Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ADP + arsenate
AMP + phosphate + ?
-
-
-
?
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
ADP + phosphate
phosphate + ADP
NDP + arsenate
NMP + phosphate + ?
NDP + phosphate
phosphate + NDP
NDP + polyphosphate
polyphosphate + NDP
-
exchange reaction
-
r
NTP + N'DP
P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate
P1(5'-adenosyl)-P4(5'-cytosyl) tetraphosphate + phosphate
CDP + ATP
-
-
not CTP + ADP
?
P1(5'-adenosyl)-P4(5'-guanosyl) tetraphosphate + phosphate
GDP + ATP
-
-
-
r
P1,P2-bis(5'-adenosyl) diphosphate + phosphate
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
P1,P3-bis(5'-adenosyl) triphosphate with CF2-bridge between P1 and P2 + phosphate
?
P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1 and P2 + phosphate
?
P1,P3-bis(5'-adenosyl) triphosphate with CHF-bridge between P1 and P2 + phosphate
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
P1,P4-bis(5'-adenosyl) tetraphosphate + chromate
?
P1,P4-bis(5'-adenosyl) tetraphosphate + molybdate
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
?
-
involved in catabolism of dinucleoside polyphosphates
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ATP + ADP
P1,P4-bis(5'-adenosyl) tetraphosphate + tungstate
?
P1,P4-bis(5'-adenosyl) tetraphosphate + vanadate
?
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
ADP + ATP
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
adenosine tetraphosphate + ADP
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
guanosine tetraphosphate + GDP
106% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
p4G + GDP
P1,P5-bis(5'-guanosyl)pentaphosphate + phosphate
?
wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 95%, respectively
-
-
?
P1,P6-bis(5'-adenosyl) hexaphosphate + phosphate
adenosine pentaphosphate + ADP
25% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate
?
P1-(5'-adenosyl)-P4-(5'-deoxythymidyl) tetraphosphate + phosphate
ATP + dTDP
68% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + dTTP, major products
-
?
P1-(5'-adenosyl)-P5-(5'-deoxythymidyl) pentaphosphate + phosphate
p4A + dTDP
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + p4dT, major products
-
?
P1-(5'-adenosyl)-P5-(5'-guanosyl) pentaphosphate + phosphate
p4A + GDP
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) pentaphosphate + phosphate
p4A + dTDP
31% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + p4dT, major products
-
?
P1-(5'-adenosyl)P4-(5'-deoxythymidyl) tetraphosphate + phosphate
ATP + dTDP
85% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP + dTTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) pentaphosphate + phosphate
p4A + GDP
30% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
P1-(5'-adenosyl)P5-(5'-guanosyl) pentaphosphate + phosphate
adenosine tetraphosphate + GDP
76% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
additional information
?
-
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
-
r
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
r
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
-
r
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
-
r
ADP + ATP
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
-
-
-
r
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
-
-
-
?
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
-
-
-
?
ADP + ATP
phosphate + P1,P4-bis(5'-adenosyl)tetraphosphate
-
-
-
?
ADP + phosphate
phosphate + ADP
-
90% activity due to isoform I
-
r
ADP + phosphate
phosphate + ADP
-
ADP/phosphate exchange reaction
-
r
ADP + phosphate
phosphate + ADP
-
ADP/phosphate exchange reaction
-
r
NDP + arsenate
NMP + phosphate + ?
-
-
-
?
NDP + arsenate
NMP + phosphate + ?
-
-
-
?
NDP + phosphate
phosphate + NDP
-
-
-
r
NDP + phosphate
phosphate + NDP
-
exchange reaction between beta-phosphate of NDP and phosphate from the medium
-
r
NDP + phosphate
phosphate + NDP
-
enzyme performs the exchange reaction also with polyphosphates
-
r
NDP + phosphate
phosphate + NDP
-
90% activity due to isoform I
-
r
NTP + N'DP
P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate
-
asymmetric catalytic site: synthesis of Ap4G or Ap4C is much faster from ATP plus CDP or GDP than from CTP or GTP plus ADP
N is A or G, N' is A, C, G, U or dA
?
