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Synonyms
rna polymerase, rna-binding protein, rna-dependent rna polymerase, rdrp, nonstructural protein, transcriptase, vp1 protein, pol iv, rna-dependent rna polymerases, ns5b polymerase,
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216.5 kDa protein
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inner layer protein VP1
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large structural protein
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M1 phosphoprotein
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nonstructural phosphoprotein
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nonstructural protein
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nonstructural protein 5B
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nucleocapsid phosphoprotein
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nucleotidyltransferase, ribonucleate, RNA-dependent
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Phage f2 replicase
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polymerase acidic protein
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polymerase basic 1 protein
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proteins, specific or class, lambda3, of reovirus
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proteins, specific or class, PB 1
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proteins, specific or class, PB 2
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replicase, phage f2
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ribonucleic acid replicase
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ribonucleic acid-dependent ribonucleate nucleotidyltransferase
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ribonucleic acid-dependent ribonucleic acid polymerase
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ribonucleic replicase
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ribonucleic synthetase
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RNA nucleotidyltransferase (RNA-directed)
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RNA transcriptase
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RNA-binding protein
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RNA-dependent ribonucleate nucleotidyltransferase
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RNA-dependent RNA polymerase
RNA-Dependent RNA Polymerase 2
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RNA-dependent RNA replicase
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RNA-directed RNA polymerase
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RNAdependent RNA polymerase
Q9LKP0
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additional information
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the RDR enzymes belong to the RDR family
RDR1
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RDR6
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RNA-dependent RNA polymerase
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RNA-dependent RNA polymerase
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additional information
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phase-distributed sRNAs are identified within the dsRNA-seq read-covered regions. sRNA sequences from Col-0 (GSM121455, GSM154336, and GSM154375) are mapped onto the sequence regions with two or more phase-distributed, RDRdependent sRNA loci
physiological function
Q9LKP0
RDR6 functions in trans-acting short interfering RNA, ta-siRNA, production. Positive regulators or effectors of SI and pistil development are regulated by ta-siRNAs, regulation, overview
physiological function
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small RNA deep sequencing reveals a functional role for RDR in promoting viral siRNA biogenesis through distinct mechanisms, overview. RDR1and RDR6 are also implicated in antiviral defense
physiological function
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the enzyme is required for the RNA-directed DNA methylation, dedicated to the methylation of target sequences, which include transposable elements, regulatory regions of several protein-coding genes, and 5S rRNA-encoding DNA arrays. Pol IV, RDR2, DRM2, and Pol V, actors of the RdDM, are required to maintain a transcriptional silencing of 5S RNA genes at chromosomes 4 and 5, regulation, overview
physiological function
isoform RDR6 is required for efficient hpRNA-induced RNA silencing in plants. Generation of wild-type and rdr6-11 Arabidopsis thaliana lines expressing green fluorescent protein and transformation with a green fluorescent protein-RNA interference construct leads to almost complete silencing of green fluorescent protein expression in the T1 generation of most green fluorescent protein-RNAi-transformed wild-type lines, whereas various levels of green fluorescent protein expression remain among the green fluorescent protein-RNAi-transformed rdr6-11 lines. Homozygous expression of green fluorescent protein-RNAi in the T3 generation is not sufficient to induce complete green fluorescent protein silencing in several rdr6-11 lines
physiological function
