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Information on EC 2.7.7.49 - RNA-directed DNA polymerase and Organism(s) Canis lupus familiaris and UniProt Accession Q6A548

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EC Tree
IUBMB Comments
Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.
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Canis lupus familiaris
UNIPROT: Q6A548
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Word Map
The taxonomic range for the selected organisms is: Canis lupus familiaris
The enzyme appears in selected viruses and cellular organisms
Synonyms
telomerase, reverse-transcriptase, telomerase reverse transcriptase, nucleoside reverse transcriptase, hiv-1 rt, hiv-1 reverse transcriptase, gag-pol, hiv reverse transcriptase, rna-dependent dna polymerase, telomerase catalytic subunit, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
telomerase reverse transcriptase
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TERT
catalytic subunit of telomerase
DNA nucleotidyltransferase (RNA-directed)
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MX162-RT
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MX65-RT
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nucleotidyltransferase, deoxyribonucleate, RNA-dependent
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P72
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reverse transcriptase
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revertase
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RNA revertase
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-
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RNA-dependent DNA polymerase
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RNA-instructed DNA polymerase
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RT
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telomerase catalytic subunit
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telomerase reverse transcriptase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.
CAS REGISTRY NUMBER
COMMENTARY hide
9068-38-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
deoxynucleoside triphosphate + DNAn
diphosphate + DNAn+1
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TERT_CANLF
1123
0
124825
Swiss-Prot
Mitochondrion (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Angelopoulou, K.; Zavlaris, M.; Papaioannou, N.; Vlemmas, I.
Canis familiaris telomerase reverse transcriptase undergoes alternative splicing
Mamm. Genome
19
647-653
2008
Canis lupus familiaris (Q6A548), Canis lupus familiaris
Manually annotated by BRENDA team