Any feedback?
Information on EC 2.7.7.30 - fucose-1-phosphate guanylyltransferase
for references in articles please use BRENDA:EC2.7.7.30Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.7.7.30 fucose-1-phosphate guanylyltransferaseSpecify your search results
Word Map
- 2.7.7.30
-
fucosylated
-
salvage
- glycans
- glycolipids
-
fucosyltransferase
- monosaccharide
- synthesis
- gdp-beta-l-fucose
- fragilis
- polysaccharides
-
nucleotide-sugars
-
bacteroides
-
lewis
-
n-linked
- gdp-d-mannose
- xyloglucans
-
fucose-containing
-
sialyl
- glycoconjugates
-
rhamnogalacturonan-ii
-
boric
-
photoaffinity
-
pectic
-
chemoenzymatic
-
alpha1,3
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
gdp-l-fucose pyrophosphorylase, atfkgp, gdp-l-fuc pyrophosphorylase, gdp-fucose pyrophosphorylase, l-fucokinase/gdp-fucose pyrophosphorylase, gtp fucose pyrophosphorylase (gfpp), gdp-l-fucose-synthesizing enzymes, gdp-l-fucose pyrophosphorylase (fpgt), 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AtFKGP
-
bifunctional enzyme with L-fucokinase and GDP-L-Fuc pyrophosphorylase
FKP
GDP-fucose pyrophosphorylase
GDP-L-Fuc pyrophosphorylase
GDP-L-fucose pyrophosphorylase
GDP-L-fucose-synthesizing enzymes
GDPfucose pyrophosphorylase
-
-
-
-
GFPP
guanosine diphosphate L-fucose pyrophosphorylase
-
-
-
-
FKP
-
bifunctional enzyme with fucokinase and GDP-L-fucose pyrophosphorylase activities
FKP
-
bifunctional enzyme with L-fucokinase and GDP-fucose pyrophosphorylase activities
FKP
-
bifunctional enzyme with L-fucokinase and guanosine 5'-diphosphate-L-fucose pyrophosphorylase activities
FKP
-
bifunctional enzyme with L-fucokinase and GDP-fucose pyrophosphorylase activities
-
GDP-fucose pyrophosphorylase
-
-
-
-
GDP-L-fucose pyrophosphorylase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
nucleotidyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
GTP:beta-L-fucose-1-phosphate guanylyltransferase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9033-14-1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-amino-6-chloropurine-beta-D-riboside 5'-triphosphate + L-fucose 1-phosphate
diphosphate + 2-amino-6-chloropurine-beta-D-riboside 5'-(alpha-L-fucosyl)diphosphate
-
-
-
-
?
2-aminoadenosine triphosphate + L-fucose 1-phosphate
diphosphate + (2-aminoadenosine diphosphate)-L-fucose
-
-
-
-
?
7-deazaguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (7-deazaguanosine diphosphate)-L-fucose
-
-
-
-
?
8-oxoguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (8-oxoguanosine diphosphate)-L-fucose
-
-
-
-
?
GTP + 6,7-dideoxy-beta-L-galacto-hept-6-enopyranose 1-phosphate
GDP-6,7-dideoxy-beta-L-galacto-hept-6-enopyranose + diphosphate
-
-
-
-
?
GTP + 6-azido-6-deoxy-beta-L-galactopyranose 1-phosphate
GDP-6-azido-6-deoxy-beta-L-galactopyranose + diphosphate
-
-
-
-
?
GTP + 6-deoxy-6-fluoro-beta-L-galactopyranose 1-phosphate
GDP-6-deoxy-6-fluoro-beta-L-galactopyranose + diphosphate
-
-
-
-
?
GTP + 6-O-methyl-beta-L-galactopyranose 1-phosphate
GDP-6-O-methyl-beta-L-galactopyranose + diphosphate
-
-
-
-
?
GTP + alpha-D-(5-cyano)arabinopyranose 1-phosphate
GDP-alpha-D-(5-cyano)arabinopyranose + diphosphate
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannopyranose
-
17.5% of activity with GDP-L-fucose
-
?
