encephalitis virus on nuclear transcription in rat brain cells]
Infertility
KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth.
Infertility, Male
DSP1 and DSP4 Act Synergistically in Small Nuclear RNA 3' End Maturation and Pollen Growth.
Influenza in Birds
Avian Influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection.
Influenza, Human
An efficient screening system for influenza virus cap-dependent endonuclease inhibitors.
Influenza, Human
Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase.
Influenza, Human
Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II.
Influenza, Human
Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.
Influenza, Human
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Influenza, Human
Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.
Influenza, Human
Characterization of the ribonucleic acid product synthesized by on influenza A2 virus-induced ribonucleic acid polymerase in vitro.
Influenza, Human
CHD6, a Cellular Repressor of Influenza Virus Replication, Is Degraded in Human Alveolar Epithelial Cells and Mice Lungs during Infection.
Influenza, Human
Cloning of the canine RNA polymerase I promoter and establishment of reverse genetics for influenza A and B in MDCK cells.
Influenza, Human
Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells.
Influenza, Human
Cloning the Horse RNA Polymerase I Promoter and Its Application to Studying Influenza Virus Polymerase Activity.
Influenza, Human
Comparison of vRNA and cRNA based reporters for detection of influenza replication.
Influenza, Human
Cyclin T1/CDK9 interacts with influenza A viral polymerase and facilitates its association with cellular RNA Polymerase II.
Influenza, Human
Deoxyribonucleic acid-dependent ribonucleic acid polymerase activity in cells infected with influenza virus.
Influenza, Human
Detection and identification of human influenza viruses by the polymerase chain reaction.
Influenza, Human
Development of a swine RNA polymerase I driven Influenza reverse genetics system for the rescue of type A and B Influenza viruses.
Influenza, Human
DNA intercalator stimulates influenza transcription and virus replication.
Influenza, Human
Efficient translation of mRNAs in influenza A virus-infected cells is independent of the viral 5' untranslated region.
Influenza, Human
Establishment and characterization of a Madin-Darby canine kidney reporter cell line for influenza A virus assays.
Influenza, Human
From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor ? and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus.
Influenza, Human
Functional association between viral and cellular transcription during influenza virus infection.
Influenza, Human
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.
Influenza, Human
Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.
Influenza, Human
Human RNA polymerase I-driven reverse genetics for influenza a virus in canine cells.
Influenza, Human
Imaging and characterizing influenza A virus mRNA transport in living cells.
Influenza, Human
Improved and simplified recombineering approach for influenza virus reverse genetics.
Influenza, Human
In vitro product of a ribonucleic acid polymerase induced by influenza virus.
Influenza, Human
In vivo activity of an inhibitor of influenza virus-induced ribonucleic acid polymerase.
Influenza, Human
Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export.
Influenza, Human
Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection.
Influenza, Human
Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle.
Influenza, Human
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.
Influenza, Human
Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription.
Influenza, Human
Influenza virus-induced ribonucleic acid nucleotidyltransferase and the effect of actinomycin D on its formation.
Influenza, Human
Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.
Influenza, Human
Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate.
Influenza, Human
Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery.
Influenza, Human
Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells.
Influenza, Human
Membrane-anchored incorporation of a foreign protein in recombinant influenza virions.
Influenza, Human
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.
Influenza, Human
Mutations in influenza virus replication and transcription: detection of amino acid substitutions in hemagglutinin of an avian influenza virus (H1N1).
Influenza, Human
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response.
Influenza, Human
Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies.
Influenza, Human
Nuclear export of influenza A virus mRNAs requires ongoing RNA polymerase II activity.
Influenza, Human
Partial and full PCR-based reverse genetics strategy for influenza viruses.
Influenza, Human
Participation of DNA-dependent RNA polymerase II in replication of influenza viruses.
Influenza, Human
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex.
Influenza, Human
Rescue of a synthetic chloramphenicol acetyltransferase RNA into influenza virus-like particles obtained from recombinant plasmids.
Influenza, Human
Reverse genetics system for Uukuniemi virus (Bunyaviridae): RNA polymerase I-catalyzed expression of chimeric viral RNAs.
Influenza, Human
RNA Polymerase II Inhibitors Dissociate Antigenic Peptide Generation from Normal Viral Protein Synthesis: A Role for Nuclear Translation in Defective Ribosomal Product Synthesis?
Influenza, Human
RNA primers and the role of host nuclear RNA polymerase II in influenza viral RNA transcription.
Influenza, Human
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
Influenza, Human
Selection of the 5'-proximal translation initiation site is influenced by mRNA and eIF-2 concentrations.
Influenza, Human
Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein.
Influenza, Human
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Influenza, Human
Specific inhibition of influenza virus-induced ribonucleic acid polymerase by gliotoxin.
Influenza, Human
Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice.
Influenza, Human
Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Influenza, Human
Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins.
Influenza, Human
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Influenza, Human
Synthesis of influenza virus polypeptides in cells resistant to alpha-amanitin: evidence for the involvement of cellular RNA polymerase II in virus replication.
Influenza, Human
Synthesis of influenza virus: new impetus from an old enzyme, RNA polymerase I.
Influenza, Human
T7 RNA polymerase can direct expression of influenza virus cap-binding protein (PB2) in Escherichia coli.
Influenza, Human
The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins.
Influenza, Human
The mouse Pol I terminator is more efficient than the hepatitis delta virus ribozyme in generating influenza-virus-like RNAs with precise 3' ends in a plasmid-only-based virus rescue system.
Influenza, Human
The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template.
Influenza, Human
The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative- and positive-strand RNA viruses.
Influenza, Human
Thogoto and Dhori virus replication is blocked by inhibitors of cellular polymerase II activity but does not cause shutoff of host cell protein synthesis.
Influenza, Human
Transcription of the influenza ribonucleic acid genome by a virion polymerase. I. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymerase.
Influenza, Human
Virus-inducible reporter genes as a tool for detecting and quantifying influenza A virus replication.
Influenza, Human
[Inhibitory effect of 3'-azido-3'-azido-3'-deoxy- ribavirin-5'-triphosphate on RNA synthesis catalyzed by RNA polymerase from influenza A virus and by cellular DNA-dependent RNA polymerase II]
Insulin Resistance
Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.
Insulin Resistance
Underlying Mechanism of Insulin Resistance: A Bioinformatics Analysis Based on Validated Related-Genes from Public Disease Databases.
Insulinoma
Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme.
Intellectual Disability
Dysregulations of sonic hedgehog signaling in MED12-related X-linked intellectual disability disorders.
Intellectual Disability
Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.
Intellectual Disability
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling.
Intellectual Disability
Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.
Intellectual Disability
Missense variants in TAF1 and developmental phenotypes: challenges of determining pathogenicity.
Intellectual Disability
Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.
Intellectual Disability
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Iron Deficiencies
Cryptic transcription mediates repression of subtelomeric metal homeostasis genes.
Keratitis
Phylogenetic diversity and microsphere array-based genotyping of human pathogenic Fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006.
Kidney Failure, Chronic
Increase in deoxyribonuclease activity in uraemic lymphocytes is caused by the cleavage of the largest polymerase I subunit.
Latent Infection
A murine RNA polymerase I promoter inserted into the herpes simplex virus type 1 genome is functional during lytic, but not latent, infection.
Latent Infection
Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A.
Leiomyoma
Screening of potential biomarkers in uterine leiomyomas disease via gene expression profiling analysis.
Leiomyoma
Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells.
Leiomyoma
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
Leiomyosarcoma
miRNA deregulation targets specific pathways in leiomyosarcoma development: an in silico analysis.
Leukemia
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.
Leukemia
A novel CDK9 inhibitor shows potent anti-tumor efficacy in preclinical hematological tumor models.
Leukemia
A Phase I Trial of Vorinostat and Alvocidib in Patients with Relapsed, Refractory, or Poor Prognosis Acute Leukemia, or Refractory Anemia with Excess Blasts-2.
Leukemia
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Leukemia
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
Leukemia
CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus.
Leukemia
Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma.
Leukemia
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.
Leukemia
DOT1L complex regulates transcriptional initiation in human erythroleukemic cells.
Leukemia
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Leukemia
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC).
Leukemia
Effect of morpholinyladriamycin analogs and adriamycin on the activities of DNA polymerase alpha and RNA polymerase II of chicken leukemia cells.
Leukemia
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
Leukemia
Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
Leukemia
Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
Leukemia
Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.
Leukemia
Identification of a RNA polymerase II initiation site in the long terminal repeat of Moloney murine leukemia viral DNA.
Leukemia
In vitro transcription of Moloney leukemia virus genes in infected cell nuclei and chromatin: elongation of chromatin associated ribonucleic acid by Escherichia coli ribonucleic acid polymerase.
Leukemia
Inhibition of human immunodeficiency virus-1 reverse transcriptase by heme and synthetic heme analogs.
Leukemia
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Leukemia
Interaction of N-trifluoroacetyladriamycin-14-O-hemiadipate with chicken leukemia RNA polymerase. Formation of drug-enzyme complex.
Leukemia
Isolation and purification of protein kinase C from human leukemia ML-1 cells phosphorylation of human leukemia RNA polymerase II in vitro.
Leukemia
Liver-directed gene therapy: quantitative evaluation of promoter elements by using in vivo retroviral transduction.
Leukemia
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Leukemia
Novel approaches to reversing anti-cancer drug resistance using gene-specific therapeutics.
Leukemia
Novel Real-Time Simultaneous Amplification and Testing Method To Accurately and Rapidly Detect Mycobacterium tuberculosis Complex.
Leukemia
Optimization of in vitro transcription and full-length cDNA synthesis using the T4 bacteriophage gene 32 protein.
Leukemia
RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies.
Leukemia
Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1.
Leukemia
Specific transcriptional initiation in vitro on murine type C retrovirus promoters.
Leukemia
Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.
