Reference on EC 2.7.7.3 - pantetheine-phosphate adenylyltransferase
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Brohn, F.H.; Trager, W.
Coenzyme A requirement of malaria parasites: enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae
Proc. Natl. Acad. Sci. USA
72
2456-2458
1975
Anas sp., no activity in Plasmodium lophurae
Nishimura, N.; Kakimoto, T.; Chibata, I.
Mechanism of coenzyme A biosynthesis by Sarcina lutea
J. Ferment. Technol.
61
95-99
1983
Micrococcus luteus
-
Hoagland, M.B.; Novelli, G.D.
Biosynthesis of coenzyme A from phosphopantetheine from pantothenate
J. Biol. Chem.
207
767-773
1954
Columba sp., Rattus norvegicus, Sus scrofa
Novelli, G.D.
Enzymatic synthesis and structure of CoA
Fed. Proc.
12
675-681
1953
Columba sp., Sus scrofa
Abiko, Y.
Pantothenic acid and coenzyme A: dephospho-CoA pyrophosphorylase and dephospho-CoA kinase as a possible bifunctional enzyme complex (ATP: pantetheine-4'-phosphate adenylyltransferase, ec 2.7.7.3 and ATP: dehospho-CoA 3'phosphotransferase, ec 2.7.1.24)
Methods Enzymol.
18A
358-364
1970
Rattus norvegicus
-
Worrall, D.M.; Tubbs, P.K.
A bifunctional enzyme complex in coenzyme A biosynthesis: purification of pantetheine phosphate adenylyltransferase and dephospho-CoA kinase
Biochem. J.
215
153-157
1983
Rattus norvegicus, Sus scrofa
Worrall, D.M.; Lambert, S.F.; Tubbs, P.K.
Limited proteolysis of pig liver CoA synthase: evidence for subunit identity
FEBS Lett.
187
277-279
1985
Rattus norvegicus, Sus scrofa
Skrede, S.; Halvorsen, O.
Mitochondrial biosynthesis of coenzyme A
Biochem. Biophys. Res. Commun.
91
1536-1542
1979
Rattus norvegicus
Skrede, S.; Halvorsen, O.
Mitochondrial pantetheinephosphate adenylyltransferase and dephospho-CoA kinase
Eur. J. Biochem.
131
57-63
1983
Rattus norvegicus
Martin, D.P.; Drueckhammer, D.G.
Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase
Biochem. Biophys. Res. Commun.
192
1155-1161
1993
Corynebacterium ammoniagenes
Zhao, L.; Allanson, N.M.; Thomson, S.P.; Maclean, J.K.F.; Barker, J.J.; Primrose, W.U.; Tyler, P.D.; Lewendon, A.
Inhibitors of phosphopantetheine adenylyltransferase
Eur. J. Med. Chem.
38
345-349
2003
Escherichia coli, Sus scrofa
Izard, T.
A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A
J. Bacteriol.
185
4074-4080
2003
Escherichia coli (P0A6I6)
Izard, T.
The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism
J. Mol. Biol.
315
487-495
2002
Escherichia coli (P0A6I6), Escherichia coli
Geerlof, A.; Lewendon, A.; Shaw, W.V.
Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli
J. Biol. Chem.
274
27105-27111
1999
Escherichia coli
Eom, S.J.; Ahn, H.J.; Kim, H.W.; Baek, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic studies of phosphopantetheine adenylyltransferase from Helicobacter pylori
Acta Crystallogr. Sect. D
59
561-562
2003
Helicobacter pylori
Aghajanian, S.; Worrall, D.M.
Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)
Biochem. J.
365
13-18
2002
Homo sapiens (Q13057), Homo sapiens, Sus scrofa (Q8MIR4), Sus scrofa
Armengaud, J.; Fernandez, B.; Chaumont, V.; Rollin-Genetet, F.; Finet, S.; Marchetti, C.; Myllykallio, H.; Vidaud, C.; Pellequer, J.L.; Gribaldo, S.; Forterre, P.; Gans, P.
Identification, purification, and characterization of an eukaryotic-like phosphopantetheine adenylyltransferase (coenzyme A biosynthetic pathway) in the hyperthermophilic archaeon Pyrococcus abyssi
J. Biol. Chem.
278
31078-31087
2003
Pyrococcus abyssi
Brown, K.L.; Morris, V.K.; Izard, T.
Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase
Acta Crystallogr. Sect. D
60
195-196
2004
Mycobacterium tuberculosis, Mycobacterium tuberculosis Rv2965c
Takahashi, H.; Inagaki, E.; Fujimoto, Y.; Kuroishi, C.; Nodake, Y.; Nakamura, Y.; Arisaka, F.; Yutani, K.; Kuramitsu, S.; Yokoyama, S.; Yamamoto, M.; Miyano, M.; Tahirov, T.H.
Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus
Acta Crystallogr. Sect. D
60
97-104
2004
Escherichia coli, Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Nalezkova, M.; de Groot, A.; Graf, M.; Gans, P.; Blanchard, L.
