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Information on EC 2.7.7.48 - RNA-directed RNA polymerase and Organism(s) Human respiratory syncytial virus A and UniProt Accession P28887

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EC Tree
IUBMB Comments
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
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This record set is specific for:
Human respiratory syncytial virus A
UNIPROT: P28887
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Word Map
The taxonomic range for the selected organisms is: Human respiratory syncytial virus A
The enzyme appears in selected viruses and cellular organisms
Synonyms
rna polymerase, rna-binding protein, rna-dependent rna polymerase, rdrp, nonstructural protein, transcriptase, vp1 protein, pol iv, rna-dependent rna polymerases, ns5b polymerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
RNA-directed RNA polymerase L
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111 kDa protein
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-
-
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180 kDa protein
-
-
-
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182 kDa protein
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-
-
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183 kDa protein
-
-
-
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186 kDa protein
-
-
-
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216.5 kDa protein
-
-
-
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2A protein
-
-
-
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3D pol
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-
-
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3D polymerase
-
-
-
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69.6 kDa protein
-
-
-
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core protein
-
-
-
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core protein VP1
-
-
-
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inner layer protein VP1
-
-
-
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L protein
-
-
-
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large structural protein
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-
-
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M1 phosphoprotein
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-
-
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NIB
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-
-
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nonstructural phosphoprotein
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-
-
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nonstructural protein
-
-
-
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nonstructural protein 5B
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-
-
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NS5B
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-
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NS5B protein
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-
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nucleocapsid phosphoprotein
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-
-
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nucleotidyltransferase, ribonucleate, RNA-dependent
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-
-
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ORF1
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-
-
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ORF1A
-
-
-
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ORF1B
-
-
-
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P protein
-
-
-
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P180
-
-
-
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P3D
-
-
-
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P66
-
-
-
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P70
-
-
-
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P88 protein
-
-
-
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PB1
-
-
-
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PB1 proteins
-
-
-
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PB2
-
-
-
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PB2 proteins
-
-
-
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Phage f2 replicase
-
-
-
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Pol
-
-
-
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polymerase acidic protein
-
-
-
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polymerase basic 1 protein
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-
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polymerase L
-
-
-
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proteins PB1
-
-
-
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proteins, PB 2
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-
-
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proteins, specific or class, lambda3, of reovirus
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-
-
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proteins, specific or class, PB 1
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-
-
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proteins, specific or class, PB 2
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-
-
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Q-beta replicase
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-
-
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Qbeta replicase
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-
-
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Qbeta-replicase
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-
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RDRP
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-
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replicase, phage f2
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-
-
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replicase, Qbeta
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ribonucleic acid replicase
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-
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ribonucleic acid-dependent ribonucleate nucleotidyltransferase
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-
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ribonucleic acid-dependent ribonucleic acid polymerase
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ribonucleic replicase
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ribonucleic synthetase
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RNA nucleotidyltransferase (RNA-directed)
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-
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RNA replicase
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-
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RNA synthetase
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RNA transcriptase
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RNA-binding protein
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-
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RNA-dependent ribonucleate nucleotidyltransferase
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-
-
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RNA-dependent RNA polymerase
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-
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RNA-dependent RNA replicase
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-
-
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RNA-directed RNA polymerase
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-
-
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sigma NS protein
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-
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transcriptase
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-
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VP1
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-
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VP1 protein
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-28-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + RNAn
diphosphate + RNAn+1
show the reaction diagram
-
-
-
ir
remdesivir triphosphate + RNAn
diphosphate + RNAn 3'-remdesivir
show the reaction diagram
-
-
-
ir
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
remdesivir triphosphate
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00003 - 0.00017
ATP
0.00001 - 0.0005
remdesivir triphosphate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gordon,C.J.; Tchesnokov,E.P.; Woolner, E.; Perry, J.K.; Feng,J.Y.; Porter, D.P.; Gtte, M.
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
J. Biol. Chem.
295
6785-6797
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2, Human respiratory syncytial virus A (P28887), Human respiratory syncytial virus A A2 (P28887)
Manually annotated by BRENDA team
Tchesnokov, E.P.; Feng, J.Y.; Porter,D.P.; Gtte, D.
Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir
Viruses
11
326
2019
Zaire ebolavirus (A0A068J9B1), Human respiratory syncytial virus A (P28887), Human respiratory syncytial virus A A2 (P28887)
Manually annotated by BRENDA team