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Information on EC 2.7.7.48 - RNA-directed RNA polymerase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9LQV2

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EC Tree
IUBMB Comments
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9LQV2
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
rna polymerase, rna-binding protein, rna-dependent rna polymerase, rdrp, nonstructural protein, transcriptase, vp1 protein, pol iv, rna-dependent rna polymerases, ns5b polymerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
111 kDa protein
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-
-
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180 kDa protein
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-
-
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182 kDa protein
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-
-
-
183 kDa protein
-
-
-
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186 kDa protein
-
-
-
-
216.5 kDa protein
-
-
-
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2A protein
-
-
-
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3D pol
-
-
-
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3D polymerase
-
-
-
-
69.6 kDa protein
-
-
-
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core protein
-
-
-
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core protein VP1
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-
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inner layer protein VP1
-
-
-
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L protein
-
-
-
-
large structural protein
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-
-
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M1 phosphoprotein
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-
-
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NIB
-
-
-
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nonstructural phosphoprotein
-
-
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nonstructural protein
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-
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nonstructural protein 5B
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-
-
-
NS5B
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-
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NS5B protein
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-
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nucleocapsid phosphoprotein
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-
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nucleotidyltransferase, ribonucleate, RNA-dependent
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-
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ORF1
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-
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ORF1A
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-
-
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ORF1B
-
-
-
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P protein
-
-
-
-
P180
-
-
-
-
P3D
-
-
-
-
P66
-
-
-
-
P70
-
-
-
-
P88 protein
-
-
-
-
PB1
-
-
-
-
PB1 proteins
-
-
-
-
PB2
-
-
-
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PB2 proteins
-
-
-
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Phage f2 replicase
-
-
-
-
Pol
-
-
-
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polymerase acidic protein
-
-
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polymerase basic 1 protein
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-
-
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polymerase L
-
-
-
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proteins PB1
-
-
-
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proteins, PB 2
-
-
-
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proteins, specific or class, lambda3, of reovirus
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-
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proteins, specific or class, PB 1
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-
-
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proteins, specific or class, PB 2
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-
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Q-beta replicase
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-
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Qbeta replicase
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-
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Qbeta-replicase
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-
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RDRP
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-
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replicase, phage f2
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-
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replicase, Qbeta
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ribonucleic acid replicase
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ribonucleic acid-dependent ribonucleate nucleotidyltransferase
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ribonucleic acid-dependent ribonucleic acid polymerase
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ribonucleic replicase
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ribonucleic synthetase
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RNA nucleotidyltransferase (RNA-directed)
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RNA replicase
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RNA synthetase
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RNA transcriptase
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RNA-binding protein
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RNA-dependent ribonucleate nucleotidyltransferase
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RNA-dependent RNA polymerase
RNA-Dependent RNA Polymerase 2
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RNA-dependent RNA replicase
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-
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RNA-directed RNA polymerase
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-
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RNAdependent RNA polymerase
Q9LKP0
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sigma NS protein
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transcriptase
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VP1
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-
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VP1 protein
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-
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additional information
-
the RDR enzymes belong to the RDR family
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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-
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-
SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-28-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
nucleoside triphosphate + RNAn
diphosphate + RNAn+1
show the reaction diagram
O82504, Q8H1K9, Q9LKP0
-
-
?
nucleoside triphosphate + RNAn
diphosphate + RNAn+1
show the reaction diagram
O82504, Q8H1K9, Q9LKP0
-
-
?
additional information
?