NTP + N'DP
P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate
-
N is A or G, not C, U or dA, and N' is A, C, G, U or dA
N is A or G, N' is A, C, G, U or dA
?
P1,P2-bis(5'-adenosyl) diphosphate + phosphate
?
-
no activity
-
-
?
P1,P2-bis(5'-adenosyl) diphosphate + phosphate
?
-
i.e. AP2A
-
-
?
P1,P2-bis(5'-adenosyl) diphosphate + phosphate
?
-
i.e. AP2A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
14% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
wild-type, 19% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 29%, respectively
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
2 ADP
26% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major product
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
preferred substrate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
19% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
19% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
no activity with
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
i.e. AP3A
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + phosphate
ADP
-
no activity with
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CF2-bridge between P1 and P2 + phosphate
?
-
low activity
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CF2-bridge between P1 and P2 + phosphate
?
-
ApCF2ppA, difluoromethylene group substituting the oxygen
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1 and P2 + phosphate
?
-
poor substrate
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1 and P2 + phosphate
?
-
i.e. ApCH2ppA, methylene group substituting the oxygen
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CHF-bridge between P1 and P2 + phosphate
?
-
low activity
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate with CHF-bridge between P1 and P2 + phosphate
?
-
i.e. ApCHFppA, fluoromethylene group substituting the oxygen
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
182% activity compared to phosphate
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
arsenolysis, at about 80% the rate of phosphorolysis
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
irreversible formation of reaction intermediate AMP-enzyme, unstable
-
-
ir
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + arsenate
?
-
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + chromate
?
-
poor substrate
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + chromate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + chromate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + molybdate
?
-
poor substrate
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + molybdate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + molybdate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
i.e. Ap4A or AppppA, substrate specificity
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
i.e. Ap4A or AppppA, substrate specificity
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
no formation of AMP observed
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
i.e. Ap4A or AppppA, substrate specificity
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
AMP-enzyme intermediate
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ATP + ADP
100% activity
-
-
ir
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
ATP + ADP
100% activity
-
-
ir
P1,P4-bis(5'-adenosyl) tetraphosphate + tungstate
?
-
no activity
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + tungstate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + vanadate
?
-
225% activity compared to phosphate
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + vanadate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate + vanadate
?
-
-
-
-
r
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
?
-
i.e. ApppCH2pA, methylene group substituting the oxygen
-
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate with CH2-bridge between P3 and P4 + phosphate
?
-
i.e. ApppCH2pA, methylene group substituting the oxygen
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
ADP + ATP
-
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
-
i.e. GP4G
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
53% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
56% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
-
arsenate can replace phosphate
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GDP + GTP
-
i.e. GP4G
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
107% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively
-
-
?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate
GTP + GDP
107% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
47% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
?
44% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
adenosine tetraphosphate + ADP
106% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
adenosine tetraphosphate + ADP
106% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
arsenate can replace phosphate
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
i.e. AP5A
-
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
arsenate can replace phosphate
-
?
P1,P5-bis(5'-adenosyl) pentaphosphate + phosphate
ADP + p4A
-
i.e. AP5A
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate
?
wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively
-
-
?
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate
?
wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively
-
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
p4G + GDP
55% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P5-bis(5'-guanosyl) pentaphosphate + phosphate
p4G + GDP
49% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
major products
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate
?
wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively
-
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate
?
wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
93% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
100% activity compared to P1,P4-bis(5'-adenosyl) tetraphosphate
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively
-
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate
ATP + GDP
80% of the activity with P1,P4-bis(5'-adenosyl) tetraphosphate
or ADP plus GTP, major products
-
?
additional information
?