systematic analysis of susceptibility and small RNA formation in Arabidopsis mutants lacking combinations of RNA-dependent RNA polymerase isoforms and dicer-like proteins. The vast majority of turnip mosaic virus-derived small interfering RNAs are dependent on dicer-like protein isoform DCL4 and RNA polymerase isoform RDR1, although full antiviral defense also requires isoforms DCL2 and RDR6. DCL4 is sufficient for antiviral silencing in inoculated leaves, but isoforms DCL2 and DCL4 are both involved in silencing in systemic tissues. Basal levels of antiviral RNA silencing and siRNA biogenesis are detected in mutants lacking isoforms RDR1, RDR2, and RDR6, indicating an alternate route to form double-stranded RNA that does not depend on the three previously characterized RNA-dependent RNA polymerase proteins
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additional information
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evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
Q8H1K9
evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
Q9LKP0
evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
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evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
Q8H1K9
evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
additional information
Q9LKP0
evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases. Eukaryotic RNA-dependent RNA polymerases share the catalytic double psi barel domain, containing a signature metal-coordination motif, with the universally conserved beta-subunit of DNA-dependent RNA polymerase
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C768Y
Q9LKP0
a C-to-T missense mutation in the first exon, the naturally occuring mutant rdr6-11 of RDR6 shows simultaneously enhanced SI and stigma exsertion, without associated increases in SRK transcript levels, phenotype, overview. The mutant exhibits stochastic stigma exsertion, and the S-locus receptor kinase, SRK, gene further enhances pistil elongation and stigma exsertion in this mutant background, a process that requires SRK catalytic activity and correlates with SRK transcript levels. rdr6-11 mutant plants are fertile and produce full siliques. By contrast, self-pollination of rdr6-11::Sb stigmas results in very low numbers of seeds per silique, indicating that mutant stigmas maintain SI into late stages of flower development even upon prolonged pollen-stigma contact
additional information
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construction of dr2 knockout mutant plants, rdr2-1, showing reduced asymmetric 5S rDNA methylation at chromosomes 4 and 5 compared to the wild-type enzyme
additional information
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construction of rdr1 and rdr6 mutants, that exhibit globally reduced levels of viral small RNA production as well as reduced strand bias in viral small RNA population, revealing an important role for these host RDRs in viral siRNA biogenesis, analysis of Tobacco Mosaic Virus small RNA profile in Arabidopsis thaliana wild-type plants as well as rdr mutants rdr1-1 and rdr6-15 by applying small RNA deep sequencing technology, overview
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Iyer, L.M.; Koonin, E.V.; Aravind, L.
Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases
BMC Struct. Biol.
3
1-23
2003
Arabidopsis thaliana, Arabidopsis thaliana (O82504), Arabidopsis thaliana (Q8H1K9), Arabidopsis thaliana (Q9LKP0), Caenorhabditis elegans, Neurospora crassa, Neurospora crassa (Q9Y7G6), Oryza sativa, Oryza sativa (Q8LHH9), Schizosaccharomyces pombe (O14227), Diaporthe perjuncta (Q8TGV4), Phomopsis sp. (Q8X1C2), Giardia intestinalis (Q95WU3), Dictyostelium discoideum (Q95ZG6), Dictyostelium discoideum (Q95ZG7), Diaporthe ambigua (Q9Q9R1), Solanum lycopersicum (Q9ZR58), Nicotiana tabacum (Q9ZRY7)
brenda
Tantikanjana, T.; Rizvi, N.; Nasrallah, M.E.; Nasrallah, J.B.
A dual role for the S-locus receptor kinase in self-incompatibility and pistil development revealed by an Arabidopsis rdr6 mutation
Plant Cell
21
2642-2654
2009
Arabidopsis thaliana (Q9LKP0), Arabidopsis thaliana
brenda
Douet, J.; Tutois, S.; Tourmente, S.
A Pol V-mediated silencing, independent of RNA-directed DNA methylation, applies to 5S rDNA
PLoS Genet.
5
e1000690
2009
Arabidopsis thaliana
brenda
Qi, X.; Bao, F.S.; Xie, Z.
Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis
PLoS ONE
4
e4971
2009
Arabidopsis thaliana
brenda
Harmoko, R.; Fanata, W.; Yoo, J.; Ko, K.; Rim, Y.; Uddin, M.; Siswoyo, T.; Lee, S.; Kim, D.; Lee, S.; Lee, K.
RNA-dependent RNA polymerase 6 is required for efficient hpRNA-induced gene silencing in plants
Mol. Cells
35
202-209
2013
Arabidopsis thaliana (Q9SG02), Arabidopsis thaliana
brenda
Garcia-Ruiz, H.; Takeda, A.; Chapman, E.J.; Sullivan, C.M.; Fahlgren, N.; Brempelis, K.J.; Carrington, J.C.
Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection
Plant Cell
22
481-496
2010
Arabidopsis thaliana (Q9LQV2), Arabidopsis thaliana (Q9SG02), Arabidopsis thaliana
brenda
Xu, T.; Zhang, L.; Zhen, J.; Fan, Y.; Zhang, C.; Wang, L.
Expressional and regulatory characterization of Arabidopsis RNA-dependent RNA polymerase 1
Planta
237
1561-1569
2013
Arabidopsis thaliana (Q9LQV2)
brenda
Qin, J.; Ma, X.; Yi, Z.; Tang, Z.; Meng, Y.
Intronic regions of plant genes potentially encode RDR (RNA-dependent RNA polymerase)-dependent small RNAs
J. Exp. Bot.
66
1763-1768
2015
Arabidopsis thaliana, Arabidopsis thaliana Col-0
brenda