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Information on EC 2.7.7.46 - gentamicin 2''-nucleotidyltransferase

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IUBMB Comments
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
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The enzyme appears in viruses and cellular organisms
Synonyms
ant(2'')-i, aminoglycoside adenylyltransferase, aminoglycoside nucleotidyltransferase 2''-i, gentamicin nucleotidyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin
show the reaction diagram
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic
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