-
-
enzyme splits the anhydride bond between the alpha and beta phosphates by phosphorolysis
-
-
?
additional information
?
-
-
no activity with P1,P3-bis(5'-adenosyl) triphosphate with CH2-bridge between P1and P2 and between P3 and P4, i.e. ApCH2pCH2pA
-
-
?
additional information
?
-
-
no activity with sulfate
-
-
?
additional information
?
-
-
P1,P6-bis(5'-adenosyl) hexaphosphate is a very poor substrate
-
-
?
additional information
?
-
-
no activity with sulfate
-
-
?
additional information
?
-
the enzyme shows no hydrolysis of AMP-NH2, and almost no activity with adenosine tetraphosphate, ATP, ADP-ribose, ADP-glucose, guanosine tetraphosphate, guanosine 5'-triphosphate, GDP-glucose, GDP-mannose, adenylyl imidodiphosphate, and guanylyl imidodiphosphate
-
-
?
additional information
?
-
the enzyme shows no hydrolysis of AMP-NH2, and almost no activity with adenosine tetraphosphate, ATP, ADP-ribose, ADP-glucose, guanosine tetraphosphate, guanosine 5'-triphosphate, GDP-glucose, GDP-mannose, adenylyl imidodiphosphate, and guanylyl imidodiphosphate
-
-
?
additional information
?
-
-
the enzyme shows no hydrolysis of AMP-NH2, and almost no activity with adenosine tetraphosphate, ATP, ADP-ribose, ADP-glucose, guanosine tetraphosphate, guanosine 5'-triphosphate, GDP-glucose, GDP-mannose, adenylyl imidodiphosphate, and guanylyl imidodiphosphate
-
-
?
additional information
?
-
-
broad substrate specificity
-
-
?
additional information
?
-
-
no substrates are phosphonate analogs of Ap4A
-
-
?
additional information
?
-
-
no substrates are 3'-adenosyltetraphosphate, poly(A), 3',5'-cAMP, NADP+, P1-bis(5'-adenosyl) monophosphate Ap2A, thymidine 5'-monophosphate-p-nitrophenylester
-
-
?
additional information
?
-
-
no activity with sulfate
-
-
?
additional information
?
-
-
no substrates are ADP, ATP, NAD+
-
-
?
additional information
?
-
-
no activity with sulfate
-
-
?
additional information
?
-
-
no activity with sulfate
-
-
?
additional information
?
-
-
no substrates are AMP, p-nitrophenylthymidine 5'-triphosphate, bis-p-nitrophenyl phosphate
-
-
?
additional information
?
-
-
no activity with sulfate
-
-
?
additional information
?
-
-
no substrates are ADP, ATP, NAD+
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(11aR,13S,14R,15S,15aR)-2,3,4,5,6,7-hexahydroxy-9,17-dioxo-9,11,11a,13,14,15,15a,17-octahydrodibenzo[g,i]pyrano[3,2-b][1,5]dioxacycloundecine-13,14,15-triyl tris(3,4,5-trihydroxybenzoate)
29.96% activity remaining
1,2,3,4,6-pentakis-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranose
35.81% activity remaining
1,2,3,6-tetrakis-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranose
47.50% activity remaining
10-(3,4-dimethoxyphenyl)-7,7-dimethyl-7,8,10,10a-tetrahydro-6H-indeno[1,2-b]quinoline-9,11-dione
24.76% activity remaining
2-(4-chlorobenzene-1-sulfonyl)-3-(methylsulfanyl)-3-[3-(trifluoromethyl)anilino]propanenitrile
1.59% activity remaining