GTP + beta-L-galactopyranose 1-phosphate
GDP-beta-L-galactopyranose + diphosphate
-
-
-
-
?
GTP + D-arabinose 1-phosphate
GDP-D-arabinopyranoside + diphosphate
-
5-10% of activity with L-fucose
-
?
N1-methylguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (N1-methylguanosine diphosphate)-L-fucose
-
-
-
-
?
N2-methylguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (N2-methylguanosine diphosphate)-L-fucose
-
-
-
-
?
O6-methylguanosine triphosphate + L-fucose 1-phosphate
diphosphate + (O6-methylguanosine diphosphate)-L-fucose
-
-
-
-
?
tricyclic guanosine triphosphate + L-fucose 1-phosphate
diphosphate + (tricyclic guanosine diphosphate)-L-fucose
-
-
-
-
?
UTP + L-fucose 1-phosphate
diphosphate + UDP-L-fucose
-
18.7% of activity with GTP
-
?
xanthosine triphosphate + L-fucose 1-phosphate
diphosphate + (xanthosine diphosphate)-L-fucose
-
-
-
-
?
ATP + L-fucose 1-phosphate
diphosphate + ADP-L-fucose
-
approx. 50% of activity with
-
?
GTP + alpha-D-arabinopyranose 1-phosphate
GDP-alpha-D-arabinopyranose + diphosphate
-
-
-
-
?
GTP + alpha-D-arabinopyranose 1-phosphate
GDP-alpha-D-arabinopyranose + diphosphate
-
-
-
?
GTP + alpha-D-arabinopyranose 1-phosphate
GDP-alpha-D-arabinopyranose + diphosphate
-
-
-
?
GTP + beta-L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
-
-
-
?
GTP + beta-L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
-
-
-
r
GTP + beta-L-fucose 1-phosphate
GDP-L-fucose + diphosphate
-
-
-
?
GTP + beta-L-fucose 1-phosphate
GDP-L-fucose + diphosphate
-
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
the monosaccharide L-fucose is found as a constituent of cell wall polysaccharides and sugar moieties of glycoproteins and has important physiological functions in seed plants
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
strict substrate specificity, no activity with L-Ara-1-P, Gal-1-P, Glc-1-P, Man-1-P, Xyl-1-P, GlcA-1-P, and Glc-NAc-1-P as glycosyl donor, and it uses specifically GTP as the nucleotide donor
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
the enzyme is involved in the salvage pathway of GDP-L-fucose
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
specific for GTP
-
r
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
pathway of fucose production, an important component of complex heterooligosaccharides
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + beta-L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
-
-
-
?
GTP + beta-L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
-
-
-
r
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
the monosaccharide L-fucose is found as a constituent of cell wall polysaccharides and sugar moieties of glycoproteins and has important physiological functions in seed plants
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
the enzyme is involved in the salvage pathway of GDP-L-fucose
-
-
?
GTP + L-fucose 1-phosphate
diphosphate + GDP-L-fucose
-
pathway of fucose production, an important component of complex heterooligosaccharides
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
additional information
Mg2+
-
maximum activity at 4 mM. No activity can be detected when the Mg2+ concentration is below 1 nM
Mn2+
-
has only a poor effect on the GDP-L-Fuc pyrophosphorylase activity of rAtFKGP compared with Mg2+
additional information
-
requires the presence of divalent metal cations at the active site
additional information
-
K+, Mn2+, Co2+, Ca2+, Cu2+, Zn2+, Ni2+, Hg2+, and Fe2+ have little effect on the enzyme activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
diphosphate
-
addition of diphosphate strongly inhibits the formation of GDP-L-Fuc by rAtFKGPi
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Neoplasms
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.8
ATP
pH not specified in the publication, temperature not specified in the publication
0.2
GTP
pH not specified in the publication, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.22
ATP
pH not specified in the publication, temperature not specified in the publication
1.55
GTP
pH not specified in the publication, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.5
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 9.5
-
approx. 85% of maximal activity at pH 6.0, approx. 70% of maximal activity at pH 9.5
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE