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Information on EC 2.7.7.41 - phosphatidate cytidylyltransferase and Organism(s) Drosophila melanogaster and UniProt Accession P56079

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This record set is specific for:
Drosophila melanogaster
UNIPROT: P56079 not found.
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
cdp-diacylglycerol synthase, cdp-dg, phosphatidate cytidylyltransferase, tam41, cdp-dag synthase, tamm41, ctp:phosphatidate cytidylyltransferase, cdp-diglyceride synthetase, cdp-dg synthase, tbcds, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CDP-diacylglycerol synthase
-
CDP-diacylglycerol synthetase
-
CDP-DAG synthase
CDP-DG
-
-
-
-
CDP-DG synthetase
-
-
-
-
CDP-diacylglyceride synthetase
-
-
-
-
CDP-diacylglycerol synthase
CDP-diglyceride pyrophosphorylase
-
-
-
-
CDP-diglyceride synthetase
-
-
-
-
CDPdiglyceride pyrophosphorylase
-
-
-
-
CTP-diacylglycerol synthetase
-
-
-
-
CTP:1,2-diacylglycerophosphate-cytidyl transferase
-
-
-
-
CTP:phosphatidate cytidylyltransferase
-
-
-
-
cytidine diphosphoglyceride pyrophosphorylase
-
-
-
-
cytidylyltransferase, phosphatidate
-
-
-
-
DAG synthetase
-
-
-
-
phosphatidate cytidyltransferase
-
-
-
-
phosphatidic acid cytidylyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
CTP:phosphatidate cytidylyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9067-83-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
show the reaction diagram
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
show the reaction diagram
-
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high enzyme content
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
integral membrane protein
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
the enzyme diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol synthesis and coordinates cell growth and fat storage. Enzyme CdsA coordinates cell/tissue growth and lipid storage through the insulin pathway. The enzyme is important for the phototransduction pathway. CdsA regulates salivary gland fat storage and cell size
metabolism
-
the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CDS_DROME
447
7
51511
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, Y.; Wang, W.; Shui, G.; Huang, X.
CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway
PLoS Genet.
10
e1004172
2014
Drosophila melanogaster, Drosophila melanogaster (P56079)
Manually annotated by BRENDA team
Blunsom, N.J.; Cockcroft, S.
CDP-diacylglycerol synthases (CDS) gateway to phosphatidylinositol and cardiolipin synthesis
Front. Cell Dev. Biol.
8
63
2020
Aeropyrum pernix, Saccharomyces cerevisiae, Drosophila melanogaster, Schizosaccharomyces pombe, Streptococcus mitis, Streptococcus oralis, Thermotoga maritima, Toxoplasma gondii, Trypanosoma brucei brucei, Eimeria falciformis, Arabidopsis thaliana (O04928), Arabidopsis thaliana (O49639), Arabidopsis thaliana (Q1PE48), Arabidopsis thaliana (Q94A03), Arabidopsis thaliana (Q9M001), Escherichia coli (P0ABG1), Danio rerio (Q3B7H2), Homo sapiens (Q92903), Homo sapiens (Q95674)
Manually annotated by BRENDA team
Laurinyecz, B.; Peter, M.; Vedelek, V.; Kovacs, A.L.; Juhasz, G.; Maroy, P.; Vigh, L.; Balogh, G.; Sinka, R.
Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila
Open Biology
6
50169
2016
Drosophila melanogaster (P56079)
Manually annotated by BRENDA team