2-(benzenesulfonyl)-3-(3-ethylanilino)-3-(methylsulfanyl)propanenitrile
-
2-(benzenesulfonyl)-3-(3-methoxyanilino)-3-(methylsulfanyl)propanenitrile
-
2-(benzenesulfonyl)-3-(3-methylanilino)-3-(methylsulfanyl)propanenitrile
-
2-(benzenesulfonyl)-3-(benzylsulfanyl)-3-[3-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-(ethylsulfanyl)-3-[3-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-(methylsulfanyl)-3-(3-nitroanilino)propanenitrile
-
2-(benzenesulfonyl)-3-(methylsulfanyl)-3-(3-propylanilino)propanenitrile
-
2-(benzenesulfonyl)-3-(methylsulfanyl)-3-[2-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-(methylsulfanyl)-3-[3-(propan-2-yl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-(methylsulfanyl)-3-[3-(trifluoromethyl)anilino]propanenitrile
docking structure
2-(benzenesulfonyl)-3-(methylsulfanyl)-3-[4-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-(propylsulfanyl)-3-[3-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-[(3,3-dimethylcyclohexa-1,5-dien-1-yl)amino]-3-(methylsulfanyl)propanenitrile
-
2-(benzenesulfonyl)-3-[(prop-2-en-1-yl)sulfanyl]-3-[3-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-[(propan-2-yl)sulfanyl]-3-[3-(trifluoromethyl)anilino]propanenitrile
-
2-(benzenesulfonyl)-3-[[3,3-bis(trifluoromethyl)cyclohexa-1,5-dien-1-yl]amino]-3-(methylsulfanyl)propanenitrile
-
2-amino-3-[(E)-([2-[(4-chlorophenyl)sulfanyl]phenyl]methylidene)amino]butanedinitrile
46.29% activity remaining
2-amino-4-(3,4-dimethoxyphenyl)-7-methyl-3-nitro-4H,5H-pyrano[4,3-b]pyran-5-one
48.50% activity remaining
2-amino-5-(4-ethoxyphenyl)-5,11-dihydro-3H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-4,6-dione
48.87% activity remaining
2-ethoxyethyl 4-(3-bromo-4-methoxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
31.80% activity remaining
2-iodo-5-[(4-methylphenyl)methyl]pyridin-3-ol
29.63% activity remaining
2-[(2-[[2-(3-fluoro-4-nitroanilino)-2-oxoethyl]sulfanyl]-1,3-benzothiazol-6-yl)carbamoyl]benzoic acid
43.56% activity remaining
2-[[6-amino-4-(2-chlorophenyl)-3,5-dicyanopyridin-2-yl]sulfanyl]-N-benzylacetamide
42.76% activity remaining
3-(3-chloro-4-hydroxy-5-methoxyphenyl)-2,3,6,7,8,9-hexahydro-5H-[1]benzothieno[2,3-d][1,3]thiazolo[3,2-a]pyrimidin-5-one
43.92% activity remaining
3-anilino-2-(4-chlorobenzene-1-sulfonyl)-3-(methylsulfanyl)propanenitrile
-
3-anilino-2-(benzenesulfonyl)-3-(methylsulfanyl)propanenitrile
-
3-[[2-(benzenesulfonyl)-2-cyano-1-(methylsulfanyl)ethyl]amino]benzonitrile
-
4-([[9-(3,4-dimethoxyphenyl)-8-oxo-4,5,6,7,8,9-hexahydro[1,2,4]triazolo[5,1-b]quinazolin-2-yl]sulfanyl]methyl)benzoic acid
33.53% activity remaining
5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-2,2',3,3'-tetrahydro-4H,4'H-[9,9'-binaphtho[2,3-b]pyran]-4,4'-dione
no activity remaining
5-(2,4-dichlorophenyl)-2-methyl-2,3,5,6-tetrahydro-4H-pyrano[2,3-a][4,7]phenanthrolin-4-one
42.23% activity remaining
7-(4-chlorophenyl)-1,7-dimethyl-N-[2-(morpholin-4-yl)ethyl]-9-oxo-8,9-dihydro-7H-furo[3,2-f][1]benzopyran-2-carboxamide