Leukemia
Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.
Leukemia
The 24,000 Da subunit is not required for the RNA synthesis activity of chicken leukemia RNA polymerase II.
Leukemia
The ability of a variety of polymerases to synthesize past site-specific cis-syn, trans-syn-II, (6-4), and Dewar photoproducts of thymidylyl-(3'-->5')-thymidine.
Leukemia
The elongation factor ELL (eleven-nineteen lysine-rich leukemia) is a selective coregulator for steroid receptor functions.
Leukemia
The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.
Leukemia
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
Leukemia
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.
Leukemia
The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells.
Leukemia
The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription.
Leukemia
The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ER? and enhancing enhancer-promoter interactions.
Leukemia
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins.
Leukemia
[Activity of DNA-dependent RNA polymerases A and B in spleen nuclei of mice infected with Rauscher leukemia virus]
Leukemia
[Application of transcription mediated amplification and real-time reverse transcription polymerase chain reaction in detection of human immunodeficiency virus RNA].
Leukemia
[Detection of serum HCV RNA in patients with chronic hepatitis C by transcription mediated amplification and real-time reverse transcription polymerase chain reaction].
Leukemia L1210
Purification and properties of RNA polymerase II from mouse leukemia L1210 ascites cells.
Leukemia, Erythroblastic, Acute
Accurate in vitro initiation of beta-globin gene transcription in induced Friend-cell nuclei.
Leukemia, Erythroblastic, Acute
Assembly of nuclear ribonucleoprotein particles during in vitro transcription.
Leukemia, Erythroblastic, Acute
Characterization of an unique RNA initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro: polymerase II-dependence, tissue specificity, and subcellular location.
Leukemia, Erythroblastic, Acute
RNA polymerase II transcripts as targets for 5-fluorouridine cytotoxicity: antagonism of 5-fluorouridine actions by alpha-amanitin.
Leukemia, Erythroblastic, Acute
USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the {beta}-globin gene locus.
Leukemia, Lymphocytic, Chronic, B-Cell
Template properties of human DNA-dependent RNA polymerase II.
Leukemia, Myeloid
Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival.
Leukemia, Myeloid
Inhibition of RNA polymerase I transcription in differentiated myeloid leukemia cells by inactivation of selectivity factor 1.
Leukemia, Myeloid
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
Leukemia, Myeloid, Acute
Aberrant hypomethylated STAT3 was identified as a biomarker of chronic benzene poisoning through integrating DNA methylation and mRNA expression data.
Leukemia, Myeloid, Acute
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Leukemia, Myeloid, Acute
Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II.
Leukemia, Myeloid, Acute
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
Leukemia, Myeloid, Acute
ELL2, a new member of an ELL family of RNA polymerase II elongation factors.
Leukemia, Myeloid, Acute
Expression and Role of the ErbB3 Binding Protein 1 in Acute Myelogenous Leukemic Cells.
Leukemia, Myeloid, Acute
Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3.
Leukemia, Myeloid, Acute
Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo.
Leukemia, Myeloid, Acute
Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia.
Leukemia, T-Cell
Host range of human T-cell leukemia virus type I analyzed by a cell fusion-dependent reporter gene activation assay.
Leukemia, T-Cell
Human T-cell leukemia virus type I Tax protein transactivates RNA polymerase III promoter in vitro and in vivo.
Leukemia, T-Cell
In vitro transcription of human T-cell leukemia virus type 1 is RNA polymerase II dependent.
Leukemia, T-Cell
Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.
Leukoencephalopathies
Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy.
Leukoplakia
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Leukoplakia, Oral
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Li-Fraumeni Syndrome
RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.
Lipodystrophy
Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction.
Liposarcoma
Localization and characterization of the RNA binding protein TLS in skin and stratified mucosa.
Liposarcoma
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.
Liposarcoma, Myxoid
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.
Liver Cirrhosis
Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1.
Liver Failure, Acute
Benzylpenicyllin and acetylcysteine protection from alpha-amanitin-induced apoptosis in human hepatocyte cultures.
Liver Neoplasms
Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis.
Liver Neoplasms
Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA binding protein MBD2.
Liver Neoplasms, Experimental
Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII.
Liver Neoplasms, Experimental
Characterization of factors that direct transcription of rat ribosomal DNA.
Liver Neoplasms, Experimental
Identification of a La protein binding site in a RNA polymerase III transcript (4.5 I RNA).
Liver Neoplasms, Experimental
Phosphorylation of deoxyribonucleic acid dependent RNA polymerase II by nuclear protein kinase NII: mechanism of enhanced ribonucleic acid synthesis.
Liver Neoplasms, Experimental
Protein kinase activity of RNA polymerase I purified from a rat hepatoma: probable function of Mr 42,000 and 24,600 polypeptides.
Liver Neoplasms, Experimental
Protein kinase NII. Interaction with RNA polymerase II and contribution to immunological cross-reactivity of RNA polymerases I and II.
Liver Neoplasms, Experimental
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Lung Neoplasms
A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network.
Lung Neoplasms
Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824.
Lung Neoplasms
CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells.
Lung Neoplasms
Cetuximab-Triptolide Conjugate Suppresses the Growth of EGFR-Overexpressing Lung Cancers through Targeting RNA Polymerase II.
Lung Neoplasms
CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC.
Lung Neoplasms
Exploring the Role and Mechanism of pAMPK?-Mediated Dysregulation of Brf1 and RNA Pol III Genes.
Lung Neoplasms
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Lung Neoplasms
Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.
Lung Neoplasms
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Lung Neoplasms
POLR1B is upregulated and promotes cell proliferation in non-small cell lung cancer.
Lung Neoplasms
RPB5-mediating protein promotes the progression of non-small cell lung cancer by regulating the proliferation and invasion.
Lung Neoplasms
The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth.
Lung Neoplasms
Whether miR-4293 rs12220909 variant affects cancer susceptibility: evidence from 11255 subjects.
Lupus Erythematosus, Systemic
Association of autoantibodies to topoisomerase I and the phosphorylated (IIO) form of RNA polymerase II in Japanese scleroderma patients.
Lupus Erythematosus, Systemic
Autoantibodies and autoantigens in the urine of SLE patients.
Lupus Erythematosus, Systemic
Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.
Lupus Erythematosus, Systemic
Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma.
Lupus Erythematosus, Systemic
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
Lupus Erythematosus, Systemic
Identification of critical genes in gastric cancer to predict prognosis using bioinformatics analysis methods.
Lupus Erythematosus, Systemic
Immunization of rabbits with purified RNA polymerase I induces a distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Phosphorylation of RNA polymerase I augments its interaction with autoantibodies of systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
Production of monoclonal antibodies against RNA polymerase I from nonimmunized autoimmune MRL/lpr mice and their use in rDNA transcription analysis.
Lymphocytic Choriomeningitis
Rescue of the prototypic Arenavirus LCMV entirely from plasmid.
Lymphoma
Detection of t(8;14)(q24;q32) by polymerase chain reaction for long DNA targets: a report of two patients with B-cell non-Hodgkin's lymphoma.
Lymphoma
Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.
Lymphoma
Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate.
Lymphoma, B-Cell, Marginal Zone
Increased sensitivity of B-cell clonality analysis in formalin-fixed and paraffin-embedded B-cell lymphoma samples using an enzyme blend with both 5'-->3' DNA polymerase and 3'-->5' exonuclease activity.
Lymphoma, Non-Hodgkin
Heat shock selectively inhibits ribosomal RNA gene transcription and down-regulates E1BF/Ku in mouse lymphosarcoma cells.
Malaria
An unusual recent expansion of the C-terminal domain of RNA polymerase II in primate malaria parasites features a motif otherwise found only in mammalian polymerases.
Malaria
The C-terminal domain of RNA polymerase II of the malaria parasite Plasmodium berghei.
Malaria
The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites.
Malnutrition
Ribonucleic acid metabolism in rat liver during long-term adaptation to malnutrition.
Mandibulofacial Dysostosis
A novel familial mutation associated with Treacher Collins syndrome: A case report.
Mandibulofacial Dysostosis
The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome.
Mandibulofacial Dysostosis
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Mandibulofacial Dysostosis
Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity.
Measles
Rescue system for measles virus from cloned cDNA driven by vaccinia virus Lister vaccine strain.
Measles
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Measles
[Rescue of minireplicon by using the cell line stably expressing the T7 RNA polymerase]
Melanoma
Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.
Melanoma
BRAF inhibition sensitizes melanoma cells to ?-amanitin via decreased RNA polymerase II assembly.
Melanoma
Cytoskeletal Filamin A Differentially Modulates RNA Polymerase III Gene Transcription in Transformed Cell Lines.
Melanoma
Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response.
Melanoma
Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.
Melanoma
Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.
Melanoma
Slow transcription of the 99a/let-7c/125b-2 cluster results in differential miRNA expression and promotes melanoma phenotypic plasticity.
Melanoma
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Melanoma
Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.
Meningitis, Bacterial
Can Broad-Range 16S Ribosomal Ribonucleic Acid Gene Polymerase Chain Reactions Improve the Diagnosis of Bacterial Meningitis? A Systematic Review and Meta-analysis.
Meningoencephalitis
Elongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus.
Mesothelioma
In Vivo Imaging of Human Malignant Mesothelioma Grown Orthotopically in the Peritoneal Cavity of Nude Mice.
Mitochondrial Diseases
Biallelic P4HTM variants associated with HIDEA syndrome and mitochondrial respiratory chain complex I deficiency.
Mixed Connective Tissue Disease
Class II ribonuclease H comigrates with, but is distinct from, the third largest subunit of calf thymus RNA polymerase I.
Molluscum Contagiosum
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.
Mouth Neoplasms
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Mouth Neoplasms
Laser capture microdissection-generated target sample for high-density oligonucleotide array hybridization.
Multiple Myeloma
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.