Overexpression and purification of Pyrococcus abyssi phosphopantetheine adenylyltransferase from an optimized synthetic gene for NMR studies
Protein Expr. Purif.
39
296-306
2005
Pyrococcus abyssi (Q9UYT0), Pyrococcus abyssi
Morris, V.K.; Izard, T.
Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase
Protein Sci.
13
2547-2552
2004
Mycobacterium tuberculosis
Kang, J.Y.; Lee, H.H.; Yoon, H.J.; Kim, H.S.; Suh, S.W.
Overexpression, crystallization and preliminary X-ray crystallographic analysis of phosphopantetheine adenylyltransferase from Enterococcus faecalis
Acta Crystallogr. Sect. F
62
1131-1133
2006
Enterococcus faecalis
Miller, J.R.; Ohren, J.; Sarver, R.W.; Mueller, W.T.; de Dreu, P.; Case, H.; Thanabal, V.
Phosphopantetheine adenylyltransferase from Escherichia coli: Investigation of the kinetic mechanism and role in regulation of CoA biosynthesis
J. Bacteriol.
189
8196-8205
2007
Escherichia coli
Rubio, S.; Whitehead, L.; Larson, T.R.; Graham, I.A.; Rodriguez, P.L.
The coenzyme a biosynthetic enzyme phosphopantetheine adenylyltransferase plays a crucial role in plant growth, salt/osmotic stress resistance, and seed lipid storage
Plant Physiol.
148
546-556
2008
Arabidopsis thaliana
Lee, H.H.; Yoon, H.J.; Kang, J.Y.; Park, J.H.; Kim, d.o..J.; Choi, K.H.; Lee, S.K.; Song, J.; Kim, H.J.; Suh, S.W.
The structure of Staphylococcus aureusphosphopantetheine adenylyltransferase in complex with 3-phosphoadenosine 5-phosphosulfate reveals a new ligand-binding mode
Acta Crystallogr. Sect. F
65
987-991
2009
Staphylococcus aureus (P63819), Staphylococcus aureus
Timofeev, V.; Smirnova, E.; Chupova, L.; Esipov, R.; Kuranova, I.
X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction
Acta Crystallogr. Sect. D
68
1660-1670
2012
Mycobacterium tuberculosis (P9WPA5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA5)
Edwards, T.E.; Leibly, D.J.; Bhandari, J.; Statnekov, J.B.; Phan, I.; Dieterich, S.H.; Abendroth, J.; Staker, B.L.; Van Voorhis, W.C.; Myler, P.J.; Stewart, L.J.
Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei
Acta Crystallogr. Sect. F
67
1032-1037
2011
Burkholderia pseudomallei (Q3JW91), Burkholderia pseudomallei
Wubben, T.; Mesecar, A.D.
Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation
Acta Crystallogr. Sect. F
67
541-545
2011
Mycobacterium tuberculosis
Cheng, C.S.; Chen, C.H.; Luo, Y.C.; Chen, W.T.; Chang, S.Y.; Lyu, P.C.; Kao, M.C.; Yin, H.S.
Crystal structure and biophysical characterisation of Helicobacter pylori phosphopantetheine adenylyltransferase
Biochem. Biophys. Res. Commun.
408
356-361
2011
Helicobacter pylori (O26010), Helicobacter pylori
Cheng, C.S.; Chen, W.T.; Chen, Y.W.; Chen, C.H.; Luo, Y.C.; Lyu, P.C.; Yin, H.S.
Substitution of asparagine 76 by a tyrosine residue induces domain swapping in Helicobacter pylori phosphopantetheine adenylyltransferase
J. Biomol. Struct. Dyn.
30
488-502
2012
Helicobacter pylori
Wubben, T.J.; Mesecar, A.D.
Kinetic, thermodynamic, and structural insight into the mechanism of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis
J. Mol. Biol.
404
202-219
2010
Mycobacterium tuberculosis (P9WPA5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA5)
Yoon, H.J.; Kang, J.Y.; Mikami, B.; Lee, H.H.; Suh, S.W.
Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine
Mol. Cells
32
431-435
2011
Enterococcus faecalis
de Jonge, B.L.; Walkup, G.K.; Lahiri, S.D.; Huynh, H.; Neckermann, G.; Utley, L.; Nash, T.J.; Brock, J.; San Martin, M.; Kutschke, A.; Johnstone, M.; Laganas, V.; Hajec, L.; Gu, R.F.; Ni, H.; Chen, B.; Hutchings, K.; Holt, E.; McKinney, D.; Gao, N.; Livchak, S.; Thresher, J.
Discovery of inhibitors of 4-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy
Antimicrob. Agents Chemother.
