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Enzyme Nomenclature
Information on EC 2.7.7.28 - nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
2.7.7.28
-
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RECOMMENDED NAME
GeneOntology No.
nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
nucleoside triphosphate + alpha-D-aldose 1-phosphate = diphosphate + NDP-hexose
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase
In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.
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CAS REGISTRY NUMBER
COMMENTARY
37278-26-5
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADPmannose + diphosphate
ATP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
UDPglucose + diphosphate
UTP + D-glucose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
UDPmannose + diphosphate
UTP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
GDP-glucose + diphosphate
GTP + D-glucose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
r
GDPmannose + diphosphate
GTP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
GDPmannose + diphosphate
GTP + D-mannose 1-phosphate
-
reaction at about half the rate of GDPglucose
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-
-
IDP-glucose + diphosphate
ITP + D-glucose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
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-
-
IDP-glucose + diphosphate
ITP + D-glucose 1-phosphate
-
reaction at 21% the rate of GDPglucose
-
r
IDPmannose + diphosphate
ITP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
r
IDPmannose + diphosphate
ITP + D-mannose 1-phosphate
-
reaction at 7% the rate of GDPglucose
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-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADPmannose + diphosphate
ATP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
UDPglucose + diphosphate
UTP + D-glucose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
UDPmannose + diphosphate
UTP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
GDP-glucose + diphosphate
GTP + D-glucose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
r
GDPmannose + diphosphate
GTP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
GDPmannose + diphosphate
GTP + D-mannose 1-phosphate
-
reaction at about half the rate of GDPglucose
-
-
-
IDP-glucose + diphosphate
ITP + D-glucose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
-
IDP-glucose + diphosphate
ITP + D-glucose 1-phosphate
-
reaction at 21% the rate of GDPglucose
-
r
IDPmannose + diphosphate
ITP + D-mannose 1-phosphate
-
the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose
-
-
r
IDPmannose + diphosphate
ITP + D-mannose 1-phosphate
-
reaction at 7% the rate of GDPglucose
-
-
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mg2+
-
requirement, maximal activity at about 5 mM, maximal activity at about twice the diphosphate-concentration
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 9
6.5 - 9
-
pH 6.5: about 40% of maximal activity, pH 9.0: about half-maximal activity
6.5 - 9
-
pH 6.5: about 40% of maximal activity, pH 9.0: about half-maximal activity
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.7.7.28)
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