Multiple Myeloma
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
Multiple Myeloma
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.
Multiple Myeloma
RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.
Multiple Myeloma
The Covalent CDK7 Inhibitor THZ1 Potently Induces Apoptosis in Multiple Myeloma Cells In Vitro and In Vivo.
Muscular Atrophy, Spinal
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Myelodysplastic Syndromes
Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.
Myelodysplastic Syndromes
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1.
Myositis
Inclusion body myositis in a patient with RNA polymerase III antibody-positive systemic sclerosis.
Myositis
Novel cytoplasmic immunolocalization of RNA polymerase II in inclusion-body myositis muscle.
Myositis, Inclusion Body
Inclusion body myositis in a patient with RNA polymerase III antibody-positive systemic sclerosis.
Myotonic Dystrophy
Transcriptional properties of RNA polymerase II within triplet repeat-containing DNA from the human myotonic dystrophy and fragile X loci.
Neoplasm Metastasis
Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases.
Neoplasm Metastasis
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine.
Neoplasm Metastasis
Mediator of RNA polymerase II transcription subunit 19 promotes osteosarcoma growth and metastasis and associates with prognosis.
Neoplasm Metastasis
Targeting super-enhancer-associated oncogenes in osteosarcoma with THZ2, a covalent CDK7 inhibitor.
Neoplasms
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
Neoplasms
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Neoplasms
A novel CDK9 inhibitor shows potent anti-tumor efficacy in preclinical hematological tumor models.
Neoplasms
A novel sensing platform using aptamer and RNA polymerase-based amplification for detection of cancer cells.
Neoplasms
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression.
Neoplasms
A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network.
Neoplasms
A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries.
Neoplasms
A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Neoplasms
Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.
Neoplasms
Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo.
Neoplasms
Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells.
Neoplasms
Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A.
Neoplasms
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.
Neoplasms
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Neoplasms
Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription.
Neoplasms
An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA.
Neoplasms
Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities.
Neoplasms
Analysis of the mechanisms mediating tumor-specific changes in gene expression in human liver tumors.
Neoplasms
Association Between Germline Mutations in BRF1, a subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.
Neoplasms
Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.
Neoplasms
ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors.
Neoplasms
Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer.
Neoplasms
Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
Neoplasms
AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
Neoplasms
Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer.
Neoplasms
Bias in detection of instability of the (C)8 mononucleotide repeat of MSH6 in tumours from HNPCC patients.
Neoplasms
Bioinformatics analysis of Ewing's sarcoma: Seeking key candidate genes and pathways.
Neoplasms
Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts.
Neoplasms
BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.
Neoplasms
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
Neoplasms
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
Neoplasms
BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.
Neoplasms
BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity.
Neoplasms
BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.
Neoplasms
Broad targeting of triptolide to resistance and sensitization for cancer therapy.
Neoplasms
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation.
Neoplasms
Cancer and systemic sclerosis: novel insights into pathogenesis and clinical implications.
Neoplasms
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
Neoplasms
CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
Neoplasms
Cell cycle dependent oscillatory expression of estrogen receptor-? links Pol II elongation to neoplastic transformation.
Neoplasms
Cetuximab-Triptolide Conjugate Suppresses the Growth of EGFR-Overexpressing Lung Cancers through Targeting RNA Polymerase II.
Neoplasms
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals constitutive expression in tumors and transcriptional interaction with viral microRNAs.
Neoplasms
Characterizing functional consequences of DNA copy number alterations in breast and ovarian tumors by spaceMap.
Neoplasms
Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription.
Neoplasms
Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
Neoplasms
Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation.
Neoplasms
Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01).
Neoplasms
Clinical consequences of the presence of anti-RNA Pol III antibodies in systemic sclerosis.
Neoplasms
Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.
Neoplasms
Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate.
Neoplasms
Conformational change of DNA binding subunit of RNA polymerase II on binding to DNA.
Neoplasms
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
Neoplasms
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
Neoplasms
CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma.
Neoplasms
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Neoplasms
Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ER?-positive breast tumorigenesis.
Neoplasms
CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma.
Neoplasms
CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage.
Neoplasms
CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition.
Neoplasms
Cyclin D1 activation in B-cell malignancy: association with changes in histone acetylation, DNA methylation, and RNA polymerase II binding to both promoter and distal sequences.
Neoplasms
Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.
Neoplasms
Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma.
Neoplasms
Cytoplasmic steroid effects on nuclear RNA polymerase activity in canine mammary carcinomas.
Neoplasms
Daunorubicin inhibition of DNA-dependent RNA polymerases from Ehrlich ascites tumor cells.
Neoplasms
Deletion mapping of tumor promotion-susceptibility gene pro1 implicates an RNA polymerase III transcription unit.
Neoplasms
Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors.
Neoplasms
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.
Neoplasms
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
Neoplasms
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Neoplasms
Dexamethasone increases the number of RNA polymerase II molecules transcribing integrated mouse mammary tumor virus DNA and flanking mouse sequences.
Neoplasms
Difference in phosphorylation of two factors stimulating RNA polymerase II of Ehrlich ascites tumor cells.
Neoplasms
DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring.
Neoplasms
Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.
Neoplasms
Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas.
Neoplasms
Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini.
Neoplasms
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics.
Neoplasms
Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors.
Neoplasms
Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.
Neoplasms
DNA binding preferences of S. cerevisiae RNA polymerase I Core Factor reveal a preference for the GC-minor groove and a conserved binding mechanism.
Neoplasms
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II.
Neoplasms
DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.
Neoplasms
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. V. Characterization of a factor repressing RNA polymerase II as a ribonucleoprotein.
Neoplasms
DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer.
Neoplasms
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. 3. Ribonuclease H and elongating activity of stimulatory factor S-II.
Neoplasms
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. I. Partial purification and characterization of RNA polymerase II.
Neoplasms
DNA-dependent RNA polymerase I from hepatomas: comparison of activity levels and properties.
Neoplasms
Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.
Neoplasms
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ER?-negative Breast Cancers to Tamoxifen through ER? Reexpression.
Neoplasms
Early increases in ribonucleic acid polymerase activities of dimethylbenzanthracene-induced mammary tumour nuclei in response to oestradiol-17beta and tamoxifen.
Neoplasms
Effect of sex hormones on RNA synthesis of androgen-dependent mouse mammary tumor (Shionogi carcinoma).
Neoplasms
Effect of tumour growth on hepatic neutral ribonuclease and its inhibitor and on RNA polymerase activity of liver nuclei.
Neoplasms
ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
Neoplasms
Elevated RNA polymerase III transcription drives proliferation and oncogenic transformation.
Neoplasms
Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes.
Neoplasms
ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells.
Neoplasms
Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis.
Neoplasms
Enhancement of ormation of the initiation complex by factor stimulating RNA polymerase II from Ehrlich ascites tumor cells.
Neoplasms
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III.
Neoplasms
ER? mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.
Neoplasms
Estrogen Receptor-? Modulation of the ER?-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer.
Neoplasms
Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.
Neoplasms
Evidence that mouse promotion-sensitivity gene pro1 is transcribed by RNA polymerase III.
Neoplasms
Evidence that stimulatory factor(s) of RNA polymerase II participates in accurate transcription in a HeLa cell lysate.
Neoplasms
Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma.
Neoplasms
Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells.
Neoplasms
Exploring the Role and Mechanism of pAMPK?-Mediated Dysregulation of Brf1 and RNA Pol III Genes.
Neoplasms
Expression of CREPT is associated with poor prognosis of patients with renal cell carcinoma.
Neoplasms
Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
Neoplasms
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Neoplasms
Fluorescent conjugated polymer-based FRET technique for detection of DNA methylation of cancer cells.
Neoplasms
Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.
Neoplasms
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Neoplasms
Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Neoplasms
Gene expression analysis of EpiDerm following exposure to SLS using cDNA microarrays.
Neoplasms
Generation of antigen-presenting cells using cultured dendritic cells and amplified autologous tumor mRNA.
Neoplasms
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Neoplasms
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative.
Neoplasms
GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism.
Neoplasms
HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells.
Neoplasms
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.
Neoplasms
Histone methyltransferase Smyd3 regulates early embryonic lineage commitment in mice.
Neoplasms
Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells.
Neoplasms
Identification of differentially expressed genes and pathways crosstalk analysis in Rheumatoid and Osteoarthritis using next-generation sequencing and protein-protein networks.
Neoplasms
Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.
Neoplasms
Identification of key biomarkers associated with development and prognosis in patients with ovarian carcinoma: evidence from bioinformatic analysis.
Neoplasms
Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis.
Neoplasms
Identification of the DNA binding subunit of RNA polymerase II from Ehrlich ascites tumor cells.
Neoplasms
In vitro effect of androgen on RNA synthesis in nuclei from androgen-independent subline of Shionogi carcinoma (CS 2).
Neoplasms
In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.
Neoplasms
Inhibition of DNA-dependent RNA polymerase from sarcoma-180 ascites tumour cells by DNA-binding antitumor antibiotics.
Neoplasms
Inhibition of Human Carcinoma and Neuroblastoma Cell Proliferation by Anti-c-myc siRNA.
Neoplasms
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Neoplasms
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Neoplasms
INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Neoplasms
Integrative Bioinformatics Analysis Reveals Potential Long Non-Coding RNA Biomarkers and Analysis of Function in Non-Smoking Females with Lung Cancer.
Neoplasms
Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers.
Neoplasms
Isolated Hepatic Perfusion with High-Dose Melphalan Results in Immediate Alterations in Tumor Gene Expression in Patients with Metastatic Ocular Melanoma.
Neoplasms
Knockdown of MED19 by Short Hairpin RNA-Mediated Gene Silencing Inhibits Pancreatic Cancer Cell Proliferation.
Neoplasms
Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation.
Neoplasms
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine.