-
-
introns called mirtrons and sirtrons might serve as the single-stranded RNA precursors for the generation of microRNA and small interfering RNA (siRNA), respectively, through an RDR (RNA-dependent RNA polymerase)-dependent pathway. sRNA high-throughput sequencing in wild-type and RDR-deficient mutant plants, overview
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform RDR1
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression is specifically localized in phloem cell layers in roots
Manually annotated by BRENDA team
primarily expressed
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
additional information
-
phase-distributed sRNAs are identified within the dsRNA-seq read-covered regions. sRNA sequences from Col-0 (GSM121455, GSM154336, and GSM154375) are mapped onto the sequence regions with two or more phase-distributed, RDRdependent sRNA loci
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RDR1_ARATH
1107
0
126214
Swiss-Prot
other Location (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C768Y
Q9LKP0
a C-to-T missense mutation in the first exon, the naturally occuring mutant rdr6-11 of RDR6 shows simultaneously enhanced SI and stigma exsertion, without associated increases in SRK transcript levels, phenotype, overview. The mutant exhibits stochastic stigma exsertion, and the S-locus receptor kinase, SRK, gene further enhances pistil elongation and stigma exsertion in this mutant background, a process that requires SRK catalytic activity and correlates with SRK transcript levels. rdr6-11 mutant plants are fertile and produce full siliques. By contrast, self-pollination of rdr6-11::Sb stigmas results in very low numbers of seeds per silique, indicating that mutant stigmas maintain SI into late stages of flower development even upon prolonged pollen-stigma contact
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis of hundreds of intronic regions encoding three or more RNA-dependent RNA polymerase-dependent sRNAs that are covered by dsRNA-seq (double-stranded RNA sequencing) reads, indicating that the intron-derived sRNAs are indeed generate from long double-stranded RNA precursors
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gene dr2, RT-PCR expression analysis
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the isoform RDR1 promoter has a broad-spectrum response to various stresses and is sensitive to 1-naphthaleneacetic acid, abscisic acid, and salicylic acid
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Iyer, L.M.; Koonin, E.V.; Aravind, L.
Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases
BMC Struct. Biol.
3
1-23
2003
Arabidopsis thaliana, Arabidopsis thaliana (O82504), Arabidopsis thaliana (Q8H1K9), Arabidopsis thaliana (Q9LKP0), Caenorhabditis elegans, Neurospora crassa, Neurospora crassa (Q9Y7G6), Oryza sativa, Oryza sativa (Q8LHH9), Schizosaccharomyces pombe (O14227), Diaporthe perjuncta (Q8TGV4), Phomopsis sp. (Q8X1C2), Giardia intestinalis (Q95WU3), Dictyostelium discoideum (Q95ZG6), Dictyostelium discoideum (Q95ZG7), Diaporthe ambigua (Q9Q9R1), Solanum lycopersicum (Q9ZR58), Nicotiana tabacum (Q9ZRY7)
Manually annotated by BRENDA team
Tantikanjana, T.; Rizvi, N.; Nasrallah, M.E.; Nasrallah, J.B.
A dual role for the S-locus receptor kinase in self-incompatibility and pistil development revealed by an Arabidopsis rdr6 mutation
Plant Cell
21
2642-2654
2009
Arabidopsis thaliana (Q9LKP0), Arabidopsis thaliana
Manually annotated by BRENDA team
Douet, J.; Tutois, S.; Tourmente, S.
A Pol V-mediated silencing, independent of RNA-directed DNA methylation, applies to 5S rDNA
PLoS Genet.
5
e1000690
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Qi, X.; Bao, F.S.; Xie, Z.
Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis
PLoS ONE
4
e4971
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Harmoko, R.; Fanata, W.; Yoo, J.; Ko, K.; Rim, Y.; Uddin, M.; Siswoyo, T.; Lee, S.; Kim, D.; Lee, S.; Lee, K.
RNA-dependent RNA polymerase 6 is required for efficient hpRNA-induced gene silencing in plants
Mol. Cells
35
202-209
2013
Arabidopsis thaliana (Q9SG02), Arabidopsis thaliana
Manually annotated by BRENDA team
Garcia-Ruiz, H.; Takeda, A.; Chapman, E.J.; Sullivan, C.M.; Fahlgren, N.; Brempelis, K.J.; Carrington, J.C.
Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection
Plant Cell
22
481-496
2010
Arabidopsis thaliana (Q9LQV2), Arabidopsis thaliana (Q9SG02), Arabidopsis thaliana
Manually annotated by BRENDA team
Xu, T.; Zhang, L.; Zhen, J.; Fan, Y.; Zhang, C.; Wang, L.
Expressional and regulatory characterization of Arabidopsis RNA-dependent RNA polymerase 1
Planta
237
1561-1569
2013
Arabidopsis thaliana (Q9LQV2)
Manually annotated by BRENDA team
Qin, J.; Ma, X.; Yi, Z.; Tang, Z.; Meng, Y.
Intronic regions of plant genes potentially encode RDR (RNA-dependent RNA polymerase)-dependent small RNAs
J. Exp. Bot.
66
1763-1768
2015
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Manually annotated by BRENDA team