32.08% activity remaining
7-(4-fluorophenyl)-1,7-dimethyl-9-oxo-N-propyl-8,9-dihydro-7H-furo[3,2-f][1]benzopyran-2-carboxamide
48.72% activity remaining
7-(4-fluorophenyl)-1,7-dimethyl-N-[3-(morpholin-4-yl)propyl]-9-oxo-8,9-dihydro-7H-furo[3,2-f][1]benzopyran-2-carboxamide
47.73% activity remaining
AMP
-
ADP/phosphate-exchange
Ap3A
-
ADP/phosphate-exchange
Ca2+
-
weak, NDP-arsenolysis or NDP/phosphate-exchange reaction
Cd2+
-
only NDP-arsenolysis or NDP/phosphate-exchange reaction
Co2+
-
weak, NDP-arsenolysis or NDP/phosphate-exchange reaction
ethyl 4-[2,5-bis(sulfanylidene)-4,5-dihydro[1,3]thiazolo[4',5':4,5]pyrimido[1,6-a]benzimidazol-3(2H)-yl]benzoate
42.80% activity remaining
methyl 3-[[2-(benzenesulfonyl)-2-cyano-1-(methylsulfanyl)ethyl]amino]benzoate
-
methylsulfanylacrylonitril
-
-
Mn2+
-
weak, NDP-arsenolysis or NDP/phosphate-exchange reaction
p-hydroxymercuribenzoate
-
-
P1,P3-bis(5'-adenosyl) triphosphate with CCl2-bridge between P1 and P2
-
i.e. ApCCl2ppA
P1,P3-bis(5'-adenosyl) triphosphate with CHCl-bridge between P1 and P2
-
i.e. ApCHClppA
P1,P4-bis(5'-adenosyl) tetraphosphate
-
ADP/phosphate-exchange
[(5E)-5-[[2-(4-carbamoylpiperidin-1-yl)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
28.09% activity remaining
Mg2+
-
only NDP-arsenolysis or NDP/phosphate-exchange reaction
Mg2+
-
inhibitory in presence of phosphate for ADP/phosphate exchange reaction
additional information
inhibitor library screening, cytotoxicity analysis, overview
-
additional information
-
inhibitor library screening, cytotoxicity analysis, overview
-
additional information
-
no inhibition by F- or adenosine 5'-tetraphosphate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
McLennan, A.G.; Mayers, E.; Hankin, S.; Thorne, N.M.; Prescott, M.; Powls, R.
The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohyrolase and phosphorylase activities
Biochem. J.
300
183-189
1994
Chlorella vulgaris, Scenedesmus basiliensis, Tetradesmus obliquus, Scenedesmus quadricauda
brenda
Guranowski, A.; Biryukov, A.; Tarussova, N.B.; Khomutov, R.M.; Jakubowski, H.
Phosphonate analogues of diadenosine 5,5-P1,P4-tetraphosphate as substrates or inhibitors of procaryotic and eucaryotic enzymes degrading dinucleoside tetraphosphates
Biochemistry
26
3425-3429
1987
Saccharomyces cerevisiae
brenda
Guranowski, A.; Starzynska, E.; Gzik, L.; Langston, S.P.; Brown, P.; Blackburn, G.M.
Methylene and halomethylene analogues of diadenosine 5'5'''-P1,P3-triphosphate (ApppA) as substrates or inhibitors of ApppA-degrading enzymes
Nucleosides Nucleotides
14
731-734
1995
Acanthamoeba castellanii
-
brenda
Guranowski, A.; Blanquet, S.
Phosphorolytic cleavage of diadenosine 5,5-P1,P4-tetraphosphate. Properties of homogeneous diadenosine 5,5-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae
J. Biol. Chem.
260
3542-3547
1985
Saccharomyces cerevisiae
brenda
Brevet, A.; Coste, H.; Fromant, M.; Plateau, P.; Blanquet, S.