Neoplasms
Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR.
Neoplasms
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Neoplasms
m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5.
Neoplasms
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Neoplasms
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery.
Neoplasms
Mature and functional viral miRNAs transcribed from novel RNA polymerase III promoters.
Neoplasms
Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative.
Neoplasms
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.
Neoplasms
Microbial Synthesis of 5-Aminolevulinic Acid and Its Coproduction with Polyhydroxybutyrate.
Neoplasms
MicroRNA expression data analysis to identify keymiRNAs associated with Alzheimer's disease.
Neoplasms
Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance.
Neoplasms
Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration.
Neoplasms
Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy.
Neoplasms
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
Neoplasms
Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control.
Neoplasms
Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells.
Neoplasms
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.
Neoplasms
New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
Neoplasms
Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis.
Neoplasms
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.
Neoplasms
p53 localizes to intranucleolar regions distinct from the ribosome production compartments.
Neoplasms
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Neoplasms
PARP-1 Regulates Estrogen-Dependent Gene Expression in Estrogen Receptor ?-Positive Breast Cancer Cells.
Neoplasms
Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer.
Neoplasms
Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease.
Neoplasms
Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies.
Neoplasms
Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription.
Neoplasms
Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells.
Neoplasms
Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I.
Neoplasms
POLR1D promotes colorectal cancer progression and predicts poor prognosis of patients.
Neoplasms
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Neoplasms
Polymorphisms in the large subunit of human RNA polymerase II as target for allele-specific inhibition.
Neoplasms
Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.
Neoplasms
Protective Effect Against Cancer of Antibodies to the Large Subunits of Both RNA Polymerases I and III in Scleroderma.
Neoplasms
Protein which interacts with a stimulatory factor of RNA polymerase II of Ehrlich ascites tumor cells.
Neoplasms
PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain.
Neoplasms
PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription.
Neoplasms
Purification and preparation of antibody to RNA polymerase II stimulatory factors from Ehrlich ascites tumor cells.
Neoplasms
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase II from the mouse plasmacytoma, MOPC 315.
Neoplasms
Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II.
Neoplasms
Purification of a new protein stimulating RNA polymerase II from Ehrlich ascites tumor cells: comparison with proteins purified before.
Neoplasms
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.
Neoplasms
Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.
Neoplasms
Recent insights into regulation of transcription by RNA polymerase III and the cellular functions of its transcripts.
Neoplasms
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors.
Neoplasms
Reciprocal regulation of miR-122 and c-Myc in hepatocellular cancer: Role of E2F1 and TFDP2.
Neoplasms
Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei.
Neoplasms
Regulation of nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Neoplasms
Regulation of rDNA transcription in response to growth factors, nutrients and energy.
Neoplasms
Regulation of RNA polymerase I by phosphorylation and production of anti-RNA polymerase I antibodies in rheumatic autoimmune diseases.
Neoplasms
Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.
Neoplasms
Regulation of RNA polymerase III transcription in response to Simian virus 40 transformation.
Neoplasms
Regulation of the nucleolar DNA-dependent RNA polymerase by amino acids in Ehrlich ascites tumor cells.
Neoplasms
Regulation of the Nucleolar DNA-Dependent RNA Polymerase by Amino Acids in Ehrlich Ascites Tumor Cells.
Neoplasms
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Neoplasms
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Neoplasms
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
Neoplasms
Retrostatin, a new specific enzyme inhibitor against avian myeloblastosis virus reverse transcriptase.
Neoplasms
Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro.
Neoplasms
RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.
Neoplasms
RNA Interference Remarkably Suppresses bcl-2 Gene Expression in Cancer Cells in Vitro and in Vivo.
Neoplasms
RNA polymerase activity in homotransplanted rat brain tumors initially induced by ethylnitrosourea.
Neoplasms
RNA polymerase I in hepatoma 3924A: mechanism of enhanced activity relative to liver.
Neoplasms
RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.
Neoplasms
RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma.
Neoplasms
RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.
Neoplasms
RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.
Neoplasms
RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.
Neoplasms
RNA polymerase III transcription--a battleground for tumour suppressors and oncogenes.
Neoplasms
RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents.
Neoplasms
Role of betaine in inhibiting the induction of RNA Pol III gene transcription and cell growth caused by alcohol.
Neoplasms
Role of Brf1 interaction with ER?, and significance of its overexpression, in human breast cancer.
Neoplasms
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Neoplasms
Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice.
Neoplasms
Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3'-ethynylcytidine treatment of human cancer cells.
Neoplasms
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Neoplasms
Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation.
Neoplasms
Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells.
Neoplasms
Sensitive detection of clonal antigen receptor gene rearrangements for the diagnosis and monitoring of lymphoid neoplasms by a polymerase chain reaction-mediated ribonuclease protection assay.
Neoplasms
Separation of a stimulatory factor of RNA polymerase II from protein kinase activity of Ehrlich ascites tumor cells.
Neoplasms
Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.
Neoplasms
Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Neoplasms
Sources and consequences of oxidative damage from mitochondria and neurotransmitter signaling.
Neoplasms
Stimulation of messenger ribonucleic acid synthesis in isolated nuclei by a protein that stimulates RNA polymerase II.
Neoplasms
Structural relationships of the three stimulatory factors of RNA polymerase II from Ehrlich ascites tumor cells.
Neoplasms
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Neoplasms
SUV420H2-Mediated H4K20 Trimethylation Enforces RNA Polymerase II Promoter-Proximal Pausing by Blocking hMOF-Dependent H4K16 Acetylation.
Neoplasms
Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents.
Neoplasms
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Neoplasms
Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.
Neoplasms
Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.
Neoplasms
Targeting RNA polymerase I transcription machinery in cancer cells by a novel monofunctional platinum-based agent.
Neoplasms
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
Neoplasms
Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth.
Neoplasms
TARGETING RNA-POLYMERASE I IN BOTH CHEMOSENSITIVE AND CHEMORESISTANT POPULATIONS IN EPITHELIAL OVARIAN CANCER.
Neoplasms
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression.
Neoplasms
Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions.
Neoplasms
The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.
Neoplasms
The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells.
Neoplasms
The differential effects of low birth weight and Western diet consumption upon early life hepatic fibrosis development in guinea pig.
Neoplasms
The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C.
Neoplasms
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Neoplasms
The emerging role of mediator complex subunit 12 in tumorigenesis and response to chemotherapeutics.
Neoplasms
The emerging role of RNA polymerase I transcription machinery in human malignancy: a clinical perspective.
Neoplasms
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Neoplasms
The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.
Neoplasms
The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability.
Neoplasms
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
Neoplasms
The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.
Neoplasms
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
Neoplasms
The most abundant nascent poly(A) + RNAs are transcribed by RNA polymerase III in murine tumor cells.
Neoplasms
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
Neoplasms
The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.
Neoplasms
The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding.
Neoplasms
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells.
Neoplasms
The potential underlying mechanism of the leukemia caused by MLL-fusion and potential treatments.
Neoplasms
The preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin.
Neoplasms
The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.
Neoplasms
The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.
Neoplasms
The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.
Neoplasms
The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.
Neoplasms
The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers.
Neoplasms
The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II.
Neoplasms
The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model.
Neoplasms
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.
Neoplasms
The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains.
Neoplasms
Transcription factor(s) of Ehrlich ascites tumor cells having affinity to the 'TATA' box and a further upstream region of the adenovirus 2 major late gene.
Neoplasms
Transcription in vitro of Ehrlich ascites tumor DNA and chromatin by purified homologous RNA polymerase II (or B).
Neoplasms
Transcription of globin genes in murine erythroleukemic cell chromatin by RNA polymerase II from mouse cells.
Neoplasms
Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.
Neoplasms
Transcriptional Responses to IFN-? Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
Neoplasms
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Neoplasms
Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.
Neoplasms
Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).
Neoplasms
Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts.
Neoplasms
TRPV1 Activation Promotes ?-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth.
Neoplasms
Tumor genotype-specific growth inhibition in vivo by antisense oligonucleotides against a polymorphic site of the large subunit of human RNA polymerase II.
Neoplasms
Tumor therapy with Amanita phalloides (death cap): stabilization of B-cell chronic lymphatic leukemia.
Neoplasms
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Neoplasms
Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.
Neoplasms
URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.
Neoplasms
UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein.
Neoplasms
von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.
Neoplasms
Von Hippel-Lindau-Coupled and Transcription-Coupled Nucleotide Excision Repair-Dependent Degradation of RNA Polymerase II in Response to Trabectedin.
Neoplasms
von Hippel-Lindau-Dependent Patterns of RNA Polymerase II Hydroxylation in Human Renal Clear Cell Carcinomas.
Neoplasms
Whether miR-4293 rs12220909 variant affects cancer susceptibility: evidence from 11255 subjects.
Neoplasms
Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth.
Neoplasms
Yeast Screens Identify the RNA Polymerase II CTD and SPT5 as Relevant Targets of BRCA1 Interaction.
Neoplasms
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.
Neoplasms
Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer.
Neoplasms
[A protein stimulating the activity of RNA polymerase II of Ehrlich ascites tumor cells (author's transl)]
Neoplasms
[Effect of actinomycin D on purified DNA-dependent RNA polymerases from normal and neoplastic tissues]
Neoplasms
[Effect of bleomycin on DNA-dependent RNA polymerase purified from normal and neoplastic tissues]
Neoplasms
[Establishment of cDNA microarray technology and analysis of gene expression profiles in human esophageal cancer cell line ECa109]
Nephrotic Syndrome
miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome.
Nervous System Diseases
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III.
Neuralgia
Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription.
Neuroblastoma
Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.
Neuroblastoma
Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma.
Neuroblastoma
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Neuroblastoma
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Neuroblastoma
TRPV1 Activation Promotes ?-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth.
Neurodegenerative Diseases
Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway.