57
6005-6015
2013
Enterococcus faecium, Staphylococcus aureus, Streptococcus pyogenes, Candida albicans (B9WCR8), Escherichia coli (P0A6I6), Haemophilus influenzae (P44805), Homo sapiens (Q06203), Streptococcus pneumoniae (Q8DNE6), Streptococcus mutans (Q8DVH2), Enterococcus faecium ARC521, Streptococcus pyogenes ARC838, Haemophilus influenzae KW20 (P44805), Streptococcus mutans UA159 (Q8DVH2), Staphylococcus aureus RN4220
Chatterjee, R.; Mondal, A.; Basu, A.; Datta, S.
Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa
Biochim. Biophys. Acta
1864
773-786
2016
Pseudomonas aeruginosa (Q9I6D1), Pseudomonas aeruginosa
Timofeev, V.; Chupova, L.; Esipov, R.; Kuranova, I.
Crystallization and preliminary X-ray diffraction study of phosphopantetheine adenylyltransferase from M. tuberculosis crystallizing in space group P3_2
Crystallogr. Rep.
60
682-684
2015
Mycobacterium tuberculosis (P9WPA5)
-
Cheng, C.S.; Jia, K.F.; Chen, T.; Chang, S.Y.; Lin, M.S.; Yin, H.S.
Experimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screening
PLoS ONE
8
e74271
2013
Helicobacter pylori (O26010), Helicobacter pylori
Gupta, A.; Singh, P.K.; Iqbal, N.; Sharma, P.; Baraigya, H.R.; Kaur, P.; Umar, M.S.; Ahmad, F.; Sharma, A.; Owais, M.; Sharma, S.; Singh, T.P.
Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii
Biochim. Biophys. Acta
1867
537-547
2019
Acinetobacter baumannii (B0VTH7), Acinetobacter baumannii, Acinetobacter baumannii SDF (B0VTH7)
Podshivalov, D.; Timofeev, V.; Sidorov-Biryukov, D.; Kuranova, I.
Virtual screening of selective inhibitors of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis
Crystallogr. Rep.
62
405-410
2017
Mycobacterium tuberculosis (P9WPA5), Mycobacterium tuberculosis H37Rv (P9WPA5)
-
Timofeev, V.; Zhukhlistova, N.; Kuranova, I.
Crystal packing of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in two crystal modifications
Crystallogr. Rep.
65
84-90
2020
Mycobacterium tuberculosis, Mycobacterium tuberculosis BT1
-
Gupta, A.; Singh, P.K.; Sharma, P.; Kaur, P.; Sharma, S.; Singh, T.P.
Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A
Int. J. Biol. Macromol.
142
181-190
2020
Acinetobacter baumannii (B0VTH7), Acinetobacter baumannii, Acinetobacter baumannii SDF (B0VTH7)
Wang, Y.; Feng, S.; Gao, H.; Wang, J.
Computational investigations of gram-negative bacteria phosphopantetheine adenylyltransferase inhibitors using 3D-QSAR, molecular docking and molecular dynamic simulations
J. Biomol. Struct. Dyn.
38
1435-1447
2020
Escherichia coli (P0A6I6)
Moreau, R.J.; Skepper, C.K.; Appleton, B.A.; Blechschmidt, A.; Balibar, C.J.; Benton, B.M.; Drumm, J.E.; Feng, B.Y.; Geng, M.; Li, C.; Lindvall, M.K.; Lingel, A.; Lu, Y.; Mamo, M.; Mergo, W.; Polyakov, V.; Smith, T.M.; Takeoka, K.; Uehara, K.; Wang, L.; Wei, J.R.; Weiss, A.H.; Xie, L.; Xu, W.; Zhang, Q.; de Vicente, J.
Fragment-based drug discovery of inhibitors of phosphopantetheine adenylyltransferase from Gram-negative bacteria
J. Med. Chem.
61
3309-3324
2018
Escherichia coli (P0A6I6), Escherichia coli, Pseudomonas aeruginosa (Q9I6D1), Pseudomonas aeruginosa
Skepper, C.K.; Moreau, R.J.; Appleton, B.A.; Benton, B.M.; Drumm, J.E.; Feng, B.Y.; Geng, M.; Hu, C.; Li, C.; Lingel, A.; Lu, Y.; Mamo, M.; Mergo, W.; Mostafavi, M.; Rath, C.M.; Steffek, M.; Takeoka, K.T.; Uehara, K.; Wang, L.; Wei, J.R.; Xie, L.; Xu, W.; Zhang, Q.; de Vicente, J.
Discovery and optimization of phosphopantetheine adenylyltransferase inhibitors with Gram-negative antibacterial activity
J. Med. Chem.
61
3325-3349
2018
Escherichia coli (P0A6I6), Pseudomonas aeruginosa (Q9I6D1)
Mondal, A.; Chatterjee, R.; Datta, S.
Umbrella sampling and X-ray crystallographic analysis unveil an Arg-Asp gate facilitating inhibitor binding inside phosphopantetheine adenylyltransferase allosteric cleft
J. Phys. Chem. B
122
1551-1559
2018
Pseudomonas aeruginosa (A0A0X1KGP2), Pseudomonas aeruginosa, Pseudomonas aeruginosa 2192 (A0A0X1KGP2)
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