Yeast diadenosine 5,5-P1,P4-tetraphosphate alpha,beta-phosphorylase behaves as a dinucleoside tetraphosphate synthetase
Biochemistry
26
4763-4768
1987
Saccharomyces cerevisiae
brenda
Avila, D.M.; Kaushal, V.; Barnes, L.D.
Immunoaffinity chromatography of diadenosine 5,5-P1,P4-tetraphosphate phosphorylase from Saccharomyces cerevisiae
Biotechnol. Appl. Biochem.
12
276-283
1990
Saccharomyces cerevisiae, Saccharomyces cerevisiae CGY 339
brenda
Guranowski, A.; Blanquet, S.
Diadenosine 5,5-P1, P4-tetraphosphate alpha, beta-phosphorylase from yeast supports nucleoside diphosphate-phosphate exchange
J. Biol. Chem.
261
5943-5946
1986
Saccharomyces cerevisiae
brenda
Guranowski, A.; Starzynska, E.; Wasternack, C.
Specific phosphorylase from Euglena gracilis splits diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) and diadenosine 5',5'''-P1,P3-tetraphosphate (Ap3A)
Int. J. Biochem.
20
449-455
1988
Acanthamoeba castellanii, Euglena gracilis
brenda
Booth, J.W.; Guidotti, G.
An alleged yeast polyphosphate kinase is actually diadenosine-5', 5"'-P1,P4-tetraphosphate alpha,beta-phosphorylase
J. Biol. Chem.
270
19377-19382
1995
Saccharomyces cerevisiae
brenda
McLennan, A.G.; Mayers, E.; Adams, D.G.
Anabaena flos-aquae and other cyanobacteria possess diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase activity
Biochem. J.
320
795-800
1996
Dolichospermum flos-aquae, Trichormus variabilis, Synechococcus sp.
brenda
Mori, S.; Shibayama, K.; Wachino, J.; Arakawa, Y.
Purification and molecular characterization of a novel diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv
Protein Expr. Purif.
69
99-105
2010
Mycobacterium tuberculosis (P9WMK9), Mycobacterium tuberculosis H37Rv (P9WMK9), Mycobacterium tuberculosis H37Rv
brenda
Mori, S.; Shibayama, K.; Wachino, J.; Arakawa, Y.
Structural insights into the novel diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv
J. Mol. Biol.
410
93-104
2011
Mycobacterium tuberculosis (P9WMK9), Mycobacterium tuberculosis H37Rv (P9WMK9), Mycobacterium tuberculosis H37Rv
brenda
Mori, S.; Kim, H.; Rimbara, E.; Arakawa, Y.; Shibayama, K.
Roles of Ala-149 in the catalytic activity of diadenosine tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv
Biosci. Biotechnol. Biochem.
79
236-238
2015
Mycobacterium tuberculosis (P9WMK9), Mycobacterium tuberculosis H37Rv (P9WMK9)
brenda
Honda, N.; Kim, H.; Rimbara, E.; Kato, A.; Shibayama, K.; Mori, S.
Purification and functional characterization of diadenosine 5,5'-P(1),P(4)-tetraphosphate phosphorylases from Mycobacterium smegmatis and Mycobacterium avium
Protein Expr. Purif.
112
37-42
2015
Mycobacterium avium (A0A0H3A0T9), Mycobacterium avium, Mycolicibacterium smegmatis (A0QWG3), Mycolicibacterium smegmatis, Mycobacterium avium 104 (A0A0H3A0T9), Mycolicibacterium smegmatis ATCC 700084 (A0QWG3)
brenda
Goetz, K.H.; Hacker, S.M.; Mayer, D.; Duerig, J.N.; Stenger, S.; Marx, A.
Inhibitors of the diadenosine tetraphosphate phosphorylase Rv2613c of Mycobacterium tuberculosis
ACS Chem. Biol.
12
2682-2689
2017
Mycobacterium tuberculosis (P9WMK9), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WMK9), Mycobacterium tuberculosis H37Rv (P9WMK9)
brenda