Neurodegenerative Diseases
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Neurodegenerative Diseases
Interpretation challenges of novel dual-class missense and splice-impacting variant in POLR3A-related late-onset hereditary spastic ataxia.
Neurodegenerative Diseases
Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases.
Neurodegenerative Diseases
Novel POLR1C mutation in RNA polymerase III-related leukodystrophy with severe myoclonus and dystonia.
Neurologic Manifestations
POLR3A variants in striatal involvement without diffuse hypomyelination.
Newcastle Disease
Development of a reverse genetics system based on RNA polymerase II for Newcastle disease virus genotype VII.
Newcastle Disease
Development of a T7 RNA polymerase expressing cell line using lentivirus vectors for the recovery of recombinant Newcastle disease virus.
Newcastle Disease
Rescue of Newcastle disease virus from cloned cDNA using an RNA polymerase II promoter.
Newcastle Disease
Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence.
Newcastle Disease
Ribonucleic acid polymerase in virions of Newcastle disease virus: comparison with the vesicular stomatitis virus polymerase.
Newcastle Disease
[Generation of newcastle disease virus strain ZJI isolated from an outbreak in the goose using reverse genetics technique]
Obesity
Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes.
Obesity
Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction.
Osteoporosis
Functions and mechanisms of circular RNAs in regulating stem cell differentiation.
Osteosarcoma
Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene.
Osteosarcoma
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Osteosarcoma
Mediator of RNA polymerase II transcription subunit 19 promotes osteosarcoma growth and metastasis and associates with prognosis.
Osteosarcoma
Short exposure to the DNA intercalator DRAQ5 dislocates the transcription machinery and induces cell death.
Osteosarcoma
Targeting super-enhancer-associated oncogenes in osteosarcoma with THZ2, a covalent CDK7 inhibitor.
Osteosarcoma
[Screening of serum marker proteins in osteosarcoma and preliminary bioinformatic analysis on POLR3F].
Ovarian Neoplasms
Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents.
Ovarian Neoplasms
TARGETING RNA-POLYMERASE I IN BOTH CHEMOSENSITIVE AND CHEMORESISTANT POPULATIONS IN EPITHELIAL OVARIAN CANCER.
Ovarian Neoplasms
Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance.
Ovarian Neoplasms
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.
Pancreatic Neoplasms
Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study.
Papilloma
Efficient ex vivo inhibition of perforin and Fas ligand expression by chimeric tRNA-hammerhead ribozymes.
Papilloma
Transcriptional enhancement by upstream activators is brought about by different molecular mechanisms for class I and II RNA polymerase genes.
Paramyxoviridae Infections
Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion.
Paramyxoviridae Infections
Minimum protein requirements for transcription and RNA replication of a minigenome of human parainfluenza virus type 3 and evaluation of the rule of six.
Paramyxoviridae Infections
Specific phosphorylated forms of glyceraldehyde 3-phosphate dehydrogenase associate with human parainfluenza virus type 3 and inhibit viral transcription in vitro.
Parasitemia
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Paratuberculosis
Detection and identification of mycobacteria by amplification of mycobacterial DNA.
Peritonitis
Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses.
Persistent Infection
Activation of ribosomal RNA transcription by hepatitis C virus involves upstream binding factor phosphorylation via induction of cyclin D1.
Persistent Infection
Efficient silencing of hepatitis B virus by helper-dependent adenovirus vector-mediated delivery of artificial antiviral primary micro RNAs.
Pituitary Neoplasms
Estrogen-induced changes in rRNA accumulation and RNA polymerase I activity in the rat pituitary: correlation with pituitary tumor susceptibility.
Plasmacytoma
Biochemistry of the amatoxins: preparation and characterization of a stably iodinated alpha-amanitin.
Plasmacytoma
In vitro transcription by mouse plasmocytoma RNA polymerase II supplemented with nuclear protein fractions.
Plasmacytoma
Initiated complexes of RNA polymerase II are concentrated in the nuclear skeleton associated DNA.
Plasmacytoma
Production of monoclonal antibody against electrophoretically purified RNA polymerase II subunits using in vitro immunization.
Plasmacytoma
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase II from the mouse plasmacytoma, MOPC 315.
Plasmacytoma
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase III from the mouse plasmacytoma, MOPC 315.
Plasmacytoma
The most abundant nascent poly(A) + RNAs are transcribed by RNA polymerase III in murine tumor cells.
Plasmacytoma
Transcription of specific genes in isolated nuclei by exogenous RNA polymerases.
Pneumonia
Exploring the Pharmacological Mechanism of Radix Salvia Miltiorrhizae in the Treatment of Radiation Pneumonia by Using Network Pharmacology.
Pneumonia
New immunodeficiency syndromes that help us understand the IFN-mediated antiviral immune response.
Polymicrogyria
Recessive Mutations in POLR3B Encoding RNA Polymerase III Subunit Causing Diffuse Hypomyelination in Patients with 4H Leukodystrophy with Polymicrogyria and Cataracts.
Porcine Reproductive and Respiratory Syndrome
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
Porcine Reproductive and Respiratory Syndrome
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Prader-Willi Syndrome
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.
Progeria
Hutchinson-Gilford progeria fibroblasts exhibit metabolically normal uridine uptake and RNA synthetic rates.
Progeria
Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch Syndrome fibroblasts.
Prostatic Neoplasms
Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.
Prostatic Neoplasms
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Prostatic Neoplasms
Effective targeting of RNA polymerase I in treatment-resistant prostate cancer.
Prostatic Neoplasms
Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.
Prostatic Neoplasms
Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells.
Prostatic Neoplasms
KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.
Prostatic Neoplasms
Molecular determinants for enzalutamide-induced transcription in prostate cancer.
Prostatic Neoplasms
Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms.
Prostatic Neoplasms
p68/DdX5 supports ?-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.
Prostatic Neoplasms
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Prostatic Neoplasms
The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Pseudorabies
In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein.
Pseudorabies
The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions.
Psoriasis
RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product.
Pulmonary Arterial Hypertension
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodelling.
Pulmonary Disease, Chronic Obstructive
miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.
Pulmonary Disease, Chronic Obstructive
SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD.
Rabies
Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system.
Rabies
Studies on the conditions required for structural and functional maturation of rabies virus glycoprotein (G) in G cDNA-transfected cells.
Rectal Neoplasms
Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue.
Renal Insufficiency
A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.
Renal Insufficiency
An effective antidotal combination of polymyxin B and methylprednisolone for ?-amanitin intoxication.
Retinoblastoma
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Retinoblastoma
BAY 1000394, a Novel Cyclin-Dependent Kinase Inhibitor, with Potent Antitumor Activity in Mono- and in Combination Treatment upon Oral Application.
Retinoblastoma
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase.
Retinoblastoma
Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.
Retinoblastoma
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Retinoblastoma
Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb.
Retinoblastoma
Growth inhibition by a triple ribozyme targeted to repetitive B2 transcripts.
Retinoblastoma
Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein.
Retinoblastoma
Mechanistic analysis of RNA polymerase III regulation by the retinoblastoma protein.
Retinoblastoma
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Retinoblastoma
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Retinoblastoma
Multiple mechanisms contribute to the activation of RNA polymerase III transcription in cells transformed by papovaviruses.
Retinoblastoma
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Retinoblastoma
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1.
Retinoblastoma
Repression of RNA polymerase III transcription by the retinoblastoma protein.
Retinoblastoma
Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription.
Retinoblastoma
RNA polymerase III repression by the retinoblastoma tumor suppressor protein.
Retinoblastoma
RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130.
Retinoblastoma
RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2.
Retinoblastoma
Specificity of the polycation-stimulated (type-2A) and ATP,Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase.
Retinoblastoma
The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.
Rhabdoid Tumor
SNF5 Reexpression in Malignant Rhabdoid Tumors Regulates Transcription of Target Genes by Recruitment of SWI/SNF Complexes and RNAPII to the Transcription Start Site of Their Promoters.
Rheumatic Diseases
Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis.
Rheumatic Diseases
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen.
Rheumatic Diseases
Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes.
Rheumatic Diseases
Understanding and interpreting antinuclear antibody tests in systemic rheumatic diseases.
Rickettsia Infections
Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii.
Rift Valley Fever
Development of a Simian RNA Polymerase I Promoter-Driven Reverse Genetics for the Rescue of Recombinant Rift Valley Fever Virus from Vero Cells.
Rift Valley Fever
Elongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus.
Rubella
Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing.
Sarcoma
Inhibition of cellular and virus-associated nucleotide polymerases by, and anti-herpes simplex virus activity of, streptovaricin derivatives.
Sarcoma
RNA synthesis in the presence of transfer RNa by DNA-dependent RNA polymerase II from mouse ascites sarcoma cells.
Sarcoma
Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme.
Sarcoma, Avian
Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system.
Sarcoma, Avian
Comparative analysis of inducible expression systems in transient transfection studies.
Sarcoma, Avian
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.
Sarcoma, Avian
In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase.
Sarcoma, Avian
Inhibition of rous sarcoma virus by alpha-amanitin: possible role of cell DNA-dependent RNA polymerase form II.
Sarcoma, Avian
Localization of active promoters for eucaryotic RNA polymerase II in the long terminal repeat of avian sarcoma virus DNA.
Sarcoma, Ewing
CDK9 Blockade Exploits Context-Dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.
Sarcoma, Ewing
Coupled alteration of transcription and splicing by a single oncogene: boosting the effect on cyclin D1 activity.
Sarcoma, Ewing
In vitro interaction between the N-terminus of the Ewing's sarcoma protein and the subunit of RNA polymerase II hsRPB7.
Sarcoma, Ewing
Localization and characterization of the RNA binding protein TLS in skin and stratified mucosa.
Sarcoma, Ewing
Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein.
Sarcoma, Ewing
Pharmaceutical Interference of the EWS-FLI1-driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma.
