Information on EC - sulfate adenylyltransferase

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
       sulfate adenylyltransferase
IUBMB Comments
The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC and adenylyl-sulfate kinase (EC
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The enzyme appears in viruses and cellular organisms
3'-phospho-adenosine-5'-phosphosulphate synthase, 3'-phosphoadenosine-5'-phosphosulfate synthase, AcATPS1, adenosine 5'-triphosphate sulphurylase, adenosine 5'-triphosphate-sulfurylase, adenosine triphosphate sulfurylase, adenosine triphosphate sulphurylase, adenosine triphosphate-sulphurylase, adenosine-5'-triphosphate sulfurylase, adenosinetriphosphate sulfurylase, more
ATP + sulfate = diphosphate + adenylyl sulfate
show the reaction diagram