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Information on EC 2.7.7.33 - glucose-1-phosphate cytidylyltransferase
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EC Tree
2.7.7.33 glucose-1-phosphate cytidylyltransferaseSpecify your search results
Word Map
- 2.7.7.33
- pyrophosphate
-
ping-pong
-
nucleotidylyltransferases
-
hexamer
- typhi
- pseudotuberculosis
-
thymidylyltransferase
- enterica
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
glucose-1-phosphate cytidylyltransferase, alpha-d-glucose-1-phosphate cytidylyltransferase, cdp-d-glucose synthase, cytidine diphosphate glucose pyrophosphorylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha-D-glucose-1-phosphate cytidylyltransferase
CDP-D-glucose synthase
CDP-glucose pyrophosphorylase
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-
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CDPglucose pyrophosphorylase
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cytidine diphosphate glucose pyrophosphorylase
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cytidine diphosphate-D-glucose pyrophosphorylase
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cytidine diphosphoglucose pyrophosphorylase
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cytidylyltransferase, glucose 1-phosphate
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alpha-D-glucose-1-phosphate cytidylyltransferase
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alpha-D-glucose-1-phosphate cytidylyltransferase
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CDP-D-glucose synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
nucleotidyl group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9027-10-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + alpha-D-xylose 1-phosphate
diphosphate + CDPxylose
-
poor substrate
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
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the structure of the enzyme with bound MgCTP reveals that the binding pocket for the nucleotide is contained within one subunit rather than shared between two. Key side chains involved in nucleotide binding include Thr14, Arg15, Lys25, and Arg111
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-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
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-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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highly specific
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: ATP, GTP
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: dATP, dGTP, dCTP, D-ribitol 5-phosphate, L-glycerol 3-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: GDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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highly specific
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: ATP, GTP
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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best substrates
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-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: dTTP, alpha-D-galactose 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: ATP, GTP
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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catalyzes bimolecular group transfer reaction
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: UDPgalactose, UDP-D-mannose, UDP-N-acetyl-D-glucosamine, dTDP-L-rhamnose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: D-ribose 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the reverse reaction: CDPparatose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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specific for base and sugar
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: GTP and D-mannose 1-phosphate
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrates in the reverse reaction: GDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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specific for CTP and alpha-D-glucose 1-phosphate
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-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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specific for CTP and alpha-D-glucose 1-phosphate
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-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: ATP, GTP
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-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDPglucose
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no substrate in the forward reaction: TTP
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?
CTP + D-glucosamine 1-phosphate
diphosphate + CDPglucosamine
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reaction at about 25% the rate with glucose 1-phosphate
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?
CTP + D-glucosamine 1-phosphate
diphosphate + CDPglucosamine
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reaction at about 15% the rate with glucose 1-phosphate
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?
CTP + D-glucose 1-phosphate
?
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first of five enzymes committed to CDP-D-abequose biosynthesis
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r
CTP + D-glucose 1-phosphate
?
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branch-point in glucose 1-phosphate anabolism
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r
CTP + D-glucose 1-phosphate
?
first step in biosynthesis of CDP-ascarylose
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r
diphosphate + CDP-glucose
CTP + alpha-D-glucose 1-phosphate
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?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
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poor substrate
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?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-glucose
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-
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-glucose
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-
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?
CTP + D-glucose 1-phosphate
?
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first of five enzymes committed to CDP-D-abequose biosynthesis
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r
CTP + D-glucose 1-phosphate
?
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branch-point in glucose 1-phosphate anabolism
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r
CTP + D-glucose 1-phosphate
?