Sarcoma, Ewing
Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line.
Scleroderma, Diffuse
Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma).
Scleroderma, Systemic
Analysis of anti-RNA polymerase III antibody positive systemic sclerosis suggests altered GPATCH2L and CTNND2 expression in scleroderma renal crisis.
Scleroderma, Systemic
Anti-RNA polymerase antibodies in systemic sclerosis (SSc): association with anti-topoisomerase I antibodies and identification of autoreactive subunits of RNA polymerase II.
Scleroderma, Systemic
Antibodies to fibrillarin, PM-Scl and RNA polymerase III detected by ELISA assays in patients with systemic sclerosis.
Scleroderma, Systemic
Antibodies to RNA polymerase III in systemic sclerosis detected by ELISA.
Scleroderma, Systemic
Atypical rapid onset Scleroderma Renal Crisis (SRC) complicated with diffuse alveolar hemorrhage and pleuro-pericardial effusions in a patient with recently diagnosed breast cancer and a positive anti-RNA polymerase III Ab.: A case report.
Scleroderma, Systemic
Autoantibodies to RNA-polymerases in Italian patients with systemic sclerosis.
Scleroderma, Systemic
Clinical and serological associations with anti-RNA polymerase antibodies in systemic sclerosis.
Scleroderma, Systemic
Clinical consequences of the presence of anti-RNA Pol III antibodies in systemic sclerosis.
Scleroderma, Systemic
Disappearance of circulating autoantibodies to RNA polymerase III in a patient with systemic sclerosis successfully treated with corticosteroid and methotrexate.
Scleroderma, Systemic
Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.
Scleroderma, Systemic
Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.
Scleroderma, Systemic
Immunochemical and molecular characterization of anti-RNA polymerase I autoantibodies produced by tight skin mouse.
Scleroderma, Systemic
Inclusion body myositis in a patient with RNA polymerase III antibody-positive systemic sclerosis.
Scleroderma, Systemic
Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort.
Scleroderma, Systemic
RNA polymerase III autoantibodies may indicate renal and more severe skin involvement in systemic sclerosis.
Scleroderma, Systemic
Scleroderma renal crisis in a Swedish systemic sclerosis cohort: survival, renal outcome, and RNA polymerase III antibodies as a risk factor.
Scleroderma, Systemic
Validation of a new immunoenzymatic method to detect antibodies to RNA polymerase III in systemic sclerosis.
Sepsis
IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis.
Severe Acute Respiratory Syndrome
Epidemiological and Clinical Findings of Short-Term Recurrence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid Polymerase Chain Reaction Positivity in 1282 Discharged Coronavirus Disease 2019 Cases: A Multicenter, Retrospective, Observational Study.
Severe Acute Respiratory Syndrome
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor.
Severe Combined Immunodeficiency
The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth.
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Sjogren's Syndrome
Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies.
Sjogren's Syndrome
Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.
Small Cell Lung Carcinoma
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Small Cell Lung Carcinoma
Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Spinocerebellar Ataxias
Nonapoptotic cell death caused by the inhibition of RNA polymerase disrupts organelle distribution.
Spinocerebellar Ataxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Spinocerebellar Ataxias
Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II.
Squamous Cell Carcinoma of Head and Neck
Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma.
Starvation
A CxxC Domain That Binds to Unmethylated CpG Is Required for KDM2A to Control rDNA Transcription.
Starvation
A DNA polymerase V homologue encoded by TOL plasmid pWW0 confers evolutionary fitness on Pseudomonas putida under conditions of environmental stress.
Starvation
A role for the transcription factor Mca1 in activating the meiosis-specific copper transporter Mfc1.
Starvation
Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription.
Starvation
Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells.
Starvation
Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.
Starvation
Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.
Starvation
Identification and characterization of DdRPB4, a subunit of Dictyostelium discoideum RNA polymerase II.
Starvation
Modulation of RNA polymerase activities in the intestine of adult rats by dietary sucrose.
Starvation
Molecular Characterization of Propolis-Induced Cell Death in Saccharomyces cerevisiae.
Starvation
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.
Starvation
Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases.
Starvation
Reference Gene Validation for Quantitative PCR Under Various Biotic and Abiotic Stress Conditions in Toxoptera citricida (Hemiptera, Aphidiae).
Starvation
Regulation of the RNA polymerase I and III transcription systems in response to growth conditions.
Starvation
Relationship between the expression of estrogen-regulated genes and estrogen-stimulated proliferation of MCF-7 mammary tumor cells.
Starvation
RNA polymerase I activation and hibernation: unique mechanisms for unique genes.
Starvation
RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex.
Starvation
S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.
Starvation
Transcription rates and transcript stabilities of macronuclear genes in vegetative Euplotes crassus cells.
Stomach Neoplasms
NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
Stomach Neoplasms
The MRTF-A/miR-155/SOX1 pathway mediates gastric cancer migration and invasion.
Stomach Neoplasms
The POLR2E rs3787016 polymorphism is associated with susceptibility to and prognosis of gastric cancer.
Stuttering
Unusual heterogeneity of the 5'-termini of human adenovirus type 2 early region E2 mRNA.
Subacute Sclerosing Panencephalitis
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Superinfection
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo.
Superinfection
Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection.
Teratocarcinoma
A conserved organization of transcription during embryonic stem cell differentiation and in cells with high C value.
Teratocarcinoma
Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Thymoma
Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing.
Trachoma
Deoxyribonucleic acid-dependent ribonucleic acid polymerase activity in purified trachoma elementary bodies: effect of sodium chloride on ribonucleic acid transcription.
Trypanosomiasis
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Trypanosomiasis, African
An essential domain of an early-diverged RNA polymerase II functions to accurately decode a primitive chromatin landscape.
Trypanosomiasis, African
Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei.
Trypanosomiasis, African
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.
Tuberculosis
Association of ? with the C-Terminal Region of the ?' Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis.
Tuberculosis
Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.
Tuberculosis
Coupling of the engineered DNA "mutator" to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces.
Tuberculosis
Crystal structure of DNA polymerase III ? sliding clamp from Mycobacterium tuberculosis.
Tuberculosis
Detection and identification of mycobacteria by amplification of mycobacterial DNA.
Tuberculosis
Detection and identification of Mycobacterium avium in the blood of AIDS patients by the polymerase chain reaction.
Tuberculosis
DNA polymerase I of Mycobacterium tuberculosis: functional role of a conserved aspartate in the hinge joining the M and N helices.
Tuberculosis
Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis.
Tuberculosis
Identification of Mycobacterium DNA in an Egyptian Pott's disease of 5,400 years old.
Tuberculosis
Novel Real-Time Simultaneous Amplification and Testing Method To Accurately and Rapidly Detect Mycobacterium tuberculosis Complex.
Tuberculosis
Purification and properties of DNA-dependent RNA polymerase from Mycobacterium tuberculosis H37RV.
Tuberculosis
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Tuberous Sclerosis
The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex.
Tuberous Sclerosis
Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays.
Tularemia
[Comparison of the structural-functional properties of DNA-dependent RNA polymerase of the tularemia microbe and intestinal bacterial]
Tumor Virus Infections
Transcription products synthesized by purified calf thymus DNA-dependent RNA polymerase on Shope papilloma virus DNA.
Urinary Bladder Neoplasms
MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides.
Urinary Bladder Neoplasms
The p63 protein isoform ?Np63? inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205.
Uterine Cervical Neoplasms
Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.
Uterine Cervical Neoplasms
Inhibition of cyclin-dependent kinases by AT7519 is effective to overcome chemoresistance in colon and cervical cancer.
Vaccinia
A Cell-Cell Fusion Assay to Assess Arenavirus Envelope Glycoprotein Membrane-Fusion Activity.
Vaccinia
A cellular factor is required for transcription of vaccinia viral intermediate-stage genes.
Vaccinia
A functional measles virus replication and transcription machinery encoded by the vaccinia virus genome.
Vaccinia
A glycine to alanine substitution in the paramyxovirus SV5 fusion peptide increases the initial rate of fusion.
Vaccinia
A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy-back nondefective interfering virus.
Vaccinia
A new cationic liposome reagent mediating nearly quantitative transfection of animal cells.
Vaccinia
A plasmid that improves the efficiency of foreign gene expression by intracellular T7 RNA polymerase.
Vaccinia
A plasmid-based reverse genetics system for mammalian orthoreoviruses driven by a plasmid-encoded T7 RNA polymerase.
Vaccinia
A protein kinase activity associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro.
Vaccinia
A role for the H4 subunit of vaccinia RNA polymerase in transcription initiation at a viral early promoter.
Vaccinia
A vaccinia virus MVA-T7-mediated recovery of infectious hepatitis A virus from full-size cDNA or from two cDNAs, both by themselves unable to complete the virus life cycle.
Vaccinia
African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases.
Vaccinia
Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce NS2 protein.
Vaccinia
An efficient helper-virus-free method for rescue of recombinant paramyxoviruses and rhadoviruses from a cell line suitable for vaccine development.
Vaccinia
Antigenic structure of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus.
Vaccinia
Assembly of functional Sindbis virus RNA replication complexes: requirement for coexpression of P123 and P34.
Vaccinia
Astrovirus ribosomal frameshifting in an infection-transfection transient expression system.
Vaccinia
Biogenesis of poxviruses: role for the DNA-dependent RNA polymerase II of the host during expression of late functions.
Vaccinia
Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system.
Vaccinia
Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel alpha-subunit expressed in mammalian cells.
Vaccinia
Cellular expression of a functional nodavirus RNA replicon from vaccinia virus vectors.
Vaccinia
Characterization of a 7-kilodalton subunit of vaccinia virus DNA-dependent RNA polymerase with structural similarities to the smallest subunit of eukaryotic RNA polymerase II.
Vaccinia
Characterization of vaccinia virus DNA topoisomerase I expressed in Escherichia coli.
Vaccinia
Cloning of the vaccinia virus ribonucleotide reductase small subunit gene. Characterization of the gene product expressed in Escherichia coli.
Vaccinia
Coding sequences enhance internal initiation of translation by hepatitis A virus RNA in vitro.
Vaccinia
Complementation of a vesicular stomatitis virus glycoprotein G mutant with wild-type protein expressed from either a bovine papilloma virus or a vaccinia virus vector system.
Vaccinia
Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells.
Vaccinia
Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity.
Vaccinia
Deletion mapping of a mouse hepatitis virus defective interfering RNA reveals the requirement of an internal and discontiguous sequence for replication.
Vaccinia
Detailed phenotypic characterization of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
Vaccinia
Effect of rifamycins and related antibiotics on the deoxyribonucleic acid-dependent ribonucleic acid polymerase of vaccinia virus particles.
Vaccinia
Efficient cleavage of p220 by poliovirus 2Apro expression in mammalian cells: effects on vaccinia virus.
Vaccinia
Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones.
Vaccinia
Efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells.
Vaccinia
Enhanced genetic rescue of negative-strand RNA viruses: use of an MVA-T7 RNA polymerase vector and DNA replication inhibitors.
Vaccinia
Enhancement of the vaccinia virus/phage T7 RNA polymerase expression system using encephalomyocarditis virus 5'-untranslated region sequences.
Vaccinia
Eukaryotic transient expression system dependent on transcription factors and regulatory DNA sequences of vaccinia virus.
Vaccinia
Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.
Vaccinia
Evidence for genetic relationship between RNA and DNA viruses from the sequence homology of a putative polymerase gene of bluetongue virus with that of vaccinia virus: conservation of RNA polymerase genes from diverse species.
Vaccinia
Expansion of poxvirus RNA polymerase subunits sharing homology with corresponding subunits of RNA polymerase II.
Vaccinia
Expression of bacteriophage T7 RNA polymerase in avian and mammalian cells by a recombinant fowlpox virus.
Vaccinia
Expression of cDNA encoding the Sendai virus hemagglutinin-neuraminidase gene: characterization of wild-type and mutant gene products.
Vaccinia
Expression of functional Bunyamwera virus L protein by recombinant vaccinia viruses.
Vaccinia
Expression of functional parvoviral NS1 from recombinant vaccinia virus: effects of mutations in the nucleotide-binding motif.
Vaccinia
Expression of hepatitis A virus precursor protein P3 in vivo and in vitro: polyprotein processing of the 3CD cleavage site.
Vaccinia
Expression of the Bunyamwera virus M genome segment and intracellular localization of NSm.
Vaccinia
Expression of the Japanese encephalitis virus NS3 and NS2b proteins as glutathione S-transferase fusions.
Vaccinia
Expression of the M gene of vesicular stomatitis virus cloned in various vaccinia virus vectors.
Vaccinia
Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing.
Vaccinia
Feline calicivirus capsid protein expression and capsid assembly in cultured feline cells.
Vaccinia
Feline calicivirus: recovery of wild-type and recombinant viruses after transfection of cRNA or cDNA constructs.
Vaccinia
Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase.
Vaccinia
Fine structure mapping of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
Vaccinia
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Vaccinia
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Vaccinia
Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion.
Vaccinia
Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids.
Vaccinia
Further characterization of the rabies virus glycoproteins produced by virus-infected and G cDNA-transfected cells using a monoclonal antibody, #1-30-44, which recognizes an acid-sensitive epitope.
Vaccinia
Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation.
Vaccinia
Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter.
Vaccinia
Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus.
Vaccinia
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
Vaccinia
High level protein expression in mammalian cells using a safe viral vector: Modified vaccinia virus Ankara.
Vaccinia
Homology between RNA polymerases of poxviruses, prokaryotes, and eukaryotes: nucleotide sequence and transcriptional analysis of vaccinia virus genes encoding 147-kDa and 22-kDa subunits.
Vaccinia
Hydrolytic cleavage of nascent RNA in RNA polymerase III ternary transcription complexes.
Vaccinia
Identification and expression of rpo19, a vaccinia virus gene encoding a 19-kilodalton DNA-dependent RNA polymerase subunit.
Vaccinia
Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.
Vaccinia
Identification of hepatitis A virus non-structural protein 2B and its release by the major virus protease 3C.
Vaccinia
Identification of the respiratory syncytial virus proteins required for formation and passage of helper-dependent infectious particles.
Vaccinia
Identification of the vaccinia virus gene encoding an 18-kilodalton subunit of RNA polymerase and demonstration of a 5' poly(A) leader on its early transcript.
Vaccinia
Identification, sequence, and expression of the gene encoding a Mr 35,000 subunit of the vaccinia virus DNA-dependent RNA polymerase.
Vaccinia
Identification, sequence, and expression of the gene encoding the second-largest subunit of the vaccinia virus DNA-dependent RNA polymerase.
Vaccinia
Induction of recombinant gene expression in stably transfected cell lines using attenuated vaccinia virus MVA expressing T7 RNA polymerase with a nuclear localisation signal.
Vaccinia
Influence of RNA polymerase II upon vaccinia virus-related translation examined by means of alpha-amanitin.
Vaccinia
Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II.
Vaccinia
Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites.
Vaccinia
Intracellular expression and processing of foot-and-mouth disease virus capsid precursors using vaccinia virus vectors: influence of the L protease.
Vaccinia
Large-scale production and purification of a vaccinia recombinant-derived HIV-1 gp160 and analysis of its immunogenicity.
Vaccinia
Localization of Bunyamwera bunyavirus G1 glycoprotein to the Golgi requires association with G2 but not with NSm.
Vaccinia
Mammalian cell expression of malaria merozoite surface proteins and experimental DNA and RNA immunisation.
Vaccinia
Mechanisms of replication-deficient vaccinia virus/T7 RNA polymerase hybrid expression: effect of T7 RNA polymerase levels and alpha-amanitin.
Vaccinia
Minimum protein requirements for transcription and RNA replication of a minigenome of human parainfluenza virus type 3 and evaluation of the rule of six.
Vaccinia
Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase.
Vaccinia
Mutagenesis of the L protein encoded by Bunyamwera virus and production of monospecific antibodies.
Vaccinia
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.
Vaccinia
Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase.
Vaccinia
Novel approach for transient protein expression in primary cultures of human dental pulp-derived cells.
Vaccinia
Novel Nonreplicating Vaccinia Virus Vector Enhances Expression of Heterologous Genes and Suppresses Synthesis of Endogenous Viral Proteins.
Vaccinia
NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs.
Vaccinia
Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses.
Vaccinia
Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.
Vaccinia
Optimization of plasmid-only rescue of highly attenuated and temperature-sensitive respiratory syncytial virus (RSV) vaccine candidates for human trials.
Vaccinia
Overexpression, purification, and late transcription factor activity of the 17-kilodalton protein encoded by the vaccinia virus A1L gene.
Vaccinia
Paramyxovirus mediated cell fusion requires co-expression of both the fusion and hemagglutinin-neuraminidase glycoproteins.
Vaccinia
Phenotypic characterization of temperature-sensitive mutants of vaccinia virus with mutations in a 135,000-Mr subunit of the virion-associated DNA-dependent RNA polymerase.
Vaccinia
Phosphorylation and modulation of brain glutamate transporters by protein kinase C.
Vaccinia
Preparation and characterisation of a subviral particle of vaccinia virus containing the DNA-dependent RNA polymerase activity.
Vaccinia
Production of pro-opiomelanocortin (POMC) by a vaccinia virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme.
Vaccinia
Purification and characterization of a DNA-dependent RNA polymerase from vaccinia virions.
Vaccinia
Purification and characterization of a transcription termination factor from vaccinia virions.
Vaccinia
Recombinant protein synthesis in Chinese hamster ovary cells using a vaccinia virus/bacteriophage T7 hybrid expression system.
Vaccinia
Reconstitution of the human chaperonin CCT by co-expression of the eight distinct subunits in mammalian cells.
Vaccinia
Recovery of a virulent strain of newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation.
Vaccinia
Recovery of infectious human parainfluenza type 2 virus from cDNA clones and properties of the defective virus without V-specific cysteine-rich domain.
Vaccinia
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Vaccinia
Regulated expression of foreign genes in vaccinia virus under the control of bacteriophage T7 RNA polymerase and the Escherichia coli lac repressor.
Vaccinia
Relationship between RNA polymerase II and efficiency of vaccinia virus replication.
Vaccinia
Replication and amplification of defective interfering particle RNAs of vesicular stomatitis virus in cells expressing viral proteins from vectors containing cloned cDNAs.
Vaccinia
Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells.
Vaccinia
Requirements for assembly of poliovirus replication complexes and negative-strand RNA synthesis.
Vaccinia
Rescue of a synthetic chloramphenicol acetyltransferase RNA into influenza virus-like particles obtained from recombinant plasmids.
Vaccinia
Rescue of bovine respiratory syncytial virus from cloned cDNA: entire genome sequence of BRSV strain A51908.
Vaccinia
Rescue of synthetic genomic RNA analogs of rabies virus by plasmid-encoded proteins.
Vaccinia
Rescue system for measles virus from cloned cDNA driven by vaccinia virus Lister vaccine strain.
Vaccinia
Ribonucleic acid polymerase induced by vaccinia virus: lack of inhibition by rifampicin and alpha-amanitin.
Vaccinia
RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences.
Vaccinia
RNA polymerase-associated protein Rap94 confers promoter specificity for initiating transcription of vaccinia virus early stage genes.
Vaccinia
RNA polymerase-associated transcription specificity factor encoded by vaccinia virus.