first step in biosynthesis of CDP-ascarylose
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r
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
additional information
Co2+
with decreasing order of efficiency: Co2+, Mn2+, Mg2+, mixture of Mn2+ and Mg2+
Co2+
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with decreasing order of efficiency in CDPglucose synthesis: Co2+, Mn2+, Mg2+ can replace Mg2+ in diphosphorolysis
Mg2+
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maximal reaction rates at molar ratios of MgCl2:diphosphate or MgCl2:CTP of 2:1
Mg2+
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optimal concentration: 3 mM MgCl2
Mg2+
with decreasing order of efficiency: Co2+, Mn2+, Mg2+, mixture of Mn2+ and Mg2+
Mg2+
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with decreasing order of efficiency in CDPglucose synthesis: Co2+, Mn2+, Mg2+
Mn2+
with decreasing order of efficiency: Co2+, Mn2+, Mg2+, mixture of Mn2+ and Mg2+
Mn2+
-
with decreasing order of efficiency in CDPglucose synthesis: Co2+, Mn2+, Mg2+, less effective in diphosphorolysis
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
CDP-ascarylose
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synonym: 3,6-dideoxy-L-mannose, strong, kinetics
CDPparatose
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synonym: 3,6-dideoxy-D-glucose, feed-back inhibition, CDPglucose partially reverses, maximal inhibition at 0.6 mM
CDPglucose
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product inhibition, competitive with respect to CTP, kinetics
CDPglucose
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product inhibition, competitive with respect to CTP, kinetics
additional information
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little or no inhibition by CDPethanolamine, CDPcholine, dTTPglucose, UDP-D-glucosamine, dCTP, dCDP, dTMP, dAMP, dGMP, dCMP, dTDP-L-rhamnose, dTDP-4-amino-4,6-dideoxy-D-glucose and its N-acetyl-derivative, UDP-D-galactose, UDP-D-glucuronic acid, UDP-N-acetyl-D-glucosamine, GDP-D-mannose, D-glucose 6-phosphate, D-glucose 1,6-diphosphate, D-galactose 1-phosphate, D-glucosamine 1-phosphate, D-mannose 1-phosphate, N-acetyl-D-glucosamine 1-phosphate, D-fructose 6-phosphate, D-fructose 1,6-diphosphate, D-ribitol 5-phosphate, L-glycerol 3-phosphate, phosphoenolpyruvate, pyruvate, ADP, AMP, GMP, UMP, beta-NAD+ or beta-NADP+; little or no inhibition by CMP, GDPglucose, UDPglucose, dTDPglucose
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additional information
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little or no inhibition by CMP, GDPglucose, UDPglucose, dTDPglucose; no inhibition by NaF, diphosphatase, 2-mercaptoethanol, paratose, CTP
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no activation by dTDP-L-rhamnose, dTDP-4-amino-4,6-dideoxy-D-glucose and its N-acetyl-derivative, UDP-D-galactose, UDP-D-glucuronic acid, UDP-N-acetyl-D-glucosamine, GDP-D-mannose, D-glucose 6-phosphate, D-glucose 1,6-diphosphate, D-galactose 1-phosphate, D-glucosamine 1-phosphate, D-mannose 1-phosphate, N-acetyl-D-glucosamine 1-phosphate, D-fructose 6-phosphate, D-fructose 1,6-diphosphate, D-ribitol 5-phosphate, L-glycerol 3-phosphate, phosphoenolpyruvate, pyruvate, ADP, AMP, GMP, UMP, beta-NAD+ or beta-NADP+
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Yersinia pseudotuberculosis Infections
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexosis. IX. Purification and properties of the cytidine diphosphate-D-glucose pyrophosphorylase from Pasteurella pseudotuberculosis. type V.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.09
alpha-D-glucose 1-phosphate
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pH 8, 37°C
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.2 - 9.5
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about half-maximal activity at pH 6.2 and about 70% of maximal activity at pH 9.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). RFBF_SALTY
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
257
0
29035
Swiss-Prot
-
A0A174FXA6_9FIRM
235
0
26428
TrEMBL
-
A0A3T2YKQ7_SALET
257
0
29023
TrEMBL
-
Q5LC63_BACFN
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)
258
0
29280
TrEMBL
-
A0A0K3B7D9_9PSEU
263
0
29565
TrEMBL
-
A0A8B2XHM6_9FIRM
256
0
29243
TrEMBL
-
A0A345DC25_9BURK
257
0
29164
TrEMBL
-
Q63N76_BURPS
Burkholderia pseudomallei (strain K96243)
258
0
29432
TrEMBL
-
A0A2H1XJ57_LEPIR
255
0
28893
TrEMBL
-
A0A5C6BYI2_9BACT
319
0
35991
TrEMBL
-
A0A6I3QRT8_9FIRM
258
0
29628
TrEMBL
-
A0A5E5QTQ3_9GAMM
57
0
6227
TrEMBL
-