Vaccinia
RNA replication by respiratory syncytial virus (RSV) is directed by the N, P, and L proteins; transcription also occurs under these conditions but requires RSV superinfection for efficient synthesis of full-length mRNA.
Vaccinia
Role of basic residues in the proteolytic activation of Sendai virus fusion glycoprotein.
Vaccinia
Selective transcription of vaccinia virus genes in template dependent soluble extracts of infected cells.
Vaccinia
Self-assembly of sapovirus recombinant virus-like particles from polyprotein in mammalian cells.
Vaccinia
Sequence analysis of a functional polymerase (L) gene of bovine respiratory syncytial virus: determination of minimal trans-acting requirements for RNA replication.
Vaccinia
Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.
Vaccinia
SP6 RNA polymerase containing vaccinia virus for rapid expression of cloned genes in tissue culture.
Vaccinia
Structure and stability of mRNA synthesized by vaccinia virus-encoded bacteriophage T7 RNA polymerase in mammalian cells. Importance of the 5' untranslated leader.
Vaccinia
Studies on the conditions required for structural and functional maturation of rabies virus glycoprotein (G) in G cDNA-transfected cells.
Vaccinia
Synthesis and intracellular localization of vaccinia virus deoxyribonucleic acid-dependent ribonucleic acid polymerase.
Vaccinia
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Vaccinia
Targeted delivery of human neurofibromin and c-Raf-1 mutants to the cytoplasmic membrane by use of the influenza virus hemagglutinin.
Vaccinia
Technical challenges in the development of reverse genetics for a viral haemorrhagic septicaemia virus (VHSV) genotype Ib isolate: Alternative cell lines and general troubleshooting.
Vaccinia
Temperature-sensitive mutations in the vaccinia virus H4 gene encoding a component of the virion RNA polymerase.
Vaccinia
The A2L intermediate gene product is required for in vitro transcription from a vaccinia virus late promoter.
Vaccinia
The alphavirus replicase protein nsP1 is membrane-associated and has affinity to endocytic organelles.
Vaccinia
The cellular immune recognition of proteins expressed by an African swine fever virus random genomic library.
Vaccinia
The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins.
Vaccinia
The H gene of rodent brain-adapted measles virus confers neurovirulence to the Edmonston vaccine strain.
Vaccinia
The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA.
Vaccinia
The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template.
Vaccinia
Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes.
Vaccinia
Transcription inhibition and other properties of matrix proteins expressed by M genes cloned from measles viruses and diseased human brain tissue.
Vaccinia
Transcription of a vaccinia virus late promoter template: requirement for the product of the A2L intermediate-stage gene.
Vaccinia
Transcripts containing a small anti-HIV hammerhead ribozyme that are active in the cell cytoplasm but inactive in vitro as free RNAs.
Vaccinia
Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses.
Vaccinia
Transient Dominant Selection for the Modification and Generation of Recombinant Infectious Bronchitis Coronaviruses.
Vaccinia
Translation of the reovirus M1 gene initiates from the first AUG codon in both infected and transfected cells.
Vaccinia
Translational control of Scamper expression via a cell-specific internal ribosome entry site.
Vaccinia
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Vaccinia
Vaccinia virus A17L open reading frame encodes an essential component of nascent viral membranes that is required to initiate morphogenesis.
Vaccinia
Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex.
Vaccinia
Vaccinia virus gene D7R encodes a 20,000-dalton subunit of the viral DNA-dependent RNA polymerase.
Vaccinia
Vaccinia virus gene encoding a 30-kilodalton subunit of the viral DNA-dependent RNA polymerase.
Vaccinia
Vaccinia virus-bacteriophage T7 expression vector for complementation analysis of late gene processes.
Vaccinia
Viable double vaccinia virus recombinants with the non-inducible phage T7 expression system.
Vaccinia
Virus-specific cytotoxic T-lymphocyte activity elicited by coimmunization with human immunodeficiency virus type 1 genes regulated by the bacteriophage T7 promoter and T7 RNA polymerase protein.
Vaccinia
[Comparative study of the morphology and antigenic properties of recombinant analogs of a Marburg virus nucleoprotein]
Vaccinia
[Construction of minigenome of Newcastle disease virus of goose origin and its preliminary application]
Vasculitis, Central Nervous System
Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins.
Vesicular Stomatitis
Coupled in vitro transcription and translation of vesicular stomatitis virus messenger RNA.
Vesicular Stomatitis
Expression of the vesicular stomatitis virus nucleocapsid protein gene in Escherichia coli: analysis of its biological activity in vitro.
Vesicular Stomatitis
In vitro synthesis of messenger RNA by a defective interfering particle of vesicular stomatitis virus.
Vesicular Stomatitis
Multigene expression in vivo: Supremacy of large versus small terminators for T7 RNA polymerase.
Vesicular Stomatitis
Ribonucleic acid polymerase in virions of Newcastle disease virus: comparison with the vesicular stomatitis virus polymerase.
Vesicular Stomatitis
Ribonucleic acid polymerase induced in L-cells infected with vesicular stomatitis virus.
Vesicular Stomatitis
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
Vesicular Stomatitis
Viral ribonucleic acid polymerase: chick-embryo cells infected with vesicular stomatitis virus or Rous-associated virus.
Virus Diseases
A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.
Virus Diseases
alpha-Amanitin-Resistant Viral RNA Synthesis in Nuclei Isolated from Nuclear Polyhedrosis Virus-Infected Heliothis zea Larvae and Spodoptera frugiperda Cells.
Virus Diseases
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Virus Diseases
Disruption of Nuclear Organization during the Initial Phase of African Swine Fever Virus Infection.
Virus Diseases
Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation.
Virus Diseases
Extensive Cooperation of Immune Master Regulators IRF3 and NF?B in RNA Pol II Recruitment and Pause Release in Human Innate Antiviral Transcription.
Virus Diseases
From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor ? and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus.
Virus Diseases
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
Virus Diseases
Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.
Virus Diseases
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.
Virus Diseases
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.
Virus Diseases
Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription.
Virus Diseases
Inhibition of host cell RNA polymerase III-mediated transcription by poliovirus: inactivation of specific transcription factors.
Virus Diseases
Lytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression.
Virus Diseases
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.
Virus Diseases
Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila.
Virus Diseases
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Virus Diseases
Relationship between RNA polymerase II and efficiency of vaccinia virus replication.
Virus Diseases
RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells.
Virus Diseases
RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection.
Virus Diseases
RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences.
Virus Diseases
Simian virus 40 small-t does not transactivate RNA polymerase II promoters in virus infections.
Virus Diseases
Terminator-specific recycling of a B1-Alu transcription complex by RNA polymerase III is mediated by the RNA terminus-binding protein La.
Virus Diseases
[Effect of the attenuated strain (TC-83) of Venezuelan equine encephalitis virus on nuclear transcription in rat brain cells]
Vitamin A Deficiency
RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient mice.
Werner Syndrome
The transcriptional response to distinct growth factors is impaired in Werner syndrome cells.
Werner Syndrome
The Werner syndrome protein is involved in RNA polymerase II transcription.
Williams Syndrome
De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
Wilms Tumor
Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.
Wiskott-Aldrich Syndrome
Dissection of Pol II trigger loop function and Pol II activity-dependent control of start site selection in vivo.
Wiskott-Aldrich Syndrome
IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II.
Wiskott-Aldrich Syndrome
Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation.
Wiskott-Aldrich Syndrome
Regulation of an IMP dehydrogenase gene and its overexpression in drug-sensitive transcription elongation mutants of yeast.
Xeroderma Pigmentosum
Cisplatin induces cytoplasmic to nuclear translocation of nucleotide excision repair factors among spiral ganglion neurons.
Xeroderma Pigmentosum
Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay.
Xeroderma Pigmentosum
Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts.
Xeroderma Pigmentosum
Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells.
Xeroderma Pigmentosum
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
Xeroderma Pigmentosum
TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA.
Xeroderma Pigmentosum
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
Xeroderma Pigmentosum
Transcription-dependent and independent DNA excision repair pathways in human cells.
Xeroderma Pigmentosum
Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair.
Xeroderma Pigmentosum
Von Hippel-Lindau-Coupled and Transcription-Coupled Nucleotide Excision Repair-Dependent Degradation of RNA Polymerase II in Response to Trabectedin.
Zika Virus Infection
Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages.
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega. Promoter-specific transcription assays by recombinant Xcc core RNAP reconstituted with external added sigma factor show that the absence of omega debilitates the transcriptional activity of Xcc RNAP
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega. Promoter-specific transcription assays by recombinant Xcc core RNAP reconstituted with external added sigma factor show that the absence of omega debilitates the transcriptional activity of Xcc RNAP
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega. Promoter-specific transcription assays by recombinant Xcc core RNAP reconstituted with external added sigma factor show that the absence of omega debilitates the transcriptional activity of Xcc RNAP
additional information
recombinant Xcc core RNAP lacking omega shows a 13fold decrease in enzymatic activity in comparison with that containing omega. Promoter-specific transcription assays by recombinant Xcc core RNAP reconstituted with external added sigma factor show that the absence of omega debilitates the transcriptional activity of Xcc RNAP
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of C-terminally His-tagged alpha subunit-encoded by gene rpoA, and coexpression of the subunits of Xanthomonas campestris pv. campestris core RNAP from plasmid pBBad22K in Escherichia coli strain BL21(DE3), overexpression with or without omega
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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cheng, C.Y.; Yu, Y.J.; Yang, M.T.
Coexpression of omega subunit in E. coli is required for the maintenance of enzymatic activity of Xanthomonas campestris pv. campestris RNA polymerase
Protein Expr. Purif.
69
91-98
2010
Xanthomonas campestris (O08348), Xanthomonas campestris (P0A0Y1), Xanthomonas campestris (Q8PC55), Xanthomonas campestris (Q8PC56)
brenda
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Release 2023.1 (January 2023)
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